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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : https://doi.org/10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is published online by the Faculty of Pharmacy, Mulawarman University, Samarinda City, East Kalimantan. Since 2019, the Jurnal Sains dan Kesehatan has been accredited to SINTA. Jurnal Sains dan Kesehatan publishes manuscripts (Original research Article, review articles, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Case Study & Full clinical trials, Clinical Pharmacy, Medicine, and other related fields. The purpose of publishing the Jurnal Sains dan Kesehatan is to provide scientific information about the development of science and technology in the field of Science and Health. Lingkup naskah Jurnal Sains dan Kesehatan mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan Jurnal Sains dan Kesehatan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 15 Documents
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Uji Aktivitas Antioksidan Ekstrak Etanol Daun Nipah (Nypa fruticans Wurmb.) dan Pembuatan Formulasi Basis Krim: Antioxidant Activity Test of Ethanol of Nipah Leaf (Nypa fruticans Wurmb.) and Cream Base Formulation Ahmad Rezky; Sabanniah Indjar Gama; Angga Cipta Narsa
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2048

Abstract

Nipah leaves (Nypa fruticans Wurmb.) is a palm plant that grows in tidal areas close to the edge of the sea which is suspected to contain secondary metabolites as antioxidants and rich in vitamins A and C. This study aims to determine the antioxidant activity of nipa leaf extract and obtain the best formula from the basic cream with varying concentrations of stearic acid and TEA. The research method used was phytochemical screening, specific and non-specific parameter tests of the extract including organoleptic, water content, pH, ash content, acid insoluble ash content, specific gravity, antioxidant activity test of nipa palm leaf ethanol extract using the DPPH method, formulation and base evaluation. cream includes organoleptic, pH, emulsion type, spreadability, and viscosity. The results obtained from the ethanol extract of nipah leaves contain secondary metabolites in the form of phenols, tannins and steroids. The results of extract specific and non-specific parameters obtained for all parameter values have occupy the applicable standards. The antioxidant activity of the ethanol extract of nipah leaves obtained the IC50 of 2,379 ppm which shows very strong antioxidant activity. The results of the evaluation of the cream base formulation found that the cream bases F1, F2, F3 occupy the cream evaluation requirements. Keywords: Nypa fruticans Wurmb., antioxidant, cream Base Abstrak Daun nipah (Nypa fruticans Wurmb.) merupakan tanaman palem yang tumbuh di daerah pasang surut yang dekat dengan tepi laut yang diduga memiliki kandungan metabolit sekunder sebagai antioksidan dan kaya akan vitamin A dan C. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak daun nipah dan mendapatkan formula terbaik dari basis krim dengan memvariasikan konsentrasi asam stearat dan TEA. Metode penelitian yang dilakukan yaitu skrining fitokimia, uji parameter spesifik dan non-spesifik ekstrak meliputi organoleptis, kadar air, pH, kadar abu, kadar abu tidak larut asam bobot jenis, uji aktivtias antioksidan ekstrak etanol daun nipah dengan metode DPPH, formulasi serta evaluasi basis krim yang meliputi organoleptis, pH, tipe emulsi, daya sebar, dan viskositas. Hasil yang didapatkan ekstrak etanol daun nipah mengandung metabolit sekunder berupa fenol, tanin, dan steroid. Hasil parameter spesifik dan non-spesifik ekstrak diperoleh semua nilai parameter telah memenuhi standar yang berlaku. Aktivitas antioksidan ekstrak etanol daun nipah didapatkan nilai IC50 sebesar 2.379 ppm yang menunjukkan aktivitas antioksidan sangat kuat. Hasil evaluasi formulasi basis krim didapatkan basis krim F1, F2, F3 memenuhi persyaratan evaluasi krim. Kata Kunci: Nypa fruticans Wurmb., antioksidan, basis krim
Analisis Karakteristik dan Profil Pengobatan Pasien Demam Berdarah Dengue Anak di Instalasi Rawat Inap Rumah Sakit Samarinda Medika Citra Tahun 2020-2021: Analysis of Characteristics and Medication Profile of Dengue Hemorrhagic Fever Patients in Children at the Inpatient Installation of Samarinda Medika Citra Hospital in 2020-2021 Jessyca Azzahra; Angga Cipta Narsa; Novianty Indjar Gama
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2049

Abstract

Dengue hemorrhagic fever (DHF) is an acute viral infectious disease caused by the dengue virus. In general, DHF treatment is supportive and symptomatic. Supportive treatment is administering replacement fluids for the body, such as intravenous fluids. As symptomatic therapy, paracetamol can be given as an antipyretic. This study aimed to determine the characteristics and treatment profile of pediatric patients diagnosed with DHF at the inpatient installation of Samarinda Medika Citra Hospital in 2020-2021. The research method used is observational research which will then be described descriptively. Based on the results of the characteristics of most patients, namely in male patients (62.4%) with school-age patients (6-18 years) (80%), the degree of severity experienced by DHF pediatric patients is degree 1 of (78, 4%) with an average length of stay of 4 days (28.8%) the average weight of pediatric patients with DHF is 20-
Efektivitas Pemberian Kombinasi Teh Daun Mint (Mentha piperita) dan Madu terhadap Intensitas Nyeri Haid (Dismenore): Effectiveness Giving a Combination of Mint Leaf Tea (Mentha piperita) and Honey Against Menstrual Pain Intensity (Dysmenorrhea) Nafara Aghnia Anfusufi; Adam M. Ramadhan; Vita Olivia Siregar
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2050

Abstract

Dysmenorrhea or menstrual pain is still a major problem for most women. There are many ways to deal with menstrual pain or dysmenorrhea, one of which is by consuming herbal drinks. Mint leaves contain menthol compounds which can reduce contractions in the myometrium so that the pain of dysmenorrhea that is felt can be reduced. Flavonoids contained in honey can reduce pain by inhibiting the formation of prostaglandins through inhibition of the cyclooxygenase enzyme. So that the combination of the two can work synergistically in reducing the intensity of dysmenorrhea pain. This study aims to determine the effectiveness of giving mint leaf tea (Mentha piperita) and honey to reduce the intensity of menstrual pain (dysmenorrhea). The research method used was quasy experimental with purposive sampling and obtained 50 respondents divided into 2 groups. The results obtained in the two groups of respondents after giving the combination of mint leaf tea and honey for 2 days were a decrease between the pretest and posttest with a significance value of 0.000 (p
Kajian Potensi Interaksi Obat pada Pasien Infeksi Saluran Kemih di RSUD Inche Abdoel Moeis Samarinda Periode Tahun 2021: Study of Potential Drug Interactions in Urinary Tract Infection Patients at Inche Abdoel Moeis Hospital Samarinda for the 2021 Period Nia Audina; Juniza Firdha Suparningtyas; Herman Herman
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2051

Abstract

Urinary Tract Infection (UTI) patients generally have co-morbidities, which allows many drugs to be prescribed. The increasing combination of drugs used can lead to an increased risk of drug interactions, which potentially affect the success of patient treatment therapy. This study aims to determine the potential for drug interactions that occur in the treatment of inpatient UTI patients at Inche Abdoel Moeis Samarinda Hospital for the 2021 period. This research is a retrospective descriptive study using a purposive sampling technique and the mechanism of drug interactions and the severity of the interaction are analyzed using Drug Interaction Checker on the drug.com website and the Medscape app. The results of the study of 45 medical records of UTI patients who met the inclusion requirements showed that there were 14 potential drug interactions found with potential pharmacokinetic and pharmacodynamic mechanisms, and there were results of the severity of drug interactions consisting of minor, moderate, and major. Keywords: Urinary tract infection; Drug interactions; Inpatient Abstrak Pasien Infeksi Saluran Kemih (ISK) umumnya memiliki penyakit penyerta sehingga memungkinkan banyak obat yang diresepkan. Meningkatnya kombinasi obat yang digunakan dapat menyebabkan peningkatan risiko terjadinya interaksi obat, yang secara potensial mempengaruhi keberhasilan terapi pengobatan pasien. Penelitian ini bertujuan untuk mengetahui potensi interaksi obat yang terjadi pada terapi pengobatan pasien ISK rawat inap di Rumah Sakit Inche Abdoel Moeis Samarinda periode tahun 2021. Penelitian ini merupakan penelitian deskriptif secara retrospektif dengan teknik purposive sampling serta mekanisme interaksi obat dan tingkat keparahan interaksi dianalisis menggunakan Drug Interaction Checker pada situs drug.com dan aplikasi Medscape. Dari hasil penelitian 45 rekam medik pasien ISK yang telah memenuhi syarat inklusi menunjukan bahwa terdapat potensi interaksi obat yang ditemukan sebanyak 14 kejadian dengan mekanisme potensi interaksi secara farmakokinetik dan farmakodinamik, serta terdapat hasil tingkat keparahan interaksi obat yang terdiri dari minor, moderate, dan mayor. Kata Kunci: Infeksi saluran kemih; Interaksi obat; Rawat inap
Analisis Proksimat Cookies dari Tepung Sukun (Artocarpus altilis) dan Tepung Buah Naga Merah (Hylocereus polyrhizus): Proximate Analysis of Cookies from Breadfruit Flour (Artocarpus altilis) and Red Dragon Fruit Flour (Hylocereus polyrhizus) Putri Diah Wulandari; Andi Tenri Kawareng; Islamudin Ahmad
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2052

Abstract

The prevalence of diabetes mellitus in Indonesia has increased from year to year, so it is necessary to make efforts to control diabetes mellitus. One of the efforts that can be done is food arrangement with a high-fibre diet. Breadfruit and red dragon fruit are foods with high fibre content. Cookies made from breadfruit flour and red dragon fruit flour have the potential to be used as a snack for diabetics. This research aims to determine the nutritional content of cookies made from breadfruit flour and red dragon fruit flour. The results from the test is water content 4.51%, total ash content 5%, acid insoluble ash content 0.34%, glucose content 1.52%, fat content 22.65%, protein content 11.65%, carbohydrate content 56.19%, and fibre content 21.5%. Cookies made from breadfruit flour and red dragon fruit have a high fibre content so that they can be used as an alternative snack for diabetics. Keywords: Breadfruit, Red dragon fruit, Diabetes mellitus Abstrak Prevalensi diabetes mellitus di Indonesia mengalami peningkatan dari tahun ke tahun, sehingga perlu dilakukan upaya pengendalian diabetes mellitus. Salah satu upaya yang dapat dilakukan yaitu dengan pengaturan makan dengan cara diet tinggi serat. Buah sukun dan buah naga merah merupakan pangan dengan kandungan serat yang tinggi. Cookies berbahan dasar tepung sukun dan tepung buah naga merah berpotensi untuk dijadikan makanan selingan bagi penderita diabetes mellitus. Penelitian ini bertujuan untuk mengetahui kandungan gizi pada cookies berbahan dasar tepung sukun dan tepung buah naga merah. Hasil dari pengujian yang dilakukan, diperoleh kadar air 4,51%, kadar abu total 5%, kadar abu tidak larut asam 0,34%, kadar glukosa 1,52%, kadar lemak 22,65%, kadar protein 11,65%, kadar karbohidrat 56,19%, dan kadar serat 21,5%. Cookies berbahan dasar tepung sukun dan buah naga merah memiliki kandungan serat yang tinggi sehingga dapat dijadikan alternatif makanan selingan bagi penderita diabetes mellitus. Kata Kunci: Buah sukun, Buah naga merah, Diabetes Mellitus
Isolasi Fungi Endofit Batang Bajakah (Uncaria nervosa Elmer) dan Pengujian Toksisitas dengan Metode BSLT: Isolation of Endophytic Fungi from Bajakah Stems (Uncaria nervosa Elmer) and Toxicity Testing by BSLT Method Umi Khusnul Khotimah; M. Arifuddin; Fika Aryati; Islamudin Ahmad
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2053

Abstract

Bajakah (Uncaria nervosa Elmer) is one of the plants that grows a lot in East Kalimantan and difficult to cultivate. Empirically, Bajakah stems are used by rural communities, especially the Dayak people for the treatment of various diseases by drinking boiled water, causing Bajakah stems to be exploited. Endophytic fungi are endophytic microbes that live in plant tissues asymptomatically and can produce secondary metabolites with various biological activities, one of which is anticancer. This study aims to isolate the endophytic fungi of the Bajakah stem and test the toxicity using the BSLT method on Artemia salina shrimp larvae as an initial screening to determine the potential of endophytic fungi as a producer of candidate drug compounds. Based on the results of the study, 2 isolates of the endophytic fungi of the Bajakah stem were obtained. The results of the toxicity test of the UN 3B isolate extract obtained an LC50 value of 21.4 ppm, while the UN 4B isolate extract was 28.2 ppm. Each extract is cytotoxic because it can cause the death of 50% of test animals at concentrations <1000 ppm. Keywords: Bajakah, endophytic fungi, cytotoxic test, BSLT Abstrak Bajakah (Uncaria nervosa Elmer) merupakan salah satu tumbuhan yang banyak tumbuh di Kalimantan Timur dan sulit dibudidayakan. Secara empiris, batang Bajakah dimanfaatkan oleh masyarakat pedalaman, khususnya masyarakat suku Dayak untuk pengobatan berbagai penyakit dengan cara meminum air rebusan, sehingga menyebabkan batang Bajakah di eksploitasi. Fungi endofit merupakan mikroba endofit yang hidup di jaringan tumbuhan secara asimtomatis dan dapat menghasilkan senyawa metabolit sekunder dengan berbagai aktivitas biologis salah satunya antikanker. Penelitian ini bertujuan untuk mengisolasi fungi endofit batang Bajakah dan uji toksisitas dengan metode BSLT terhadap larva udang Artemia salina sebagai skrining awal untuk mengetahui potensi fungi endofit sebagai penghasil kandidat senyawa obat. Berdasarkan hasil penelitian diperoleh 2 isolat fungi endofit batang Bajakah. Hasil uji toksisitas ekstrak isolat UN 3B diperoleh nilai LC50 sebesar 21,4 ppm, sedangkan ekstrak isolat UN 4B sebesar 28,2 ppm. Pada masing-masing ekstrak bersifat sitotoksik karena dapat menyebabkan kematian 50% hewan uji pada konsentrasi <1000 ppm. Kata Kunci: Bajakah, fungi endofit, uji sitotoksik, BSLT
Bioaktivitas Ekstrak Etil Asetat Hasil Fermentasi Fungi Endofit Batang Bajakah (Uncaria nervosa Elmer.): Bioactivity of Ethyl Acetate Extract from Fermentation of the Endophytic Stem of Bajakah (Uncaria nervosa Elmer.) Khoirunnisa Khoirunnisa; Novianty Indjar Gama; M. Arifuddin; Rolan Rusli
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2054

Abstract

Uncaria nervosa Elmer. or commonly known as Bajakah is a plant endemic to Kalimantan which is believed to treat cancer. Utilization of endophytic fungal microorganisms is an effort to maintain the sustainability of plants that have the ability to transfer genetics from their host plants. The aims of this study were to determine the amount of yield, to obtain the types of secondary metabolites contained in the ethyl acetate extract, and to determine the toxicity of endophytic fungi isolates based on LC50 values for Artemia salina larvae. The methods used were isolation of endophytic fungi, endophytic fungi extraction, phytochemical tests using TLC and cytotoxic testing using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina larvae as test animals. The total yield of isolate G1A1 and isolate G1A3 were 0.0084% and 0.0078%, respectively. The results of the phytochemical screening of isolate G1A1 were tannins (Rf = 0.55) and triterpenoids (Rf = 0.6). Isolate G1A3 contains triterpenoids (Rf = 0.5) and flavonoids (Rf = 0.9). The LC50 value of isolate G1A1 was 512.86 ppm and isolate G1A3 was 660.7 ppm which has the potential to be cytotoxic. Keywords: endophytic fungi, TLC, BSLT Abstrak Uncaria nervosa Elmer. atau biasa dikenal dengan Bajakah merupakan tanaman endemik Kalimantan yang dipercaya dapat mengobati kanker. Pemanfaatan mikroorganisme fungi endofit menjadi upaya dalam menjaga keberlangsungan tumbuhan yang memiliki kemampuan transfer genetik dari tanaman inangnya. Tujuan dari penenlitian ini adalah mengetahui jumlah rendemen, mendapatkan jenis metabolit sekunder yang terkandung dalam ekstrak etil asetat, dan mengetahui toksisitas isolat fungi endofit berdasarkan nilai LC50 terhadap larva Artemia salina. Metode yang digunakan adalah isolasi fungi endofit, ekstraksi fungi endofit, uji fitokimia dengan KLT dan pengujian sitotoksik dengan metode Brine Shrimp Lethality Test (BSLT) menggunakan hewan uji dari larva Artemia salina. Jumlah rendemen isolat G1A1 dan isolat G1A3 masing-masing sebesar 0,0084% dan 0,0078%. Hasil skrining fitokimia isolat G1A1 adalah tanin (Rf = 0,55) dan triterpenoid (Rf =0,6). Pada isolat G1A3 mengandung triterpenoid (Rf = 0,5) dan flavonoid (Rf = 0,9). Nilai LC50 isolat G1A1 sebesar 512,86 ppm dan pada isolat G1A3 sebesar 660,7 ppm yang berpotensi sebagai sitotoksik. Kata Kunci: fungi endofit, KLT, BSLT
Pengaruh Pemberian Teh Kulit Buah Salak (Salacca zalacaa) Terhadap Kadar Glukosa Darah Mencit yang di Induksi Aloksan: Effect of Salak Fruit Skin Tea (Salacca zalacca) on Blood Glucose Levels in Alloxan Induced Mice Novia Dwi Ribatul; Fajar Prasetya; Satriani Badawi
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2055

Abstract

Diabetes mellitus is a non-communicable disease and is one of the main causes of death in the world. Treatment of diabetes mellitus is generally handled by administering antidiabetic drugs and administering insulin, but in the long term of consumption there are side effects resulting from administering these drugs and also the cost of treatment is increasingly expensive, so diabetics use traditional methods to neutralize blood levels. blood glucose by administering salak fruit skin tea. Salak fruit skin (Salacca zalacca) is a waste that has been scientifically proven to reduce blood glucose levels. This study aims to find out the initial information on the potential of zalacca skin tea to reduce blood glucose levels in diabetic mice and to find out how many doses are effective in lowering blood glucose levels. This research method used white male mice, which consisted of 3 groups, each of which was given zalacca skin tea at a dose of 70 mg/kgBW, 140 mg/kgBW, and 210 mg/kgBW. Alloxan was used as an inducer of diabetes for three days intraperitoneally. Blood glucose measurement using a glucometer (Easy Touch GCU). The results showed that giving zalacca skin tea could reduce blood glucose levels in diabetic mice and a dose of 210 mg/kgBW showed the best results in reducing blood glucose by 40.94%. So it can be said that salak skin tea (Salacca zalacca) has antidiabetic activity. Keywords: Antidiabetic, Salak skin tea, alloxan induction Abstrak Diabetes melitus merupakan suatu penyakit tidak menular dan menjadi salah satu penyebab utama kematian di dunia. Pengobatan diabetes melitus pada umumnya di tangani dengan pemberian obat-obatan antidiabetes serta pemberian insulin, namun dalam jangka waktu konsumsi yang panjang terdapat efek samping yang dihasilkaan dari pemberian obat tersebut dan juga biaya pengobatan yang semakin mahal, sehingga penderita diabetes menggunakan cara tradisional untuk menetralkan kadar glukosa darah dengan pemberian teh kulit buah salak. Kulit buah salak (Salacca zalacca) merupakan salah satu limbah yang terbukti secara ilmiah dapat menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui informasi awal potensi teh kulit buah salak dapat menurunkan kadar glukosa darah mencit diabetes dan mengetahui berapa dosis yang efektif dalam menurunkan kadar glukosa darah. Metode penelitian ini menggunakan mencit jantan putih, yang terdiri dari 3 kelompok masing-masing diberi teh kulit buah salak dengan dosis 70 mg/kgBB, 140 mg/kgBB dan 210 mg/kgBB. Digunakan aloksan sebagai penginduksi diabetes selama tiga hari secara intrapeitoneal. Pengukuran glukosa darah menggunakan glukometer (Easy Touch GCU). Hasil penelitian menunjukkan pemberian teh kulit salak dapat menurunkan kadar glukosa darah pada mencit diabetes dan dosis 210 mg/kgBB menunjukkan hasil terbaik dalam menurunkan glukosa darah yaitu sebesar 40,94%, Sehingga dapat dikatakan teh kulit buah salak (Salacca zalacca) memiliki aktivitas sebagai antidiabetes. Kata Kunci: Antidiabetes, Teh kulit buah salak, Induksi aloksan
Uji Efektivitas Ekstrak Daun Cemba (Senegalia rugata) terhadap Penyembuhan Luka Sayat pada Kelinci (Oryctogalus cuniculus): Testing the Effectiveness of Cemba (Senegalia rugata) Leaves Extract on Cure Incision Wounds Healing in Rabbits (Oryctolagus cuniculus) Dewi Rahmadina; Novita Eka Putri Kartab; Niken Indriyanti
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2056

Abstract

Wound medicine is a pharmaceutical preparation that helps speed up wound healing. Wound medications such as povidone-iodine contain antiseptics to prevent infection. Povidone iodine has bactericidal activity, low toxicity, and affordable price. However, in some cases, povidone-iodine can cause allergies. Cemba leaves (Senegalia rugate) are an endemic plant empirically used to heal open wounds. This study aims to determine the yield of cemba leaf extract, the ability of cemba leaf extract to heal cuts, and the concentration of cemba leaf extract, which can provide the best activity as a wound healer. This test uses rabbits as subjects which will be given treatment in the form of a control test of cemba leaf extract with an ointment base concentration variant of 5%, 10%, and 15%; for the comparison control, a negative control is used in the form of the base, positive control in the form of betadine ointment, and standard control. Based on the research that has been done, it was found that the yield of cemba leaf extract was 31.82%. The results of the phytochemical screening showed that cemba leaf extract contained secondary metabolites in the form of alkaloids, flavonoids, tannins, steroids, and saponins. The test results showed that a 5% cemba leaf extract and positive control concentration could heal wounds on the 10th day. Keywords: Cemba leaf, Povidone iodine, Cut wound healing, Phytochemical screening Abstrak Obat luka adalah sediaan farmasi yang membantu mempercepat proses penyembuhan luka. Obat luka seperti povidone iodine mengandung antiseptik untuk mencegah infeksi. Povidone iodine memiliki aktivitas bakterisidal, toksisitasnya rendah, dan harganya terjangkau. Akan tetapi pada beberapa kasus, povidone iodine dapat menimbukan alergi. Daun cemba (Senegalia rugata) adalah tanaman endemik yang secara empiris dimanfaatkan sebagai penyembuh luka terbuka. Penelitian ini bertujuan untuk mengetahui hasil rendemen dari ekstraksi daun cemba, kemampuan ekstrak daun cemba sebagai penyembuh luka sayat, konsentrasi ekstrak daun cemba yang dapat memberikan aktivitas paling baik sebagai penyembuh luka sayat. Pengujian ini menggunakan kelinci sebagai subjek yang akan diberikan perlakuan berupa kontrol uji ekstrak daun cemba dengan varian konsentrasi basis salep yaitu 5%, 10%, dan 15%, untuk kontrol pembanding digunakan kontrol negatif berupa basis, kontrol positif berupa salep betadine, dan kontrol normal. Berdasarkan penelitian yang telah dilakukan, didapatkan besar rendemen ekstrak daun cemba sebesar 31,82%. Hasil skrinning fitokimia yang dilakukan, diketahui ekstrak daun cemba mengandung metabolit sekunder berupa alkaloid, flavonoid, tanin, steroid, dan saponin. Hasil uji menunjukkan bahwa ekstrak daun cemba konsentrasi 5% dan kontrol positif  dapat menyembuhkan luka pada ± hari ke-10. Kata Kunci: Daun cemba, Povidone iodine, Penyembuhan luka sayat, Skrinning fitokimia
Uji Perbandingan Antioksidan dari Produk Teh Daun Kelor, Teh Bunga Rosella dan Teh Daun Melati dengan Metode Seduhan Suhu Konstan: Comparison Test of Antioxidants from Moringa Leaf Tea, Rosella Flower Tea and Jasmine Leaf Tea with Constant Temperature Stewing Method Abdul Rahim; Yuyun Febriani; Muhlisun Azim; Nur Rezky Khairun Nisaa
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2057

Abstract

Free radicals are known as an atom that does not have an electron pair and is unstable and only has one electron. Free radicals will act quickly to find their electron pairs. Jasmine leaves are rich in polyphenol antioxidants. Apart from jasmine, one type of plant that is suspected of being an antioxidant is moringa (Moringa oleifera, Lamk). Moringa plant has been known for centuries as a multipurpose plant full of nutrients and medicinal properties. Moringa leaves contain primary metabolites such as protein, fat, carbohydrates, various minerals, vitamins and amino acids. Rosella flowers contain many secondary metabolites, including polyphenols and falvonoids. The purpose of this study was to determine the highest antioxidant activity in tea from several tea brands (moringa leaf tea, rosella flower tea and jasmine leaf tea) using the DPPH method with tea brewing standards in accordance with those regulated in SNI 01-1902-1995 with levels constant temperature. Quantitative test results showed that the IC50 value of Rosella flower tea was 148 ppm (moderate antioxidant), the IC50 value of jasmine tea was 80 ppm (strong antioxidant) and the IC50 value of Moringa leaf tea was 88 ppm (strong antioxidant). Keywords: Antioxidant, Rosella flower, Moringa leaves, jasmine, Tea Abstrak Radikal bebas dikenal sebagai suatu atom yang tidak memiliki pasangan elektron dan tidak stabil serta hanya memiliki satu elektron. Radikal bebas akan cepat beraksi untuk mencari pasangan elektronnya. Daun melati kaya akan antioksidan polifenol. Selain tanaman melati, salah satu jenis tumbuhan yang diduga sebagai antioksidan adalah kelor (Moringa oleifera, Lamk). Tanaman kelor telah dikenal selama berabad-abad sebagai tanaman multiguna padat nutrisi dan berkhasiat obat. Daun kelor mengandung metabolit primer seperti protein, lemak, karbohidrat, berbagai mineral, vitamin dan asam amino. Bunga Rosella banyak mengadung senyawa metabolit sekunder antara lain polifenol dan falvonoid. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan tertinggi pada teh dari beberapa merk dagang teh (teh daun kelor, teh bunga rosella dan teh daun melati) menggunakan metode DPPH dengan standar penyeduhan teh sesuai dengan yang diatur dalam SNI 01-1902-1995 dengan tingkatan suhu yang konstan. Hasil uji kuantitatif menunjukkan bahwa nilai IC50 teh bunga Rosella 148 ppm (antioksidan sedang), nilai IC50 teh melati 80 ppm (antioksidan kuat) dan nilai IC50 teh daun kelor 88 ppm (antioksidan kuat). Kata Kunci: Antioksidan, Bunga Rosella, Daun kelor, Melati, Teh

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