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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 194 Documents

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VACCINE FOR NEUROCYSTICERCOSIS: A PRESENT UPDATE Wiwanitkit, Viroj
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Cysticercosis is an important tropical parasitic worm infestation. This infection can result in cyst in any organs of human beings including to brain. The brain involvement of cysticercosis or neurocyticercosis is an important neurological infection that can cause serious neuruological problem. A good sanitation is the basic prevention for cysticercosis. Nevertheless, the hope is the use of vaccination. Here, the author briefly reviews and discusses on the present situation of neurocysticercosis vaccine.

LEVELSâ€™ INFLUENCE OF IFN-Î³ AND IL-10 IN CHILDREN WITH EPILEPTICUS STATUS Salim, Irfan Agus; Muid, Masdar; Sujuti, Hidayat
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. Seizures are a common clinical manifestation in the emergency room. Nearly 5% of children aged under 16 years. Seizures are important as a sign of neurological disorders. Members of interferon are widely studied with seizures and epileptogenesis is interferon-Î³. In a study by Choi in 2011, a study of seizures in humans showed that the condition of status epilepticus increased levels of interferon-Î³ which is quite high compared to patients not status epilepticus seizures. In response to the aftermath of the seizure, Interferon-Î³ system induces the formation of IL-10 acts as an anti-inflammatory agent that aims to put an end to the action of Interferon-Î³. Objective. To know role of Interferon-Î³ and IL-10 in children with status epilepticus.Methods. This research using cross sectional design with recruiting 30 study sample consisted of 15 children in the seizure group SE and 15 children in the group without SE seizures. Measured levels of IFN-Î³ and interleukin-10 by ELISA. Results were analyzed with the Mann-Whitney and corelation Spearman to see the relationship levels of IFN-Î³ and IL-10 in children with status epilepticus with SPSS-23.Results. The results showed significant differences between groups SE and convulsive seizures non SE ;IL10 (p = 0.000) and IFN-Î³ (p= 000).Conclusion. There areÂ significantÂ correlationÂ betweenÂ theÂ levelsÂ ofÂ IFN-Î³Â andÂ IL-10 with statusÂ epilepticus.Â

PHYSICAL ACTIVITIES, SITTING TIME AND FRAILTY SYNDROME IN ELDERLY (A CROSS SECTIONAL STUDY AMONG ELDER PERSON BY FRIED CRITERIA) Sunarti, Sri; Hariyanti, Tita; Chriswantara, Rizâ€™q Threevisca
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. Physical activity is being a protective factor of frailty syndrome. Sedentary life style is related to frailty, comorbidities and mortality. Sitting time is associated with greater risk of dying from all causes of mortality. The correlations between physical activities, sitting time and frailty have not been studied at Indonesia.Objective. To know the correlations between physical activities, sitting time and frailty syndrome among elder person in Malang.Methods. Survey method is used in this research among elders of >60 years old in Malang. Quistionnaire-based interview was asked to respondesn and frailty measurement based on Friedâ€™s Criteria.Results. Physical activities measured with MET (Metabolic Rate) conversely related to frailty condition in elderly and sitting time correlate well with frailty.Conclusion. Physical activities and sitting time have strong correlation with frailty in Malang.

BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMERâ€™S DISEASE Indra, Muhamad Rasjad; Marhaendraputro, Eko Arisetijono; Hidayat, Rudi Rakhmad
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversibleÂ neuronal cell loss, which can interfere with social and occupational functioning. The theory of ACHÂ (Amyloid Cascade Hypothesis) states there are deposits and misfolding of beta amyloid protein thus leadÂ to the formation of plaques and tangles in neurons cells.Objective. To identify the immunogenicity of beta amyloid polyclonal antibodies that can be developed as a first step early diagnosis of Alzheimer's disease.Methods. Rrandomized group post test only design conducted on rabbits. Blood samples were taken from rabbits that had been injected antigen once a week for 5 weeks. Variables were found in this study is the formation of beta amyloid polyclonal antibody with detection levels using dot blot and ELISA methods.Results. It has been reproduced specific polyclonal antibody beta amyloid which has been evidenced by the bond between the antigen with the antibody in a dot blot.Conclusion. The beta amyloid antibodies can be produced through production techniques with a polyclonal antibody against beta amyloid antigen induced rabbit.

DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) Pramesti, Fathia Annis; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Rahayu, Masruroh
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Status epilepticus is an emergency condition in the field of neurology are often undiagnosed and are associated with high mortality and long-term disability. One type of status epilepticus is nonconvulsive status epilepticus (NCSE) in which the diagnosis of NCSE is very difficult because the clinical manifestations appear is agitation or confusion, nystagmus or bizarre behavior such as lip smacking or take goods in the air.The diagnosis was based on clinical features, especially the mental status or the disrupted of consciousness and the changes in the EEG. Diagnosis of NCSE is an important first step, which can avoid the delay in therapy in order to prevent irreversible brain damage. Treatment is by administering benzodiazepines and antiepileptic drugs, while the prognosis is determined by the etiology and associated with brain damage there.

EFFECTS OF ACUTE STRESS DURATION ON THE RAT BRAIN MAST CELL ACTIVATION Paundralingga, Obed Trinurcahyo Kinantyo; Darkim, Darmawan; Munir, Badrul; Daeng, Bonaventura Handoko
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Background. Stress of varying duration and types are known to affect the number and activation level ofÂ cerebral mast cells (MCs) via plasma CRH. Although MC number is known not to be increased in acuteÂ stress, elevated plasma CRH might still activate brain MCs.Objective. To investigate the effect of acute stress of incremental duration to the activation level ofÂ thalamic and hippocampal mast cells using elevated platform test to elicit stress in male Wistar rats.Methods. This research used randomized post-test only control group design with 4 control group of 30, 60, and 90 minute stress exposure. Mast cell activation of the regiotalamus and hippocampus is assessed by histomorphometrics.Results. In the hippocampus, we found a significant difference of MC activation between control and experimental groups (p=0.014; p<0.05) but not among the incremental duration of acute stress. However, MC activation was not different between control and experimental groups in the thalamus.Conclusion. Acute stress exposure increases MC activation without recruiting further MCs in specific cerebral region but the duration of acute stress itself does not affect the activation level.

THE CORRELATION OF WAIST HIP RATIO TO ISCHEMIC STROKE PROBABILITY OF POPULATION IN SEKARBELA MATARAM Setiadi, Qisthinadia Hazhiyah; Harahap, Herpan Syafii; Indrayana, Yanna
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. Stroke is the third cause of death worldwide. Ischemic stroke is the most common type of stroke with high prevalence. Obesity is one of ischemic stroke risk factor, but its correlation with higher ischemic stroke risk remains unclear. Studies about correlation of waist hip ratio (WHR) and ischemic stroke risk is still contradictive. Objective. This study was aimed to explore the correlation between WHR and ischemic stroke probability.Methods. This was a descriptive analytic study using cross sectional design. The population of this study was resident in Sekarbela Mataram aged 55-84 years old. This study was conducted 63 participants. They were interviewed and received a measurement of WHR and ischemic stroke probability. The ischemicstroke probability was assessed by using assessment of Framingham stroke risk score. Data were analyzed by using Pearson correlation.Results. Among 63 participants, 51 (81%) were abdominal obesity and 12 (19%) were normal based on WHR measurement. Pearson correlation analysis showed that there was no correlation between WHR and ischemic stroke probability (p = 0,11).Conclusion. There was no correlation between WHR and ischemic stroke probability of population in Sekarbela Mataram

BIOMOLECULAR MECHANISM OF ANTI EPILEPTIC DRUGS Husna, Machlusil; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of therapy for epilepsy. An understanding of the pharmacodynamics and pharmacokinetics of these drugs would be very helpful in choosing the right medication and develop a study to determine the drugs mechanism further. Mechanism of action of AED (anti epileptic drug) can be categorized into four main groups: (1) modulation of voltage-gated ion channels, including sodium, calcium, and potassium; (2) increase in GABA inhibition through an effect on GABA-A receptors, the GAT-1 GABA transporter, or GABA transaminase; (3) direct modulation of the synaptic release of such SV2A and Î±2Î´; and (4) inhibition of excitatory synapses through ionotropik glutamate receptors including AMPA receptors. AED work to balance the process of inhibition and excitation in the brain, so it can be used both for epilepsy and other diseases with similarities with the pathophysiology of epilepsy.

COMPARISON OF INTUBATION QUALITY AND HAEMODYNAMIC RESPONSE IN ENDOTRACHEAL INTUBATION BETWEEN SUPERIOR LARINGEUS AND TRANSTRACHEAL BLOCK AND MUSCLE RELAXANTS Primadita, Hanggia; Murti, Bhisma; Santosa, Sugeng Budi
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. Endotracheal intubation stimulates various responses such as coughing and bucking, bronchial and laryngeal spasm and hemodynamic changes. Muscle relaxants facilitate easy intubation, but not suppressing hemodynamic response. Superior laryngeus and transtracheal block is presume to suppress hemodynamic changes while maintain intubation quality.Objective. To compare intubation quality and hemodynamic response from superior laryngeus and transtracheal block and muscle relaxants.Methods. Intubation quality is assessed using Helbo-Hansen Raulo and Trap Anderson. Blood Pressure, pulse and saturation were measured before and after intubation.Results. All intubation is acceptable in muscle relaxants group (100%), one unacceptable in block group (5.9%). After intubation hemodynamic in both groups were significantly different (p=<0.05) for systolics (148.35Â±26.33 vs 109.53Â±15.98), diastolics (94.88Â±20.18 vs 68.00Â±15.54), MAP (109.65Â±21.18 vs 79.94Â±16.94), and for pulse (101.71Â±16.34 vs 87.47Â±20.03), except for saturation (99.35Â±0.79 vs 99.35Â±0.99).Conclusion. Muscle relaxant and block deliver similar intubation quality, however block giving out better hemodynamic response stability.

GRAPEâ€™S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATSâ€™ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL Indra, Muhamad Rasjad; Lie, Zanella Yolanda
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidantsÂ that can pass through blood brain barrier and can induce release neurotrophic factor that contribute inÂ ERK 1/2 pathway mechanism in post stroke.Objective. To prove that grape peel and seed extract can regenerate neuron in brain functional.Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extractâ€™s effect in neuron repairment. The repairment is monitored from ladder rung walking test score.Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 Â± 0, 0.001028933 Â± 0.011664445, 0.123214286 Â± 0.019834983, 0.064744427 Â± 0.024296721, 0.03781401 Â± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron.Conclusion. Grapeâ€™s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.

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