Jurnal Kedokteran Diponegoro
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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<![CDATA[CASE REPORT DIAGNOSIS AND TREATMENT OF VERNAL KERATOCONJUNCTIVITIS ]]>
<![CDATA[Fariz Auliadi Khalil]]>;
<![CDATA[Risa Ayu Nilmarani]]>;
<![CDATA[Syarifah Rohaya]]>;
<![CDATA[Diana Novita]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.38080
<![CDATA[Background: Vernal keratoconjunctivitis (VKC) is a bilateral ocular allergic disease mediated by hypersensitivity reactions. VKC events occur in boys in the first decade of life and continue until puberty. Early identification and effective treatment are essential because the condition is recurrent and potentially burdensome to the patient's quality of life. This case report examines the diagnosis, management, and therapy options for patients with VKC and highlights the significance of the clinician's involvement in cases with VKC.Case Presentation: We report a case, a boy, 8 years old, came to the eye clinic at Cut Meutia Hospital with pain in both eyes, red eyes, decreased vision, and increased eye discharge. This complaint has been experienced for the past few years, and most appeared when the patient played under the sun or when the patient's allergy came. Examination showed mild conjunctival inflammation, pseudoptosis, and papillae on the limbus.Conclusion: The patient was diagnosed with VKC and received several treatments, including artificial tear and dexamethasone.]]>
<![CDATA[Effect of Breadfruit Leaf Extract on Sperm Quality in Diabetic Male Wistar Rats ]]>
<![CDATA[Rafi Ilmansyah]]>;
<![CDATA[Ulya Hasna Khairunnisa]]>;
<![CDATA[Cendikia Sengkalaning Pangrukti]]>;
<![CDATA[Rifki Rizaldi]]>;
<![CDATA[Rr Mahayu Dewi Ariani]]>;
<![CDATA[Donna Hermawati]]>;
<![CDATA[Eka Chandra Herlina]]>;
<![CDATA[Acmad Zulfa Juniarto]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.37700
<![CDATA[Background: Diabetes mellitus can lead to various complications, one of the most devastating complications is infertility. Meanwhile, the antioxidant compounds of breadfruit leaves have been shown to help heal oxidative stress and therefore prevent infertility in diabetic patients. Therefore, this study aimed to determine the effect of breadfruit leaves in improving sperm quality parameters in male diabetic Wistar rats.Methods: In this study, twenty four male rats were used and were classified into four groups. Two of the four groups were alloxan-induced diabetics and were treated with a graded dose of breadfruit leaf extract. The two control groups received no therapy and the treatment was administered for 30 days. The rats were terminated after day 31 and sperm concentration, morphology, motility, and spermatogenesis were examined. Result: The results showed that breadfruit leaves increase sperm quality parameter levels compared to the control groups. The group that received a 400 mg/kg dose of breadfruit leaves showed the most significant improvement in terms of the level of sperm parameters compared to the other group that received a dose of 100 mg/kg breadfruit leaves. Conclusions: The protective effect of breadfruit leaves significantly reduced sperm damage caused by diabetes mellitus in Wistar Rats.]]>
<![CDATA[Post COVID-19 Immunization Herpes Zoster Reactivation In Asia : A Literature Review ]]>
<![CDATA[Nurul Nisa Ulfa]]>;
<![CDATA[Danisa Diandra Safarina]]>;
<![CDATA[Puguh Riyanto]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i3.37292
<![CDATA[Background: The COVID-19 vaccine that targets viral mRNA has been created and can be used as an effort to end the COVID-19 pandemic that has hit the world since 2020. The COVID-19 vaccine currently being developed has proven its effectiveness and safety in the general adult population.Objective: To identify reactivation of Herpes Zoster virus post COVID-19 vaccine.Methods: This article review discusses four case reports of Herpes Zoster following the COVID-19 immunization in Asia which were obtained from various sources such as Pubmed Medline Embase.Results: The mRNA-type vaccine is associated with skin manifestations with an increased incidence (14.4%) of Herpes Zoster which was observed around 6-8 days after administration of the first dose of vaccine (BNT162b2 vaccine) and 1.5% after administration of the mRNA- 1273 which occurred in the Asian Oceanian race. COVID-19 vaccine substances such as polyethylene glycol (PEG), the polysorbate present in mRNA vaccines, and polysorbate 80 are suspected causing an allergic reactions.Conclusion: Health workers must be careful in administering the COVID-19 vaccine, especially to individuals who have risk factors that can decrease their immune system so it can cause reactivation of Herpes Zoster. ]]>
<![CDATA[CASE REPORT : FISH BONE CORPAL IN ESOPHAGUS ]]>
<![CDATA[Adilla Afra Amri]]>;
<![CDATA[Fahrizal Fahrizal]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.37924
<![CDATA[Esophageal foreign bodies are sharp or blunt objects or food that gets stuck and wedged in the esophagus due to being swallowed either intentionally or accidentally.A 53-year-old male patient arrived complaining of constant, worsening swallowing pain that has persisted for the past four days. The discomfort was initially experienced above the throat, but after attempting several traditional procedures to remove the bones, the pain was felt to shift to the region below the throat. Before going to the hospital, Patient has a history of consuming tuna bones. A fishbone was found in the esophagus area after an esophagoscopy was done.]]>
<![CDATA[Correlation between Maternal Characteristics and The Incidence of COVID-19 in Pregnant Woman: A Cross-Sectional Study ]]>
<![CDATA[Sekar Ayu Putri Utami]]>;
<![CDATA[Rini Aryani]]>;
<![CDATA[Rita Kartika Sari]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.37722
<![CDATA[Background: COVID-19 is an infectious disease that attacks the respiratory tract. Pregnancy is considered as a risk factor because during pregnancy several physiological changes occur, namely increased expression of ACE2, changes in the respiratory system, and changes in the immune system, which make pregnant women more susceptible to SARS-CoV-2 infection. Objective: This study aims to determine the relationship between the characteristics of pregnant women and the incidence of COVID-19.Methods: This observational analytic study used 51 samples of pregnant women, both infected with COVID-19 and those who were not, which were taken using a total sampling technique. The characteristics of pregnant women were taken through secondary data in the form of medical records at K.R.M.T. Wongsonegoro Regional Public Hospital Semarang, then analyzed univariately and bivariately using Spearman's test and contingency coefficient.Results: The results obtained from the bivariate analysis were p = 0.863 (> 0.005) for the comorbid history variable, p = 0.367 (> 0.005) for the body mass index variable, and p = 0.423 (> 0.005) for the hypertension incident variable.Conclusion: The results of this study concluded that there was no correlation between the characteristics of pregnant women (history of comorbidities, body mass index, and incidence of hypertension) with the incidence of COVID-19 in patients at K.R.M.T. Wongsonegoro Regional Public Hospital Semarang.]]>
<![CDATA[Factors Affecting Drug Use in the Household Environment During the Covid-19 Pandemic ]]>
<![CDATA[Raditiya Firda Maulany]]>;
<![CDATA[Eva Annisaa']]>;
<![CDATA[Ragil Setia Dianingati]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.37419
<![CDATA[Background:Inappropriate use of drugs is a big problem all over the world. The COVID-19 pandemic causes people to be easily influenced by information circulating about drugs that are efficacious to ward off COVID-19 so that many people consume excess drugs to protect themselves from COVID-19. The COVID-19 pandemic has also caused people to take health supplements to protect themselves from COVID-19.Objective:The purpose of this study was to determine the factors that influence drug use during the COVID pandemic.Methods:This research was an observational study with a cross sectional design. Sample was 115 respondents chosen by purposive sampling. Bivariate statistical test used was chi-square and multivariate test used was binary logistic regression. Results:Bivariate analysis result showed that age and distance from health care service did not significantly affect the drug use (p value > 0,05). Education, occupation, income, knowledge were significantly influence the drug use (p value < 0,05). In the multivariate analysis, the OR for education was 4,807, OR for occupation was 4,612, OR for income was 0.146. OR for knowledge 3,400.Conclusion:It can be concluded that the factors that significantly affect the use of drugs in the household environment of the Kota Sub-District Kudus Regency during the COVID-19 pandemic are occupation, education, income and knowledge]]>
<![CDATA[Anatomy Practice during COVID-19 Pandemic ]]>
<![CDATA[Arif Wicaksono]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i4.37014
<![CDATA[Background: Anatomy learning required practice to understanding and comprehend. Anatomical practice used aids such as cadaver. Cadaver was a corpse preserved for anatomy learning. Practice using cadavers was a way of studying the human body with very real details and experiences and must be done offline. The Coronavirus Disease 2019 (COVID-19) pandemic had limited lives, learning, and practice due to the risk of transmission. The interest in understanding some material offline must be facilitated with a supportive environment by medical institutions.Objective: This study will provide recommendation in implementing safe anatomy practice during COVID-19 pandemic.Methods: This article used literature review of anatomical practice and health protocols from books, journals, and guides from home and abroadResults: offline anatomy practice using cadaver should be implemented to help student understand human body more specific and more detail.Conclusion: Health protocol should and can be implemented in offline anatomy practice during COVID-19 pandemic. Anatomy practice can be performed during pandemic using strict health protocols. ]]>
<![CDATA[Case Report: Hyperglycemia in Pregnancy and The Impacts on Fetal Welfare ]]>
<![CDATA[Stella Andani]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i5.37831
<![CDATA[Background: Hyperglycemia in pregnancy is related to the outcome of pregnancy. According to the American Diabetes Association, diabetes diagnosed in the second or third trimester of pregnancy without a history of diabetes is associated with macrosomia, perinatal complications, and neonatal and maternal morbidity.Case Presentation: This study involved 3 pregnant women with different characteristics of age, parity, and gestational age. All the women in the cases were found to have high glucose levels in the 2nd trimester of pregnancy and received therapy.Conclusion: Based on observational studies, patients with pregestational DM have better outcomes if the HbA1c level is <6-6.5%. In the second and third trimesters, the risk of macrosomia, preterm delivery, and preeclampsia is lower if the HbA1c level is <6%. Keywords: BMI, Diabetes Gestational, Glucose level, Pregestational Diabetes ]]>
<![CDATA[Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant ]]>
<![CDATA[Tuti Ratnasari]]>;
<![CDATA[Faizah Fulyani]]>;
<![CDATA[Endang Mahati]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i5.39577
<![CDATA[Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection. The mutated spike protein in the Omicron variant increases virus transmissibility and potentially threatens the effectiveness of COVID-19 vaccines and antibody therapies. Herbal plants, such as Indian Ayurveda, African herbal plants, and Traditional Chinese Medicines (TCM), have been studied as SARS-CoV-2 potential therapy in several countries.Objective: This review explores potential phytochemical herbals that target spike protein omicron based on the available molecular docking studies.Methods: We collected research articles on the molecular docking of phytochemicals that target spike protein omicron. Combination of several keywords: in silico OR molecular docking AND spike omicron, were used as input for Google search. Out of 83 articles from Google search, eight articles matched the inclusion criteria and were selected in this review.Result: Protodioscin from Carica papaya and Landomycin A from Aloe vera are the most potential phytochemical inhibitors against spike protein with the free binding energy of -10.77 kcal/mol and -10kcal/mol, respectively. ]]>
<![CDATA[Level Of Patient Satisfaction With Pharmaceutical Services In The Outpatient Pharmaceutical Room, Mandiraja Community Health Center 1 ]]>
<![CDATA[Novita Endang Fitriyani]]>;
<![CDATA[Iva Rinia Dewi]]>;
<![CDATA[Dian Novita Octavia]]>
<![CDATA[ Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v12i5.39231
<![CDATA[Background: Pharmaceutical services are direct and responsible services to patients with the aim of improving the patient's quality of life. Satisfaction is a feeling of pleasure or disappointment that arises after comparing product performance with expected performance. Satisfaction and service are two things that cannot be separated, with the satisfaction of related parties, they can correct each other how far the improvement in the services that have been provided. Measurement of satisfaction uses five dimensions of service quality, namely tangible evidence (Tangible), responsiveness (responsiveness), assurance (assurance), empathy (Emphaty) and reliability (Reliability). Objective: This study was to describe the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Puskesmas Mandiraja 1. Methods: The type of research was descriptive using a cross sectional approach with the sampling technique of accidental sampling and data collection using questionnaires. Results: Based on the results of calculations on each research indicator the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Mandiraja 1 Health Center is generally categorized as satisfied with the percentage of 75%. The real evidence dimension is 74.15%, the responsiveness dimension is 75.01 %, assurance dimension of 77.44%, the empathy dimension is 75.15% and reliability dimension of 71.07%. Conclusion: Based on the results of the study, the level of patient satisfaction with pharmaceutial services in the outpatient pharmacy room at Puskesmas Mandiraja 1 was in the satisfed category]]>
