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Marcellino Rudyanto
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Department Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga Surabaya, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia
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Berkala Ilmiah Kimia Farmasi
Published by Universitas Airlangga
ISSN : 23028270     EISSN : 28081048     DOI : http://dx.doi.org/10.20473/bikfar.v8i2.31763
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
to facilitate interaction, discussion, and updating of research ideas in the fields of pharmacy, Pharmaceutical Chemistry, Medicinal Chemistry, Drug Development, Organic synthesis, Analytical chemistry, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Nutraceutical / functional foods.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 5 Documents
 1 
Search results for , issue "Vol. 7 No. 2 (2020): DESEMBER" : 5 Documents clear
Analgesic Activity of Acyl-Salicylic Acid Derivatives And In Silico Docking Study For Their Potency As Cyclooxygenase-2 Inhibitors Nuzul Wahyuning Diyah; Anindi Lupita Nasyanska; Bambang Tri Purwanto; Siswandono Siswandono
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.626 KB) | DOI: 10.20473/bikfar.v7i2.29302

Abstract

A series of acyl salicylic acid derivatives were screened to investigate their analgesic activities and their potency as cyclooxygenase-2 (COX-2) inhibitors. Fourteen compounds (BS1–14) were assayed by acetic acid induced writhing test. Their ability for interaction with COX-2 was studied through a docking simulation at the COX-2 active site (PDB. 5IKQ). The results of the analgesic activity test gave 3 compounds that produce ED50< 0.39 mmol/kg body weight, lower than aspirin as a positive control. The compounds BS3 and BS4 showed excellent analgesic activity and the tert-butyl substituted molecule BS3 (O-(4-tert-butylbenzoyl)-salicylic acid analog) showed the highest analgesic activity with ED50 of 0.26 mmol/kg. Based on in silico molecular docking, it is known that almost all of the tested ligands (12 compounds) showed a higher binding affinity for COX-2 than meclofenamic acid which is a COX-2 inhibitory NSAID. The results of in vivo analgesic activity were justified with the outcome of in silico investigation. Molecular docking of acyl-salicylates confirmed in vivo experiments and it was found that BS3 was the most active compound as an analgesic agent and the most potent as a COX-2 inhibitor among the evaluated compounds.a
Validasi Metode KLT-Densitometri Pada Penetapan Kadar (-)-Epigallocatechin Gallate (EGCG) Dalam Teh Hijau Chusnul Chatimah; Sugijanto sugianto; Achmad Toto Poernomo
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.523 KB) | DOI: 10.20473/bikfar.v7i2.29303

Abstract

Latar Belakang Daun teh (Camellia sinensis L.) memiliki banyak manfaat untuk kesehatan. Daun teh hijau mengandung banyak senyawa polifenol dalam kadar tinggi, antara lain turunan catechin epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) dan epigallocatechin gallate (EGCG). Komponen bioaktif yang paling dominan adalah EGCG. Sebuah metode TLC-Densitometry sederhana telah dikembangkan untuk penentuan (-)-Epigallocatechin gallate dalam produk teh hijau. Metode ini menggunakan silika gel F 254 sebagai fase diam dan fase gerak kloroform-asam asetat-asam format-isopropanol (16:2:2:8). Hasil Panjang gelombang maksimum terdeteksi pada 278 nm. Respon linieritas ditemukan (-)-Epigallocatechin gallate antara 0,5043 g–2,5215 g dengan regresi persamaan Y = 5409,8 X – 569,97 (r = 0,9996; Vxo= 3,94%). Metode divalidasi untuk menentukan deteksi tiruan (0,0188 g), kuantisasi batas (0,0627µg), akurasi (91,41%), presisi untuk standar EGCG (4,47%) dan presisi metode (7,01 %). Kesimpulan hasil ini menunjukkan bahwa EGCG dalam produk teh hijau dapat dideteksi dengan metode TLC-Densitometry. Dengan menggunakan metode, konsentrasi EGCG pada produk teh hijau adalah 3,33%.  
Pengaruh Sumber Karbon Organik Terhadap Produksi Protease Fibrinolitik Bacillus Sphaericus BM 9.1 Dengan Solid State Fermentation (SSF) Afrilia Diana Fitri; achmad Toto Poernomo; Muhammad Faris Adrianto
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.602 KB) | DOI: 10.20473/bikfar.v7i2.29269

Abstract

Enzim fibrinolitik merupakan kelompok enzim protease serin yang mampu menghancurkan bekuan darah (fibrin) pada berbagai penyakit trombotik. Sumber enzim fibrinolitik dapat diperoleh dari mikroorganisme. Bacillus sp merupakan salah satu mikroorganisme yang berpotensi menghasilkan enzim fibrinolitik. Medium memiliki peran penting dalam menumbuhkan dan memproduksi enzim fibrinolitik. Dalam medium, sumber karbon yang cukup diperlukan untuk pertumbuhan bakteri. Dalam fermentasi mikroba, sumber karbon sangat diperlukan untuk pembentukan biomassa dan produksi energi. Media yang digunakan dalam penelitian ini adalah media Nutrient agar yang ditambahkan sumber karbon organik. Sumber karbon yang digunakan adalah glukosa, fruktosa, sukrosa, dan pati dengan konsentrasi masing-masing 1% b/v. Penambahan sumber karbon dengan konsentrasi 1% b/v pada medium menunjukkan pengaruh yang berbeda terhadap produksi enzim fibrinolitik oleh Bacillus sphaericus BM 9.1. Jadi di antara semua sumber karbon yang diuji, fruktosa menghasilkan indeks fibrinolitik tertinggi (2,86 ± 0,03). Langkah selanjutnya adalah mengoptimalkan konsentrasi sumber karbon fruktosa. Optimasi konsentrasi fruktosa diuji pada konsentrasi 1%, 2%, 3%, dan 4%. Semua konsentrasi telah diuji, konsentrasi fruktosa 1% b/v menghasilkan indeks fibrinolitik tertinggi (2,82 ± 0,04).  
The Effect of Methyl and Chloro Substituent Compounds in Amida Derivatives Synthesis from p-Metoxicynamic Acid with Microwaves Irradiation Ruri Intan Nurcahyaningtyas; Juni Ekowati Ekowati; Marcellino Rudyanto
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.52 KB) | DOI: 10.20473/bikfar.v7i2.29300

Abstract

Background: The difference in the nature of these aromatic amine substituents, i.e. methyl and chloro will affect the N atom of aniline as a nucleophile to attack the carbonyl C atom in the p-methoxcycinnamoyl chloride in the synthesis two amides derivate of p-methoxycinnamic acid, namely N-(p-methylphenyl)-p-methoxycinnamide and N-(p-chlorophenyl)-p-methoxycinnamide. Aim: to obtain the N-(p-methylphenyl)-p-methoxycinnamide and the N-(p-chlorophenyl)-p-metoxicinamide compound from p-methoxycinamic acid using the microwave irradiation method as source of energy. Beside that, it also to determine the effect of the presence of methyl and chloro substituents in para position of aromatic amines in the yields of reactions. Method: The reactions were carried out by microwave irradiation at three powers, i.e 120 watts, 200 watts, 280 watts. After separation and purification steps, the products were identified by spectrometric methods. Result: At power of 200 watts for reaction time of 7.5 minutes, the yield of N-(p-methylphenyl)-p-methoxycinamide is larger than N-(p-chlorophenyl)-p-methoxycinnamamide. The percentage of the product synthesis of N-(p-methylphenyl)-p-methoxycinamide was 51.84% and the percentage of N-(p-chlorophenyl)-p-methoxycinnamamide was to 47.20%. Conclusion: The effect of substituent methyl is increase the percentage yield of N-(p-methylphenyl)-p-methoxycinamide compound than that substituent chloro of N-(p-chlorophenyl)-p-methoxycinamide compound under the same reaction conditions. Based on the identification of the structure of the synthesized compound using a UV spectrophotometer, infrared spectrophotomers and 1H-NMR spectrometer it can be concluded that the synthesized compounds are N-(p-methylphenyl)-p-methoxycinnamide and N- (p-chlorophenyl)-p-methoxycinnamide.  
Inhibitory Activity Of Roselle Flower (Hibiscus Sabdariffa L.) Aqueous Extract - Sodium Alginate Gel Against Staphylococcus aureus ATCC 25923 Esti Hendradi; Isnaeni Isnaeni; Arya Putra Damari
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.334 KB) | DOI: 10.20473/bikfar.v7i2.29301

Abstract

Staphylococcus aureus is one type of bacterium that causes skin infections resistant to some antibiotics. This encourages research to find new antibacterials by using substances from natural sources, often called medicinal plants. Aqueous extract of Roselle (Hibiscus sabdariffa L.) flower (AERF) was selected as one of natural ingredients for antibacterial in gel dosage form, in which sodium alginate was used as a matrix base. In this study, determination of the sodium alginate concentration effects (2.5%, 3% and 3.5%) on the properties of the gel was performed. The characteristics evaluated included pH, viscosity, and dispersive power; that should be met standard requirement and the gel ability to inhibit Staphylococcus aureus ATCC 25923 growths.  A diffusion test method was used to determine the Minimum Inhibitory Concentration (MIC) of the AERF powder against the test bacteria. The study results showed that AERF gel preparation with a composition of 3% sodium alginate and 3% roselle extract had better properties (pH, viscosity, and dispersive power) than the matrix and extract concentrations of 2.5% and 3.5% respectively. It was found that the optimum formula obtained a MIC of 0.04 mg/ml. In line with these results, it is expected that the AERF gel preparation will be stable, safe, and acceptable when used and might be recommended as antibacterial topical dosage form against Staphylococcus aureus. In the future, inhibitory activity against resistant pathogenic bacteria could be evaluated and developed.  

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