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All Journal VALENSI Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Alchemy : Journal of Chemistry EduChemia (Jurnal Kimia dan Pendidikan) Indonesian Journal of Chemical Science International Journal Of Science, Technology & Management (IJSTM)

Damar Nurwahyu Bima

Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. H. Soedarto SH Tembalang, Semarang 50275, Indonesia

Author-ID : 1921168

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Transportation

Published : 8 Documents Claim Missing Document

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Articles

Mengungkap Potensi Metabolit Sekunder Tanaman Herbal Indonesia untuk Menghentikan Metastasis Kanker Payudara: Pendekatan in-silico Amalina, Nur Dina; Suzery, Meiny; Cahyono, Bambang; Bima, Damar Nurwahyu
Indonesian Journal of Chemical Science Vol 9 No 3 (2020)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v9i3.41146

Kanker payudara adalah penyakit dengan kasus kematian tertinggi kedua setelah penyakit kardiovaskular. Kemoterapi yang merupakan pilihan utama terapi kanker hingga saat ini terbukti menyebabkan beberapa efek samping berbahaya. Oleh karena itu, ada kebutuhan mendesak untuk mengembangkan terapi berbasis herbal yang efektif untuk membunuh sel kanker dan meminimalkan efek samping. Dalam penelitian ini, bertujuan untuk mengevaluasi interaksi molekuler secara in silico beberapa senyawa metabolit sekunder herbal Indonesia dengan indikasi terapeutik untuk pengobatan antikanker. Hasil penelitian ini menunjukkan bahwa semua metabolit sekunder dari Citrus sp., Curcuma sp., Caesalpinia sappan, dan Alpinia galanga memiliki interaksi yang lebih kuat dengan protein NF-ÃŽÂºB dibandingkan dengan doksorubisin. Interaksi paling kuat adalah senyawa kurkumin yang merupakan metabolit sekunder dari Curcuma sp. Namun simulasi awal ini hanyalah langkah awal untuk mengembangkan kombinasi senyawa-senyawa tersebut sebagai agen antikanker yang lebih potensial. Lebih penting lahi bahwa senyawa metabolit sekunder dari Citrus sp., Curcuma sp., C. sappan, dan A.galanga berpotensi di kembangkan sebagai agen kemoterapi alami dengan mempengaruhi proliferasi sel.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v9i3.41146

Kanker payudara adalah penyakit dengan kasus kematian tertinggi kedua setelah penyakit kardiovaskular. Kemoterapi yang merupakan pilihan utama terapi kanker hingga saat ini terbukti menyebabkan beberapa efek samping berbahaya. Oleh karena itu, ada kebutuhan mendesak untuk mengembangkan terapi berbasis herbal yang efektif untuk membunuh sel kanker dan meminimalkan efek samping. Dalam penelitian ini, bertujuan untuk mengevaluasi interaksi molekuler secara in silico beberapa senyawa metabolit sekunder herbal Indonesia dengan indikasi terapeutik untuk pengobatan antikanker. Hasil penelitian ini menunjukkan bahwa semua metabolit sekunder dari Citrus sp., Curcuma sp., Caesalpinia sappan, dan Alpinia galanga memiliki interaksi yang lebih kuat dengan protein NF-ÎºB dibandingkan dengan doksorubisin. Interaksi paling kuat adalah senyawa kurkumin yang merupakan metabolit sekunder dari Curcuma sp. Namun simulasi awal ini hanyalah langkah awal untuk mengembangkan kombinasi senyawa-senyawa tersebut sebagai agen antikanker yang lebih potensial. Lebih penting lahi bahwa senyawa metabolit sekunder dari Citrus sp., Curcuma sp., C. sappan, dan A.galanga berpotensi di kembangkan sebagai agen kemoterapi alami dengan mempengaruhi proliferasi sel.

Synthesis of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base Salicylaldehyde and Antibacterial Activity Ismiyarto Ismiyarto; Niken Windi Saputri; Liswinda Zafirah Rahmatia; Purbowatiningrum Ria Sarjono; Ngadiwiyana Ngadiwiyana; Nor Basid Adiwibawa Prasetya; Damar Nurwahyu Bima
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.19866

The development of compounds with a better antibacterial activity is highly needed. One way to achieve this is by modifying the structure of the compound using chitosan as a starting material, because of its abundant natural source in Indonesia, its biodegradable properties, and its structure where free amines are present. This study aims to obtain Mn(II) -Carboxymethyl Chitosan Schiff Base-Salicylaldehyde complex to increase its antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative). Schiff Base carboxymethyl chitosan-salicylaldehyde was synthesized from carboxymethyl chitosan with salicylaldehyde. Next, the Schiff Base Carboxymethyl Chitosan-Salicylaldehyde was complexed with MnCl2.4H2O and then characterized by FTIR, UV-Vis Spectrophotometer, and AAS and tested for antibacterial activity with the disc diffusion method against Staphylococcus aureus and Escherichia coli. The product of Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a brownish yellow solid with a yield of 64% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 11 mm) and Escherichia coli (clear zone diameter 13 mm). The product of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a black solid with a yield of 59% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 13 mm) and Escherichia coli (clear zone diameter 17 mm).

Synthesis, Characterization and Antioxidant Activity of Kobalt (II)-Hydrazone Complex Yulyani Nur Azizah; Irma Mulyani; Deana Wahyuningrum; Damar Nurwahyu Bima
EduChemia (Jurnal Kimia dan Pendidikan) Vol 5, No 2 (2020)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

The potency of the first-row transition metal complexes with Schiff's base ligand as an antioxidant has been widely studied by researchers. In this study, hydrazone-type Schiff base compounds, salicylaldehyde-2,4-dinitrophenylhydrazone (SDPH), resulted from the condensation of salicylaldehyde (1.5 mmol) and 2,4-dinitrophenylhydrazine (1.5 mmol) were synthesized and characterized with 1H-NMR. The synthesized SDPH was used as ligands in the formation of Co(II) metal complexes. The Co(II)-SDPH complexes were synthesized with reflux reaction at 60oC for 6 hours in molar ratio 1:3. Triethylamine is used to synthesis Co(II)-SDPH, which serves to deprotonate SDPH ligands. ESI-MS analysis showed that the complex is a neutral dimeric complex.The complex has the chemical formula [Co2(SDPH)2[(Et)3N]2(acn)2(OH)2} ([M+Na]+ = 1061 g/ mol), shown on the ESI-MS spectrum. Coordinate bonds between Co (II) metal ions with ligands are observed in the presence of shifting of the C=N wave number, as well as the loss of the vibrating peaks of the O-H groups to the infrared spectra of complexes. The IR spectrum of complexes was suggested that SDPH behave as a bidentate ligand through the azomethine nitrogen atom and phenolic oxygen atom. The ligand and its Co(II) complex have been screened for antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazine). Based on the activity test results, the IC50 value of Co(II)-SDPH complex was lower than ligand. These results show that Co(II)-SDPH are potentials as antioxidants.

Effects of Temperature and Heating Time on Degradation and Antioxidant Activity of Anthocyanin from Roselle Petals (Hibiscus sabdariffa L.) Meiny Suzery; Burhan Nudin; Damar Nurwahyu Bima; Bambang Cahyono
International Journal of Science, Technology & Management Vol. 1 No. 4 (2020): November 2020
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v1i4.78

The effects of temperature and heating time on the degradation and antioxidant activity of anthocyanin compounds from roselle petals (Hibiscus sabdariffa L.) have been evaluated from this research. The purpose of this study is to determine, the degradation and antioxidant activity of anthocyanin compounds on variations of temperature and heating time. In this study anthocyanin was extracted from roselle petals using ethanol solvent at 25oC. Then the anthocyanin extract obtained was dissolved into aqueous solution. The solution was then heated at 40oC, 60oC and 80oC for 60 minutes. The degradation of anthocyanin compounds was analyzed by calculating the total of anthocyanin contents, while the antioxidant activity was evaluated using the DPPH method. The results showed that Total Anthocyanin Content (TAC) from the extract solution before heating was 144.28 mg/L. Meanwhile the total value of anthocyanin in the 60 minutes after heating at 400C, 600C and 800C are 108.88 mg/L, 88.84 mg/L and 63.78 mg/L respectively. Heating at 80oC decreases antioxidant activity by increasing the IC50 value to 86.8 ppm higher than the conditions before heating. The increase of temperature and length of the heating process made the anthocyanin structure degraded. Degradation was indicated by the reduction of total anthocyanin content and the decrease of antioxidant activity.

Electrocoagulation Method Using Al/Graphite Electrode for Removal Surfactant LAS (Linear Alkylbenzene Sulfonate) Nafisa Khairunisa; Suhartana Suhartana; Damar Nurwahyu Bima
Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Vol 18, No 3 (2021): November 2021
Publisher : Universitas Diponegoro

An increasing number of laundries have caused water contamination by surfactants. One commonly used surfactant is LAS (Linear Alkylbenzene Sulfonate), a material difficult to decompose, polluting the environment. Electrocoagulation was carried out using Al/Graphite electrode, applied to LAS surfactant artistic waste. This study aims to determine the functional ability of the Al/Graphite electrode in reducing surfactant through electrocoagulation. Various variations were carried out, on the voltage parameters (3,6,9,12) Volt; NaCl concentration (0;0.4;0.8;1.2;1.6;2) g/L; pH (3,5,7,9,11) and time (10,20,30,40,50) minutes. To analyze the changes in the sample before and after electrocoagulation, characterization was carried out using a UV-VIS spectrophotometer and FTIR. A kinetic study was conducted to determine the reaction order of electrocoagulation surfactant. Based on a study, removal at condition voltage 9 Volt, initial pH of the solution 9, electrocoagulation time 50 minute, and the addition of NaCl electrolyte 2 g/L, obtained surfactant concentration was 0,785 mg/L with removal efficiency 97,45%. UV-VIS spectra show a decreased absorption at a wavelength of 653 nm. FTIR spectra showed the presence of absorption on the same functional groups, which indicated that most of the surfactant pollutants could be separated from the wastewater through the electrocoagulation process. The second-order reaction was obtained in the surfactant electrocoagulation process.

Electrochemical Peroxidation Method for Reduction of Chemical Oxygen Demand (COD) Carbofuran in Furadan 3GR Pesticides Ayu Sri Wahyuni; Suhartana Suhartana; Damar Nurwahyu Bima
Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Vol 18, No 2 (2021): July 2021
Publisher : Universitas Diponegoro

Carbofuran is a pollutant compound derived from the pesticide Furadan 3GR which is widely used in agriculture. Various methods of carbofuran degradation have been carried out, one of which is the conventional electrochemical method. This study used an electrochemical peroxidation process to degrade Carbofuran in the pesticide Furadan 3GR. This study aims to determine the optimum conditions (time, Na2SO4 concentration, and volume addition of H2O2) for electrochemical peroxidation and to compare the effectiveness of electrochemical and electrochemical peroxidation methods by measuring the parameter of carbofuran COD reduction. The significance of the electrochemical peroxidation method and the conventional electrochemical method was compared as a preliminary test. The COD reduction of Carbofuran using traditional electrochemical methods and electrochemical peroxidation was 45.76% and 88.70%, respectively. Batch carbofuran electrochemical peroxidation process was accomplished to ascertain the optimum conditions under various operation times, the concentration of Na2SO4, and the additional volume of H2O2. The largest COD reduction of 93.78% was obtained at 10 minutes, 75 mM Na2SO4, and 2 mL H2O2. The UV-Vis spectrophotometric absorption of Carbofuran at a wavelength of 274 nm was significantly reduced from 1.377 to 0.131 at optimum conditions. The IR spectrum measurement results indicate a reduction in absorbance for the N-H group (3383 cm-1) and the C=O group (1643 cm-1) at optimum conditions. Overall, the electrochemical peroxidation process proved to be an appropriate technique for COD reduction of Carbofuran in Furadan 3GR pesticides.

Optimization of Electrocoagulation Conditions in the Degradation Process of Carbofuran Waste (Furadan 3GR) Using Al/Graphite Electrodes Damar Nurwahyu Bima; Kumala Devi; Suhartana Suhartana; Sriyanti Sriyanti
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15360

Electrocoagulation is one of the electrochemical methods for treating wastewater and separating pollutants. In this research, the electrocoagulation using Al/Graphite electrodes was applied to artistic wastewater containing carbofuran to see the reduction of its chemical oxygen demand(COD). The electrocoagulation process was chosen in this study based on several advantages, including easy to separate between impurities and the sample and a simple operating system. Several parameters such as electrolysis time, variations in electrolyte concentration, and the effect of pH have been investigated for their impact on the electrocoagulation process. The results showed that the proportion of the best reduction in chemical oxygen demand (COD) was 64.40%. The best conditions were an electrolysis time of 60 minutes, an electrolyte concentration of 0.15 M, and a pH of 10. The results also show that the decrease in chemical oxygen demand (COD) dependson those parameters. These results were investigated further by characterization using UV-Vis spectrophotometry and FTIR spectroscopy. The results of the UV-Vis spectrum showed a decrease in intensity at a wavelength of 275 nm. Analysis of the FTIR spectrum between the initial sample and the results of the electrocoagulation showed that there were similar absorption peaks but with much smaller intensity, indicating that the effluent's pollutants have been deposited.Keywords: Electrocoagulation, Carbofuran, Al/Graphite, COD

Co-Authors Amalina, Nur Dina Ayu Sri Wahyuni Bambang Cahyono Burhan Nudin Deana Wahyuningrum Irma Mulyani Ismiyarto Ismitarto Kumala Devi Liswinda Zafirah Rahmatia Meiny Suzery Nafisa Khairunisa Ngadiwiyana M.Si. S.Si. Niken Windi Saputri Nor Basid Adiwibawa Prasetya Purbowatiningrum Ria Sarjono Sriyanti Sriyanti Suhartana Suhartana Suhartana Suhartana Yulyani Nur Azizah

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