Article Per Year (5 Year)
p-Index From 2019 - 2024
1.953
P-Index
This Author published in this journals
All Journal VALENSI Science and Technology Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research JURNAL PENELITIAN FARMASI & HERBAL JURNAL KAJIAN KESEHATAN MASYARAKAT JURNAL INOVASI KESEHTAN MASYARAKAT Jurnal Pengabdian Masyarakat Putri Hijau Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Journal of Pharmaceutical and Sciences.
Linda Margata
Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : VALENSI

 1 
Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form Nerdy Nerdy; Linda Margata; Dian Ika Perbina Meliala; Bunga Mari Sembiring; Selamat Ginting; Effendy De Lux Putra; Atika Mulyati; Tedy Kurniawan Bakri
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 2, November 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i2.22158

Abstract

The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry method to identify and determine metformin hydrochloride in marketed tablet dosage form. This research included preparation of standard, analysis of samples, and validation of method. The specific wavenumber obtained for qualitative analysis was 1645.68 cm–1 and 1574.8 cm–1. The specific area obtained for quantitative analysis with a single baseline ranged from 1701.53 cm–1 to 1535.66 cm–1. All metformin hydrochloride marketed tablet dosage forms were analyzed and met all of the qualitative and quantitative requirements. The methods met the requirements of method validation for accuracy with a percentage of recovery of 100.22 %, precision with relative standard deviation of 0.48 %, linearity with a correlation coefficient of 0.9992, limit of detection of 11.17 mg per mL, limit of quantitation of 33.84 mg per mL, and good specificity results. In this study, the Fourier Transform Infrared spectrophotometry method was successfully developed and validated for application in identification and determination of metformin hydrochloride in marketed tablet dosage form.
Co-Authors Atika Mulyati Bahrainur, Refi barus, dewi Br. Tarigan, Dhita Millenia Bunga Mari Sembiring Dewi Sartika Br Haloho Dian Ika Perbina Meliala Effendy De Lux Putra Faisal Yusuf Fujiko, Muflihah Girsang, Rostiodertina Hamdhani Hamdhani Hariati Hariati Hasanah, Fenny Jhan Saberlan Linta Meliala Martha Arizona Muharni Saputri Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Ningrum, Siti Rahmi Palas Tarigan Parhan Parhan Puji Lestari Razali Razali Sarah Damayanti Selamat Ginting Siagian, Nurul Aini Sudewi Sudewi Tedy Kurniawan Bakri Tedy Kurniawan Bakri Urip Harahap Vonna Aulianshah