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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 319 Documents
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Pengembangan Aplikasi Komputer Pengolah Data Konsentrasi Obat Dalam Plasma Untuk Studi Pemodelan Parameter Farmakokinetik A, Sukmadjaja; S, Lucy; Q, Muhammad
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Abstract

A computer application named Farmakomatic 1.0 had been developed to calculate pharmacokinetic parameters from plasma drug concentration data following intravenous and oral administration with one and two compartment model using a program application Microsoft® Visual Basic 6.0®. The application was evaluated using two plasma drug concentration data. Calculation results of the Farmakomatic 1.0 and manual calculation using Microsoft® Excel 2003® were not different.
Uji Hambatan Tumorigenesis Sari Buah Merah (Pandanus Conoideus LAM.) Terhadap Tikus Putih Betina Yang Diinduksi 7,12 Dimetilbenz(a)Antrasen (DMBA) Mun‘im, Abdul; Andrajati, Retnosari; Susilowati, Heni
Majalah Ilmu Kefarmasian Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

Red fruit (Pandanus conoideous Lam.) has been known by public as a medicine for any kind of diseases, among of them is for cancer. To determine the carcinogenesis inhibition effect of red fruit extract , we have examined the effect on 7,12- dimethylbenz[a]anthrasene (DMBA)-induced rat lungs cancer model in female Sprague-Dawley rats. The extract was tested at 0.21 ml/200 g bw; 0.43 ml/200 g bw and 0.88 ml/ 200 g bw. The experiment was terminated at day 120. Lung histology was used to evaluate carcinogenesis inhibition. The result showed that the extract at 0.21 ml/200g bw improved lung carcinogenesis inhibition than other dose.
Uji Efektivitas Antimikroba Beberapa Merek Dagang Pembersih Tangan Antiseptik Radji, Maksum; Suryadi, Herman; Ariyanti, Dessy
Majalah Ilmu Kefarmasian
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Abstract

In Modern life, peoples are more conscious to keep their healthy. One of the way to keep our body healthy is by keeping our hand clean. Washing hands with soap and water, sometimes is unpractical since it need water to rinse off the soap. Prod-uct innovation has been developed to overcome the unpractical side, which is called antiseptic hand wash or hand sanitizer. This study has been done to evaluate the antimicrobial activity of some hand sanitizer products marketed in Jakarta. The re-sult showed that alcohol-based hand sanitizer and triclosan-based hand sanitizer used in this experiment were significantly reduce bacterial counts on hands, but not all of the samples are effective in reducing fungal counts on hands.
Analisis Zat Warna Sintetik Terlarang Untuk Makanan Yang Beredar Di Pasaran Azizahwati, Azizahwati; Kurniadi, Maryati; Hidayati, Heidi
Majalah Ilmu Kefarmasian Vol. 4, No. 1
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Abstract

The use of synthetic food colorants is increasing because of its advantages. However, it is found that not all food colorants which are sold in the market are safe to be consumed. The purpose of this research was to identify synthetic food colorant samples which are sold in market and to find out whether they contain safe food colorants or not. Extraction did not need to be done on samples. Analysis was done using color reaction and paper chromatography. Densitometry was done to support the identification result. The result of this research showed that 10 out of 31 samples that were tested contain synthetic food colorants that must not be used for food. The ten samples were seven red colorants (three samples containing Merah K4, the two others containing Rhodamine B, and two samples containing Scarlet GN), one orange colorant (containing Orange G), one yellow colorant (containing Metanil Yellow) and one chocolate colorant (containing Chocolate Brown FB).
Pengaruh Pemberian Ekstrak Biji Klabet (Trigonella foenum-graecum L.) Terhadap Perkembangan Kelenjar Mamae Tikus Putih Betina Galur Wistar Agustini, Kurnia; Wiryowidagdo, Sumali; Kusmana, Dadang
Majalah Ilmu Kefarmasian
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Abstract

Phytoestrogen is the chemical compound contains in plant which has estro-genic like effect. Estrogen has important function on woman’s sexual organ, such as proliferation of uterine and vaginal cornification. Phytoestrogen are weak agonists for estrogen and illicit statistic significantly increases in uterine wet weight, at definite dose, in uterothrophic bioassay. Biji Klabet or Fenugreek seed (Trigonella foenum-graecum L.) contains steroidal sapogenins such as diosgenin, tigogenin, gitogenin, yamogenin and trigoneoside, that suspected having an estrogen-like ef-fect or as phytoestrogen. The aim of this research was to investigate the estrogenic effect of fenugreek’s ethanolic extract in ovariectomized and immature rats models. These models represent the climacteric/menopause phase, where estrogen level is very low because ovary produces no estrogen. The testing animals were divided into normal group, ovariectomized control group, estradiol control group and three level doses of fenugreek extract (30mg/200gBW; 60mg/200gBW and 120mg/200gBW). The result indicated that start on 60mg/200gBW, fenugreek extract significantly could increasing mammary gland proliferation. Empirically fenugreek containing diosgenin, that caused breast enhancement. This research showed that treatment with fenugreek extract can caused proliferation of mammary gland, both on imma-ture and ovariectomized rats.
Uji Aktivitas Penghambatan Enzim A-Glukosidase Daun Kalanchoe Pinnata Pers Efizal, Efizal; Soemiati, Atiek; Hanafi, M; Dwiyanti, Indah
Majalah Ilmu Kefarmasian Vol. 4, No. 1
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Abstract

The study of inhibitory activity against the a-glucosidase enzyme of Kalanchoe pinnata Pers. leaves has been carried out. In vitro, the methanol extract, n-hexane fraction, ethyl acetate fraction and methanol-water (1:1) fraction inhibited a-glucosidase enzyme activities with IC50 value 72.8, 982.6, 194.6 and 293.8 ug/mL, respectively. In vivo, the study was conducted in normal ddY mice by using oral glucose tolerance test. The administration of methanol extract dose 0.5, 1.0 g/kg of body weight and ethyl acetate fraction dose 1.0 g/kg of body weight can suppress the blood glucose level at 30 min significantly (p<0.05) if compared with control after oral administration of sucrose (3 g/kg of body weight), and their activity were similar with acarbose 0.01 g/kg of body weight (p>0.05).
Pengaruh Konseling Tentang Terapi Obat Tbc Terhadap Kepatuhan Penderita Tbc Paru Pada Terapi Obat Periode Februari-Mei 2007 Di Kelurahan Pancoran Mas-Depok Husnawati, Husnawati; Andrajati, Retnosari; Harianto, Harianto
Majalah Ilmu Kefarmasian Vol. 4, No. 2
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The objective of this study was to know the patients’ characteristics, antituber-culosis drug use, and to analyzed the influence of counselling about tuberculosis therapy on patient’s adherence in Pancoran Mas-Depok. This study was quasi experiment design (non randomized control group pretest-postest design). The in-clusion criteria were the people with tuberculosis who took antituberculosis drugs from February – May 2007 in Pancoran Mas-Depok, and followed pretest and postest. Total samples were fifty two respondents. Respondents were divided into two groups, intervention group and control group. Both of groups were given questionnaire (pre-test). After that, intervention group were given counselling about tuberculosis therapy. A month later, both of groups were given a similar questionnaire (postest). Data was analysed with t-test. The result of this study showed that majority of respondents in intervention and control group were productive aged, low education, employee, but majority of intervention group were women and majority of control group were men. The results of this study showed that there was a significant different of adherence to tuberculosis therapy between intervention group and control group (p value = 0,007). There was influence of conselling on patient’s adherence to tuberculosis therapy.
Penetapan Kadar Triprolidina Hidroklorida dan Pseudoefedrina Hidroklorida Dalam Sediaan Sirup Obat Influenza Secara Kromatografi Lapis Tipis Densitometri Hayun, Hayun; Leswara, Nelly D.; Masrijal, Camelia D.P.
Majalah Ilmu Kefarmasian
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Abstract

The determination of pseudoephedrine hydrochloride and triprolidine hydro-chloride in influenza syrup medicine has been performed using TLC densitometric method. Pseudoephedrine hydrochloride and triprolidine hydrochloride were extracted using chloroform at pH 12 from the syrup, and separated using HPTLC silica Kie-selguhr glass plates 60 F 254, 20x10 cm2 as stationary phase, and a mixture of methanol, ammonia and chloroform (40:2:30) as mobile phase. The plates were ana-lyzed using Camag TLC Scanner 3 with UV-detector at 257 nm for pseudoephe-drine hydrochloride and at 290 nm for triprolidine hydrochloride. The results showed that the linearity, limit of detection, and limit of quantitation of the method for pseudoephedrine hydrochloride were 0.9999, 0.0064 µg, and 0.2124 µg respectively; while for triprolidine hydrochloride were 0.9999, 0.0076 µg, and 0.0254 µg respec-tively. The coefficient of variance (CV) of repeatability for the two substances were less than 2.0%; and the recovery values for pseudoepherine hydrochloride and triprolidine hydrochloride were 99.98 + 1.05% and 99.73 + 1,54% respectively. The result showed that the samples analysed contained pseudoephedrine hydrochloride 94.36% of the labeled ammount, and triprolidine hydrochloride 94.44% of the la-beled ammount.
Pengaruh Milling Terhadap Laju Disolusi Campuran Metampiron-Fenilbutason (7:3) Soewandhi, Sundani Nurono; Haryana, Aris
Majalah Ilmu Kefarmasian Vol. 4, No. 2
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Abstract

In pharmaceutical process, milling is a common process to produce particle in certain expectation size. Impact of milling process could lead to physical interaction. Dissolution rate will change as an impact of physical interaction. To observe physical interaction between methampyrone and phenylbutazone during milling process, is needed to analyze its X-ray diffractogram, DSC thermogram and dissolution rate. Data of X-ray diffractogram, differential scanning calorimetry and dissolution test, showed that physical interaction occurred after 5,5 hours and 18 hours of milling and cause enhancement of dissolution rate of phenylbutazone. Dissolution rate of methampyrone was constant after 5,5 hours of milling. Decreasing dissolution rate of methampyrone occured after 18 hours of milling.
Analisis Epigalokatekin Galat Dalam Minuman Teh Hijau Siap Saji Kurniadi, Maryati; Leswara, Nelly D.; Rinayanti, Yola
Majalah Ilmu Kefarmasian Vol. 4, No. 2
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Epigallocatechin gallat (EGCg) is a polyphenol constituent in tea that has antioxidant effect. The purpose of this research was to identify and examine qualitative and quantitative EGCg in green tea preparations which were stored in different condition, that was in a refrigerator and in an open air. The results showed that all samples containing EGCg. The examination of EGCg concentration in the sample was done by thin layer chromatography densitometric method using cellulose plate. N-propanol - acetic acid - water (1:1:5) was the selected eluent. Linear regression equation from calibration curve was y = -1204.071 + 7.495 x, with correlation factor (r) = 0.99911. EGCg concentration from sample that stored in refrigerator sample number one was 0.00293% w/v, sample number two was 0.00298% w/v, and sample number three was 0.00328% w/v. EGCg concentration from sample that stored in open air was lower than LOD.

Page 4 of 32 | Total Record : 319

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