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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 12 Documents

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Search results for , issue " Vol 26, No 3 (2014): BIKKK DESEMBER 2014" : 12 Documents clear

Urticaria and Angioedema: Retrospective Study Wirantari, Nadia; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Urticaria is a common disorder that often presents with angioedema. Angioedema which may lead to laryngeal involvement, asphyxiation, and urticaria lasting more than 72 hours, are indications of hospitalization. Purpose: To describe the distribution, duration of hospitalization, trigger factor, clinical form, diagnostic, and therapeutic approach in urticaria and angioedema patients in Dermaro-venerelogy Departement Dr. Soetomo General Hospital during year 2011-2013. Methods: Retrospective study using medical records of new patients with urticaria and/ or angioedema in Dermatovenereology Ward st thduring 1 January 2011 until 31 December 2013. Basic data, anamnesis, physical examination, diagnostic, and therapeutic approach are recorded. Results: There were 42 new patients with urticaria and/or angioedema (2.3% of all Dermatoveneorology inward patients), with mean length of stay 4-6 days (57.1%), chief complaint of itch, hives, and swelling (42.8%), lesions occur for less than 6 weeks (92.9%), for the first time (54.8%), with episodes of less than 72 hours (45.3%). Urtica and angioedema were the most often clinical findings (38.1%), complete blood count and urinalysis were routinely examined (100% and 97.6% respectively). Treatment combination of corticosteroid and antihistamin H1 was the most commonly prescribed (64.0%). Conclusion: Urticaria along with angioedema was the most common condition in inward patients, thus combination therapy of antihistamin H1 and corticosteroid were most often needed.Key words: urticaria, angioedema, retrospective study.

Correlation of Expression p16 on Genital Wart Lesions with Various Degrees of Cervical Dysplasia Rahmawati, Asri; Damayanti, Damayanti; SP, Cita Rosita; Lumintang, Hans
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Introduction: Infection of Human Papillomavirus (HPV) can cause condylomata acuminata. High-risk HPV types have proteins E6 and E7 called âoncoproteinâ for its role in the occurrence of cancer. E7 protein causing no active bond pRb and E2F is regulated by CDK inhibitors, such as p16INK4a . Overexpression p16INK4a could be obtained from pre cancerous lesions. Pap smear, the standard screening method, is performed to detect early malignancy of the cervix, but have low sensitivity. The presence of tumor markers, p16INK4 ,will help early detection of malignancy. Purpose: To evaluate the profile of p16INK4a expression in condylomata acuminata lesions with various degrees of cervical dysplasia. Methods: Discriptive, observational, cross seetional study by performed p16INK4a immunohistochemical examination in lesions condylomata acuminata and cytologic examination on cervical biopsy. Results: Results of cervical cytology (pap smear) from 18 samples showed Low-grade Squamous Intraepithelial Lesions (LSIL) in 10 patients (55.6%) and Negative for Intraepithelial Lesion or Malignancy (NILM) in 8 patients (44.4%). Immunohistochemical examination obtained p16INK4a expression with score of 1 (sporadic) in 8 patients (44.4%), with score of 2 (focal) in 7 patients (38.9%) and with score of 3 (diffuse) in 3 patients (16.7%).Â From 3 patients with diffuse expression of p16INK4a , 2 patients (66,6%) showed LSIL from cytology cervix and 1 patient (33,3%) revealed NILM. Spearman correlation test results showed no significant correlation between p16INK4a expression in cervical dysplasia with p = 0.24 (p> 0,05). Conclusion: There were three samples of diffuse, with most of Low-grade Squamous Intraepithelial Lesions (LSIL) in cervical dysplasia, it indicates there is a potential of p16INK4a as a marker of malignancy in condylomata acuminata. Key words : condylomata acuminata, p16INK4a , cervical dysplasia.

Patch Test and Repeated Open Application Test (ROAT) in Allergic Contact Dermatitis Noviandini, Anggraeni; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: The clinical relevance of patch test reaction is often difficult to determine. Repeated Open Application Test (ROAT) have been developed to further evaluate the significance of patch test result. Purpose: Understanding methods, procedures, and reactivity of patch test and ROAT, so thatmay be used to help identify with a high risk of developing allergic contact dermatitis. Reviews: The validity of patch test is limited. Various attempts have been made at modifying the patch test, primarily in order to increase the sensitivity of the skin and thus enhance the reliability and validity of the results, such as ROAT. Several experimental studies have compare the result of patch testing with the outcome of ROATs and these have defined correlations between the threshold concentration at patch testing (MEC) and outcome of ROAT, and also shed light on some factors that may influence the outcome of ROATs. Results of patch testing with serial dilutions of colophony, cinnamic aldehyde, and isoeugenol have shown concordance with the outcome of ROATs. On the other hand, poor correlation between patch test reactivity and ROAT were demonstrated in another study on isoeugenol,hydoxycitronellal, formaldehyde dan chromium. Conclusion: Patch test and ROAT are two methods that may be used toidentify allergen exposure and MEC Allergic Contact Dermatitis reaction.Key words: patch test, repeated open application test (ROAT), allergic contact dermatitis (ACD).

Increasing of Skin pH level in Childhood Atopic Dermatitis Primadiarti, Pedia; Rahmadewi, Rahmadewi; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Atopic dermatitis (AD) has multifactorial etiologies such as genetic, environment, and imbalance of immunology basis.Â AD is marked with skin barrier dysfunction, whichcharacterized by fillagrin mutation. Fillagrin itself has an important role in skin hydration and pH adjustment, so that its functional nor amount defect will lead to hydration and pH adjustment impair, as well as shown in AD phenotype. Purpose: To evaluatethe difference of skin pH in AD (lesional and non lesional area) and normal children. Methods:Â Phase 1 study was descriptive observational study, to determinenormal skin pH in 98 children. The following phase 2 was observational analitic study in 38 AD patients todeterminepH level of atopic group (lesional and non lesional skin).Results: pH level of normal children skin was 4.86Â±0.461, lesional skin in AD was 5.86Â±0.564, and in nonlesional skin was 5.20Â±0.460. One way ANOVA test revealed value p=0.000, post hoc analysis value was p=0.000. Conclusions: Higher pH level was observed on AD patients. Skin pH is an important factor in the pathogenesis of AD, main concern in the treatment of AD is maintaining skin pH, which is important to reduce AD exacerbation.Key words: fillagrin, pH of atopic dermatitis,pH of normal children.

Ki-67 Immunohistochemistry Examination in Pityriasis Rubra Pilaris Sari, Diana Kartika; Prakoeswa, Cita Rosita Sigit; Soemarno, Troef
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Pityriasis rubra pilaris (PRP) is a papulosquamous disorder of unknown etiology. PRP is often difficult to be distinguished with psoriasis in early phase of the disease. Purpose: To deliver information about Ki-67 immunohistochemistry examination in PRP. Reviews: The diagnosis of PRP can be established by histological examinations or even immunohistochemistry. The best treatment options are retinoids, photochemotherapy (PUVA), and antimetabolites (methotrexate). Conclusion: Immunohistochemistry examination can provide complete feature to distinguish between PRP and psoriasis because of its high specifity.Key words: Ki-67 immunohistochemistry, pityriasis rubra pilaris, diagnosis.

Profile of Peanut Spesific-IgE in Atopic Dermatitis L, Indiarsa Arief; Lumintang, Hans; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background : Atopic Dermatitis (AD) is a chronic reccurent disease. One of the environmental factors which possibly involved in the reccurency of AD is food allergy such as peanut. Peanut allergy in the pathogenesis of AD is by induction IgE and T cells. Peanut-spesific IgE allergen are observed in AD patient. Purpose: To identify the distibution of serum IgE concerning the peanut antigens according to AD. Methods:This trial was cross sectional descriptive study, which studied 33 atopic dermatitis patients, which fulfill inclution criterias.We describe the anamnesis, physical examination, peanut-spesific IgEÂ and the severity of AD using SCORAD index. Results: There were 7 patients (21,2%) with positive result of peanut-spesific IgE. The positive result of peanut-spesific IgE were noted most often on AD patients who suffer from severe grade of AD severity score (85,7%) but not found in class 3 or more (where antibody can detect significanly, often clinical manifestasion appeared when had sensitisation). Conclusion: The positive result of peanut-spesific IgE class 1 (0,35- 0,7 IU/mL)Â 5 people (15,1%) andÂ class 2 (0,7-3,5 IU/mL) 2 people (6,1%) were noted most often on AD patients who suffer from severe grade of AD severity scoreKey words: atopic dermatitis, peanut-spesific IgE.

Occupational Contact Dermatitis: Retrospective Study Witasari, Dinar; Sukanto, Hari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Occupational skin disease is the second largest occupational disease in Europe after musculoskeletal injury.Most common occupational skin disease is contact dermatitis as many as 70-90%. Determining the cause of contact dermatitis in occupational environment is very important to avoid causing substances and to establish healing as well as reducing the recurrence rate. Purpose: To evaluate the management of new patients with occupational contact dermatitis in Allergy Immunology Division, Dermatology and Venerology outpatient clinic Dr. Soetomo General Hospital Surabaya in period of 2010-2012. Methods: Retrospective study of new patients with occupational contact dermatitis in Allergy Immunology Division during 2010-2012. Results: New patient of occupational contact dermatitis during the period of 2010-2012 were 50 new persons, predominantly occured in male in reproductive age (25-44 year old), irritant contact dermatitis (ICD) occured more frequent than allergic contact dermatitis (ACD). The majority of subjects were factory workers, with the most suspected ingredients was chemicals. About 21.7% patients underwent patch test. The therapy mostly given were antihistamines and topical steroids. There were 46% of patients who did not visit outpatient clinic again. Conclusions: New patients of occupational contact dermatitis in Allergy Immunology Division during the period of 2010-2012 were as many as 50 new patients. Patch test should be performed to establish the diagnosis and determine the cause of contact dermatitis materials.Key words: occupational contact dermatitis, patch test, retrospective study.

Tinea Capitis Kerion Type: A Case Report Anggarini, Dyah Ratri; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Tinea capitis is a superficial fungal infection. Kerion is one of its form, which is an inflammation form due to a hypersensitivity reaction to fungal infection caused by group Mycosporum and Trichophyton. Purpose: To understand the clinical manifestation, species causing agent, and management of tinea capitis.Â Case management: A four-year-old boy, 17 kg, came with a mass on the head, accompanied with pain, fever, and hair loss since 1 week before hospitalization, it appeared after playing with the neighbors pets. General examination showed enlargement of the right preauricular lymph node. Dermatological examination revealed a mass in the head 7 cm in size with pus, partially covered with crust, and there were also warm and pain on palpation. Wood lamp examination was negative, but in potassium hydroxide examination showed spores outside and inside the hair shaft. Result of fungal cultures was T. mentagrophytes. Routine blood tests obtained only leukocytosis, which was 12.390/ÂµL. The patient was treated with griseofulvin, erythromycin, wet dressing, and ketokonazole shampoo. It was shown good results after therapy for 8 weeks. Conclusions: Tinea capitis caused by T. mentagrophytes presenting an inflammatory reaction, causing a fungal infection in the hair shaft. Auxiliary examination for the diagnosis of tinea capitis can be done in various ways, the easiest one is by potassium hydroxide 20% examination, fungal culture is then performed to determine the species causing the infection. Therapeutic use of griseofulvin is still the main choice.Key words: tinea capitis kerion type, T. mentagrophytes, griseofulvin.

Candida Species Profile of Vulvovaginal Candidiasis in HIV/AIDS Patients Treated With Systemic Antibiotic Widasmara, Dhelya; Suyoso, Sunarso; Murtiastutik, Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Vulvovaginalis Candidiasis (VVC) is a vulva and vaginal infection of Candida, which one of predisposition factors is systemic antibiotics. Humoral immunity does not play a role on VVC, thus VVC in HIV/AIDS patients is as much as VVC in immunocompetent patient. Purpose: Identify the profile of Candida sp. of VVC in HIV/AIDS patients who got systemic antibiotics. Methods: Descriptional study to identify the pattern of Candida sp. of VVC in HIV/AIDS patient who got systemic antibiotic with cultures of Saboroud Dextrose Agar, Cornmeal Tween80 with Carbohydrat Test and Candida CHROM agar. Results: Broad-spectrum antibiotics were given to HIV/AIDS patient with VVC at Dr. Soetomo general hospital Surabaya two times higher than narrow-spectrum antibiotics (66,7% vs. 33,3%), they were ciprofloxacin (42,8%), ceftazidime (19,1%) and ceftriaxone (4,8%); theÂ narrow-spectrum antibiotics were cotrimoxazole (19,0%) and rifampicin (14,3%). Conclusion: C.albicans (57,1%) and C. glabrata (9,6%) were found in VVC of HIV/AIDS patients that have been given broad-spectrum antibiotics, while C. albicans (28,6%) & C. glabrata (4,7%) also found in VVC of HIV/AIDS patients that have been given narrow-spectrum antibiotics. C. dubliniensis were not found in this studyKey words: Candida spp, vulvovaginal candidiasis, HIV/AIDS, antibiotics

Dermoscopy Supports the Diagnose of Papulosquamous Disorders Alinda, Medhi Denisa; Hutomo, Marsudi; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: The diagnose of papulosquamous skin disorder was established by clinical symptoms. However, some of papulosquamous manifestation are alike with each other and lead to misdiagnostic. Histopathology examination usually can help to establish diagnose but this method is invasive and time consuming. Purpose: To evaluate dermoscopic features of papulosquamous disorder. Methods: Descriptive observasional cross sectional study, total sampling in ward and out patient clinic of Dermato-venereology Department Dr. Soetomo General Hospital. Twenty four samples were included in the study, followed by the procedures from anamnesis, physical examination, dermoscopy procedures, and histopathology examination. Results: From 24 samples, 19 samples showed plaque psoriasis describing 12 ring patterns, 1 cluster pattern, 2 patchy patterns, 2 reguler patterns, and 2 unspesiï¬c patterns; 3 samples showed nummular dermatitis describing 2 cluster patterns and 1 unspesiï¬c pattern; and 2 samples showed pityriasis rosea describing 2 pheripery patterns. Conclusion: Dermoscopy can support the diagnosis of papulosquamous skin disorder especially plaque psoriasis.Key words: papulosquamous disorder, dermosocopy, histopathology examination, plaque psoriasis.

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