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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 15 Documents
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Search results for , issue "JKKI, Vol 11, No 2, (2020)" : 15 Documents clear
Effects of methanol extracts of insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats Raden Edi Fitriyanto; Sugiarto Sugiarto; Dwi Tonang Ardiyanto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art11

Abstract

Background: Obesity can lead to insulin resistance contributing to diabetes mellitus (DM). Empirically, insulin leaves of Tithonia diversifolia (Hems.) A. Gray (Td) can be used as a traditional DM medicine.Objective: This study aims to determine effects of Td methanol extracts on insulin resistance and secretion in DM rats induced by a high-fat diet and alloxan.Methods: This study was a randomized pre and post-test control group. Its research subjects were divided into five groups: a normal group, an obese group with diabetes without therapy (KN), an obese group with DM treated by the Td extracts with a dose 50 mg/kg, 250 mg/kg, and 500 mg/kg. The DM obesity was induced by a high-fat diet followed by administration of alloxan with a dose of 135 mg/kg intraperitoneally. The Td extracts was administered after 7 days of DM induction by using gastric swabs. Insulin resistance in the rats was measured based on HOMA-IR index values, while their insulin secretion was based on HOMA-B values. A statistical analysis was conducted by a 95% confidence level.Results: Blood glucose levels decreased to normal levels in all the groups administered by the Td extracts, except in the KN group. The HOMA-IR index values in all groups treated by the Td extracts did not increase except in the KN group. The HOMA-B index values in groups with doses of 50 and 250 mg/kgBW experienced a higher increase and significantly differed with the KN group.Conclusion: The administration of the Td extracts with doses of 50 and 250 mg/ kgBW in the DM rats could decrease blood glucose levels, could prevent insulin resistance and could increase insulin secretion. 
Assessments of quality of life in burn patients after hospital treatment in Jember Agnellia Maulidya Utami; Ulfa Elfiah; Desie Dwi Wisudanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art8

Abstract

Background: Burn injuries can contribute to physical and psychological problems affecting quality of life (QoL). The QoL is a parameter to assess medical results after treatment. In Indonesia, studies concerning burn patients’ QoL after treatment are still limited.Objective: This study aims to observe correlations between 8 dimensions of QoL after treatment and histories of burn severity, numbers of surgical procedures, and lengths of hospital stayMethods: A cross sectional study was conducted in December 2018. Subject criteria of this study were patients who have experienced burn injuries for the last 2 years and have been treated at dr. Soebandi Hospital Jember. Then all the patients were discharged from the hospital by following medical advice in recovered conditions. They were asked to complete SF-36 questionnaires that consist of 8 dimensions of QoL. Every dimension was correlated with histories of burn severity, numbers of surgical procedure, and lengths of hospital stay. Next, the obtained data were analysed by Pearson and Spearman.Results: 13 subjects or patients were analysed. Most of them (38.5%) were adults in a range of 41 – 50 years old and were male (69.2%). A bivariate analysis found a significant negative correlation between burn severity and QoL in physical functions, bodily pains, and mental health dimensions (p=0.030, p=0.012, p=0.044). A significant negative correlation was also reported between numbers of surgical procedures and QoL in physical role dimensions (p=0.047). Lengths of hospital stay had a significant negative correlation with physical functions and physical role dimensions (p=0.044, p=0.031).Conclusion: This study revealed significant correlations between burn severity, numbers of surgical procedures, length of hospital stay and the various dimensions of QoL. This study also provided data of QoL, so in the future burn centres can identify dimensions of QoL after burn injuries and can improve their burn management and patient care to improve their QoL.
Prevalence of constipation and lifestyle risk factors related to constipation in an adult population of South Tangerang Hoirun Nisa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art6

Abstract

Background: Constipation is a common bowel complaint in a general population that can negatively impact a quality of life. Unhealthy lifestyles play major roles in causing the constipation. Objective: This study was aimed to estimate prevalence of the constipation and identify lifestyle risk factors related to constipation in a general adult population.Methods: A cross-sectional survey was conducted on 227 adults aged =20 years, who lived in East Ciputat, South Tangerang. Information about demographic characteristics, lifestyle habits, and bowel habits was collected through in-person interviews. Chi-square test and logistic regression were used for data analysis.Results: The prevalence of self-reported constipation in the general adult population was 21.6%. The common symptoms included defecation time =5 minutes (39.6%), sensations of incomplete evacuation (37.9%), and frequency of defecation <1/day (34.4%). Married status was related to a decreased risk of constipation (odds ratio= 0.31; 95% confidence interval= 0.11-0.89). Lifestyle factors of smoking, sedentary job, body mass index, and physical activity were less related to the risk of constipation.Conclusion: The prevalence of constipation was relatively high in the general adult population in South Tangerang. Further studies are needed to explore the relationships between lifestyle risk factors and constipation in other populations.
The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus Tri Agusti Sholikah; Sri Wulandari; Indah Ariesta; Muhammad Arif Rakhman Hakim; Muhammad Hafizhan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art10

Abstract

Background: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality The pathogenesis of DM involves pancreatic ß-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids are antioxidants that play a role in reducing pancreatic ß-cell damage or damage to other tissues, which potentially reduce blood glucose levels.Objective: To determine the hypoglycemic effects of tapak liman using the DM rat models.Methods: Twenty-eight Wistar albino rats (Rattus novergicus) were divided into four groups: the normal control group (KKn), not induced by streptozotocin-nicotinamide (STZ-NA) intraperitoneal; negative control group (KK-), induced by STZ-NA; treatment group 1 (KP1), induced by STZ-NA and 150 mg/kg body weight of tapak liman plant extract; and the treatment group 2 (KP2), induced by STZ-NA and 300 mg/kg body weight of tapak liman. Blood glucose levels were measured on the 7th day after STZ-NA induction and the 28th day after the administration of tapak liman plant extract. The results were analyzed for statistical significance.Results: There was a significant decrease in blood glucose levels in KP1 and KP2 (p= 0.05). The decrease in blood glucose in KP1 had not reached normal levels compared to KP2.Conclusion: Administration of tapak liman plant extract at a dose of 300 mg/kg body weight in DM rat models reduced blood glucose levels to normal.
Rhabdomyosarcoma metastases to the bone marrow of a 2-year-old male patient: A case report Tri Ratnaningsih; Wirimena Hurimah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art13

Abstract

Rhabdomyosarcomas are the most common pediatric soft tissue sarcomas. However, rhabdomyosarcoma cases that manifest as a systemic disease or showing diffuse metastasis in the bone marrow are sporadic. The most common sites of metastasis due to rhabdomyosarcoma include lungs, lymph nodes, and bone marrow. The bone marrow involvement is seen in about 30% of cases of metastasis. We report a case of a 2-year-old boy with complaints of right eye protrusion. The result of a head CT-scan arouses suspicion of rhabdomyosarcoma. On physical examination, protrusion of the eye and swelling of the neck with a fixed and flat surface were observed. Peripheral blood examination resulted in pancytopenia (hemoglobin: 4 g/dL, leukocytes: 3,490 cells/µL, platelets: 16,000 cells/µL). The peripheral blood morphologies showed lymphoblasts and myeloblasts, whereas the bone marrow biopsy result showed infiltration of tumour cells (rosette cell form). Chest imaging examination showed suspected of skeletal metastases in bilateral scapulae and bilateral costae. Pancytopenia with tumour cells metastasis to the bone marrow was found in this case. Diagnosis of rhabdomyosarcoma with multiorgan metastasis and the presence of tumour cells in the bone marrow was based on clinical features, physical examination, laboratory examinations, and other supporting investigations.
Multidrug-resistant Klebsiella pneumoniae from clinical isolates at dr. Soeradji Tirtonegoro central hospital Klaten Handi Virawan; Titik Nuryastuti; Hera Nirwati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art3

Abstract

Background: Klebsiella pneumoniae is a Gram-negative bacterium that often causes nosocomial infections. Use of broad-spectrum antibiotics as an empiric therapy has contributed to increases of K. Pneumoniae strains that are resistant to antibiotics. Therefore, a test on antibiotic susceptibility of K. pneumoniae is needed as a guide in treating a definitive therapy. Objective: This study aimed to measure the percentages of multidrug-resistant (MDR) of K. pneumoniae and its susceptibility at dr. Soeradji Tirtonegoro Central Hospital, Klaten, Central Java in 2017. Methods: This study was a descriptive study using secondary data at the Clinical Microbiology Laboratorium of dr. Soeradji Tirtonegoro Central Hospital, Klaten. The K. pneumoniae was isolated from patients hospitalized in the hospital from January 1, 2017, to December 31 2017. Identifications of the K. pneumoniae were conducted by a colony morphology observation, a gram staining, and a biochemical test. The test of antibiotics susceptibility used Kirby-Bauer method based on Clinical and Laboratory Standards Institute (CLSI). The data were analyzed by univariate analysis.Results: In 2017, there were 213 K. pneumoniae isolates from various clinical samples. Among them, 122 isolates were MDR K. pneumoniae (57.28%). The majority of MDR K. pneumoniae were resistant to a wide range of antibiotics. The MDR K. pneumoniae had only a good sensitivity to meropenem (98.43%), amikacin (93.75%), nitrofurantoin (88.89%), and fosfomycin (88.89%). In contrast, all non-MDR K. pneumoniae had good sensitivity to all tested antibiotics, except to ampicillin.Conclusion: The percentage of MDR K. pneumoniae isolates at the dr. Soeradji Tirtonegoro Cental in 2017 was 57%. Meropenem and amikacin could be considered as empirical therapies to cure an MDR K. pneumoniae infection. 
Hubungan antara Disfungsi Tiroid dengan Profil Lipid pada Pasien Struma di Klinik Litbang GAKI Magelang Yusi Dwi Nurcahyani; Prihatin Broto Sukandar; Raden Edi Fitriyanto; Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art5

Abstract

Background: Relationship between thyroid hormones and lipid profiles in patients with struma is a common condition found in IDD endemic areas. Objective: This study observes relationships between thyroid functions and lipid profiles in woman patients of childbearing age with struma. Methods: This paper is a cross-sectional study of 83 subjects/patients who met inclusion and exclusion criteria in this study. Total cholesterol, LDL, HDL, TSH, and free T4 concentration were measured in all the patients. Lipid concentrations in patients with thyroid dysfunction and patients with euthyroid were compared by using a linear regression model. Results: Total cholesterol, LDL, and HDL was significantly lower in patients with primary hyperthyroidism (N=19) than in patients with euthyroid (N=48) (mean±SD 122.8±20.09 mg/dl vs 187.3±33.66 mg/dl, p=0.000 unadjusted, p= 0.000 adjusted for age and BMI); (63.5±16.33 mg/dl vs 121.7±29.71 mg/dl, p=0.000 unadjusted, p= 0.000 adjusted for age and BMI); (48.8±9.66 mg/dl vs 53.6±8.49 mg/dl, P=0.049 unadjusted, p=0.026 adjusted for age and BMI. Serum total cholesterol and LDL was lower in patients with subclinical hyperthyroidism (N= 14) than in patients with euthyroid (N=48), but it was not statistically significant (181.6±32.07 mg/dl vs 187.3±33.66 mg/dl, p=0.577 unadjusted, P=0.719 adjusted for age and BMI); (110.5±14.83 mg/dl vs 121.7±29.71 mg/dl, p=0.181 unadjusted, p=0.250 adjusted for age and BMI). Serum HDL was similarly elevated in patiemts with subclinical hypothyroidism (N=14) than in patients with euthyroid (N=48), but it was not statistically significant (57.4±11.04 mg/dl vs 53.6±8.49 mg/dl, p=0.185 unadjusted, p=0.229 adjusted for age and BMI).Conclusion: Serum total cholesterol, LDL and HDL was significantly lower in patients with primary hyperthyroidism, but it was not significant for subclinical hyperthyroidism.
Efektivitas Ekstrak Kulit Batang Mimba (Azadirachta indica A.Juss) Sebagai Gastroprotektor Elisa Nuraida; Dwi Sutiningsih; Mohammad Hadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art7

Abstract

Background: Gastric ulcer is a digestive problem that has a high prevalence rate, peptic ulcer can cause complications such as bleeding in the gastrointestinal tract, perforation, recurrence, cancer and even death. The neem stem bark extract has a compound that can be a gastroprotective activity so that it can reduce the number of gastric ulcer and gastric acid levels. Gastroprotective effects of neem bark extract in combination have been widely studied can reduce gastric ulcer, but no one has examined the extract of neem bark as a single gastroprotector.Objective: This study aims to determine the dose of extract that can prove the extract of neem stem bark can inhibit the ulcer index by macroscopic observation and microscopic images of in ratsMethods: This research is a purely experimental study carried out in July – September 2019. The neem stem bark extract was given to Wistar male white rats with various dosages for seven days orally, after 24 hours of fasting, induced gastric ulcer with ibuprofen 400 mg/kg. Mice were dissected to activate the ulcer index after 8 hours of induction of gastric ulcer. Result: The ulcus index of negative group (ibuprofen), positive group (ranidin), and extracts of mimba rods 250, 500, 1000, and 2000 CMG/kgBB in a row were 7.13, 16.76, 7.41, 2.32, and 2.00 (p= 0.034). Microscopic observations suggest a much better picture of histology after this extract.Conclusion: The extract of a mimba bark has gastroprotective activity at 2,000 mg/kgBB.
PHYLOGENY MAGNITUDE OF Mycobacterium tuberculosis BASED ON GENOMIC ANALYSIS Budi Yanti; Mulyadi Mulyadi; Soetjipto Soetjipto; Ni Made Mertaniasih; Muhammad Amin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art12

Abstract

Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, drug resistance, host interaction, latency, and vaccine effectiveness. It is necessary to have better understanding of MTB relationships based on similarities in genome sizes and phylogenetic analysis. This paper observes the relationships of MTB based on nucleotide through phylogenetic frameworks. The MTB species consist of six lineages, and each lineage has various size of genomes . This difference contributes to virulence of MTB affecting levels of severity, morbidity, and mortality of diseases. Genetic diversity of MTB can contribute to global threats in the world such as outbreak of tuberculosis, Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) tuberculosis.
Nutritional profile in Indonesian elderly subpopulation Deasy Irawati; Ardiana Ekawanti; Anom Josafat
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art4

Abstract

Background: Data on malnutrition in the developing countries showed that 1–3 elderly in every 5 elderly were malnourished. However, the data in Indonesia were limited. Malnutrition in elderly is often underdiagnosed and thus it usually goes undetected at earlier stage.Objective: The aim of this study was to examine nutritional profile of elderly by using several indicators: anthropometry, Mini Nutritional Assessment (MNA) Questionnaire, and dietary intake.Methods: A cross-sectional study was conducted among community dwelling elderly (aged =60 years) and elderly in the institutional care. The outcome variables were prevalency of malnutrition (undernutrition and overnutrition) and macro and micronutrient intake. Nutrition profiles were assessed using anthropometry, MNA and 24-hour food recalls. Comparative analysis between continuous variables was conducted using Mann-Whitney or ANOVA. Differences between categorical variables were assessed using Chi-square tests or Fisher’s exact test.Results: Based on BMI, in total, 1 in 2 elderly was either undernutrition or overnutrition. Based on MNA, 1 in 2 elderly were malnourished or at risk of malnutrition. Place of residency and gender were associated with the distribution of malnutrition in elderly (p<0.001). Approximately 1 in 2 elderly from the community dwelling group were overweight and obese whereas 1 in 3 elderly from the institutional care group were severely thin and thin. The intakes of 4 in 5 elderly were deficient in vitamin D, calcium, vitamin E and folate.Conclusion: Elderly in our population group were experiencing the double burden of malnutrition and this coexisted with micronutrient deficiency.

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