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All Journal Sosiohumaniora Majalah Kedokteran Bandung Althea Medical Journal Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education JURNAL KESEHATAN SAMODRA ILMU
Ike Rostikawati Husen
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjajaran , Bandung - INDONESIA
Arts Humanities Economics, Econometrics & Finance Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Effect of Neem Leaves Extract (Azadirachta Indica) on Wound Healing Rubianti, Irra; Chundran, Naveen Kumar; Husen, Ike Rostikawati
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.66 KB)

Abstract

Background: Neem leaves (Azadirachta Indica) have active ingredients such as nimbidin and sodium nimbidate which possess/possesinganti-inflammatory, antibacterial, antifungal and antiviral properties that help in healing process and also contains an excellent nutrition which plays/playing a vital role information of collagen and formation of new capillaries. The aim of this experimental study is to evaluate healing activity of neem leaves.Methods: This experiment was conducted in Pharmacology Lab of Universitas Padjadjaran on October 2012. Twenty seven rats were grouped randomly into 3 groups and 1.5cm of excision wound was created. Negative control group was treated with a topical application of saline solution (sodium chloride0.9%), treatment group with a topical application of neem leaves extract and positive control group had been treated with a topical application of povidone-iodine for 15 days. Healing was assessed by the longest diameter of the raw surface of wound on days 0, 5, 10 and 15. The data were then analyzed using Mann-Whitney U test.Results: There was a significant reduction in the longest diameter of wound in group of neem leaves extract, compared with group sodium chloride 0.9%,.and there was no significant difference in the longest diameter of wound between neem leaves, extract and povidone iodine. Conclusions: Neem leaves extract has the same wound healing rate compared to povidone iodine. A further study in human should be conducted in the future. [AMJ.2015;2(1):199–207]
Antiplatelet Drugs and Its Gastrointestinal Side Effects among Ischemic Stroke Patients in Dr. Hasan Sadikin General Hospital 2011 A/L Rajendram, Ananthakrishnan; Husen, Ike Rostikawati; Basuki, Andi
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

 Background: Antiplatelet drugs with known side effects are given in long term therapies to prevent secondary ischemic stroke. Gastrointestinal side effect is the most prevalent issue. The aim of this study was to identify which antiplatelet drugs have the most gastrointestinal side effects and the duration of administration. Methods: Seven hundred twenty six medical records were obtained from the Medical Record Department of Dr.Hasan Sadikin General Hospital Bandung from August to December 2011. Inclusion criteria were >18 years old and treated by long term antiplatelet drugs with complete medical records. Data analyzed descriptively consist of antiplatelet type, gastrointestinal effects, and drug administration duration. Results: Of 726 medical records only 246 were enrolled this study. Aspirin 80 mg was the most frequent drug given to ischemic stroke patients (65.9%). GI bleeding and nausea were the two side effects mostly found in aspirin >80 mg group (90%; 95% respectively). The side effects was found after less than 3 months in the aspirin >80 mg group, while it took longer to appear in clopidogrel 75 mg group. Conclusions: Aspirin (>80 mg) presents the most frequent gastrointestinal side effect compared to low dose aspirin 80 mg , clopidogrel, and combination of clopidogrel and aspirin.Keywords: Antiplatelet, ischemic stroke, side effects DOI: 10.15850/amj.v2n1.425  
Treatment Failure of Ampicillin to Children with Pneumonia at Dr. Hasan Sadikin General Hospital Bandung from 2014–2015 Suharno, Kania Devi; Husen, Ike Rostikawati; Sudarwati, Sri
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Abstract

Background: Pneumonia is one of the causes of death in infants in developing countries especially Indonesia. Appropriate treatment is needed to decrease mortality rate in children due to pneumonia. Ampicillin is one of first choices empirical antibiotic to children with severe pneumonia. The study was aimed to determine the failure rate of ampicillin in children with severe pneumonia.Methods: This study was a descriptive study which used medical records as source of data. Subjects were children aged 2–59 months with World Health Organization (WHO) defined with severe pneumonia and treated with intravenous ampicillin during January 2014 to July 2015 at Dr. Hasan Sadikin General Hospital Bandung. Samples were obtained using total sampling method while variables were analyzed using statistics software.Results: This study acquired 107 patients who met the inclusion criteria with 23.36% of them aged 2–11 months and 62.21% aged 12–23 months. Majority of subjects were male amounted as 63.55% while female occupied 36.45%. Treatment failure on the third day was 45.8% while 16.7% on the sixth day of therapy with majority failure due to existence of lower chest indrawing.Conclusions: Treatment failure on the third and sixth day of therapy still high that is characterized by the existence of lower chest indrawing as its main factor. [AMJ.2017;4(1):100–6]DOI: 10.15850/amj.v4n1.1029
Detection of Streptococcus pyogenes from Throat Swab in Acute Pharyngitis Patients Maulana, Ibnu Tsabit; Megantara, Imam; Husen, Ike Rostikawati
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Pharyngitis is an inflammation of throat that may be caused by viral and bacteria. Although Streptococcus pyogenes is only responsible for 5−15% of cases of pharyngitis in adults. Antibiotics are highly prescribed for this infection, thus it could lead to antibiotic resistance. The main reason for antibiotic overprescription is the difficulty to obtain a rapid and correct etiological diagnosis. This study aimed to determine the frequency of Streptococcus pyogenes from throat swab in patient with acute pharyngitis in Padjadjaran Clinic.Methods: This study was a descriptive study. Specimen was taken from the patients in Padjadjaran Clinic on September until October 2014. Thirty-five patients with acute pharyngitis that met the selection criteria were recruited for throat swab. Then, specimens obtained were performed an identification testing to determine whether there was a colonization of Streptococcus pyogenes. Results: Thirty five patients were found with acute pharyngitis consist of 14 male and 21 female, with age ranged between 16−34 years old. From the identification testing result, Streptococcus pyogenes was not found from throat swabs of patient with acute pharyngitis in Padjadjaran Clinic.Conclusions: This study found no colonization of Steptococcus pyogenes in throat swabs of acute pharyngitis patients in Padjadjaran Clinic, however Streptococcus pyogenes was not the causative fact of acute pharyngitis. [AMJ.2016;3(1):69–72] DOI: 10.15850/amj.v3n1.716
Prophylactic Antibiotic Pattern in Open Reduction Internal Fixation for Closed Fractures at Dr. Hasan Sadikin General Hospital Bandung in 2013 Edwiza, Deviana Suciani; Husen, Ike Rostikawati; Arsa, Widya
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

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Abstract

Background: Surgical site infection remains a serious complication of a surgery. Prophylactic antibiotics should be used in open reduction and internal fixation to prevent surgical site infection. This study aimed to study the pattern of prophylaxis used in internal fixation of closed fractures as this surgery is considered as a high-risk orthopedic procedures.Methods: This retrospective-descriptive study was performed from August to October 2014. Subject was closed fracture patient who underwent open reduction and internal fixation at Dr. Hasan Sadikin General Hospital Bandung in 2013. Data about characteristics of patients and pattern of the use of prophylactic antibiotics were obtained from patients’ medical record.Results: Medical records from 76 patients who underwent ORIF were analyzed.  Sixty eight patients (68.4%) were given 1 gram cefazolin intravenously as preoperative antibiotic prophylaxis. Timing for administration of antibiotics was 30–60 minute preoperatively in 34 (44.2%) patients. All Patients were given postoperative prophylaxis for 4.09 ± 1.36 days in average. The antibiotic most commonly used was cefazolin in 51 (63%) patients. All patients were prescribed an oral antibiotic at discharge. Cefadroxil was the most common antibiotic prescribed for patients at discharge. Conclusions: Cefazolin is the most common preoperative prophylactic antibiotic given to patients. All Patients are given postoperative prophylaxis and prescribed an antibiotic at discharge. 
Efek Hepatoprotektif Rosella (Hibiscus sabdariffa L.) pada Tikus Model Hepatitis Husen, Ike Rostikawati; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 44, No 2 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Hepatitis disebabkan oleh polutan yang menimbulkan stres oksidatif. Secara tradisional rosella (Hibiscus sabdariffa L.) mengandung flavonoid, suatu antioksidan yang digunakan untuk mengobati penyakit hati. Penelitian bertujuan menentukan efek hepatoprotektif ekstrak etanol bunga rosella segar (EEBRS) terhadap kadar malondialdehid (MDA) hati, serum glutamic piruvic transaminase (SGPT), dan kerusakan morfologi hepatosit tikus model hepatitis dibandingkan dengan efek vitamin E. Telah dilakukan penelitian ekperimental laboratorik di Departemen Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Agustus 2009 dengan menggunakan 25 ekor tikus Wistar jantan dibagi dalam 5 kelompok. Kelompok 1/kontrol negatif, kelompok 2/kontrol positif (model hepatitis-karbon tetraklorida/CCl4), kelompok 3 dan 4 merupakan model hepatitis yang selama 8 hari sebelumnya mendapat EEBRS 125 mg/kgBB/hr (kelompok 3) dan vitamin E 2,7 IU/hari per oral (kelompok 4), sedangkan kelompok 5 mendapat EEBRS. Pengamatan dilakukan 48 jam setelah induksi dengan CCl4. Analisis statistik menggunakan uji analysis of varian (ANOVA) dan uji Tukey. Hasil penelitian menunjukkan bahwa EEBRS mencegah kenaikan kadar MDA hati dan SGPT, berbeda secara bermakna dibandingkan dengan kontrol positif (MDA p=0,00; SGPT p=0,041) dan tidak berbeda bermakna dibandingkan dengan kelompok 4 (MDA p=1,00; SGPT p=0,192). Gambaran histopatologi hati kelompok 3 berupa vakuolisasi makrovesikular, pada tikus model hepatitis berupa vakuolisasi mikrovesikular, sedangkan vitamin E menghambat kerusakan morfologi. Simpulan, EEBRS memiliki efek hepatoprotektif sebagai antioksidan pada tikus model hepatitis namun efeknya tidak lebih baik dibandingkan dengan vitamin E. [MKB. 2012;44(2):83–9].Kata kunci: Hepatosit, MDA, rosella, SGPT The Hepatoprotective Effect of Rosella (Hibiscus sabdariffa L.) on Hepatitis Model Rats Hepatitis is initiated by pollutant which caused oxidative stress. Rosella (Hibiscus sabdariffa L.) contain flavonoid, an antioxidant which has been used traditionally in treating liver disease. The study aims to define the hepatoprotective effects of fresh rosella calyx ethanol extract (FRCEE) on hepatitis model rats with liver malondialdehyde (MDA) and serum glutamic piruvic transaminase (SGPT) level and hepatocyte morphology damage compared to vitamin E’s effects. The laboratory experimental study has been conducted on August 2009 at Department Pharmacology and Therapy Faculty of Medicine Padjadjaran University/Dr. Hasan Sadikin Hospital in 25 male Wistar rats, divided into 5 groups. Group 1 was negative control, group 2 was positive control (carbon tetrachloride/CCl4-hepatitis model rats), group 3 and 4 were hepatitis model rats that subsequently given 125 mg/kgBW of FRCEE (group 3) and 2.7 IU of vitamin E (group 4) for 8 days; group 5 was given FRCEE. Observations were done 48 hours after CCL4 induction. The results were analyzed by analysis of varian (ANOVA) and Tukey. The result showed that FRCEE inhibited increasing of liver MDA and SGPT level significantly different compared to positive control (MDA p=0.00, SGPT p=0.041) but not significantly different to group 4 (MDA p=1.00, SGPT p=0.192). Histological features showed macrovesicular on group 3, microvesicular vacuole on group 2; whereas vitamin E inhibited morphological damage. In conclusion, FRCEE has hepatoprotective effect on hepatitis model rats as antioxidant, but not superior compared to vitamin E. [MKB. 2012;44(2):83–9].Key words: Hepatocyte, MDA, rosella, SGPT DOI: http://dx.doi.org/10.15395/mkb.v44n2.128
Prophylactic Antibiotic Pattern in Open Reduction Internal Fixation for Closed Fractures at Dr. Hasan Sadikin General Hospital Bandung in 2013 Deviana Suciani Edwiza; Ike Rostikawati Husen; Widya Arsa
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (627.537 KB)

Abstract

Background: Surgical site infection remains a serious complication of a surgery. Prophylactic antibiotics should be used in open reduction and internal fixation to prevent surgical site infection. This study aimed to study the pattern of prophylaxis used in internal fixation of closed fractures as this surgery is considered as a high-risk orthopedic procedures.Methods: This retrospective-descriptive study was performed from August to October 2014. Subject was closed fracture patient who underwent open reduction and internal fixation at Dr. Hasan Sadikin General Hospital Bandung in 2013. Data about characteristics of patients and pattern of the use of prophylactic antibiotics were obtained from patients’ medical record.Results: Medical records from 76 patients who underwent ORIF were analyzed.  Sixty eight patients (68.4%) were given 1 gram cefazolin intravenously as preoperative antibiotic prophylaxis. Timing for administration of antibiotics was 30–60 minute preoperatively in 34 (44.2%) patients. All Patients were given postoperative prophylaxis for 4.09 ± 1.36 days in average. The antibiotic most commonly used was cefazolin in 51 (63%) patients. All patients were prescribed an oral antibiotic at discharge. Cefadroxil was the most common antibiotic prescribed for patients at discharge. Conclusions: Cefazolin is the most common preoperative prophylactic antibiotic given to patients. All Patients are given postoperative prophylaxis and prescribed an antibiotic at discharge. 
Treatment Failure of Ampicillin to Children with Pneumonia at Dr. Hasan Sadikin General Hospital Bandung from 2014–2015 Kania Devi Suharno; Ike Rostikawati Husen; Sri Sudarwati
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.667 KB)

Abstract

Background: Pneumonia is one of the causes of death in infants in developing countries especially Indonesia. Appropriate treatment is needed to decrease mortality rate in children due to pneumonia. Ampicillin is one of first choices empirical antibiotic to children with severe pneumonia. The study was aimed to determine the failure rate of ampicillin in children with severe pneumonia.Methods: This study was a descriptive study which used medical records as source of data. Subjects were children aged 2–59 months with World Health Organization (WHO) defined with severe pneumonia and treated with intravenous ampicillin during January 2014 to July 2015 at Dr. Hasan Sadikin General Hospital Bandung. Samples were obtained using total sampling method while variables were analyzed using statistics software.Results: This study acquired 107 patients who met the inclusion criteria with 23.36% of them aged 2–11 months and 62.21% aged 12–23 months. Majority of subjects were male amounted as 63.55% while female occupied 36.45%. Treatment failure on the third day was 45.8% while 16.7% on the sixth day of therapy with majority failure due to existence of lower chest indrawing.Conclusions: Treatment failure on the third and sixth day of therapy still high that is characterized by the existence of lower chest indrawing as its main factor. [AMJ.2017;4(1):100–6]DOI: 10.15850/amj.v4n1.1029
Detection of Streptococcus pyogenes from Throat Swab in Acute Pharyngitis Patients Ibnu Tsabit Maulana; Imam Megantara; Ike Rostikawati Husen
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (543.878 KB)

Abstract

Background: Pharyngitis is an inflammation of throat that may be caused by viral and bacteria. Although Streptococcus pyogenes is only responsible for 5−15% of cases of pharyngitis in adults. Antibiotics are highly prescribed for this infection, thus it could lead to antibiotic resistance. The main reason for antibiotic overprescription is the difficulty to obtain a rapid and correct etiological diagnosis. This study aimed to determine the frequency of Streptococcus pyogenes from throat swab in patient with acute pharyngitis in Padjadjaran Clinic.Methods: This study was a descriptive study. Specimen was taken from the patients in Padjadjaran Clinic on September until October 2014. Thirty-five patients with acute pharyngitis that met the selection criteria were recruited for throat swab. Then, specimens obtained were performed an identification testing to determine whether there was a colonization of Streptococcus pyogenes. Results: Thirty five patients were found with acute pharyngitis consist of 14 male and 21 female, with age ranged between 16−34 years old. From the identification testing result, Streptococcus pyogenes was not found from throat swabs of patient with acute pharyngitis in Padjadjaran Clinic.Conclusions: This study found no colonization of Steptococcus pyogenes in throat swabs of acute pharyngitis patients in Padjadjaran Clinic, however Streptococcus pyogenes was not the causative fact of acute pharyngitis. [AMJ.2016;3(1):69–72] DOI: 10.15850/amj.v3n1.716
Effect of Neem Leaves Extract (Azadirachta Indica) on Wound Healing Naveen Kumar Chundran; Ike Rostikawati Husen; Irra Rubianti
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.66 KB)

Abstract

Background: Neem leaves (Azadirachta Indica) have active ingredients such as nimbidin and sodium nimbidate which possess/possesinganti-inflammatory, antibacterial, antifungal and antiviral properties that help in healing process and also contains an excellent nutrition which plays/playing a vital role information of collagen and formation of new capillaries. The aim of this experimental study is to evaluate healing activity of neem leaves.Methods: This experiment was conducted in Pharmacology Lab of Universitas Padjadjaran on October 2012. Twenty seven rats were grouped randomly into 3 groups and 1.5cm of excision wound was created. Negative control group was treated with a topical application of saline solution (sodium chloride0.9%), treatment group with a topical application of neem leaves extract and positive control group had been treated with a topical application of povidone-iodine for 15 days. Healing was assessed by the longest diameter of the raw surface of wound on days 0, 5, 10 and 15. The data were then analyzed using Mann-Whitney U test.Results: There was a significant reduction in the longest diameter of wound in group of neem leaves extract, compared with group sodium chloride 0.9%,.and there was no significant difference in the longest diameter of wound between neem leaves, extract and povidone iodine. Conclusions: Neem leaves extract has the same wound healing rate compared to povidone iodine. A further study in human should be conducted in the future. [AMJ.2015;2(1):199–207]
Co-Authors Ananthakrishnan A/L Rajendram Ananthakrishnan A/L Rajendram, Ananthakrishnan Andi Basuki, Andi Apriliani, Purwandyarti Arsa, Widya Cantika Iva Nugrahani Dani Hilmanto Deviana Suciani Edwiza Dewi M.D Herawati Edwiza, Deviana Suciani Elis Suryani Nani Sumarlina Erni Hernawati Farid Husin Firman Fuad Wirakusumah Herri S. Sastramihardja Ibnu Tsabit Maulana Ibnu Tsabit Maulana, Ibnu Tsabit Imam Megantara Irra Rubianti Irra Rubianti, Irra Kania Devi Suharno Laksono Trisnantoro M. Nurhalim Shahib Mieke Hemiawati Satari Muhammad Nurhalim Shahib Nanan Sekarwana Naveen Kumar Chundran Naveen Kumar Chundran, Naveen Kumar Ponpon S. Idjradinata Rangga Saptya Mohamad Permana Sri Sudarwati SRI SUDARWATI Suharno, Kania Devi Undang Ahmad Darsa Veratiwi Veratiwi Widya Arsa Yuniar Dwi Yanti