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Perbandingan Aktivitas Antibakteri Ekstrak Etanol Bunga Brokoli (Brassica oleracea var. italica Plenck) dan Kembang Kol (Brassica oleracea var. botrytis DC.) terhadap Propionibacterium acnes salsabila soedradjat; Livia Syafnir; Indra Topik Maulana
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.162 KB) | DOI: 10.29313/bcsp.v2i2.4686

Abstract

Abstract. Acne is a skin disease that often occurs in all circles that causes inflammation. The main cause of acne is the bacteria Propionibacterium acnes. This study aims to compare the antibacterial activity ethanol extract of broccoli flower and ethanol extract of cauliflower to the acne-causing bacteria P. acnes measured from the diameter of the resulting inhibition zone, as well as to compare the parameters and characteristics of each materials. The study began with standard parameter determination test, then phytochemical screening and antibacterial activity test for P. acnes. The results showed that broccoli contains alkaloids, flavonoids, phenolic compounds, tannins, quinones, saponins, steroids, monoterpenes and sesquiterpenes. Cauliflower contains alkaloids, flavonoids, phenolic compounds, tannins, quinones, saponins, steroids, triterpenoids, monoterpenes and sesquiterpenes. The results of the comparison test of antibacterial activity of ethanol extract broccoli flower and ethanol extract cauliflower to P. acnes with test concentrations of 1%, 5%, 10%, 15% and 20% using the well method showed negative results, where the two ingredients were not able to inhibit the growth rate of bacteria P. acnes. In the positive control, namely clindamycin, which showed an average diameter of the inhibition zone of 32.65 mm, the antibiotic produced antibacterial activity against the growth of P. acnes. This could be due to the fact that the two extracts were not active at all as antibacterial P. acnes, but had other antibacterial activities. Abstrak. Jerawat adalah penyakit kulit yang sering terjadi pada semua kalangan yang menyebabkan inflamasi. Penyebab utama terjadinya jerawat adalah bakteri Propionibacterium acnes. Penelitian ini bertujuan untuk membandingkan aktivitas antibakteri antara ekstrak etanol bunga brokoli dengan ekstrak etanol kembang kol terhadap bakteri penyebab jerawat P. acnes diukur dari diameter zona hambat yang dihasilkan, serta untuk membandingkan parameter dan karakteristik dari masing-masing bahan. Penelitian diawali dengan uji penetapan parameter standar lalu penapisan fitokimia dan dilakukan uji aktivitas antibakteri terhadap P. acnes. Hasil penelitian menunjukkan bahwa pada brokoli mengandung senyawa alkaloid, flavonoid, fenolik, tanin, kuinon, saponin, steroid, monoterpen dan seskuiterpen. Pada kembang kol mengandung senyawa alkaloid, flavonoid, fenolik, tanin, kuinon, saponin, steroid, triterpenoid, monoterpen dan seskuiterpen. Hasil uji perbandingan aktivitas antibakteri ekstrak etanol bunga brokoli dan kembang kol terhadap P. acnes pada konsentrasi uji 1%, 5%, 10%, 15% dan 20% menggunakan metode sumuran menunjukkan hasil negatif, dimana kedua bahan tersebut tidak mampu menghambat laju pertumbuhan dari bakteri P. acnes. Pada kontrol positif yaitu klindamisin menunjukkan rata-rata diameter zona hambat sebesar 32,65 mm maka antibiotik tersebut menghasilkan aktivitas antibakteri terhadap pertumbuhan P. acnes. Hal tersebut dapat disebabkan karena kedua ekstrak tidak aktif sama sekali sebagai antibakteri P. acnes, melainkan aktivitas antibakteri lain.
Studi Penelusuran Pustaka Hasil Telaah In Silico Aktivitas Antiviral dari Senyawa Aktif Bahan Alam terhadap Virus Corona Dandi Rustandi; Indra Topik Maulana
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.944 KB) | DOI: 10.29313/bcsp.v2i2.4726

Abstract

Abstract. The Corona virus or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which emerged at the end of 2019, is considered a global public health problem, because it causes high morbidity and mortality. Some potential targets of the corona virus are spike proteins, RNA dependent RNA polymerase, ACE2 and viral proteases. Indonesia is one of the countries with high biodiversity. Some examples of plants that have been tested for their medicinal properties are pomegranate, turmeric, tea, and finger roots. The chemical compounds contained in it, both in the form of secondary metabolites, macromolecules and genetics, are very potential for various benefits for mankind, especially the people of Indonesia. The purpose of this literature search is to collect data related to active compounds that have antiviral activity against SARS-CoV-2. This research was conducted by examining scientific journals obtained from Google Scholar, Taylor, Pubmed, Springer, and Science Direct. The active compounds found in pomegranate peel, turmeric, tea, justicia adhatoda leaves, and finger roots have antiviral activity from the corona virus, where these compounds have high structural stability of protein-ligand complexes and have high energy binding affinity according to with their respective protein targets. These active compounds from natural ingredients can be used as a data base that can later be used for further research on in vitro and in vivo tests. Abstrak. Virus corona atau Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang muncul pada akhir tahun 2019, dianggap sebagai masalah kesehatan masyarakat global, karena menyebabkan morbiditas dan mortalitas yang tinggi. Beberapa target potensial dari virus corona adalah protein spike, RNA dependen RNA polimerase, ACE2 dan protease virus. Indonesia adalah salah satu negara yang tinggi akan keanekaragaman hayatinya. Beberapa contoh tanaman yang telah teruji khasiatnya dalam pengobatan yaitu seperti delima, kunyit, teh, dan akar jari. Senyawa kimiawi yang terkandung di dalamnya baik berupa kandungan metabolit sekunder, makromolekul maupun genetik sangat potensial untuk beragam manfaat bagi umat manusia khususnya masyarakat indonesia. Tujuan dari penelitian penelusuran pustaka ini adalah untuk mengkoleksi data terkait dengan senyawa-senyawa aktif yang memiliki aktivitas sebagai antiviral terhadap SARS-CoV-2. Penelitian ini dilakukan dengan cara menelaah jurnal-jurnal ilmiah yang didapatkan dari Google Scholar, Taylor, Pubmed, Springer, dan Science Direct. Senyawa-senyawa aktif yang terdapat pada kulit delima, kunyit, teh, daun justicia adhatoda, dan akar jari memiliki aktivitas antiviral dari virus corona, dimana senyawa-senyawa ini memiliki stabilitas struktural kompleks protein-ligan yang tinggi serta memiliki afinitas pengikatan energi yang tinggi sesuai dengan target protein masing-masing. Senyawa-senyawa aktif dari bahan alam ini bisa dijadikan sebagai data base yang nantinya dapat dilakukan untuk penelitian lebih lanjut pada uji invitro maupun invivo.
Penelusuran Pustaka Tanaman yang Berpotensi sebagai Antibakteri untuk Penyakit Infeksi Saluran Kemihluran Kemih Kenny Utami Prameswari; Indra Topik Maulana; Vinda Maharani Patricia
Bandung Conference Series: Pharmacy Vol. 3 No. 1 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i1.6347

Abstract

Abstract. Urinary Tract Infection is a disease that has a fairly high prevalence in Indonesia. The common treatment for this disease is using antibiotics. However, uncontrolled and irrational use causes resistance to these antibiotics. Thus, medicinal plants that have the potential to inhibit UTI-causing bacteria can be used as an alternative to reduce the occurrence of resistance to these antibiotics. MIC value (Minimum Inhibitory Concentration) is a parameter of plants that have potential. The results of the literature search show that there are several plants that have the potential to be antibacterial for UTIs, namely Garlic (Allium sativum), Fennel (Foeniculum vulgare mill), Seribu Leaf (Achillea mille folium) Horse Chestnut (Aesculus hippocastanum L.), Parsley ( Petroselinum crispum), Rosemary (Rosmarinus officinalis), Rosella (Hibiscus sabdariffa), Syrian Rue (Peganum harmala L.), Horsetail Ferns (Equisetum ramosissimum Desf. Stem), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, and Cumin White (Cuminum cyminum). Abstrak. Penyakit Infeksi Saluran Kemih merupakan penyakit yang memiliki prevalensi yang cukup tinggi di Indonesia. Pengobatan umum yang dilakukan untuk menangani penyakit tersebut adalah menggunakan antibiotik. Namun, penggunaan yang tidak terkontrol dan tidak rasional menyebabkan resistensi terhadap antibiotik. Sehingga, tanaman-tanaman obat yang berpotensi untuk menghambat bakteri penyebab ISK dapat dijadikan alternatif untuk mengurangi terjadinya resistensi. Nilai KHM (Konsentrasi Hambat Minimum) merupakan parameter dari tanaman yang memiliki potensi. Hasil dari penelusuran pustaka menunjukkan bahwa terdapat beberapa tanaman yang berpotensi sebagai antibakteri untuk penyakit ISK yaitu Bawang Putih (Allium sativum), Berangan Kuda (Aesculus hippocastanum L. ), Rosemari (Rosmarinus officinalis), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, dan Jintan Putih (Cuminum cyminum).
Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil Sani Ega Priani; Desti Puspa Rahayu; Indra Topik Maulana
Borneo Journal of Pharmacy Vol. 4 No. 2 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i2.1942

Abstract

Cod liver oil (CLO) has long been used as medicine or as a functional food. The CLO is a potential source of vitamin D, vitamin A, and omega fatty acids (eicosapentaenoic acid/EPA and docosahexaenoic acid/DHA). Self-nanoemulsifying drug delivery system (SNEDDS) can enhance dissolution, absorption, and bioavailability of hydrophilic and lipophilic substances for oral administration. The objective of this study was to develop a SNEDDS of CLO with good physical characteristics and stability. The optimization formula was carried out using various ratios of oil, surfactant, and cosurfactant. The physical properties of SNEDDS were determined by transmittance percentage, dispersibility, robustness, thermodynamics stability (heating-cooling cycle, centrifugation, and freeze-thaw cycle), and globule size distribution. The optimum formula of CLO-SNEDDS was obtained at a ratio of surfactant and cosurfactant 2 : 1 and a comparison of oil and surfactant mixtures 1 : 6. The CLO-SNEDDS meets the requirement of percent transmittance (97.90±0.85), dispersibility (grade A), and stability based on robustness and thermodynamic stability tests. Diluted SNEDDS has an average globule size of 125 nm with a polydispersity index (PDI) of 0.515. CLO-SNEDDS preparation has good physical characteristics and stability.
Co-Authors Abdul Kudus Ainun Navisah Alfiah Nurulfikri Aqila Dliya Zhafira Atrie Cahya Ramdhani Bertha Rusdi Budi Prabowo Soewondo Dandi Rustandi Desti Puspa Rahayu Devinur Rahmawati Dwiratnasari Elsya Nurul Mauludiyah Esti Rachmawati Sadiyah Fairuz Rifdah Permanasari Inge Aprianti Isnaeni Nur Azizah Kenny Utami Prameswari Khaerunnisa Kiki Mulkiya Yuliawati Livia Syafnir Lu'lu Ulul Albab Muhammad Daffa Adilah Nanda Aulia Rahma Nur Alifah Suhara Nur Azizah Suhara Reza Abdul Kodir Reza Abdul Kodir REZA ABDUL KODIR, REZA ABDUL Rifa Safira Rinda Sri Partina Rizka Wulan Sari Rosa Afriliani Salma Azizah salsabila soedradjat Sani Ega Priani Sri Nur Azizah Tiara Deviani Vinda Maharani Patricia Yani Lukmayani