Abstract - Smart cities are essential things that must be applied in the face of globalization and competition. In smart city 5.0, three important things discussed are human resource development, smart marketing, and information technology. These three things cannot be separated from each other because they are related. Furthermore, the smart city 5.0 article is a development from the previous article, namely smart city 1.0-3.0. Smart City 5.0 provides four important formulas for developing a smart city and a framework to guide its implementation. The four formulas and the resulting framework will develop in the next article, namely intelligent intelligence. It will continue to make prototypes and smart city intelligence applications. The result of this article is a framework that is a concept and strategy in developing a smart region that is part of a smart city. This article is still under development and research will continue. Furthermore, the development of this research will certainly require several more stages in reaching the top of the research, namely a big picture of a smart city and performance measurement for each process contained in a smart city. Therefore, it takes the right steps and formulas to produce a smart city 5.0 framework Keywords - Smart city, Human resource, Marketing, Technology, Innovation