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All Journal JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Pharmacology and Clinical Pharmacy Research JFIOnline Pharmaceutical Sciences and Research (PSR)
Slamet Ibrahim
Sekolah Farmasi ITB Bandung
Health Professions Medicine & Pharmacology Nursing Public Health

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Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
Co-Authors Abdul Mutalib Ahmad Muhtadi Aliya Nur Hasanah Eli Halimah, Eli Entris Sutisna, Entris Fikri, Fauzan H.Tjahjono, Daryono H.Tjahjono, Daryono Ida Musfiroh, Ida Ilma Nugrahani Jutti Levita Kartasasmita, Rahmana E Kartasasmita, Rahmana E Mursadad, Amir N.S, Sundani Nawawi, Asari Nursamsiar Nursamsiar Nursyamsiah, Tresna Nursyamsiah, Tresna Rahmana Emran Kartasasmita Saeful Amin, Saeful Saptarini, Nyi M. Sukmadjaja Asyarie Sumiwi, Sri A. Sundani Nurono Soewandhi