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Rancangan Pusat Informasi dan Konsultasi Obat, Kosmetika, dan Makanan di Unisba Sani Ega Priani
MIMBAR (Jurnal Sosial dan Pembangunan) Volume 25, No. 1, Year 2009
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/mimbar.v25i1.278

Abstract

Among other things, health quality is an important indicator to judge life quality in Indonesia.  But, despite juggling efforts conducted by many institutions,  a serious lack of  health quality still become one of the greatest problems in Indonesia.  Improvement of health quality,  therefore,  is inevitably. As part of such improvement, Unisba in its fifty years could positioned themselves as government partner by building a center of information and consultation for food, cosmetics, and drink. In this center, people will be informed by trained specialist concerning nutritious food, healthy drinks, and cosmetics.  In fact,  this center will provide every information  dedicated  for  people  concerning  healthy lifestyle from medical perspective without betrayed the core teachings of Islam.
In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil Sani Ega Priani; Dinnanda Yussepina Wulansari; Fitrianti Darusman
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v11i1.18048

Abstract

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% of post-pubertal women. Caffeine and grape seed oil were known can be used as an anti-cellulite agent. Microemulsion systems are known could enhance the diffusion rate of drugs through the skin. This study was conducted to develop a microemulsion gel containing caffeine and grape seed oil and determine the effect of caffeine's in vitro diffusion profile. Microemulsion gel was prepared using tween 80 as a surfactant, glycerin as cosurfactant, viscolam mac 10 as a gelling agent. The preparations were evaluated by organoleptic, pH, viscosity, rheology, spreadability, globule size, and thermodynamic stability tests. In vitro diffusion tests were performed by Franz diffusion cell. The result showed that microemulsion containing 1 % of caffeine and 5% of grapeseed oil has good physical characteristics and stability with an average globule size 126 ±17 nm. Microemulsion gel system could enhance the cumulative release amount of caffeine through synthetic membrane compared with gel system. Drug release kinetics of caffeine from microemulsion gel system follows the Higuchi model.
Formulasi dan Evaluasi Sediaan Mikroemulsi Untuk Penghantaran Transdermal Ketoprofen dengan Fasa Minyak Labrafil M1944CS Priani, Sani Ega; Darijanto, Sasanti Tarini; Suciati, Tri; Iwo, Maria Immaculata
Jurnal Matematika dan Sains Vol 19 No 3 (2014)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ketoprofen termasuk obat anti inflamasi non steroid (NSAIDs) untuk pengobatan simptomatik nyeri dan inflamasi. Pemakaian ketoprofen secara transdermal diketahui mampu menghantarkan zat aktif untuk mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan per oral, sehingga  mengurangi resiko efek samping sistemik. Penelitian ini bertujuan untuk mendapatkan mikroemulsi ketoprofen yang stabil secara fisik untuk penghantaran transdermal. Optimasi formula mikroemulsi dibuat menggunakan fasa minyak labrafil M 1944 CS, surfaktan Cremophor EL, serta kosurfaktan etanol, propilenglikol, dan gliserin. Evaluasi sediaan meliputi pengamatan organoleptik, pH, viskositas, dan  ukuran globul, serta pengujian stabilitas fisik menggunakan metode sentrifugasi dan freeze thaw. Selanjutnya dilakukan uji difusi in vitro dan uji iritasi kulit dan mata pada kelinci. Formula mikroemulsi optimum mengandung labrafil 15%, cremophor EL 30%, dan propilenglikol 10%. Sediaan mikroemulsi memenuhi kriteria stabilitas fisik berdasarkan uji sentrifugasi dan freeze thaw. Nilai pH dan viskositas sediaan relatif stabil selama 120 hari penyimpanan pada suhu kamar. Mikroemulsi ketoprofen memiliki ukuran globul rata-rata 29,3 nm. Jumlah ketoprofen terdifusi selama 180 menit pengujian adalah 386,6 ± 61,2 µg/cm2. Sediaan mikroemulsi mengiritasi ringan pada kulit tetapi tidak mengiritasi mata. Kata kunci: Ketoprofen, Mikroemulsi, Transdermal, Difusi.   Formulation and Evaluation of Microemulsion for Ketoprofen Transdermal Delivery Using Labrafil M1944CS as an Oil Phase Abstract Ketoprofen belongs to NSAIDs and is commonly applied  for symptomatic treatment of pain and inflamation. Transdermal route of ketoprofen application enables the delivery of this active substance to reach its effective concentration in target organ but with lower plasma concentration compared to that of per oral application and hence can reduce systemic side effects. The objectives of this study are to obtain microemulsion formulation of ketoprofen for transdermal delivery. Microemulsion was formulated using Labrafil M 1944 CS as an oil phase, cremophor EL as surfactant and etanol, propylene glycol, glycerin as cosurfactans. Evaluation of ketoprofen microemulsion included organoleptic evaluation, pH, viscocity, globul diameter, and physical stability test using centrifugation and freeze thaw methods. Skin permeation was evaluated in vitro using spangler membrane and irritation effect test on rabbits. The optimum formulation of microemulsion was labrafil 15%, cremophor EL 30%,and  propylene glycol 10%. Microemulsion of ketoprofen did not show any changes during freeze thaw and centrifugation tests which indicated its stability. The viscosity and pH of preparations were relatively stable for 120 days storage at room temperature. Average globule  diameter of microemulsion was 29.3 nm. The total ketoprofen diffused was 386.6 ± 61.2 µg/cm2 for 180 minutes of testing time. The microemulsion showed slight irritation effect on the skin but no irritation effect on the eyes. Keywords : Ketoprofen, Microemulsion, Transdermal, Diffusion.
The development of antioxidant peel-off facial masks from cinnamon bark extract (Cinnamomum burmannii) Sani Ega Priani; Restianti Mutiara; Dina Mulyanti
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.902 KB) | DOI: 10.12928/pharmaciana.v10i1.14193

Abstract

The bark of cinnamon (Cinnamomum burmannii) contains cinnamaldehyde and other active substances with potent antioxidant properties. Antioxidants are effective at preventing and reducing UV-induced skin damages and skin aging. This study was intended to formulate and characterize the antioxidant peel-off facial masks containing cinnamon bark extract and the combination of polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) as gelling agents. The ethanol extract of cinnamon bark and the developed peel-off mask were evaluated for their antioxidant activities by the α,α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method and for their physical characteristics. The cinnamon bark extract exhibited a very strong antioxidant activity, as evidenced by IC50= 10.04 ± 0.08 ppm. As for the formulated peel-off mask, it had excellent physical characteristics, which were identified during organoleptic observations and pH, viscosity, spreadability, and film drying time evaluations. Similar to its constituent extract, this mask produced significantly potent antioxidant effects, with IC50= 47.31 ± 1.47 ppm. For these reasons, peel-off facial masks containing cinnamon bark extract have not only excellent physical characteristics but also powerful antioxidant properties.
Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Sani Ega Priani; Nurrayyan Nurrayyan; Fitrianti Darusman
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.782 KB) | DOI: 10.12928/pharmaciana.v7i2.7387

Abstract

Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS  was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.
Formulasi Sediaan Emulgel Untuk Penghantaran Transdermal Ketoprofen Priani, Sani Ega; Darijanto, Sasanti Tarini; Suciati, Tri; Iwo, Maria Immaculata
Acta Pharmaceutica Indonesia Vol 38, No 1 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.55 KB)

Abstract

Ketoprofen adalah obat golongan anti inflamasi non-steroid (AINS) yang banyak digunakan untuk mengobati nyeri dan inflamasi. Penggunaan oral ketoprofen dapat menimbulkan berbagai efek samping sistemik. Pemakaian transdermal diketahui mampu mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan oral, sehingga dapat mengurangi resiko efek samping sistemiknya. Penelitian ini bertujuan untuk membuat sediaan emulgel untuk penghantaran transdermal ketoprofen. Propilenglikol 10% dan menthol 3% digunakan sebagai peningkat penetrasi. Sediaan dievaluasi meliputi pengamatan organoleptik, pH, viskositas, serta pengujian stabilitas fisik menggunakan metode sentrifugasi dan freeze thaw. Selanjutnya dilakukan uji difusi in vitro dan uji iritasi kulit dan mata pada kelinci. Sediaan emulgel memenuhi kriteria stabilitas fisik berdasarkan uji sentrifugasi dan freeze thaw. Nilai pH dan viskositas sediaan relatif stabil selama kurun waktu penyimapanan 120 hari pada suhu kamar. Propilenglikol dan mentol dapat meningkatkan difusi perkutan ketoprofen, yang berbeda signifikan dibandingkan emulgel tanpat peningkat penetrasi (p<0,05). Formula emulgel bersifat sedikit mengiritasi kulit dengan nilai indeks iritasi kutan 0,83-1,17 (nilai maksimal 8), tetapi tidak mengiritasi mata.Kata kunci: Ketoprofen, transdermal, emulgel, peningkat penetrasi.AbstractKetoprofen as an non-steroidal anti-inflammatory drugs (NSAIDs) used for pain and inflamation treatment. However, there are some serious adverse effects associated with oral use of NSAIDs. Transdermal route is known to reach effective local concentration with low plasma concentration resulting in reduction systemic adverse effects. The objectives of this study was to formulate emulgel of ketoprofen for transdermal delivery. Ketoprofen emulgel was prepared using 10% of propilene glycol and 3% of menthol as penetrant enhancer. Evaluation of preparation included organoleptic evaluation, pH, viscocity, and physical stability test using centrifugation and freeze thaw method. Skin permeation was evaluated in vitro using spangler membrane and irritation effect test on rabbits. Emulgels were stable after centrifugation and freeze thaw test. The viscosity and pH of preparations were relatively stable during storage at room temperature for 120 days. Propylenglycol and menthol increased diffusion rate of ketoprofen, differ significantly from emulgel without enhancer (p<0.05). Emulgel preparation were slightly irritate to the skin with irritation index 0.83-1.17 (maximum value 8) but was not irritate to the eyes.Keywords: Ketoprofen, transdermal, emulgel, penetrant enhancer
Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Priani, Sani Ega; Nurrayyan, Nurrayyan; Darusman, Fitrianti
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.782 KB) | DOI: 10.12928/pharmaciana.v7i2.7387

Abstract

Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS  was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.
Uji Aktivitas Inhibitor Tirosinase Ekstrak Kulit Buah Cokelat (Theobroma cacao L.) dan Formulasinya dalam Bentuk Sediaan Nanoemulsi Sani Ega Priani; Ainul Fatihah Halim; Sri Peni Fitrianingsih; Livia Syafnir
Jurnal Sains Farmasi & Klinis Vol 8, No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.1.1-8.2021

Abstract

Limbah kulit buah cokelat diketahui mengandung berbagai senyawa aktif seperti polifenol dan flavonoid sehingga berpotensi memiliki aktivitas inhibitor tirosinase. Untuk meningkatkan kemampuan penetrasi ekstrak pada penghantaran topikal akan dikembangkan menjadi sediaan nanoemulsi. Tujuan dari penelitian ini untuk menguji aktivitas inhibitor tirosinase ekstrak kulit buah cokelat dan memformulasikannya menjadi sediaan nanoemulsi yang memiliki sifat fisik yang baik. Simplisia diekstraksi dengan metode maserasi menggunakan etanol 70% dan selanjutnya diuji aktivitas inhibitor tirosinasenya dengan metode dopakrom berbasis colorimetric enzymatic assay. Sediaan nanoemulsi ekstrak kulit buah cokelat dibuat dengan menggunakan minyak biji anggur, tween 80 sebagai surfaktan, dan gliserin sebagai kosurfaktan untuk selanjutnya dikarakterisasi secara fisik. Hasil uji menunjukkan ekstrak kulit buah cokelat memiliki aktivitas inhibitor tirosinase dengan nilai IC50 199,98 ppm. Sediaan nanoemulsi mengandung ekstrak kulit buah cokelat penampilan fisik yang jernih dan homogen, pH 6,21±0,02, viskositas 1070 ± 24,5 cps, sifat alir Newtonian, dengan ukuran globul 108 ±15 nm. Sediaan nanoemulsi memiliki stabilitas fisik yang baik berdasarkan uji sentrifugasi, heating cooling, dan freeze thaw. Disimpulkan bahwa ekstrak kulit buah cokelat terbukti memiliki aktivits inhibitor tyrosinase dan telah berhasil diformulasikan menjadi sediaan nanoemulsi dengan sifat fisik dan stabilitas yang baik.
The immunostimulant activity of Tibb an-Nabawi natural products: a literature review Sani Ega Priani
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art5

Abstract

Abstract Background: Enhancing the immune system is very important during the Covid-19 pandemic to prevent infections and reduce the risk of disease severity. Therefore, it is necessary to use natural products with an immunostimulant effect. In Islam, there is a system of treatment or disease prevention based on Al-Quran and Hadith, which is called Tibb an-Nabawi or prophetic medicine. Objective: This research aims to conduct a literature study of Tibb an-Nabawi, which has proved to be able to increase the immune system, based on Islamic and scientific approaches.Method: The research was based on a systematic literature review using research articles from the last ten years. The inclusion criteria were articles discussing the immunostimulatory activity of Tibb an-Nabawi, while the exclusion criteria were immune system enhancing herbs that were not Tibb an-Nabawi.Results: Based on the literature studies, it is known that at least six natural products based on Tibb an-Nabawi have scientifically proved to increase the immune system, namely black cumin, honey, dates, ginger, garlic, and pumpkin. The mechanism of immune system enhancement is different in each substance, but in general, they can increase humoral or cellular immunity. The active compounds contained in each of these ingredients contribute to the resulting immunostimulant activity.Conclusion: Black cumin, honey, dates, ginger, garlic, and pumpkin are natural products based on Al-Quran and Hadith, which have scientifically proved to enhance the immune system.Keywords: Tibb an-Nabawi, Thibbun Nabawi, immune system, immunostimulant, pandemic Intisari  Latar belakang:  Peningkatan sistem imun sangat penting di masa pandemic Covid-19 untuk mencegah infeksi dan menurunkan resiko keparahan penyakit. Oleh karena itu, penggunaan bahan alam dengan efek meningkatkan aktivitas sistem imun perlu dilakukan. Dalam Islam dikenal istilah thibbun Nabawi yakni pengobatan atau pencegahan penyakit berbasis Al-Quran dan Hadist.Tujuan: Melakukan studi literatur tentang bahan thibbun Nabawi yang terbukti meningkatkan sistem imun disertai kajian dari sisi Islami dan juga ilmiahnya.Metode: Penelitian berbasis systematic literature review, dengan menggunakan artikel penelitian 10 tahun terakhir. Kriteria inklusi meliputi artikel-artikel membahas aktivitas imunostimulan dari bahan-bahan thibbun Nabawi dan kriteria eksklusi adalah bahan alami peningkat sistem imun yang bukan merupakan thibbun Nabawi. Hasil: Berdasarkan studi literatur diketahui bahwa sedikitnya ada 6 bahan thibbun Nabawi yang terbukti secara ilmiah mampu meningkatkan sistem imun yakni jintan hitam, madu, kurma, jahe, bawang putih, dan labu kuning. Mekanisme peningkatkan sistem imun berbeda beda untuk setiap bahan namun secara umum bahan bahan tersebut mampu meningkatkan imunitas humoral ataupun selular. Senyawa aktif yang terkandung dalam setiap bahan tersebut berkontribusi terhadap aktivitas immunostimulant yang dihasilkanKesimpulan: Jintan hitam, madu, kurma, jahe, bawang putih, dan labu kuning merupakan bahan alam berbasis thibbun Nabawi yang terbukti secara ilmiah mampu meningkatkan system imun.Kata kunci : Thibbun Nabawi, sistem imun, imunostimulan, pandemik
Identifikasi Aktivitas Inhibitor Enzim Tirosinase Senyawa Turunan Flavonoid pada Kulit Buah Cokelat (Theobroma cacao L) secara In Silico Sani Ega Priani; Taufik Muhammad Fakih
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 2 (2021): Vol 17, No 2 (2021) Alchemy Jurnal Penelitian Kimia
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.2.45317.168-176

Abstract

Limbah kulit buah cokelat diketahui mengandung berbagai senyawa aktif, termasuk di antaranya adalah golongan flavonoid. Senyawa flavonoid diketahui berpotensi memiliki aktivitas inhibitor enzim tirosinase, suatu enzim yang menstimulasi proses pembentukan melanin. Penelitian ini bertujuan untuk mengevaluasi interaksi antara senyawa flavonoid dari kulit buah cokelat dengan enzim tirosinase menggunakan metode penambatan molekuler secara in silico. Pengujian dilakukan dengan beberapa tahapan yakni preparasi makromolekul enzim, pemodelan molekul senyawa uji, identifikasi sisi aktif molekul enzim, identifikasi dan evaluasi penambatan molekuler, serta simulasi dinamika molekuler senyawa uji dengan molekul enzim. Hasil simulasi penambatan molekuler antara molekul enzim dengan ligan alaminya yakni tirosin memberikan energi ikatan sebesar -4,91 kkal/mol. Senyawa flavonoid dari kulit buah cokelat yakni apigenin, epikatekin, katekin, kaemferol, kuersetin, dan kuersitrin  diketahui memiliki afinitas pada sisi aktif enzim tirosinase dengan energi ikatan berturut turut -6,14; -6,17; -6,01; -5,89; -6,13; -6,81 kkal/mol. Hasil simulasi dinamika molekuler menunjukkan kuersitrin memiliki stabilitas yang baik dengan nilai RMSD rata-rata dan nilai energi bebas ikatan MM/PBSA masing-masing sebesar ±1,73 Å dan -80,12 kJ/mol. Hasil penelitian menunjukkan bahwa senyawa turunan flavonoid tersebut mampu berikatan dengan sisi aktif enzim tirosinase dengan afinitas yang lebih baik dibandingkan dengan ligan alaminya diamati dari nilai energi ikatannya. Senyawa turunan flavonoid yang terkandung dalam kulit buah cokelat berpotensi menjadi inhibitor kompetitif dari enzim tirosinase.Identification of In Silico Tyrosinase Inhibitory Activity of Flavonoid Derivative Compounds in Cocoa Pod Husk (Theobroma cacao L.). Cocoa pod husk was known to contain several active compounds, such as flavonoids. Flavonoid compounds are known to potentially have inhibitory activity of the tyrosinase, the enzyme which stimulates melanin synthesis.This study was conducted to evaluate the molecular interaction between flavonoids from cocoa pod husk with tyrosinase enzyme using in silico molecular docking method. The study was carried out through several stages, including preparation of enzyme macromolecules, modeling the molecule of the test compound, identifying the active site of the enzyme molecule, identifying and evaluating molecular docking, and molecular dynamics simulations of the test compound with the enzyme molecule. Molecular docking simulation between the enzyme and its natural ligand (tyrosine) produces binding energy of -4.91 kcal/mol. Flavonoid compounds from cocoa pod husk, including apigenin, epicatechin, catechin, kaempferol, quercetin, dan quercitrin, have an affinity on the active site of the enzyme with binding energy were -6.14; -6.17; -6.01; -5.89; -6.13; -6.81 kcal/mol, respectively. Then the molecular dynamics simulation shows quercitrin has good stability interaction with the average RMSD value and the MM/PBSA binding-free energy values of ±1.73 Å and -80.12 kJ/mol, respectively. The results showed that flavonoids of cocoa pod husc extract have an affinity to the active site of the enzyme, with a stronger binding energy than the original ligand. The flavonoid compounds of cocoa pod husk potential as a competitive inhibitor of the tyrosinase enzyme.