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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 319 Documents
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Epidemiologi Dan Diagnosis Dengue Di Indonesia Zilhadia, Zilhadia
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Abstract

Dengue fever/DF and dengue hemorrhagic fever/DHF is a global public health problem that occured in tropical and subtropical region. Epidemic dengue occurs every years, and it continues to be a major health problem in Indonesia. Due to its asymptomatic nature, a reliable, rapid and accurate dengue diagnosis is needed. Dengue diagnosis method based on molecular dengue virus properties and it will be developed by researcher. Dengue rapid test isnewly method. This article explaine about dengue epidemiology, molecular dengue virus properties, clinical diagnosis, serology diagnosis and progress research of dengue virus.
Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi Nugrahani, Ilma; Asyarie, Sukmadjaja; N.S, Sundani; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Abstract

Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.
Formulasi dan Uji Kestabilan Fisik Suspensi Topikal yang Mengandung Ekstrak Nerii Folium sebagai Antibakteri dalam Sediaan Anti Jerawat Djajadisastra, Joshita; Munim, Abdul; Hidayah, Octaviarini
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Abstract

Nerium oleander is one of the plants that can be developed to be a herbal medicine because the leaf extract has an antibacterial activity against some microorganisms and empirically had been used to solve the acne problem. The anti acne formulation should not make the acne worse because of mistaken to choose the dosage form. The suspension dosage form (has no oil content makes the acne worse) containing the dried leaf extract of Nerium oleander in 97% alcohol was chosen to be formulated by varying respectively carbomer, sodium carboxy methyl cellulose and tragacanth as a suspending agent. The concentration of Nerii folium extract in the suspension was based on the Minimal Inhibitory Concentration of the extract against Propionibacterium acnes and Staphylococcus. The evaluation of the formula was done by physical stability test including organoleptic test (color and odor), pH, volume of sedimentation, mean particle diameter size, viscosity stored in low temperature of 4oC, room tperature of 28oC, and high temperature of 40oC, cycling test and mechanical test.The results showed that suspension with sodium carboxy methyl cellulose as the suspending agent has better physical stability than carbomer or tragacanth.
Sintesis dan Uji Aktivitas Antibakteri N,N'-Divanilidenaetilendiamina Hayun, Hayun; Munim, Abdul; Hariria, Dini; Aunillah, Ulfah
Majalah Ilmu Kefarmasian
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Abstract

The study of synthesis and antibacterial activity test of N,N'-divanilidene-ethylendiamine was performed. N,N'-divanilidene-ethylendiamine was synthesized by reacting vaniline with ethylendiamine in ethanol pH 1, and the structure was elucidated based on IR and 1H-NMR spectra data. Antibacterial activity test was performed using minimum inhibition concentration method (MIC) against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, and Escherichia coli ATCC 25922. The results showed that N,N'-divanilidene-ethylendiamine has antibacterial activity with MIC of 2 mg/mL against the the bacteria.
Determination of Ethanol In Employee's Blood Who Work In "X" Alcoholic Beverage Industry Using 1-Propanol as an Internal Standard by Gas Chromatography Harmita, Harmita; Mansur, Umar; Rahmadani, Suchi
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Abstract

Ethanol not only caused drunk, but also in certain amount it can caused death. Because of the side effect of ethanol was dangerous if there sufficient concentration in blood and the penetration which is relatively easy so it was important to know how much ethanol in blood, especially on official employee in alcoholic beverage industry. A gas chromatography method using a capillary column CBP-10 and flame ionization detector (FID) has been developed and validated for the detection and quatification of ethanol in blood. Gas chromatography was performed in isothermal mode with column temperature 60oC. Helium was used as carrier gas with flow rate 1.0 mL/min. Quantification was performed with the uses of 1-propanol as an internal standard (IS). The method was linear in the concentration range of 0.001-0.8% v/v with coefficient of corelation 0.9998. The lower limit of quantification (LLOQ) was found to be 0.001% v/v. This method was validated with precisions (CV) 0.53-3.47% and accuracies (% diff) 3.86-7.46%. Result of ethanol recovery varied from 96.14-107.46%. The result of validation method fulfilled for the given criteria.
Pengembangan Sediaan Dengan Pelepasan Dimodifikasi Mengandung Furosemid Sebagai Model Zat Aktif Menggunakan Sistem Mukoadhesif Sutriyo, Sutriyo; Rachmat, Hasan; Rosalina, Mita
Majalah Ilmu Kefarmasian
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Abstract

Drug bioavailability is one of the parameter which is used to evaluate the effectiveness of pharmaceutical dosage form. Rate of dissolution and drug residence time in gas-trointestinal tract is a factor which can influence the bioavailability. Solid dispersion and mucoadhesive drug delivery system is one of the method which can be used to solve the problem concerning the rate of dissolution and residence time in gastrointes-tinal tract. In this research mucoadhesive microgranule had been made with furo-semide as a drug model and Carbopol 934P® as a mucoadhesive polimer. The mucoadhesive microgranules resulted from this investigation has a particle size range of 425-850 µm, and was evaluated by type 1, 100 rpm speed and phosphate buffer pH 5.8 dissolution test and by wash off test. Furosemide was made in solid dispersion with polyvinylpyrrolidone (PVP K30®) with weight ratio of 1:7 using solubility method. The results showed increasing the dissolution rate of furosemide in solid dispersion compared to pure furosemide. Increasing the concentration of Carbopol 934P® in microgranule will cause inhibition of drug release and increasing the amount of microgranule sticked to gastric and intestinal mucous.
Validasi Metode Analisis Cilostazol Dalam Plasma In Vitro Secara Kromatografi Cair Kinerja Tinggi Harahap, Yahdiana; Mansur, Umar; Estherina, Christine
Majalah Ilmu Kefarmasian Vol. 5, No. 1
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Abstract

Cilostazol is an antiplatelet agent with the mechanism of action by inhibiting phos-phodiesterase III (PDE III). Referred to Food and Drug Administration(FDA),cilostazol is a drug recommended to be bioequivalence (BE) studied. A high-perfor-mance liquid chromatographic (HPLC) method with ultraviolet detector for in vitro determination of cilostazol in human plasma had been developed and validated. Cilostazol and pioglitazone as internal standard were extracted from human plasma by protein precipitation method using methanol. The mobile phase consisting of ac-etonitrile-potassium di-hydrogen phosphate buffer 50 mM (40:60) was used at the flow rate of 1.5 mL/min on reversed phase C18 column (SunfireTM, 5 µm, 250x4.6 mm), and was detected at wavelength of 257 nm. Linearity was established within concentration range of 20-2000 ng/mL with coefficient correlation (r) was 0,9999. Accuracy (% diff) of this method was -14.67% up to 8.84% with precision (CV) being 0.98% to 4.93%, and absolute recovery was established to be 82.26% to 119.85%. Cilostazol in plasma was stable for 30 days in -200C storage.
Evaluasi Penggunaan Sediaan Farmasi Intravena Untuk Penyakit Infeksi Pada Salah Satu Rumah Sakit Swasta Di Kota Bandung Surahman, Emma; Mandalas, Esther; Kardinah, Endah Ismu
Majalah Ilmu Kefarmasian Vol. 5, No. 1
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Abstract

An usage evaluation of intravenous pharmaceutical dosage form for infectious dis-eases at one of the private hospitals in Bandung by retrospective method on October to December 2005 had been done based on the rationality of drug used according to the certain criteria. The result of the evaluation from 1170 prescriptions found that the combination of two or more drugs was 7.78%, no drug dose improper, no duplication of drug used, nor interaction with another drugs were found. The preparation of intravenous pharmaceutical dosage form had been well done, but the aseptic tech-nique still less of attention.
Uji Aktivitas Antimikroba dan Uji Sitotoksik Ekstrak Etanol Akar Tanaman Akar Kucing (Acalypha indica Linn), Daging Buah Mahkota Dewa (Phaleria macrocarpa (Sheff) Boerl) dan Sari Buah Merah (Pandanus conoideus Lam) Radji, Maksum; Sari, Ratna Chandra; Sumiati, Atiek
Majalah Ilmu Kefarmasian Vol. 5, No. 1
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Abstract

The antimicrobial activity and cytotoxic effect of ethanol extract of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam, had been carried out. The results of the research showed that those ethanol extracts had antimi-crobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosae ATCC 27853 and Candida albicans. The determi-nation of cytotoxic effects of those ethanol extracts by brine shrimp lethality test (BSLT) using Artemia salina Leach showed that LC50 of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam were 1,279 ug/ml, 0.123 ug/ml and 0.054 ug/ml respectively.
Pembuatan Teh Herbal Campuran Kelopak Bunga Rosella (Hibiscus sabdariffa) dan Herba Seledri (Apium graveolens) Munim, Abdul; Hanani, Endang; Mandasari, Andita
Majalah Ilmu Kefarmasian
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Abstract

Rosella calyx (Hibiscus sabdariffa) has been reported exhibited on decreasing high blood pressure activity. Celery herb (Apium graveolens) has been acknowledged as an antihypertension herb with vasodilator and diuretic effect. Combination of the extracts was expected to provide synergism effect on decreasing high blood pressure. This study was intended to prepare the combination of herbal tea from standardized extracts of rosella calyx and celery herb. Standardization of rosella calyx and celery herb included determination of several specific and non-specific parameters. Three different formulas of herbal tea were prepared that would be hedonically tested to obtain the most favorable herbal tea formula from the 30 panelists. The most favorable formula was formula C which contained rosella calyx (2 gram) and celery herb (0.5 gram).

Page 5 of 32 | Total Record : 319

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