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Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia
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Pediatric Sciences Journal
Published by Universitas Brawijaya
ISSN : 27220427     EISSN : 27221474     DOI : https://doi.org/10.51559/pedscij
Core Subject : Health,
Health Professions Public Health
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 40 Documents
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Quality of life in children with chronic disease in Malang city assessed using pediatric quality of life inventoryTM Yaalmolly Vinothini Ravindran; Irfan Agus Salim; Haryudi Aji Cahyono
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.36

Abstract

Introduction: A chronic disease is known to be a condition that affects daily function and daily activity which tends to cause someone to be hospitalized. A chronic disease in children triggers several changes in physical, social, emotional, and educational aspects and it can affect the quality of life and development of the child. The purpose of this study is to determine the quality of life of children with chronic disease in Malang city using PedsQLTM. Method: This study is an analytic observational study using a cross-sectional design. Data collection was using purposive (non-probability) sampling with a total sample of 82 respondents. Data collection was carried out using a generic PedsQLTM questionnaire version 4.0 with a google form. Data analysis was performed using Univariate analysis (Descriptive Respondents) and bivariate analysis (Correlation Analysis using Chi-Square). Results: The results showed that the factors that are significantly associated with the quality of life of children are the type of disease and the child's nutritional status (p-value= 0.005; 0.009< Level of Significance = 0.05) while other factors such as age, gender, parents' knowledge, and education background, duration of disease, parents' social and economic condition and several children are not significantly associated with the quality of life. Conclusion: The factors that are significantly associated with the quality of life of children were the type of disease and nutritional status.
Intravenous aminophylline treatment for severe asthma exacerbation in a toddler: an evidence-based case report Merrynta Rahmania; Ery Olivianto
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.39

Abstract

Introduction: Asthma is the most prevalent chronic condition in childhood causing enormous morbidity and mortality worldwide. Acute severe exacerbations are potentially life-threatening and often need hospitalization. Incomplete or poor response to initial treatment requires additional interventions that commonly are intravenous second-line drugs, of which Aminophylline is one of them. Although Aminophylline is costly and effective, views are polarising that its use is unsafe. Herein we report a case of intravenous aminophylline use in severe asthma exacerbation in a toddler. Case description: A 3-year-old boy previously diagnosed with asthma came to the emergency room due to severe shortness of breath. He had breathlessness which was more pronounced when he was lying down. He looked restless and irritable. Bilateral wheezing, tachypnea, tachycardia and chest withdrawal were noted. Because of poor response to standard initial treatment, intravenous Aminophylline was given and showed complete relief without the occurrence of the anticipated serious adverse event. Conclusion: When first-line inhaled/nebulized medication fails to control a child's asthma exacerbation, Aminophylline may be utilized. It must be considered a cost-effective treatment for acute asthma exacerbations, especially for developing countries with limited health budgets, even though it is thought to have a narrow therapeutic range and a large inter-individual variance in clearance.
The importance of correct management in a 15-year-old boy with severe pulmonary arterial hypertension associated with patent ductus arteriosus Dyahris Koentartiwi; Devi Albaiti Jannati; Ardhanis Ramadhanti; Heny Martini
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.44

Abstract

Background: Pulmonary arterial hypertension (PAH) is a condition in which pulmonary vascular pressure increases and is associated with diverse diseases or aetiologies. In children, 50% of PAH cases are caused by congenital heart disease (CHD), especially due to large left-to-right shunts. Large systemic to pulmonary shunts may develop in PAH if left untreated or repaired late. PAH, when present, markedly increases morbidity and mortality in patients with CHD. Case presentation: We present a 15-year-old boy with a large patent ductus arteriosus (PDA) and severe pulmonary arterial hypertension. Catheterization under general anaesthesia was performed at the age of 16 years. We performed an acute vasoreactivity test (AVT), with the AVT result showing pulmonary arterial hypertension with high flow and low resistance. Transcatheter closure (TCC) of PDA was performed, resulting in no residual PDA. Meanwhile, the echocardiographic finding showed that there was still class II pulmonary arterial hypertension. We then gave heart failure medication and selective pulmonary vasodilator for 6 months. Post-treatment, pulmonary artery systolic pressure was significantly lower (TR Vmax 2.31 m/s, TR Max PG 21 mmHg, estimated PAP 24 mmHg). In this case, clinical evaluation, CXR, ECG, echocardiography, and cardiac catheterization data were presented with a review of the current guidelines regarding the management of paediatric patients with PAH associated with PDA. Summary: TCC of PDA is an option to treat pulmonary hypertension in PDA patients. Combined use of drugs and TCC PDA proves beneficially synergistic effect with better outcomes and may reduce mortality.
Comorbidities as risk factors for clinical outcomes in pediatric patients with COVID-19: a comprehensive literature review Saptadi Yuliarto; Kurniawan Taufiq Kadafi; Rakhman Tyas Perdana; Takhta Khalasha
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.40

Abstract

Background: The population that in a high risk to have a svere COVID-19 infection is children. The difficulties can influence the risk of controlling their hygiene and be worsened by the immaturity immune system, especially in children with comorbidities. Moreover, this problem needs to be prioritized in children. Despite in worldwide spread of severe COVID-19 infection, there are limited data regarding severe COVID-19 disease in children. Thus, we investigated the effects of comorbidities as risk factors for clinical outcomes in paediatric patients with COVID-19. Methods: This comprehensive literature review was from the PubMed, Google Scholar, and Science Direct databases through January 2021. The keywords used to obtain the literature include “COVID-19”, “coronavirus”, ” pediatric”, ”children”, ”severity”, ”comorbidity”, ”mortality”, ”death,” and “intensive”. The article with the inclusion criteria was involved. The information about the COVID-19 severity and underlying comorbidities in children were the main criteria that were enrolled. Results: The severe clinical risk factors in paediatric patients with COVID-19 that are reported most often are chronic lung disease (including asthma) (4312 critical patients), obesity (1007 critical patients), diabetes mellitus (815 patients), cardiovascular disorders (677 patients) and neurological disorders (542), prematurity (183 patients) and immunosuppression conditions including malignancy (143 patients). Other conditions in the form of hematological disorders, airway abnormalities, malnutrition and gastrointestinal disorders can also contribute to the clinical severity of paediatric COVID-19 patients. Conclusion: Children with underlying diseases such as obesity, chronic lung disease, cardiovascular disease, and neurologic disease had a higher risk of severe COVID-19 than children without comorbidities.
Relationship between inhaled steroids and anthropometric status of pediatric patients with chronic asthma Harjoedi Adji Tjahjono; Ery Olivianto; Alfidha Muntaz; Irfan Agus Salim; Fadilah mutaqin
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.53

Abstract

Background: Asthma is a chronic inflammatory respiratory disease characterized by breathlessness, wheezing, and coughing symptoms. Asthma management aims to control the frequency of asthma exacerbations and ensure optimal growth and development in children. Inhaled steroids are anti-inflammatory medications that inhibit the synthesis of pro-inflammatory cytokines such as IL-4, IL-9, IL-13, and IL-17, which play a role in the pathogenesis of asthma. However, using inhaled steroids at high doses and for a long duration can have side effects on children's height. This research aims to examine the relationship between the use of inhaled steroids and the growth in height of children with asthma. Methods: simple linear regression analysis and multiple linear regression analysis. Results: the analysis indicate a correlation between daily dose and height increment in children aged 5-10 years (p = 0.005 < 0.05), but no significant correlation was found in children aged 10-18 years (p = 0.722 > 0.05). The analysis of total duration shows a correlation with height increment in both age groups (5-10 years, p = 0.035 < 0.05; 10-18 years, p = 0.001 < 0.05). The analysis also reveals a correlation between the simultaneous total duration and total dose with height increment in both age groups (5-10 years, p = 0.005 < 0.05; 10-18 years, p = 0.008 < 0.05). Conclusion: this study found a correlation between daily dose and height in both age groups, a correlation between total duration and height in the 5-10-year-old age group, and a correlation between simultaneous total duration and total dose with height in both age groups.
The correlation between levels of vitamin D (25(HD)D) and the occurrence of necrotizing enterocolitis (NEC) in preterm infants Eko Sulistijono; Brigitta Ida Resita Vebrianti Corebima; Yesi Adisti Pramitasari
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.48

Abstract

Introduction: One of the causes of gastrointestinal emergencies in newborns is necrotizing enterocolitis (NEC). A fetus is fully dependent on transfer from the mother as it lacks endogenous 25(OH)D production. Transplacental vitamin D transmission mainly occurs due to the elevated risk of vitamin D insufficiency in preterm newborns during the third trimester of pregnancy. This research is important to raise awareness about the importance of early initial screening of vitamin D levels in preterm infants in Indonesia. Methods: This study used an observational research design which is a cohort study, taking place during March–May 2020 in the neonatology inpatient ward of dr. Saiful Anwar General Hospital Malang. The enzyme-linked immunosorbent assay (ELISA) technique was used to measure the amount of vitamin D in the blood. The Kolmogorov-Smirnov test and the Levene test were used to determine whether the data were normal and homogeneous, respectively. Result: It was found that vitamin D levels in preterm infants with NEC were lower (10.18 ± 4.07 ng/mL) than in preterm infants without NEC (16.95 ± 4.45 ng/mL). The bivariate analysis result showed that vitamin D deficiency increased the risk of NEC by 10.7 times with p-value = 0.033 (95% CI 1.2-24.9). Furthermore, multivariate analysis found that vitamin D deficiency increased the occurrence of NEC by 19.4 times with a p-value = 0.043 (95%CI 0.7-21.7) and respiratory distress could increase the incidence of NEC by 9.4 times with a p-value =0.02 (95%CI 1.2-70). Conclusion: Vitamin D (25(OH)D) levels were lower in preterm infants with necrotizing enterocolitis compared to preterm infants without necrotizing enterocolitis. This study showed a significant correlation between vitamin D(25(OH)D) levels and the case of necrotizing enterocolitis in preterm infants.
Coronavirus disease 2019 (COVID-19) and polyarthritis juvenile idiopathic arthritis (JIA) comorbidity in children at emergency Wisma Atlet Kemayoran: the first case report with two months follow up Nia Fitriyani; Fitria Mahrunnisa; Tiona Romauli
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.50

Abstract

Background: Infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is often mild and asymptomatic in youngsters. However, in other circumstances, such as juvenile rheumatoid arthritis (JRA), COVID-19 necessitates special consideration because of the general immune system harm associated with autoimmune disorders and the iatrogenic side effects of corticosteroids. The multisystem inflammatory syndrome in children (MIS-C), which manifests 4-6 weeks after infection as a high fever, organ dysfunction, and markedly elevated markers of inflammation, is one manifestation of the COVID-19 disease that can cause secondary vasculitis or present with vasculitis or hyperinflammation manifestations. The association between MIS-C and SARS-CoV-2 infection shows that post-infectious immunological dysregulation plays a role in the pathogenesis. This study aimed to present a case of COVID-19 and JRA comorbidity in children at emergency Wisma Atlet Kemayoran. Case Report: A 10-year-old boy was admitted to COVID-19 Emergency Hospital Wisma Atlet Kemayoran with complaints of anosmia. The patient had a history of polyarthritis JRA, has been diagnosed since January 2020 and has routinely received methylprednisolone 4 mg/day and one tablet of calcium lactate once daily. No abnormalities were discovered during a general physical examination or a Pediatric Gait, Arms, Legs, and Spine (pGALS) assessment. On laboratory testing, leukocytosis and thrombocytosis are present. Thorax and extremities were radiologically examined within acceptable bounds. According to national guidelines for mild COVID-19 in children, the patient got routine treatment, which included a multivitamin. The patient also continued receiving methylprednisolone and calcium lactate while he was treated. After 12 days of treatment, the patient tested negative for COVID-19. One month after treatment, there was no hyperinflammatory reaction or recurrence of JRA. Conclusion: In pediatric patients diagnosed with COVID-19 and JRA, it is important to continue corticosteroid treatment with an adjusted dose. Even though this treatment has the possibility of causing immunosuppression which can complicate the healing process of COVID-19, we need to prevent the recurrence of JRA in patients.
Correlation of Vitamin D and nutritional status in pediatric systemic lupus erythematosus Muhammad Zulfikar Mahfudz; Harjoedi Adji Tjahjono; Irfan Agus Salim; Fadilah Mutaqin
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.56

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune illness affecting various organ systems, including the skin, joints, kidneys, cardiovascular, and neurological systems. Because of its immunomodulatory properties, vitamin D has been linked to the etiology and therapy of SLE. The link between vitamin D and nutritional status in pediatric systemic lupus erythematosus (pSLE) is complicated and multifaceted. This study aims to see if there is a link between vitamin D and nutritional status in children with systemic lupus erythematosus. Method: This study design was cross-sectional to determine factors influencing children with SLE. The study was conducted at Saiful Anwar Hospital in Malang from January 1, 2021, to June 30, 2022, and was approved by the hospital's research ethics committee. Statistical analysis was performed using the Shapiro-Wilk test for normality and Pearson correlation with SPSS 25 statistical analysis software. Results: All samples (32 children) were female, with a mean age of 14.1 ± 1.5 years. The mean vitamin D level was 18.32 ± 2.15 ng/mL, mean body mass index (BMI) was 19.51 ± 1.49 kg/m2. Regarding the nutritional status of children with SLE, 10 children were classified as malnourished (30%), while 19 children had good/normal nutritional status (60%). Three children had overweight (10%). There was a positive correlation between BMI and vitamin D in children with SLE (p=0.000, r=0.630). Conclusion: The majority of SLE youngsters have inadequate vitamin D levels. Vitamin D and the nutritional health of children with pediatric systemic lupus erythematosus have a significant favorable association.
Global impact of climate change on children's health in the world Kurniawan Taufiq Kadafi; Dimas Dwi Saputro; Martinus Martin Leman; Aslinar; Badai Buana Nasution; Dimas Tri Anantyo; Niken Wahyu Puspaningtyas; Fathy Zuandy Pohan; I Nyoman Arie Purwana; Muhammad Reza; Jaya Ariheryanto Effendy; Yogi Prawira; Piprim Basarah Yanuarso
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.57

Abstract

Climate change has a close relationship with the greenhouse effect. The greenhouse effect is needed by the earth, but if there are too many greenhouse gases in the atmosphere this will increase the earth's temperature. Children are a group of people who have a high vulnerability to climate change. Climate change will affect children's health through 4 impacts, namely direct impacts on children's health, impacts on children's health through ecosystems, impacts on children's health through human behavior, and health impacts on children due to natural disasters. To anticipate the impact of climate change on children's health, parents and the government must take anticipatory steps so that children can be saved from the extreme dangers of climate change.
Relationship between vitamin D levels with nutritional status and children's obesity in Saiful Anwar Hospital, Malang Anik Puryatni; Harjoedi Adji Tjahjono; Hanna Tetty
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.59

Abstract

Background: Obesity is a condition marked by an excessive buildup of body fat tissue and is characterized by a recognizable clinical picture. An imbalance between energy intake and energy output leads to obesity. Both obesity and vitamin D insufficiency are serious health issues of the present. It was claimed that the mobilization of free fatty acids from adipose tissue might be impacted by active vitamin D (1,25-dihydroxy vitamin D). This study aimed to find a relationship between vitamin D levels with nutritional status and children's obesity in Saiful Anwar Hospital. Methods: This study used a cross-sectional approach with a consecutive sampling method. Seventy-five subjects met the inclusion criteria in the Saiful Anwar Hospital Malang pediatric ward in February-March 2022. The samples were then examined for vitamin D levels. Subjects were grouped based on good nutritional status, overweight, and obesity. The basic characteristics of the research subjects included gender, age, anthropometric status, nutritional status, and vitamin D levels. Results: The results showed that vitamin D levels were lower in overweight and obese children (median 17.6 and 14.08 kg/m2) than in normal nutrition children (median 34 kg/m2). Vitamin D and children's nutritional status had a significant relationship (p=0.001). Conclusion: Vitamin D levels and children's nutritional status were significantly correlated, with vitamin D levels being lower in overweight and obese children than in children with normal nutrition.

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