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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 932 Documents
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COMPARISON OF ANTIBACTERIAL EFFECTIVENESS OF HERBAL TOOTHPASTE AND FLUORIDE ON THE GROWTH OF Streptococcus mutans Rosalia Indri Dewanti; V Rizke Ciptaningtyas; Ryan Halleyantoro; Gustantyo Wahyu Wibobo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35640

Abstract

Background: Streptococcus mutans was the most dominant bacteria in caused caries. Caries could be prevented by chemical plaque control methods used toothpaste. Toothpaste had antibacterial properties by helped to prevent bacteria from colonized. There were two antibacterial ingredients in toothpaste, fluoride and herbal ingredients. Aim: Determined the antibacterial effect of toothpaste with herbal and fluoride content on the growth of Streptococcus mutans. Methods: This study was an experimental study with a post-test only control group design. This research method was a diffusion method by means of wells. The sample used was the Streptococcus mutans colony. The study was divided into four groups, namely herbal toothpaste, fluoride toothpaste, positive control (chlorhexidine), and negative control (aquadest sterile) which were replicated 16 times in each group. The results of this study was the diameter of the resistance zone. Results: The average diameter of the zone of inhibition results obtained 12.49 mm (herbal toothpaste), 14.66 mm (fluoride toothpaste), 21.70 mm (chlorhexidine) and aquadest sterile there were no inhibition zones. There was a significant difference with the p value
Mat Pilates Excercise Increaase Peak Expiratory Flow Rate in Young Adults with Obesity Nugrahani Wiraningrum; Erna Setiawati; Tanti Ajoe Kesoema; Yuswo Supatmo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkd (dmj).v11i6.32628

Abstract

Background: Obesity is one of the main problems that keep growing in the world including in Indonesia. Obesity can cause various health problems, one of which is respiratory problems and decreased of pulmonary function parameters in the form of peak expiratory flow rate (PEFR). One of the methods that can be used to increase the pulmonary function parameters of the peak expiratory flow is Mat Pilates exercise. Mat Pilates exercise works by strengthening the core area between the pelvis, abdomen and back, which aims to increase the strength, flexibility and endurance of the respiratory muscles, by that Mat Pilate exercise can increase the peak expiratory flow. However, there have not been any studies that discuss the effect of Mat Pilates exercise on the peak expiratory flow rate in obese young adults.Aim: To prove that Mat Pilates exercise can increasae peak expiratory flow rate of young adults with obesity.Methods: This study used quasi experimental pretest and posttest design and was done in August until October 2020. The subjects were 33 female aged 18-23 years with BMI>27, divided in 2 groups. Experimental group (n=15) was instructed to do 8 weeks of Mat Pilates exercise (3 times a week) and control group (n=18) was instructed to not do any exercise. Peak expiratory flow rate was measured with peak flow meter. Data’s significance was analyzed with Paired T Test and Independent T Test.Results : A significant increase (p<0,001) in peak expiratory flow rate before and after Mat Pilates Exercise. The peak expiratory flow rate at the pretest between the 2 groups was no significant differences (p=0,841). The posttest peak expiratory flow rate of Mat Pilates exercise group (339,44 ± 53,71) was significant (p=0,027) higher than the control group (294,26 ± 56,97). The increase of PERF on Mat Pilates exercise group (45,00 ± 37,27)  is higher significantly (p=<0,001) than the increase on control group (4,07 ± 14,98).Conclusion: Mat Pilates exercise can increase peak expiratory flow rate in young adult with obesity.
A Bibliometric Analysis of Nanocrystalline Cellulose Research as Medical Implant Using VOSviewer Deaniar Hafilah; Asep Bayu Dani Nandiyanto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i6.35896

Abstract

Background: Nanocrystalline cellulose has potential for biomedical applications due to its abundant material availability, biodegradability, biocompatibility, and low weight. Research on nanocrystalline cellulose as medical implants has rarely been studied in the past 10 years, although this material has tremendous potential such as bone implants and cardiovascular implants. Objective: This study aims to analyze the development of research on nanocrystalline cellulose as medical implants using a bibliometric approach with computational analysis using VOSviewer. Methods: The article data was obtained using the Publish or Perish software by retrieving the database from Google Scholar. The keyword “nanocrystalline cellulose, medical implants, biomedical" is used with the publication time span from 2012 to 2020. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. Results: Research on the application of nanocrystalline cellulose has been carried out several times, this can be proven from computational mapping analysis using VOSviewer which shows the term "nanocrystalline cellulose" is in the same cluster as the term "medical implant". However, research on the application of nanocrystalline cellulose as medical implants is still rarely carried out, this is evidenced by the small frequency indicated by the two terms. Conclusion: Based on the results of mapping the collected article data, research on the application of nanocrystalline cellulose as medical implants is an interesting topic. However, this topic is still rarely studied. Therefore, this review can be a starting point for selecting the topic of research on the application of nanocrystalline cellulose materials as medical implants as a consideration for determining the research theme to be taken.
THE EFFECTIVENESS OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON PLASMA MALONDIALDEHYDE LEVEL IN DEMENTIA MICE Muhammad Ilham; Endang Mahati; Muflihatul Muniroh; Yora Nindita
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35304

Abstract

ABSTRACTBackground: Antioxidant is a substance that can catch and neutralize free radicals so that the process of oxidative stress can be stopped and cell damage can be avoided. Kaffir lime peel contains antioxidant compounds that have the potential to be the neuroprotective agent and can protect neurons from free radical-induced damage.Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the plasma malondialdehyde (MDA) level of mice induced by Scopolamine (SCM).Method: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups consisting of a healthy control (K+), Negative Control (K-), extract 5 mg/20gBW group (P1), 10 mg/20gBW group (P2), 20 mg/20gBW group (P3). SCM was injected intraperitoneally on days 1-7 and kaffir lime peel extract was given orally on days 2-7, the MDA levels testing of mice using TBARS method on day 8. Data analysis used One-Way ANOVA test and continued with Post Hoc LSD test.Results: The mean MDA levels of K+, K-, P1, P2, P3 were 4,212; 4,644; 3,481; 4,555; 4,733 nmol/mL, respectively. MDA levels of P1 were lower than K-, even though there were no statistically significant differences.Conclusion: There was no effect of administration kaffir lime peel extract (Citrus hystrix) on MDA levels in mice with scopolamine-induced dementia.Keywords: Citrus hystrix, malondialdehyde, dementia, mice
Correlation between HbA1c Levels and Severity of Diabetic Retinopathy Putri Lenggo Geany; Riski Prihatningtias; Arief Wildan; Maharani Cahyono
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35569

Abstract

Background: In recent years, Diabetes Mellitus (DM) has emerged as the world's leading cause of death with the potential to develop micro vascular complications in the form of retinopathy. HbA1c is an indicator to identify hyperglycemia and plays an important role in monitoring the development of complications due to DM. This study is undertaken determine the relationship between HbA1C levels and the severity of diabetic retinopathy in DM patients. Aim: To identify the relationship between HbA1c levels and different stages of diabetic retinopathy. Method: An analytic observational, cross sectional design, using patients’ medical record. Patient data consisted of gender, age, DM duration, HbA1c levels, and stages of diabetic retinopathy. Non parametric correlation Spearman’s rho was chosen for statistical analysis. Result: A total of 72 DM patients consisted of 29 men and 43 women with a mean DM duration 10.4 years. A total of 37 patients were diagnosed with diabetic retinopathy with 30 NPDR respondents (41.7%) and 7 PDR respondents (9.7%). The average HbA1C levels based on the patient's diabetic retinopathy stages, as follows; normal attained 6.49% (SD ± 0.95), NPDR 8.17% (SD ± 1.77), and PDR 8.47% (SD ± 1, 10). Spearman's non-parametric test showed a strong and significant relationship (p
Case Report: Myopericarditis in 19 Years Old Male Bonfilio Neltio Ariobimo; Dinar Rakanita Bestari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36457

Abstract

Inflammation of the pericardium due to either an infectious or non-infectious etiology, which is known as pericarditis. About 1% of hospitalized patients had this illness, and 5% of those patients complained of chest discomfort. About one-third of individuals with acute pericarditis had cardiac involvement, suggesting that the two diseases may have similar etiologies. We describe a 19-year-old man who experienced chest discomfort and was later diagnosed with myopericarditis. Empirical treatment utilizing NSAIDs and colchicine produced excellent outcomes in terms of symptom relief, ECG improvement, and CRP decrease. To reduce morbidity and mortality from sudden cardiac death, it is critical to recognize the signs and symptoms that fit the criteria for myopericarditis.. 
RELATIONSHIP BETWEEN LEUKOCYTE COUNT AND PROTEINURIA IN COVID-19 PATIENTS Anggar Setiorini; Indranila Kustarini Samsuria; Dwi Retnoningrum; Ariosta Ariosta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36757

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a disease caused by SARS-CoV-2 with flu-like symptoms that could be serious in high-risk individuals. The use of laboratory parameters is determined as a predictor in improving the quality of care and thereby reducing mortality and morbidity. One of the laboratory parameters itself is hematological examination, including leukocyte count. Several studies had shown that an increase in WBC count was independently associated with an increased risk of proteinuria.Aim: To determine the relationship between leukocytes and proteinuria in COVID-19 patients.Method: This cross-sectional study with retrospective data collection had a sample of patients with COVID-19 at Diponegoro National Hospital aged 19-60 years. The independent variable in this study was leukocyte count, while the dependent variable in this study was proteinuria. The type of data used was secondary data obtained by examining the medical records of COVID-19 patients. Data analysis between leukocyte count and proteinuria variables in patients with COVID-19 was tested using a bivariate chi-square analysis.Results: Samples that met the inclusion criteria were 34 samples with confirmed COVID-19. From the results of the chi square test, it was found that leukocytes to proteinuria had a p value of 0.601 (p>0.05), which meant that there was no significant relationship between the number of leukocytes and proteinuria.Conclusion: There was no significant relationship between leukocyte count and proteinuria in patients with COVID-19.
The Effects Of Purple Grape Juice (Vitis Vinifera) On Spermatozoa Motility Of Male Wistar Rats (Rattus Norvegicus) Exposed To Electric Cigarette Smoke Ishak Raharjo Putranto; Dhega Anindita Wibowo; RR Mahayu Dewi Ariani; Donna Hermawati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36490

Abstract

Background: Infertility in men can be caused by decreased motility of spermatozoa. Electric cigarette smoke containing nicotine can produce free radicals that cause a decrease in sperm motility. Purple grape juice which contains flavonoids can act as antioxidants that can increase the motility of spermatozoa. Objective: To prove the effect of administering purple grape juice on sperm motility of male Wistar rats exposed to electric cigarette smoke.Methods: This research is an experimental study with a post-test-only control group design. Sample consisted of 28 male Wistar rats divided randomly into 4 groups, namely negative control, positive control (given electric cigarette smoke), treatment one (given electric cigarette smoke + purple grape juice 3 mL/day), and treatment two (given electric cigarette smoke + purple grape juice 5 mL/day). The adaptation was carried out for 1 week, followed by treatment for 4 weeks, then the sperm of Wistar rats were collected and the sperm motility of Wistar rats was examined. Statistical test used Saphiro Wilk and Kruskal Wallis test.Results: Progressive motility rate of K(-), K(+), P1, P2 groups consecutively: 58.33 ± 7,52; 26,66 ± 8,16; 31,66 ± 7,52; 43,33 ± 12,11. Non progressive motility rate of K(-), K(+), P1, P2 groups consecutively: 26,66 ± 10,32; 55 ± 8,36; 43,33 ± 12,11; 35 ± 12,24. Immotility rate of K(-), K(+), P1, P2 consecutively: 18,33 ± 9,83; 28,33 ± 14,71; 20 ± 6,32; 16,66 ± 5,16. Kruskal Wallis test found a significant difference in progressive motility (p=0.002) and non-progressive motility (p=0.005).Conclusion: Purple grape juice affects sperm motility of male wistar rats exposed to electric cigarette smoke.
AN ANALYSIS OF SHOOTING ACCURACY TOWARDS ARCHERY ATHLETE’S ARM LENGTH, ARM STRENGTH, AND BODY MASS INDEX (A Study of KONI Bandung District, Archery Division) Ghaida Zakia Noor
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.32446

Abstract

Background. Accuracy in archery is the ability to achieve (point) against the target or Target Face when the arrows are out of the bow using a high level of consentration in carrying out a series of shooting techniques. Based on many numbers of arrow athletes who won the championship by balancing their body balance and maintaining their stamina.Purpose. To understand the possibility of any potencies or some overviews of sleeve length, arm muscle strength, limb length, and body mass towards the archery accuracy in archery athletes.Method. This research is an analytic observational research with a cross sectional approach, which is a research that emphasizes measurement time or data observation one time at a time, which is done on the dependent variable and independent variable. This research only makes observations, without giving any intervention on researched variables. The data analysis used is pearson correlation test and using hypothesis test, and by performing a linear regression test.Result. The pearson correlation test using sleeve length towards the accuracy of archery showed the correlation score (r) equal to 0,576 (p=0,002) significant (p<0.05), limb length towards the archery accuracy with the correlation score (r ) equal to 0,631 (p=0,001) significant (p<0,05). And the hipothesis test obtained the arm length, limb length, and body mass index showed that there was not any meanignful correlation towards the accuracy of archery, and dominantly correlating with the arm muscle strength.Conclusion. The accuracy in archery has a high effect, namely with sufficient training to build good muscle strength.Key Words. Accuracy of archery, exercise, arm muscle strength.
Case Report: Lesson Learned from Delayed Definitive Treatment of Stage 4 HIV Patient with Cerebral Toxoplasmosis – A Case Report Galih Ricci Muchamad; Muchlis Achsan Udji Sofro
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36701

Abstract

Background: Cases of cerebral toxoplasmosis continue to burden people living with HIV/AIDS (PLWHA). This surge in cases is primarily due to patients’ delayed definitive treatment, missed follow-up, and insufficient diagnostic equipment in some regions, particularly in developing countries such as Indonesia.Case Presentation: We report on a 35-year-old male referred to the emergency department with impairment in four extremities from a secondary healthcare facility. Specific atypical symptoms that mimicked subacute meningitis were identified during the physical examination. Internists, neurologists, and rehabilitation medicine professionals were associated with the management.Conclusion: We suggest that improved early diagnosis and treatment of HIV patients to prevent opportunistic infections, including cerebral toxoplasmosis, is needed, particularly in primary healthcare facilities in developing countries.

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