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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
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Formulasi dan Evaluasi Stabilitas Fisik Krim Minyak Biji Kelor (Moringa oleifera L.) Awalludin Awalludin; Robert Tungadi; Endah Nurrohwinta Djuwarno
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 2 (2022): Agustus 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i2.433

Abstract

Minyak biji kelor merupakan tanaman yang memiliki efek antioksidan karena memiliki kandungan flavanoid yang tinggi, sehingga perlu dilakukan pengembangan minyak biji kelor dalam bentuk sediaan krim. Penelitian ini bertujuan untuk memformulasi serta mengevaluasi sediaan krim. Penelitian ini merupakan penelitian eksperimental laboratorium. Sediaan krim dibuat dengan dengan tiga formula konsentrasi minyak biji kelor yang berbeda yaitu FI (3%); FII (4%); FIII (5%). Evaluasi stabilitas sediaan krim meliputi pengamatan organoleptik (bau, warna, tekstur), uji homogenitas, uji pH, uji viskositas, dan uji daya sebar. Hasil pemeriksaan mutu sediaan organoleptik menunjukkan bahwa semakin tinggi konsentrasi dalam sediaan krim maka semakin kental pula sediaan tersebut, uji homogenitas sediaan menunjukkan susunan yang homogen, uji pH yang dihasilkan 5,8-6,1, uji viskositas sediaan yang dihasilkan 5900 Cp, 5300 Cp, dan 5240 Cp, dan uji daya sebar yang dihasilkan 7 cm, 6,5 cm, 5,5 cm. Maka dapat disimpulkan bahwa FI, FII dan FIII krim minyak biji kelor dapat diformulasikan sebagai sediaan krim.Moringa seed oil is a plant that has an antioxidant effect because it has a high flavonoid content, so it is necessary to develop Moringa seed oil in the form of cream preparations. This study aims to formulate and evaluate cream preparations. This research is an experimental laboratory research. Cream preparations were made with three different concentration formulas of Moringa seed oil, namely FI (3%); FII (4%); FIII (5%). Evaluation of the stability of the cream preparation included organoleptic observations (smell, color, texture), homogeneity test, pH test, viscosity test, and spreadability test. The results of the quality inspection of organoleptic preparations showed that the higher the concentration in the cream preparation, the thicker the preparation, the homogeneity test of the preparation showed a homogeneous arrangement, the pH test produced was 5.8 -6.1, the viscosity test of the preparation produced 5900 Cp, 5300 Cp , and 5240 Cp, and the resulting dispersion test was 7 cm, 6.5 cm, 5.5 cm. So it can be concluded that FI, FII and FIII Moringa seed oil cream can be formulated as a cream preparation.
Skrining Fitokimia dan Potensi Antimikroba Herba Kemangi (Ocimum americanum L.) Terhadap Staphylococcus aureus, Salmonella typhi dan Candida albicans Putri Ayu Anggraini; St. Ratnah; Sesilia TR Dewi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 2, No 2 (2022): Agustus 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v2i2.423

Abstract

Ocimum spp. merupakan salah satu tanaman yang digunakan sebagai bahan obat tradisional, karena memiliki senyawa antioksidan, antikanker dan antimikroba. Tujuan penelitian ini adalah untuk mengetahui senyawa fitokimia dan potensi antimikroba ekstrak Herba Kemangi (Ocimum americanum L.) terhadap Staphylococcus aureus, Salmonella typhi dan Candida albicans berdasarkan zona hambat. Ekstraksi dilakukan dengan maserasi menggunakan etanol 96%. Metode kerja yang digunakan yaitu pembuatan simplisia, ekstraksi, skrining fitokimia, pengujian aktivitas antimikroba dengan metode disc diffusion. maka diperoleh rata-rata zona hambat pada bakteri Staphylococcus aureus konsentrasi 2% b/v sebesar 11,3 mm, 4% b/v sebesar 14,3mm, 8% b/v sebesar 17,6 mm, kontrol positif (clindamycin) sebesar 26 mm dan kontrol negatif 0 mm. Pada bakteri Salmonella typhi konsentrasi 2% b/v sebesar 12,6 mm, 4% b/v sebesar 15,6 mm, 8% b/v sebesar 19,3 mm, kontrol positif (ciprofloxacin) sebesar 29,3 mm dan kontrol negatif 0 mm. Pada Candida albicans konsentrasi 2% b/v sebesar 0 mm, 4% b/v sebesar 6,6 mm, 8% b/v sebesar 8,3 mm, kontrol positif (nystatin) sebesar 12,3 mm dan kontrol negatif 0 mm.Ocimum spp. is one of the plants used as ingredients in traditional medicine, because it has antioxidant, anticancer and antimicrobial compounds. The purpose of this study was to determine the phytochemical compounds and antimicrobial potential of the Herba Basil extract ( Ocimum americanum L.) against Staphylococcus aureus , Salmonella typhi and Candida albicans based on the zone of inhibition. Extraction was carried out by maceration using 96% ethanol. The working method used is the manufacture of simplicia, extraction, phytochemical screening, antimicrobial activity testing with the disc diffusion method . the average inhibition zone of Staphylococcus aureus was 11.3 mm, 4% w/v was 14.3 mm, 8% w/v was 17.6 mm, positive control (clindamycin) was 26 mm and 0 mm negative control. In Salmonella typhi the concentration of 2% w/v was 12.6 mm, 4% w/v was 15.6 mm, 8% w/v was 19.3 mm, positive control (ciprofloxacin) was 29.3 mm and control negative 0 mm. In Candida albicans the concentration of 2% w/v was 0 mm, 4% w/v was 6.6 mm , 8% w/v was 8.3 mm, positive control (nystatin) was 12.3 mm and negative control was 0 mm.
Formulasi dan Uji Mutu Sediaan Sabun Padat Ekstrak Daun Pisang Kepok (Musa paradisiaca Linn.) dengan Variasi Konsentrasi Minyak Kelapa Mayang Aditya Ayuning Siwi; Fendy Yoga Wardhana; Dwi Septiawati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.466

Abstract

Sabun padat akan bernilai jual lebih jika diperkaya pula dengan bahan natural. Ekstrak daun pisang kepok (Musa paradisiaca Linn.) mengandung senyawa flavonoid, saponin dan tannin yang dapat digunakan sebagai senyawa antioksidan sehingga memungkinkan untuk digunakan sebagai bahan aktif pada pembuatan sabun padat. Tujuan penelitian ini adalah untuk memformulasikan ekstrak daun pisang kepok menjadi sabun padat dan melakukan uji mutu sediaan. Metode yang digunakan adalah metode eksperimental. Formulasi sabun padat menggunakan variasi konsentrasi minyak kelapa 25% dan 30%. Uji mutu yang dilakukan yaitu uji organoleptis, uji pH, uji kadar air, uji tinggi dan stabilitas busa. Pengujian dilakukan pada hari ke-1 dan hari ke-7. Hasil uji organoleptis menunjukkan bahwa bau sediaan stabil. Hasil uji pH, uji kadar air, uji tinggi dan stabilitas busa semakin baik pada hari ke-7 penyimpanan. Kesimpulan dari penelitian ini adalah ekstrak daun pisang kepok dapat diformulasikan menjadi sediaan sabun padat dan sabun padat yang dibuat telah memenuhi syarat uji mutu.Solid soap will be more valuable if it is also enriched with natural ingredients. Kepok banana leaf extract (Musa paradisiaca Linn.) contains flavonoids, saponins, and tannins that can be used as antioxidant compounds, making it possible to use them as active ingredients in the manufacture of solid soap. The purpose of this study was to formulate Kepok banana leaf extract into solid soap and test the quality of the preparation. The method used is the experimental method. Solid soap formulation using various concentrations of coconut oil 25% and 30%. The quality tests carried out were organoleptic tests, pH tests, moisture content tests, height and stability of foam tests. Tests were carried out on day 1 and day 7. The organoleptic test results showed that the odor of the preparation was stable. The results of the pH test, water content test, height and stability of foam test were getting better on the 7th day of storage. The conclusion of this study is that Kepok banana leaf extract can be formulated into solid soap preparations, and the solid soap made has met the quality test requirements.
Tinjauan Literatur: Potensi Tanaman Famili Apiaceae sebagai Imunomodulator dan Antioksidan Deani Sucia Fakhira; Nova Patricia; Novia Saumi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.422

Abstract

Sistem imun merupakan sebuah sistem untuk mempertahankan dan melindungi keutuhan tubuh yang dapat menyerang sel-sel dalam tubuh. Penyakit yang berhubungan dengan sistem imun diantaranya HIV, Covid-19, dan influenza. Suatu zat yang dapat merangsang, menekan atau memodulasi salah satu dari komponen sistem kekebalan tubuh disebut imunomodulator. Penelitian ini dilakukan untuk mengetahui kandungan kimia dan mekanisme zat aktif dari kelompok tanaman famili Apiaceae sebagai imunomodulator dan antioksidan. Metode yang digunakan dalam penelitian ini yaitu penelitian kualitatif dengan metode tinjauan literatur sistematis. Hasil penelaahan pustaka famili Apiaceae memiliki aktivitas kandungan sebagai imunomodulator dan antioksidan diantaranya Daucus carota (wortel), Apii graveolus (seledri), Centella asiatica (pegagan), Nigella sativa (jinten), Foenicullum vulgare (adas hitam), dan Pimpinella anisum (adas manis) dengan kandungan flavonoid, saponin, tanin, dan vitamin C yang bekerja meningkatkan respon imun terhadap sistem kekebalan tubuh. The immune system is a system to maintain and protect the integrity of the body that can attack cells in the body. Diseases related to the immune system include HIV, Covid-19, and influenza. A substance that can stimulate, suppress or modulate one of the components of the immune system is called an imunomodulator. This research was conducted to determine the chemical content and mechanism of active substances from the Apiaceae family of plants as imunomodulators and antioxidants. The method used in this study is qualitative research using a systematic literature review method. The results of a literature review of the Apiaceae family have content activity as immunostimulants and antioxidants including Daucus carota (carrot), Apii graveolus (celery), Centella asiatica (gotu kola), Nigella sativa (cumin), Foenicullum vulgare (black fennel), and Pimpinella anisum (aniseed) contains flavonoids, saponins, tannins, and vitamin C which work to enhance the immune response against the immune system.
Efektifitas Pemberian Minyak Kuda (Equus caballus) untuk Mempercepat Penyembuhan Luka Pada Kelinci Jantan (Oryctolagus cuniculus) Nur Intang; Hendra Stevani; Ratnasari Dewi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.432

Abstract

Minyak kuda (Equus caballus) sering digunakan oleh masyarakat Jeneponto untuk menyembuhkan luka, namun bukti ilmiah tentang hal tersebut masih kurang. Tujuan penelitian ini adalah untuk mengetahui efektifitas dari minyak kuda pada penyembuhan luka kelinci jantan (Oryctolagus cuniculus). Minyak kuda diperoleh dari lemak kuda pada bagian perutnya yang dibuat dengan metode destilasi uap air. Minyak yang diperoleh kemudian diberikan pada kelinci jantan yang terlebih dahulu diberikan luka sepanjang 3 cm dengan kedalaman 0,2 cm, kemudian untuk pembanding digunakan betadin dan sebagai kontrol negatif tidak diberi perlakuan. Pengamatan dilakukan selama 7 hari dengan melihat perubahan panjang luka pada kelinci jantan. Hasil penelitian menunjukkan bahwa terjadi penurunan luka yang signifikan antara tiap perlakuan dimana pada hari ke-7 rata-rata menunjukkan adanya perubahan namun kelompok perlakuan dengan pemberian minyak kuda lukanya sudah sembuh dibandingkan dengan betadin dan kontrol negatif. Berdasarkan hasil penelitian dan analisis data maka dapat disimpulkan bahwa  pemberian minyak kuda murni efektif dalam menyembuhkan luka kelinci jantan namun efeknya tidak jauh berbeda dengan betadin.Horse oil (Equus caballus) is often used by the people of Jeneponto to heal wounds, but scientific evidence regarding this is still lacking. The purpose of this study was to determine the effectiveness of horse oil on wound healing in male rabbits (Oryctolagus cuniculus). Horse oil is obtained from horse fat in the stomach, which is made by the steam distillation method. The oil obtained was then given to male rabbits, which were first given a 3 cm wound with a depth of 0.2 cm, then betadine was used as a comparison, and as a negative control, they were not given any treatment. Observations were made for 7 days by observing changes in the length of the wound in male rabbits. The results showed that there was a significant reduction in wound size between each treatment; on the 7th day, the average showed a change, but the treatment group with horse oil had healed compared to betadine and negative controls. Based on the results of the research and data analysis, it can be concluded that giving pure horse oil is effective in healing the wounds of male rabbits, but the effect is not much different from betadine.
Aktivitas Antibakteri Ekstrak Buah Pare (Momordica charantia L.) Terhadap Bakteri Vibrio cholerae dan Bacillus cereus Nurul Ismawati; Alfrida Monica Salasa; Dwi Rachmawaty Daswi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.611

Abstract

Buah pare (Momordica charantia L.)  merupakan tanaman yang memiliki bau khas yang dimanfaatkan oleh masyarakat sebagai sayuran dan untuk pengobatan tradisional seperti batuk berdahak dan disentri. Buah pare memiliki kandungan senyawa alkaloid, flavonoid, saponin, tannin, dan triterpenoid yang dapat memiliki aktivitas sebagai antibakteri. Penelitian ini bertujuan untuk menentukan aktivitas antibakteri berdasarkan diameter zona hambat ekstrak buah pare terhadap Vibrio cholerae dan Bacillus cereus. Buah pare dikeringkan lalu di maserasi dengan pelarut etanol 96% dilanjutkan uji skrinning fitokimia dan uji aktivitas antibakteri dengan metode disc diffusion konsentrasi ekstrak 2%, 4%, 8% kontrol positif menggunakan antibiotik kloramfenikol dan kontrol negatif DMSO. Hasil penelitian menunjukkan ekstrak buah pare memiliki aktivitas terhadap bakteri Vibrio cholerae dan Bacillus cereus dan konsentrasi yang memiliki zona hambat terbesar adalah konsentrasi 8%.Bitter gourd fruit (Momordica charantia L.) is a plant that has a distinctive smell and is used by the community as a vegetable and for traditional medicine such as cough with phlegm and dysentery. Bitter gourd contains alkaloids, flavonoids, saponins, tannins, and triterpenoids that have antibacterial activity. This study aims to determine the antibacterial activity based on the diameter of the inhibition zone of bitter melon extract against Vibrio cholerae and Bacillus cereus. Bitter gourd fruit was dried and then macerated with 96% ethanol as a solvent, followed by phytochemical screening tests and antibacterial activity tests using the disc diffusion method with extract concentrations of 2%, 4%, and 8% as positive controls using chloramphenicol antibiotics and DMSO as a negative control. The results showed that bitter melon extract had activity against the bacteria Vibrio cholerae and Bacillus cereus, and the concentration that had the largest inhibition zone was 8%.
Potential Antibacterials of Merang Padi Extract (Oryza sativa) on the Growth of Gram Positive and Gram Negative Bacteria Masniah Masniah; Rini Andarwati; Ahmad Purnawarman Faisal; Mimin Wulandari
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.620

Abstract

Padi straw (Oryza sativa) is one type of stem produced from padi tree trunks. Antibacterial activity testing was carried out by agar diffusion method using paper disc as a backup by observing the formation of a clear zone indicating the presence of antibacterial activity. Variations in the concentration of the padi straw extract test solution were made with a %w/v ratio between 100% pure padi straw extract and DMSO adjusted at various test concentrations, namely, 5%, 10%, 15%, 20%, and 25%. The results showed that the n-hexane fraction of padi straw did not have antibacterial activity because there was no inhibition zone or kill zone indicated by the fraction at both low and high concentrations. While the ethanol extract showed antibacterial activity at a concentration of 15%, the ethyl acetate fraction and the n-butanol fraction had antibacterial activity indicated by the presence of an inhibitory zone at a concentration of 7%. The results of the t-test on the ethanol extract of the test bacteria obtained a Tcount value of 14,687 which means it is very significant or very significantly different because Tcount is greater than Ttable (5% and 1%). This shows that the oxytetracycline antibiotic is better than the potency of the ethanol extract of straw on the test bacteria.
Physical Characteristics of Processed Food Meatballs Based on Mussels (Anadara granosa) Youstiana Dwi Rusita; Wynne Afra Shafira; M Ali Nasikin
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 1 (2023): Februari 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i1.621

Abstract

Seafood is great for consumption by various age groups because it is rich in protein, fat, vitamins and minerals. One of the seafood that is often used by the community is shellfish. Mussels (Anadara granosa) is a type of shellfish commonly eaten by Asian people because it has economic value and excellent nutritional content for consumption, especially a source of protein and minerals. One of the processed forms of mussels is meatball. The purpose of the study was to determine the results of physical quality (organoleptic and pH), chemical quality (fat and protein) in mussels meatballs (Anadara granosa). This types of research carried out quantitative research using descriptive. The test parameters are organoleptic test, pH test, protein content test using the biuret method and fat content test using the soxhletation method. The results of the organoleptic test showed a green-black color, a normal smell typical of meat, a normal taste for meatballs, a chewy texture and a pH of 6.807. The results of the protein content test in mussel meatballs were 2.972% and the fat content test had a level of 9.1186%. Based on the physical tests, mussels meatballs meet the criteria.
Formulasi Fast Disintegrating Tablet Ekstrak Rimpang Kunyit (Curcuma domestica) dan Perasan Umbi Kentang (Solanum tuberosum L) Muhaini Zulfikar; Arisanty Arisanty; Sisilia Tresia Rosmala Dewi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.483

Abstract

Fast Disintegrating Tablet (FDT) merupakan tablet yang dapat dipecah dalam waktu kurang dari 60 detik saat diletakkan di atas lidah dengan jumlah air yang minimal. Kunyit dan kentang digunakan untuk  menurunkan kadar asam dalam lambung yang bertujuan untuk mengobati pasien penderita gastritis. Tujuan penelitian ini membuat formulasi FDT rimpang kunyit (Curcuma domestica) dan perasan umbi kentang (Solanum tuberosum L) dengan variasi konsentrasi sodium starch glycolate sebagai bahan penghancur yaitu formula I (2%), formula II (3%) dan formula III (4%). Penelitian dilakukan dengan metode observasi laboratorium. Tablet yang dihasilkan diuji mutu fisik tablet meliputi; keseragaman ukuran, keseragaman bobot, kekerasan, keregasan, dan waktu hancur. Hasil penelitian menunjukkan bahwa formulasi I, II,dan III telah memenuhi persyaratan pengujian granul maupun pengujian tablet. Konsentrasi bahan penghancur sodium starch glycolate yang paling baik sebagai bahan penghancur pada tablet FDT adalah pada formula III dengan konsentrasi sodium starch glycolate 4% dengan waktu hancur rata-rata 27 detik.Fast Disintegrating Tablet (FDT) is tablet that can be broken down in less than 60 seconds when placed on the tongue with minimal amounts of water. Turmeric and potatoes are used to reduce acid levels in the stomach, which aims to treat patients with gastritis. The purpose of this study was to make FDT formulations of turmeric (Curcuma domestica) and potato tuber juice (Solanum tuberosum L) with varying concentrations of sodium starch glycolate as a disintegrant, namely formula I (2%), formula II (3%) and formula III (4%). The research was conducted using the laboratory observation method. The tablets produced were tested for their physical quality, including size uniformity, weight uniformity, hardness, firmness, and disintegration time. The results showed that formulations I, II, and III met the requirements of granule and tablet testing. The best disintegrant concentration of sodium starch glycolate as a disintegrant in FDT tablets is Formula III, with a concentration of 4% sodium starch glycolate and an average disintegration time of 27 seconds.
Uji Aktivitas Antibakteri Ekstrak Daun Pepaya (Carica papaya L.) terhadap Pertumbuhan Bakteri Vibrio cholerae dan Salmonella thypi Nining Fadilah Utami; Dwi Rachmawaty; Arisanty Arisanty
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): Agustus 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.678

Abstract

Tanaman  pepaya (Carica  papaya L.) sudah  lama dipakai untuk obat herbal serta dipercaya mempunyai kegunaan dalam pengobatan, salah satunya untuk memperlambat pertumbuhan pada bakteri. Adapun senyawa aktif yang ada di tumbuhan pepaya mempunyai kegunaan seperti karpain, alkaloid, flavonoid, saponin, dan tannin. Tujuan dari penelitian ini guna mengetahui aktivitas dari antibakteri pada ekstrak daun pepaya pada pertumbuhan Vibrio cholerae dan Salmonella thypi berdasarkan diameter zona hambat. Ekstrak dari daun pepaya diperoleh melalui metode maserasi lalu dilanjutkan dengan skrining fitokimia serta pengujian aktivitas antibakteri dengan memakai metode disc diffusion, kontrol positif digunakan kloramfenikol serta kontrol negatif digunakan DMSO. Hasil dari pengujian SPSS yaitu konsentrasi ekstrak 2% potensial dimanfaatkan untuk antibakteri guna Vibrio cholerae dan Salmonella thypi.Papaya plants (Carica papaya L.) have long been used for herbal medicine and are believed to have medicinal uses, one of which is to slow the growth of bacteria. The active compounds in papaya plants have uses such as karpain, alkaloids, flavonoids, saponins, and tannins. The purpose of this study was to determine the antibacterial activity of papaya leaf extract on the growth of Vibrio cholerae and Salmonella thypi based on the diameter of the inhibition zone. Extract from papaya leaves was obtained through the maceration method, followed by phytochemical screening and antibacterial activity testing using the disc diffusion method. The positive control used chloramphenicol, and the negative control used DMSO. The results of the SPSS test showed that the 2% extract concentration could potentially be used as an antibacterial for Vibrio cholerae and Salmonella typhi.

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