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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 14 Documents
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Search results for , issue "Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 14 Documents clear
CORRELATION BETWEEN HOUSE DUST MITE DENSITY WITH HEALTHY HOUSE CRITERIA AND ASTHMA STATUS IN PEDIATRIC PATIENTS Shobrina Insan Sakina Armunanto; Dian Puspita Dewi; Dodik Pramono; Moh Syarofil Anam
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30270

Abstract

Abstract Background: Asthma is a chronic respiratory disease most often found in children and has the highest prevalence in developing countries. House dust mites are the second most common trigger of asthma whose habitat is influenced by the criteria for a healthy.Objective: Understanding the correlation between sleep density and asthma status in pediatric patients and criteria for a healthy house.Methods: This study was an analytical observational method with a cross sectional study design that took place from June to October 2020. It involved 25 respondents of children with asthma patients aged 3-11 years. There is a confounding variable, namely the criterion score for a healthy house. Dust samples were collected in the bedroom of the respondent diagnosed with bronchial asthma. The identification process using the floating method was carried out at the Parasitology Laboratory, Faculty of Medicine, Diponegoro University, Semarang Indonesia. Respondent data were analyzed using statistical software programs. Non-parametric test with lambda correlation test.Results: The mean of house dust mite’s density in the respondent's house was 3.68 ± 2.32. House dust mite’s density was associated with the criteria for a healthy house (p <0.05), but house dust mite density was not related to the asthma status of pediatric patients (p> 0.05).Conclusion: There is no correlation between pediatric asthma status and house dust mite density. 
Factors Associated with the Non-Adherence of TB Screening in Children Aged Lidwina Vania Shaynaputri; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30184

Abstract

Background: TB screening in children having close contact with smear-positive TB patients is urgent to conduct to improve the case detection rate and to achieve the “End TB” target. In fact, the implementation of screening in Indonesia is still inadequate.Objective: To analyze the factors associated with the non-adherence of TB screening in children aged <15 years with smear-positive TB patients’ close contact.Methods: A cross-sectional study was conducted in Semarang between February and August 2020. Subjects were children <15 years old with smear-positive TB patient's close contact. Data were collected from interviewed parents or guardians of the child using a structured questionnaire. Chi-square or Fisher's exact test analysis was used to identify the factor associated with non-adherence to TB screening in children.Results: A total of 84 children were recruited into this study. The proportion of children who did not undergo the screening is still high (86,9%), and there was a significant association with children's age (OR 13,556, 95% CI=3.135-58,613), parents' age (OR 41,143, 95% CI=4,025-420,604), parents’ education level (OR 0,114, 95%CI=0.027–0.477), distance to health facilities, knowledge level, perceived barriers, and cues to action. There was no significant association between children’s gender, economic level, perceived threats with non-adherence of screening.Conclusion: Children and parents’ age, education level, distance to health facilities, knowledge level, perception of barriers, and cues to action associated with the non-adherence of TB screening in children aged <15 years with smear-positive TB patients’ close contact.
Histopathology of Seminiferous Tubules of Wistar Rats (Rattus norvegicus) Exposed to Electric Mosquito Repellent with Active Ingredient D-Allethrin Salwa Nabila Izzati; Desy Armalina; RR. Mahayu Dewi Ariani; Fanti Saktini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.31588

Abstract

Background: An increase in mosquito-borne diseases has resulted in the use of mosquito repellents, especially electric ones in Indonesia. One of the active ingredients of electric mosquito repellent, namely d-allethrin, cangenerate free radicals resulting in oxidative stress. Oxidative stress on the testes can interfere with the spermatogenesis stage in the seminiferous tubules.Objective: Determine the histopathology of seminiferous tubules of Wistar rats exposed to electric mosquito repellents with the active ingredient d-allethrin.Methods: This study used a true experimental design with a post test only control group design. A sample of 25 Wistar rats was divided into 5 groups. The control group (K) was given only standard feed. Treatment group 1 (P1), treatment group 2 (P2), treatment group 3 (P3), and treatment group 4 (P4) were exposed to electric mosquito repellents with active ingredient d-allethrin sequentially for 8 hours/day, 12 hours/day, 18 hours/day, and 24 hours/day. After 30 days the rats were terminated. The testes were taken for histopathological observation with HE staining and assessed according to the Johnsen score criteria.Results: Based on the score, the mean value of the control group was 9.4, P1: 8.36, P2: namely 7.68, P3: 5.84, and P4: 5.64.The results of statistical tests using the one way Anova showed a significant difference (p <0.001).Conclusion: Exposure to electric mosquito repellent containing the active ingredient d-allethrin caused differences in the histopathology of seminiferous tubules score of Wistar rats.
THE EFFECT OF SUBMERSION IN ORANGE JUICE AND FERMENTED MILK ON COLOR CHANGES OF NANOHIBRID COMPOSITE RESIN Attila Yulaicha; Diah Ajeng Purbaningrum; Dwi Retnoningrum; Ariosta Ariosta
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30459

Abstract

Background: Color changes in nanohibrid composite resins can occur due to 2 factors, intrinsic and extrinsic factors. Beverage can be the one of the extrinsic factor such as orange juice and fermented milk. The pH content of this both of drink will affect the change in color of the composite resin. Low pH conditions will cause the release of H+ which has an impact on the degradation and breaking of polymer chain bonds. Aim: To determine the effect of orange juice and fermented milk on the color change of nanohibrid composite resin. Methods: An experimental study with the post test control group design and a total sample of 6 samples. Soaking for 24 hours at 37ºC in artificial saliva, orange juice, and fermented milk. After 24 hours the color changes were measured using a colorimeter. Statistical test using Independent T-test.Results : Significant differences in color changes in nanohibrid composite resins between the two sample groups (p = 0.00). Independent T-test showed the results of a significant difference between 2 groups.Conclusion: Orange juice affect the change in color of nanohibrid composite resin. There was a significant difference between orange juice and fermentedKeywords: Nanohibrid composite resin, Color change, Orange juice, Fermented milk.
Relationship of Sleep Quality with Short-Term Memory and Reaction Time in First Year Medical Students of Diponegoro University Rizki Gatot Febrian; Santoso Jaeri; Muflihatul Muniroh; Darmawati Ayu Indraswari
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.31391

Abstract

Abstract Background: Sleep disturbance is a disorder that includes a lack of quantity and quality of sleep. Students, especially medical students, have a high risk of getting sleep disorders of poor sleep quality and quantity. Poor sleep quality can interfere with memory. Besides, poor sleep quality also results in fatigue, which can lead to increased reaction time.Aim: To determine the relationship between sleep quality and short-term memory and reaction time in first-year medical students of Diponegoro University.Methods: This Observational study used a cross-sectional design with first-year medical students of Diponegoro University as the subjects. Kolmogorov-Smirnov was applied as the normality test, then the hypothesis test between sleep quality and short-term memory used the Pearson Chi-Square test, while sleep quality and reaction time used the Mann-Whitney U test. Results: Two hundred students participated in the study. Eighty two people (41%) had good sleep quality, 118 people (59%) had poor sleep quality. The p value of the relationship between sleep quality and short-term memory showed insignificant result (p=0.791). Meanwhile, the Mann-Whitney test to measure the relationship between sleep quality and reaction time was also insignificant (p=0.270).Conclusion: There is no significant relationship between sleep quality with reaction time and short-term memory in first-year medical students of Diponegoro University.
THE EFFECT OF CARBONATED, ISOTONIC AND YOGHURT DRINKS IMMERSION ON THE ROUGHNESS OF BULK-FILL COMPOSITE RESIN Ayu Khoirun Nisa; Diah Ajeng Purbaningrum; Lusiana Batubara; Faizah Fulyani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30521

Abstract

Background: Composite resins are dental restorative materials that are widely used and have high aesthetic value compared to other materials. However, acidic environmental conditions can degrade the composite resins, resulting in increased surface roughness of the resin, and consequently lead to an increased risk of caries.Objective: the purpose of this study was to evaluate the effect of immersion in acidic drinks on the surface roughness of composite resins,Method: In this study 24 samples of bulk fillTM  composite resins were used. Samples were divided into four groups. Each sample was immersed for 5 seconds in either artificial saliva (control), carbonated beverage, isotonic, or yogurt, and followed by 5 seconds immersion in saliva. This cycle was repeated for 20 times for 14 consecutive days. The roughness of composite resin before and after 14 days immersion was measured by using a profilometer. Microscopic structures were analyzed by Scanning electron Microscope (SEM). Statistical analysis was used paired t-test, Anova and Post Hoc LSD.Results: Data from each sample group was normally distributed- with p > 0.05. The paired t-test for each group showed a p-value < 0.05, which indicates there was a significant difference between surface roughness before and after immersion. ANOVA analysis revealed that there was a difference in the surface roughness between groups LSD test, showed that there was difference in the surface roughness between artificial saliva with carbonated drink, isotonic drink with carbonated drink, yoghurt drink with carbonated drink (p<0.0001), between artificial saliva group with yoghurt drink, yoghurt drink with carbonated drink, yoghurt drink with isotonic drink (p <0.05) which means there was a significant difference between group. Meanwhile, the isotonic drinks with artificial saliva obtained results (p>0.05), which means there is no significant difference.Conclusion: Exposure of carbonated drinks, yoghurt drinks, and isotonic drinks can significantly increase the roughness of the surface Bulk Fill resin composite compared to exposure of artificial saliva.Keywords: Composite resin, Bulk Fill, Surface Roughness, Acid
Selectivity of Ethanol Extract of Parijoto (Medinilla speciosa) Fruit in HepG2, Widr, 4T1, and Vero cell lines widyandani sasikirana; eva Annisaa&#039;; nuraini ekawati; Intan Rahmania Eka Dini; Estevina Tumbilaka
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.32010

Abstract

Background: Parijoto, one of the melastomaceae family, has been known to have cytotoxic activity in some cancer cell lines, such as HeLa, MCF-7, and T47D. Aims: We aim to know about the selectivity of ethanol extract of Parijoto fruit in cell line HepG2, WiDr, 4T1, and Vero. Cytotoxic was determined by MTT assay. Method: Extract was added in three serial concentration three serial concentrations (125 µg/mL–500 µg/mL), while the positive  control doxorubicin gives in 2,5 µg/mL – 20 µg/mL for cancer cell and 40 µg/mL -100 µg/mL for Vero cell.  Results: Results showed that ethanol extract of parijoto fruit gave low activity in HepG2 and Vero cell (IC50: 250 µg/mL) and moderate activity in WiDr and 4T1 (IC50: 81,58 µg/mL and 158,72 µg/mL). Conclusion: The highest selectivity index is given in WiDr cell (SI> 3) means that the ethanol extract of parijoto fruit is a promising cytotoxic agent for colorectal cancer therapy.
EFFECT OF LEMON AROMATHERAPY ON THE ANXIETY LEVEL OF DENTAL EXTRACTION PATIENTS IN RSND SEMARANG Hayuratri Purwalalita Laksmidevi; Devi Farida Utami; Arinta Puspita Wati; Maria Belladonna Rahmawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30522

Abstract

Background: Dental treatment that is often done is the tooth extraction procedure. The treatment and the use of sharp instruments such as syringes, pliers, bein during extraction can cause anxiety. Anxiety will be responded by several changes in the body such as the increasing of MAP, pulse rate, and respiratory rate. Handling anxiety can be done with aromatherapy, one is lemon aromatherapy.Aim: To determine the effect of lemon aromatherapy on anxiety levels and the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate in tooth extraction patients at RSND SemarangMethod: Experimental study with pretest and posttest control group design with sampling simple random to get 40 respondents that indicated as extraction teeth patient. Respondents were divided into 2 groups: 20 control respondents and 20 intervention respondents. Anxiety level was measured by the Modified Dental Anxiety Scale (MDAS) questionnaire. Data that was not distributed normally were the difference in pulse rate and the difference in respiratory rate, while the results of the homogeneity test obtained data that were not homogeneous were the difference between the MDAS questionnaire and the difference in the MAP. The rest of the mentioned data above were all distributed normally and homogeneous. Analysis of differences in anxiety levels between before and after lemon aromatherapy was given using paired t-test, analysis of differences in anxiety levels between the control group and the intervention group using the independent t-test, and to analyzing the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate using the Spearman test..Results: There was a significant difference in anxiety scale between before and after lemon aromatherapy was given p = 0,000135 (p <0.05) and between the control group and the intervention group p = 0.000002 (p <0.05). There was a positive correlation between anxiety levels with the results of MAP, pulse rate, and respiratory rate.Conclusion: Anxiety of tooth extraction patients shows a decreased after inhaling lemon aromatherapy. When someone is anxiety, there will be an increase in MAP, pulse rate, and respiratory rate.Keywords: Anxiety, tooth extraction, lemon aromatherapy, MAP, pulse rate, respiratory rate.
Association Between Birth Weight and Quality of Life in Early and Middle Adolescence Eva Latifatun Ni&#039;mah; Dimas Tri Anantyo; Adhie Nur Radityo Suswihardhyono; Teddy Wahyu Nugroho
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30073

Abstract

Background: Children with low birth weight tend to have a higher risk of experiencing abnormal growth and developmental delays. While the risk of developing obesity in the later years is higher in children with high birth weight. Physical and psychological conditions can affect the quality of life of adolescents.Objective: To analyze the association between birth weight and quality of life in early and middle adolescents.Methods: This cross-sectional study involved 120 students aged 13-16 years in Semarang City in which a consecutive sampling method was used.  The study was conducted in August 2020. Research subjects need to fill up the PedsQL, PAQ, birth history, and socio-economic questionnaires. Statistical analyses used were Chi-square and logistic regression tests.Results: Birth weight was significantly associated with quality of life (p=0.002). A history of abnormal birth weight increases the risk of experiencing poor quality of life as a teenager (p=0.002; OR=3.987). Low birth weight was associated with decreased physical function (p=0.001), whereas high birth weight was associated with reduced social and school functioning (p=0.013; 0.032). Gender was significantly associated with quality of life (p=0.016). Girls tend to have a higher risk of experiencing poor quality of life (p=0.021; OR=4.021).Conclusion: Birth weight has a significant association with quality of life in early and middle adolescents. Adolescents with a history of LBW or HBW were more likely to experience decreased quality of life than adolescents with a history of NBW.Keywords: Adolescence, Birth weight, Quality of Life.
TIME IN THERAPEUTIC RANGE (TTR) IN ATRIAL FIBRILLATION WITH WARFARIN THERAPY IN SEMARANG, INDONESIA Della Dafina Sekarsari; Pipin Ardhianto; Erwin Kresnoadi; Mochamad Ali Sobirin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30046

Abstract

Background: Atrial fibrillation is one of the factors forming thromboembolism. The thromboembolism can be prevented with warfarin. A side effect of warfarin is increasing the occurrence of bleeding, these therapy requires an evaluation of its usage. These evaluations can be seen in the Time in Therapeutic Range (TTR) patients. TTR is the duration in which the International Normalized Ratio (INR) patients in referral value are 2.0-3.0. TTR > 70% can prevent bleeding on FA patients with warfarin therapy.Aim: To determine TTR in patients receiving warfarin with atrial fibrillation.Methods: This study was descriptive with a cross-sectional design for six months at Dr. Kariadi Hospital Semarang. TTR was calculated using Rosendaal's Methods after collecting three INRs and patients' demographics.Results: Total subject was 111 patients with an average age of 52,63 and the TTR average is 53,75. TTR in this study was divided into two groups, that groups were poor TTR (TTR < 70%) with 82 patients (73.88%) and good TTR (≥70%) with 29 patients (26.12%).Conclusions: The average TTR in FA patients with warfarin therapy was 53,75%. 

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