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Bipolar Disorder with Psychosis Featured in Patient with Systemic Lupus Erythematosus Liya Maulidianti; I Putu Diatmika; Indah Sapta Wardani
Jurnal Psikiatri Surabaya Vol. 12 No. 1 (2023): May
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v12i1.34880

Abstract

Abstracts Introductions: Bipolar disorder (BD) is a mental disorder that imposes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks, characterized by biphasic mood episodes of mania or hypomania and depression. More than half of all individuals diagnosed with BD experience psychosis features in their lifetime. The cause of BD is not entirely known, study claims that BD may occur due to or associated with autoimmune diseases. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with various physical manifestations, including neuropsychiatric features. Case: This case report will discuss a 22-year-old female with BD admitted to the emergency room due to solid psychosis features. The patient was diagnosed with SLE 3 years ago but never controlled prior to the disease history. The psychiatrist’s treatment in the emergency room was an extra injection of haloperidol 5 mg IM and diazepam 10 mg IM, continued with oral medication clozapine 25 mg two times a day and additional therapies such as cognitive behavioral therapy (CBT) and family therapy. The treatment from the internist was symptomatic medication due to the acute SLE symptoms, followed by autoimmune medicines such as steroids and hydroxychloroquine. Conclusions: BD may be associated with SLE. Psychosis features generally occur in BD, usually in the manic period. Treatment should be done for both psychiatric and internal medicine problems. As the SLE symptom was controlled, the BD symptom improved.
Vitamin D: Role in Autoimmune Disease: Vitamin D: Role in Autoimmune Disease Indah Sapta Wardani
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 9 No. 1 (2023): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v9i1.441

Abstract

Vitamin D has been associated with regulation on bone metabolism.  Recently, the extra skeletal effect of vitamin D has been researched. Increasing evidence demonstrated strong association between vitamin D and many biological process that regulate immune responses. Vitamin D deficiency is known to be related to the development of the autoimmune diseases. The discovery of the vitamin d receptor in multiple immune cell lineage supports vitamin D with a novel role in modulating immune function and its subsequent role in the development or prevention of autoimmune disease. Vitamin d Deficiency is related to development and severity of reumathoid arthritis (RA), Systemic Lupus Erythematosus (SLE), multiple sclerosis, Type 1 diabetes mellitus and inflammatory bowel disease. Normal level of vitamin D is required for immune function focus on therapeutic and prevention effect in autoimmune disease.
KAJIAN PUSTAKA: MEKANISME KEKURANGAN VITAMIN D DAN PENGARUHNYA PADA PENYAKIT DEGENERATIF Indah Sapta Wardani; Zanetha Mauly Ilawanda
Jurnal Medika Malahayati Vol 7, No 2 (2023): Volume 7 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i2.10426

Abstract

Abstrak: Kajian Pustaka: Mekanisme Kekurangan Vitamin D Dan Pengaruhnya Pada Penyakit Degeneratif. Defisiensi vitamin D merupakan masalah kesehatan masyarakat di seluruh dunia yang sering ditemukan. Di negara dengan pajanan sinar matahari yang cukup, defisiensi vitamin D masih merupakan masalah kesehatan. Banyak faktor yang berkontribusi pada defisiensi vitamin D antara lain paparan sinar matahari dan tidak adekuatnya asupan nutrisi yang mengandung vitamin D. Defisiensi vitamin D dihubungkan dengan berbagai penyakit degeneratif seperti osteoporosis dan fraktur, penyakit kardiovaskular, dan diabetes melitus. Peran suplementasi vitamin D dalam makanan dan pemahaman mengenai pentingnya paparan sinar matahari diperlukan sebagai salah satu strategi untuk pencegahan dan tatalaksana terkait defisiensi vitamin D.