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All Journal Jurnal Berkala Epidemiologi Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) Sari Pediatri Paediatrica Indonesiana Health Notions Jurnal Medik Veteriner Amerta Nutrition Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Media Gizi Kesmas Indian Journal of Forensic Medicine & Toxicology MEDICINUS
Roedi Irawan
Child Health Department, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Serum Level of 25-Hydroxyvitamin D in Children with Epilepsy Receiving Long-Term Antiepileptic Treatment Chasan Ismail; Roedi Irawan; Darto Saharso
MEDICINUS Vol 33 No 2 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.621 KB) | DOI: 10.56951/medicinus.v33i2.59

Abstract

Background: Long-term treatment with antiepileptic drugs (AED) requires monitoring of potential side effects, one of them is the decreasing in serum vitamin D level. Low serum vitamin D level is also a global health problem in healthy children. There are conflicting results regarding the low serum vitamin D level in epileptic children due to treatment with AED. Purpose: This study aimed to compare serum vitamin D level between healthy children and children with epilepsy receiving long-term AED treatment in Soetomo General Hospital. Methods: This was a cross-sectional study conducted in the pediatric neurology clinic of Soetomo general academic hospital from August 2018 to July 2019. Subjects are children ages 2-18 years with epilepsy receiving AED treatment for over 6 months (n=22), with healthy children as control (n=22). Peripheral serum 25-hydroxyvitamin D level were measured using enzyme-linked fluorescence assay (ELFA) method. The differences of those groups were analyzed by comparing the mean of 25-hydroxyvitamin D level of both groups using Anova and T-test (95% CI). Results: Low serum vitamin D level were identified in 27% children with epilepsy and 13% healthy children. The mean of serum 25-hydroxyvitamin D level in children with epilepsy and healthy children was 21.5 ng/ml (SD 8.41) and 34.3 ng/ml (SD 10.09), respectively. There was a significant difference between groups (p<0.05). Conclusion: Children with epilepsy receiving long-term AED treatment have lower level of serum 25-hydroxyvitamin D than healthy children.
Evaluation of the Progressivity Parameters of Chronic Kidney Disease after Branched-Chain Amino Acid Supplementation in Children Esthy Poespitaningtyas; Roedi Irawan; Ninik Asmaningsih Soemyarso; Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1467

Abstract

Chronic Kidney Disease (CKD) is not an uncommon issuein children. Chronic kidney disease is the abnormality of structure or function of the kidney that occurs for more than three months. The presence of a longitudinal decline in Glomerulus Filtration Rate (GFR), proteinuria, and hypertension Are the characteristics of CKD. One of the recommendations of nutritional supplementation as the prevention of CKD is by the administration of oral Branched-Chain Amino Acid (BCAA). To date, there has been no research to analyze the effects of the BCAA on children with stage 2-4CKD. This study aimed to analyze the effect of BCAA in inhibiting the progressivity of stage 2-4 CKD in children and improving nutritional status. A study with randomized pre-post test controlled trial design was performed in the Outpatient Clinic of Pediatric Nephrology in Dr. Soetomo Hospital with stage 2-4CKD. The subjects were divided into two groups, such as the BCAA and placebo, and were monitored for eight weeks to be evaluated the GFR, albumin, proteinuria, blood pressure, and nutritional status.Sixteen children with stage 2-4 CKD dominated by 71.4% of male patients were enrolled in this study. The mean age was 12.5 (SD 2.90) years. Approximately 50% (p=0.767) stage 2 chronic kidney, 50% (p=1.000) moderate malnutrition, and 64.28% (p=1.000) short stature were found, with nephrotic syndrome as the most common underlying cause of CKD (p=0.149). In BCAA group, decrease of GFR -5.08±7.13 (p=0.055), increase of serum albumin 0.20±0.23 (p=0.062), decrease of delta systole -11.57±15.08 (p=0.565) and diastole -4.85±16.25 (p=0.708), weight loss -0.07±1.01 (p=0.828), an increase of height 0.14±0.24 (p=0.771), and a decrease in BMI -0.03±0.74 (p=0.389) were reported. It was concluded that branched-chain amino acid (leucine, isoleucine, and valine) supplementation did not provide a significant effect to inhibit progressivity of stage 2-4CKD in children and improvement of nutritional status.
Co-Authors Alexander Leonard Caesar Josediputra Alifah Fajriyyatul Izzah Ana Qonitatillah Ayuning Tetirah Ramadhani Boerhan Hidajat Boerhan Hidayat Boerhan Hidayat Budi Prasety Chasan Ismail Christine Florens Christine Florens Darto Saharso Dina Angelika Dwi Lestari Avianti Eddy Bagus Wasito Esthy Poespitaningtyas Frieska Piesesha Hanindita, Meta Herdiana Hanindita, Meta Herdiana Hardiani, Kartika Hardiyani, Kartika Hartojo Hartojo Hidayatunnikmah, Nina I Dewa Gede Ugrasena I Gusti Ayu Putu Eka Pratiwi Indri Safitri Mukono Jusak Nugraha Kartika Hardiyani Khadijah Rizky Sumitro Khadijah Rizky Sumitro Mahrus A. Rahman Masayu Ramadhani Polanunu Meity Ardiana Melvanda Gisela Putri Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Miriawati Miriawati Muhammad Faizi Nanda Hudawarrahmah Ninik Asmaningsih Soemyarso Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja, Nur Aisiyah Nur Aisiyah Widjaya Nur Aisiyah Wijaya Nur Aisyah Widjaja Nur Aisyah Widjaja Piesesha, Frieska Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rina Elizabeth Risa Etika, Risa Rizky Arisanti Maharani Siti Nurul Hidayati Siti Nurul Hidayati Taufiq Hidayat Widati Fatmaningrum Widati Fatmaningrum Widjaja, Nur Aisyah Wigati, Kristanti Wanito Windhu Purnomo Windhu Purnomo