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Zulfiayu Sapiun
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
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Uji Mutu Fisik dan Penetapan Kadar Magnesium Hidroksida pada Tablet Kunyah Antasida dengan Nomor Batch Berbeda Puji Laili Rahmaningrum; Sony Andika Saputra
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.462

Abstract

Antasida merupakan obat penetral asam lambung yang digunakan untuk membantu mengatasi gangguan pencernaan penderita gastritis. Uji mutu fisik dan penetapan kadar dijadikan parameter untuk mengetahui mutu suatu obat. Penelitian ini bertujuan untuk memastikan mutu fisik dan kadar magnesium hidroksida pada obat antasida bermerek dengan nomor batch berbeda sesuai dengan spesifikasi. Uji mutu fisik yang dilakukan meliputi uji keseragaman ukuran, keseragaman bobot, kerapuhan, dan kekerasan tablet, sedangkan metode yang digunakan pada penetapan kadar magnesium hidroksida adalah spektrofotometri UV-Vis dengan pengompleks Eriochrome Black Tea (EBT). Hasil uji mutu fisik telah memenuhi persyaratan yang ditetapkan Farmakope Indonesia Edisi III dan non Farmakope. Hasil optimasi penentuan panjang gelombang maksimum dan operating time didapatkan pada 408 nm dengan operating time stabil pada menit ke 5-15. Hasil dari penetapan kadar pada masing-masing sampel uji diperoleh rerata sebesar 94,844% dan 98,282%. Kadar tersebut memenuhi persyaratan pada Farmakope Indonesia Edisi VI. Hasil uji statistik Independent T-Test dengan  = 0,05 menunjukkan tidak ada perbedaan yang signifikan.Antacids are stomach acid-neutralizing drugs that are used to help treat digestive disorders in gastritis sufferers. Physical quality tests and assays are used as parameters to determine the quality of a drug. This study aims to ensure the physical quality and levels of magnesium hydroxide in branded antacid drugs with different batch numbers according to specifications. Physical quality tests carried out included tests for size uniformity, weight uniformity, friability, and tablet hardness, while the method used to determine magnesium hydroxide levels was UV-Vis spectrophotometry with Eriochrome Black Tea (EBT) complex. The results of the physical quality test have met the requirements set by the Indonesian Pharmacopoeia Edition III and non-Pharmacopoeia. Optimization results for determining the maximum wavelength and operating time were obtained at 408 nm with a stable operating time of 5–15 minutes. The results of the assay in each test sample obtained an average of 94.844% and 98.282%, respectively. These levels meet the requirements of the Indonesian Pharmacopoeia, Edition VI. Independent T-Test statistical test results with α = 0.05 showed no significant difference.
Isolasi dan Aktivitas Antibakteri Fungi Endofit Daun Miana (Coleus scutellarioides (L.) Benth) terhadap Propionibacterium acne dan Pseudomonas aeruginosa Novita Novita; Sesilia Rante Pakadang; Arisanty Arisanty
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.537

Abstract

Daun miana (Coleus scutellarioides (L.) Benth) mempunyai banyak jenis khasiat yang difungsikan menjadi obat, penurunan demam, batuk, influenza, penetralisir racun, antiseptik maupun yang lainnya. Bagian tanaman yang difungsikan menjadi obat yaitu bagian daun. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri isolat fungi endofit daun pada Propionibacterium acne dan Pseudomonas aeruginosa, jenis penelitian yang digunakan adalah eksperimental. Adapun metode pengujian dari penelitian yang dilakukan dengan berupa isolasi dan pemurnian fungi endofit dari daun miana, identifikasi fungi daun miana penghasil bakteri, pengujian diameter zona hambat fungi endofit daun miana terhadap P. acne dan P. aeruginosa dengan metode difusi menggunakan teknik sumuran. Hasil penelitian diperoleh 4 isolat yang digunakan Mukor sp, (putih), Aspergillius niger (hitam), Aspergillius fumigatus (hijau), Rhzipus sp, (abu-abu). Isolat fungi endofit dari daun miana memiliki aktivitas antibakteri pada pertumbuhan P. acne dan P. aeruginosa.Miana leaves (Coleus scutellarioides (L.) Benth) have many types of properties that are used as medicine, including reducing fever, cough, influenza, neutralizing poisons, antiseptics, and others. The part of the plant that is used as medicine is the leaf. The purpose of this study was to determine the antibacterial activity of leaf endophytic fungal isolates on Propionibacterium acne and Pseudomonas aeruginosa. The type of research used was experimental. The testing methods of the research were isolation and purification of endophytic fungi from miana leaves, identification of miana leaf fungi-producing bacteria, and testing the diameter of the inhibition zone of miana leaf endophytic fungi against P. acne and P. aeruginosa by diffusion method using the well technique. The results obtained were four isolates: Mukor sp. (white), Aspergillius niger (black), Aspergillius fumigatus (green), and Rhzipus sp. (gray). Endophytic fungi isolated from miana leaves have antibacterial activity against the growth of P. acne and P. aeruginosa.
Analisis Kemoterapi pada Pasien Tn. “AM” dengan Acute Lymphoblastic Leukaemia (ALL) disertai HIV Positif dan Hepatitis B Hartati Hartati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.617

Abstract

Leukemia Limfoblastik Akut (ALL/LLA) adalah proliferasi ganas sel limfoid yang tersumbat pada tahap awal diferensiasi yang dapat menyerang sumsum tulang, darah, dan situs ekstrameduler. Penatalaksanaan leukemia meliputi terapi kuratif dan suportif. Studi kasus ini bertujuan untuk memperoleh gambaran tentang regimen kemoterapi pasien ALL yang disertai Hepatitis B Kronik dan HIV positif. Pengumpulan data menggunakan desain deskriptif dengan metode wawancara serta observasi langsung kondisi pasien dan e-rekam medik, e-resep yang dikaji kesesuaiannya berdasarkan protokol kemoterapi. Berdasarkan sequencing regimen kemoterapi diperoleh bahwa pasien menerima regimen Hyper CVAD dengan nilotinib, dimana penilaian resiko Chemotherapy Induced Nausea Vomiting diperoleh bahwa protokol kemoterapi yang diterima termasuk dalam kategori Moderate Emetogenic. Regimen ini juga disertai dengan pemberian Methotrexate dosis tinggi sebagai profilaksis CNS. Akan tetapi, untuk mengurangi resiko nefrotoksisitas akibat pemberian Methotrexate dosis tinggi, maka diperlukan tambahan natrium bikarbonat dan allopurinol untuk mencegah TLS pada pasien dengan ALL.Acute Lymphoblastic Leukaemia (ALL) is a malignant proliferation of lymphoid cells that are occlude at an early stage of differentiation and can invade the bone marrow, blood, and extramedullary sites. Management of leukemia includes curative and supportive therapy. This case study aims to obtain an overview of the chemotherapy regimen of ALL patients with chronic hepatitis B and HIV. Data were collected in a descriptive design with interview methods and direct observation of patient conditions and e-medical records. E-prescriptions were reviewed for suitability based on chemotherapy protocols. Based on the chemotherapy regimen sequencing, it was found that the patient received the hyper-CVAD regimen with nilotinib, while the chemotherapy-induced nausea and Vomiting risk assessment found that the chemotherapy protocol received was included in the Moderate Emetogenic category. This regimen is also accompanied by the administration of high doses of Methotrexate as CNS prophylaxis. However, to reduce the risk of nephrotoxicity due to the administration of high doses of Methotrexate, it is necessary to add sodium bicarbonate and allopurinol to prevent TLS in patients with ALL.
Formulasi Chewy Gummy “T-Sepis” (Temulawak, Serai, dan Jeruk Nipis) sebagai Upaya Peningkatan Kesehatan Masyarakat di Masa Pandemi Covid-19 Levina Hadi Vania Armilda; Cici Nurul Syamsiyah; Nur Aji
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.669

Abstract

Seluruh dunia terkena dampak puncak gelombang COVID-19. Kekebalan dapat ditingkatkan dengan senyawa yang disebut imunomodulator. Potensi temulawak, serai, dan jeruk nipis yang berkhasiat sebagai imunomodulator diformulasikan dalam bentuk sediaan chewy gummy. Metode yang digunakan yaitu eksperimental. Kombinasi zat berkhasiat menggunakan metode axial. Dilakukan uji organoleptik. Optimasi basis yang paling baik adalah formula 3 yaitu gelatin 40%, sukrosa 20%, dan akuadest 40%. Optimasi zat berkhasiat yang paling baik yaitu formula 4, konsentrasi paling tinggi terletak pada serai, sedangkan temulawak dan jeruk nipis mempunyai konsentrasi yang sama. Kesimpulan dari penelitian ini yaitu chewy gummy T-Sepis berpotensi sebagai imunostimulan.The whole world is being impacted by the peak of the COVID-19 wave. Immunity can be boosted by compounds called immunomodulators. The potency of temulawak, lemongrass, and lime, which are efficacious as immunomodulators, is formulated in the form of chewy gummy preparations. The method used is experimental. The combination of efficacious substances using the axial method. Organoleptic tests were carried out. The best base optimization is formula 3, namely 40% gelatin, 20% sucrose, and 40% aquadest. The best optimization of nutritious substances is formula 4. The highest concentration is found in lemongrass, while temulawak and lime have the same concentration. The conclusion of this study is that chewy gummy T-Sepis has the potential to be an immunostimulant.
Toxicity Activity and Total Phenolic Content of Soursop Leaves from Three Regions in South Sulawesi, Indonesia Faradiba Abdul Rasyid; Asni Amin; Sukmawati Sukmawati; Kurnia Putri Djakariani; Riska Riska; Moch. Rayhan Aliansyah; Cindy Artika Sari
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.674

Abstract

The fruit plant known as the soursop (Annona muricata L.) is indigenous to the Caribbean, Central America, and South America. The leaves of soursop contain substances with the potential to be cytotoxic, such as phenols and anonaceous acetogenins. Numerous variables, including geographic location, climatic conditions, and pest or disease disturbance factors, might impact a compound's phenol levels and toxicity. This study aims to investigate whether there are variations in the phenolic content and toxicity of the ethanol extract of soursop leaves that are grown in Gowa, Takalar, and Pinrang, three distinct regions in South Sulawesi, Indonesia. The Folin-Ciocalteu reagent was used to evaluate the total phenolic content, whereas Artemia salina Leach larvae were used for the BSLT method of the toxicity test. The results showed that the extracts of soursop leaves from Gowa, Pinrang, and Takalar had total phenolic contents of 3.7588% mg GAE/g, 0.9686% mg GAE/g, and 1.3832% mg GAE/g, respectively. Gowa, Pinrang, and Takalar have LC50 values of 38.19 µg/mL, 34.35 µg/mL, and 70.95 µg/mL, respectively, indicating their toxicity. The conclusion is that there were differences in the phenolic content and toxicity level of the ethanol extract of soursop leaves. All of these areas could source raw materials of soursop for the development of herbal medicines with cytotoxicity, i.e., anticancer, because they have LC50< 1,000 µg/mL.

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