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Pediatric Sciences Journal

pedscij
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Published by Universitas Brawijaya

ISSN : 27220427 EISSN : 27221474 DOI : https://doi.org/10.51559/pedscij

Core Subject : Health,

Health Professions Public Health

Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists

Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health

Articles 40 Documents

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Effect Of Vitamin D3 On Transforming Growth Factor - Β1 In Pediatric Patients With Stage 1 To 3 Chronic Kidney Disease: An Experimental Study And Randomized Controlled Trials Krisni Subandiyah; Richi Aditya
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: In Indonesia, Chronic Kidney Disease (CKD) is a severe health problem both in terms of treatment and health costs. One way to reduce mortality is by blocking the progression of the disease. Transforming Growth Factor-β1 (TGF-β1) is a marker of progression from CKD through its fibrosis pathway. One mechanism for interfering with the TGF-β1 signaling pathway is by giving vitamin D3(cholecalciferol). This study aims to find out that supplementation of vitamin D3 can increase plasma 25(OH)D levels and reduce TGF-β1 levels in children with CKD. Methods: The study was approved by the hospital's ethical committee, designed as a randomized clinical trial, double-blind, pre and post-test control group, which involved 30 subjects diagnosed as CKD stage 1-3. Subjects were divided into two groups; the vitamin D3-treated group and the placebo group. TGF-β1 and vitamin D plasma level was measured by ELISA method. Results: Vitamin D levels increased by 9.35 compared to the placebo group. The magnitude of the increase from the Wilcoxon statistical test results obtained p=0.001 (p<0.05), so there was a significant increase in vitamin D levels after supplementing vitamin D3. In the group given vitamin D3 supplementation, it was found that TGF-β1 levels had decreased by 108.64. The reduction from the Wilcoxon statistical test results obtained p=0.001 (p<0.05), so there was a significant decrease after vitamin D3 supplementation. Based on the Spearman correlation test, there is a meaningful relationship between increased vitamin D levels with a reduction of TGF-β1 levels. The correlation coefficient is -0.753, which is harmful. The correlation coefficient is in a substantial range. Conclusion: We concluded that vitamin D3 could increase 25(OH)D plasma level and decrease TGF-β1 levels significantly in children with stage 1 until 3 of CKD.

Post-Traumatic Stress Disorder Following Surgery: A Case Report of A Three-Year-Old Child with Deep Dermal Burn Injury Hajeng Wulandari; Ariani
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: In the past few years, there has been increased recognition that children, who have a history of traumatic incidences, can develop post-traumatic stress disorder (PTSD), just like in adults. Case: We presented a case of PTSD in a 3-year-old child hospitalized in the hospital for two days due to combustion (deep dermal burn injury) in his left hand, stomach, and both of his legs. The patient started to experience parasomnia such as nightmares, raves, difficulty to sleep and awakened from sleep (for one month from the beginning of wound treatment and debridement). The patient also had two re-experiencing symptoms: nightmare and emotional distress (anxiety, anger) after a traumatic stimulus. From his temperament scale and character assessment, there was dysregulation disorder. From the PEDSQL parent's reports, there was also decreased quality of life. Conclusion: First-line therapy of PTSD for the pediatric population is supportive psychotherapy with trauma-focused cognitive behavioral therapy (TF-CBT) that results in a remarkable improvement in child's psychiatric outcome.

Fecal secretory immunoglobulin a, human ß defensin-2, and calprotectin levels in preterm neonates who consumes breast milk only, formula milk only, and combination Eko Sulistijono; Putri Primawardani; Rusdian N. Ningsih; Bernardinus P.A. Pradipta
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Background: Secretory immunoglobulin A, human ß-defensin2 and calprotectin play an essential role in digestive system defense. This study aims to assess fecal SIgA, hBD-2, and calprotectin in preterm neonates (as inflammation marker) with different feeding patterns. Method: This study was cohort designed included 39 preterm neonates, which were categorized into breast milk only, formula milk only, and combination. Fecal SIgA, hBD-2, and calprotectin measured by ELISA. Results: Fecal SIga in the breast milk only group were significantly higher (p<0.005). Fecal HBD-2 and calprotectin in the formula milk only group were highest but not significantly different (p=0.463) with the combination group. Conclusion: Fecal SIgA levels that consumed breast milk only were significantly higher. Fecal HBD-2 and calprotectin levels that consumed formula milk only were highest but not significantly different from the combination group.

Clinical and laboratory profiles of pediatric asthma patients with house dust mite (HDM)–specific subcutaneous immunotherapy: A single center, cross sectional study Desy Wulandari; Wisnu Barlianto
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: House dust mite (HDM) allergy has been reported as an actual cause of asthma in children. Subcutaneous immunotherapy (SCIT) is a recommended treatment for HDM allergy patients. However, there were limited data about the characteristic of pediatric patients with HDM-SCIT, particularly in Indonesia. This study was aimed to evaluate the characteristic of pediatric patients with allergic asthma. Methods: Study participants were pediatric patients confirmed with HDM allergy from Skin Prick Test (SPT) in the pediatric allergy-immunology outpatient clinic in Saiful Anwar Hospital Malang, Indonesia. Patients who were treated with HDM-SCIT in the early build-up phase of treatment were included in this study. Demographic and clinical characteristics of the patients were recorded. Peripheral blood samples were drawn to evaluate the total eosinophil count (TEC), total basophil count (TBC), neutrophil-lymphocyte ratio (NLR), specific IgE (sIgE) and total IgE (t-IgE) level. Clinical diagnosis of asthma was classified according to the Global Initiative for Asthma (GINA) criteria. The evaluation of asthma control was assessed by the Asthma Control Test (ACT) score. Results: Thirty-two patients were enrolled in this study, including 14 male and 18 female. The mean age of children was 6.92 ± 2.60 years old. There were 21 subjects with uncontrolled asthma and 11 subjects with partially controlled asthma. Demographic characteristics including age, sex, nutritional status and family history were not significantly different between uncontrolled and partially controlled asthma groups (p> 0.05). TEC, TBC, NLR, and tIgE were not different significantly among groups (p> 0.05). This study showed that the mean of sIgE serum level was higher in uncontrolled asthma compared to partially controlled asthma group (p= 0.022). Moreover, it was a negative significant correlation between sIgE serum level and ACT score (p= 0.002, r= -0.532). Conclusion: Higher sIgE levels were correlated with poor asthma control in HDM-SCIT patients.

Sphingomonas paucimobilis an unusual cause of subdural empyema in pediatric: a case report Annisa Muhyi; Amalia Aswin
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: Acute bacterial meningitis continues to be a neurological emergency with high mortality and morbidity Case: We report the case of a pediatric patient with subdural empyema due to Sphingomonas paucimobilis. A 2-month-old infant developed fever, generalized seizures, and worsening general status. He had a cough for two weeks, and a chest X-ray showed pneumonia. Laboratory tests reveal marked leukocytosis, a white blood cell count of 28.500/mL, and an elevated platelet level of 654.000 mg/dL. A computerized brain tomography revealed an empyema subdural. A cerebrospinal fluid analysis showed unclear fluid, revealed cell count 3560 cells, 90% mononuclear and 10% polymorphonuclear, red blood cell count of 0/mm3, protein of 370 mg/dL, and glucose of 35 mg/dL. His cerebrospinal fluid culture showed Sphingomonas paucimobilis sensitive to cephalosporin, levofloxacin, meropenem, imipenem, gentamycin, tobramycin and amikacin. He was treated empirically with meropenem. The patient had a rapid recovery from the seventh day of treatment and was discharged on hospital day 14. Conclusion: We highly recommend raising awareness about subdural empyema as a complication for acute bacterial meningitis caused by S. paucimobilis in community-acquired infection.

An Eleven Year Old Boy with Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Desy Wulandari; Wisnu Barlianto; Nisak Humairok
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: The prospective studies have estimated that the DRESS syndrome incidence rate is about 1 per 1000 to 10,000 with the mortality rate is to be around 10% to 20%. Case: We have been reported a case of DRESS in an eleven-year-old boy who came to the emergency room with the chief complaint of maculopapular rash in the body that had been happened for three days. The rash was first appeared in the arms area and thus spread to the trunk, abdomen, and lower extremities. The erythema was well-demarcated, purplish in color. There was a history of fever a week before admission which reached 40 0 Celcius. There are multiple histories of drug administration, either orally or intravenously to this patient, and made the diagnosis of drug reaction is highly possible. The management of these patients consists of suspending suspected drugs and implementing supportive measures. Conclusion: Regarding pharmacological treatment, the use of systemic corticosteroids for a prolonged period with a gradual decrease is suggested, to avoid relapses.

Correlation of Regulatory T Cells Percentage and Lung Tuberculosis in Children Melinda; Ery Olivianto; HMS Chandra Kusuma
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: The prevalence of TB in Indonesia reaches 1.59 new cases per 1000 population and 27.3% are pediatric patients. Currently in Indonesia, the incidence of TB in children is still high, even though the Bacille Calmette Guerin (BCG) vaccination has been a mandatory immunization program since 1977. The role of T-Regulatory Cell (Treg) in the Mtb infection is very complicated. Method: This observational study using cross sectional analyzed quantity of Treg Cells in the circulation of pediatric TB and non-TB patients. Measurement of circulatory Treg cell percentage was performed using Flow Cytometry. Result: We found that pediatric TB patients have significantly higher that were almost two-fold higher Treg cell percentage compared to non-TB patients (3.51% vs. 1.86%; p < 0.001). It is concluded that there is an increase in the percentage of Treg cells in children with pulmonary TB compared to children who didn’t had TB infection. Conclusion:This finding provides an understanding of the complex mechanism of Treg cells in children with pulmonary tuberculosis, so that it can become the basis for the development of management of pediatric pulmonary TB and reduce morbidity and mortality of children due to pulmonary TB.

Mechanical ventilation practice of pediatric patients with Covid-19 in Indonesian tertiary hospital Kurniawan Taufiq Kadafi; Erviani Maulidya; William Prayogo Susanto; Saptadi Yuliarto
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Background: Coronavirus Disease-2019 (COVID-19) in children tend to have milder clinical manifestation. However, some develop critical conditions and require mechanical ventilation in the Pediatric Intensive Care Unit (PICU). Various modalities are recommended for mechanical ventilation, such as High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP), or invasive ventilation with intubation. This study aims to describe the clinical feature, ventilation modalities usage, and the outcome of children with critical COVID-19. Methods: This is a retrospective study in COVID-19 children with respiratory distress who were treated in the COVID-19 isolation PICU room of Saiful Anwar General Hospital for one year. The data was gained from the medical record and analyzed descriptively. Data were analyzed using Ms. Excel for Windows. Results: A total of 51 children with COVID-19 were admitted to Saiful Anwar general Hospital in one year period, with 12 of them in critical condition and 6 children require mechanical ventilation. The main signs developed were fever and dyspnea. Invasive mechanical ventilation applicated in 5 patients, and only 1 patient received Non-Invasive Ventilation (NIV). The mean of PEEP used in invasive ventilation is 7-9 cmH2O, lower than ESPNIC’s recommendation of 8-10 cmH2O. Length of ventilator usage is 2-21 days, with 2 patients passed away, both with a comorbid and organ system injury. Conclusion: The mechanical ventilation setting must be determined individually based on the patients’ condition, despite several guidelines providing the recommendation.

Stroke in pediatric: a review Nugroho Danu; Melinda; Astarini Hidayah
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Stroke in children was defined as the clinical and radiological manifestation of stroke, with radiological evidence of cerebral infarction or hemorrhage. Pediatric stroke can be divided into ischemic and hemorrhagic stroke. The etiology is very different, and diagnostic procedures are often more in-depth to look for etiology. Stroke is classically characterized by acute focal neurologic deficits such as hemiplegia, speech, or gait disturbances; presentation is highly dependent on the child’s age and may be non-specific. When acute focal neurologic deficits are found in childhood, one should think about stroke until proven otherwise. There is no standard therapy based on a systematic review of a randomized clinical trial. Therapeutic recommendations are the consensus of experts, extrapolated from the recommendations for stroke therapy for the adult population. Understanding stroke in children is complicated because it has broad differential diagnosis, and complications that occur. Therefore, early recognition of childhood stroke by pediatricians is very important with the implementation of targeted and neuroprotective therapies.

Good outcome of newborn septic arthritis with holistic treatment: a case report Muhammad Irvan Avandi; Brigitta Ida Resita Vebrianti Corebima; Eko Sulistijono; Talita Clarissa Sinatra
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: Septic arthritis (SA) is a serious joint infection associated with significant morbidity that can cause permanent damage with articular cartilage destruction, osteonecrosis, and lifelong deformities. Here we present a good outcome of newborn septic arthritis with prompt treatment. Case Presentation: A one-month-old boy was brought with swelling of both knee joints two weeks before admission. He has a history of preterm birth and was hospitalized in the Neonatal Intensive Care Unit (NICU) because of neonatal pneumonia and sepsis. Several days after treatment, he came with swollen on both knees, both knee joint synovial liquid and sputum culture showed Klebsiella pneumoniae. Magnetic Resonance Imaging (MRI) was found intra articular fluid and erosion of the epiphyseal cartilage suspect infection process. After establishing the diagnosis of SA, we initiated treatment with cloxacillin 60 mg/kgs body weight for 14 days. He underwent debridement and physiotherapist. One year after discharge, the physical examinations showed normal findings and had a normal gait. Conclusion: It can be concluded that prompt diagnosis and treatment of SA on the newborn will have a good outcome with no sequelae. An early diagnosis of SA can guide clinicians to initiate a standardized treatment and improve patient outcomes.

Page 2 of 4 | Total Record : 40

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Krisni Subandyah

Contact Email
pedscijournal@gmail.com

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+6281337051550

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pedscijournal@gmail.com

Editorial Address
Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia

Location
Kota malang,

Jawa timur

INDONESIA

Abstract

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Krisni Subandyah

Contact Email pedscijournal@gmail.com

Phone +6281337051550

Journal Mail Official pedscijournal@gmail.com

Editorial Address Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia

Location Kota malang, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Krisni Subandyah

Contact Email
pedscijournal@gmail.com

Phone
+6281337051550

Journal Mail Official
pedscijournal@gmail.com

Editorial Address
Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia

Location
Kota malang,

Jawa timur

INDONESIA