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All Journal Medicina E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico Indonesian Journal of Cancer

Anak Agung Ayu Ngurah Susraini

SMF Patologi Anatomi, Fakultas Kedokteran Universitas Udayana, RSUP Sanglah Denpasar, Bali, Indonesia

Author-ID : 2936954

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 18 Documents Claim Missing Document

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Karakteristik klinikopatologi osteosarkoma berdasarkan usia, jenis kelamin, lokasi, dan tipe histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar tahun 2012 -2016 Putu Agus Aryanda Putra; Anak Agung Ngurah Susraini; I Wayan Juli Sumadi
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: Osteosarcoma was the most common primary bone tumor, and there are only a few studies discussed the clinicopathological characteristics of Osteosarcoma.Aim: This study aimed to determine the clinicopathological features of Osteosarcoma based on age, sex, type, and the location in Anatomical Pathology Laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016.Method: This research was a cross sectional descriptive study which obtains data from the medical record in Anatomical Pathology laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016. The total sample is 44 cases by total sampling technique. The data were processed using SPSS version 20.Result: In this study, the majority of Osteosarcoma patients were in age group 0 â€“ 24 years as many as 30 cases (68.2%) and rarely found in the age group 49 -72 years for 2 cases (4.5%). Osteosarcoma was slightly higher in a male about 23 cases (52.3%) and 21 cases in female (47.7%).Conclusion: the Histopathological type that mostly found was Conventional Osteosarcoma as many as 41 cases (93.2%) and the most common site of Osteosarcoma was in femur about 24 cases (52.2%).Â Osteosarkoma merupakan tumor primer pada tulang yang paling sering ditemukan, namun tidak banyak penelitian yang hanya membahas karakteristik klinikopatologi Osteosarkoma.Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi Osteosarkoma berdasarkan usia, jenis kelamin, tipe, dan lokasi di Laboratorium Patologi Anatomi RSUP Sanglah RSUP Sanglah Denpasar pada tahun 2012 â€“ 2016.Metode: Penelitian ini merupakan studi deskriptif cross sectional yang dilaksanakan di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar menggunakan catatan rekam medis periode tahun 2012 -2016. Teknik pengambilan sampel menggunakan total sampling, dengan total jumlah sampel sebanyak 44 orang. Data diolah menggunakan SPSS versi 20. PenderitaHasil: Osteosarkoma pada penelitian ini paling sering ditemukan pada kelompok usia 0 â€“ 24 tahun sebanyak 30 kasus (68,2%) dan paling sedikit pada kelompok usia 49 â€“ 72 tahun terdapat 2 kasus (4,5%). Jumlah kasus Osteosarkoma sedikit lebih tinggi kasusnya pada pria yaitu, sebanyak 23 kasus (52,3%) sedangkan pada wanita ditemukan sebanyak 21 kasus (47,7%).Simpulan: Tipe histopatologi yang paling sering ditemukan adalah Conventional Osteosarcoma sebanyak 41 kasus (93,2%) dan lokasi tersering pada tulang femur sebanyak 24 kasus (52,2%).

Karakteristik gambaran sitologi pap-smear sebagai tes skrining untuk lesi pra-kanker serviks di RSUP Sanglah, Denpasar, Bali Putu Risky Yoga Pradnyana; Anak Agung Ayu Ngurah Susraini; I Gusti Ayu Sri Mahendra Dewi
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Cervical cancer is the second most often cancer that occurs in women worldwide after breast cancer and as many as 84% of the cases occur in developing countries. Pap Smear is a screening method that widely used for cervical cancer screening. The aim of the study is to obtain the characteristic data of pap smear cytology as a pre-cervical cancer screening in Sanglah General Hospital 2016 â€“ 2017 period.Methods: This study was descriptive research with cross sectional study design. The sampling technique is total sampling where the research data comes from the cytology registration book results of the Anatomical Pathology Laboratory at Sanglah General Hospital Denpasar 1 January 2016 - 31 December 2017 period which has fulfilled the inclusion criteria and does not meet the exclusion criteria. Data were analyzed using SPSS version 20 for Windows.Results: This study collected as many as 590 samples. Most of the pap smear patients at Sanglah General Hospital Denpasar were 41-50 year old group as many as 188 people (31.86%), most of the patients parities were nullipara parities as many as 324 people (54.92%), most had no complaints as many as 261 people (44.24%) and most of the pap smear cytology description was Reactive Cellular Changes Associated with Inflammation (RCCI) as many as 261 people (44.64%).Conclusion: Most of the respondents who underwent pap-smear test as a screening step for pre-cancerous lesions had a cytological picture of Reactive cellular changes associated with Inflammation (RCCI)

Hubungan antara Tumor Infiltrating Lymphocytes (TIL), ekspresi Programmed Death-Ligan 1 (PD-L1) pada sel tumor dan TIL dengan kedalaman invasi pada karsinoma urotelial kandung kemih tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia Luh Ayu Widayanti; I Gusti Ayu Sri Mahendra Dewi; Herman Saputra; Anak Agung Ayu Ngurah Susraini; Ni Putu Sriwidyani; I Made Muliarta
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Urotelial carcinoma is one of carcinoma with increasing morbidity and mortality. The depth of invasion is one of risk factors that influence recurrence and survival rate in urotelial carcinoma. Patient with deeper invasion has poorer prognosis in recurrence and survival rate. Generally, carcinoma have microenvironment such as tumor infiltrating lymphocytes (TIL) to eliminate the tumor cells, in proliferative area. Cancer cells can avoid host immunity through PD-1/PD-L1 pathway. This study aimed to determine the association between TIL and PD-L1 expression with the depth of invasion of urotelial carcinoma.Methods: This study was a cross sectional analytic study with 37 samples size. The samples were taken from paraffin block of patients with urotelial bladder carcinoma non-specific type, that has performed resection and histopathological examination at Anatomical Pathology Laboratory Sanglah Hospital Denpasar, from January 1st, 2015 to December 31th, 2019. Rediagnosis was carried out to assess the histopathological diagnosis, TIL and depth of invasion. Then PD-L1 immunohistochemistry was performed. Data were analyzed by Chi-Square test with p<0.05. Data were analyzed using SPSS version 20 for Windows.Results: In this study on bladder urothelial carcinoma non-specific type at Sanglah Hospital Denpasar, we found there is no association between TIL and the depth of invasion (p=0.471). There is association between PD-L1 expression in tumor cells with the depth of invasion (p=0.006), OR 7.04 (CI 95% =1.64-30.20). There is association between PD-L1 expression in TIL with the depth of invasion (p=0.001), OR 13.2 (CI 95% = 2.62-66.43).Conclusion: There is association between PD-L1 expression in tumor cells an PD-L1 expresion in TIL with the depth of invasion. Positive expression of PD-L1 in tumor cells and TIL are more likely to become advance invasion. Tumor Infiltrating Lymphocytes (TIL) and PD-L1 expression on TIL can be used as predictive factors for the depth of invasion in urotelial carcinoma. Latar Belakang: Karsinoma urotelial merupakan salah satu karsinoma dengan morbiditas dan mortalitas yang terus meningkat. Salah satu faktor risiko yang mempengaruhi rekurensi dan survival rate pada karsinoma urotelial adalah kedalaman invasi. Invasi yang lebih dalam memiliki prognosis yang lebih buruk. Karsinoma umumnya disertai lingkungan mikro antara lain tumor infiltrating lymphocytes (TIL) yang berfungsi untuk mengeliminasi tumor. Sel kanker memiliki kemampuan untuk menghindari imun host antara lain melalui ikatan PD-1 dengan PD-L1. Tujuan dari penelitian ini untuk mengetahui hubungan antara TIL dan ekspresi PD-L1 dengan kedalaman invasi pada karsinoma urotelial.Metode: Penelitian ini merupakan studi analitik potong lintang dengan besar sampel adalah 37, yang berasal dari blok parafin penderita karsinoma urotelial kandung kemih tipe tidak spesifik yang diperiksa histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar dari 1 Januari 2015 sampai 31 Desember 2019. Rediagnosis preparat dilakukan untuk menilai diagnosis histopatologi, TIL serta kedalaman invasi. Kemudian dilakukan pulasan imunohistokimia PD-L1. Data dianalisis dengan uji Chi-Square dengan nilai p<0,05. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Hasil penelitian ini menunjukkan bahwa pada karsinoma urotelial kandung kemih tipe tidak spesifik di RSUP Sanglah Denpasar, tidak terdapat hubungan yang signifikan antara TIL dengan kedalaman invasi (p=0,471). Terdapat hubungan yang signifikan antara ekspresi PD-L1 pada sel tumor dengan kedalaman invasi (p=0,006) dengan OR 7,04 (IK 95% =1,64-30,20), antara ekspresi PD-L1 pada TIL dengan kedalaman invasi (p=0,001) dengan OR 13,20 (IK 95% = 2,62-66,43).Kesimpulan: Terdapat hubungan antara ekspresi PD-L1 pada sel tumor dan pada TIL dengan kedalaman invasi pada karsinoma urotelial kandung kemih tipe tidak spesifik di RSUP Sanglah Denpasar. Ekspresi positif PD-L1 pada sel tumor dan pada TIL memiliki kemungkinan lebih besar untuk menjadi invasi lanjut.

Kimura's disease: a neoplasm mimicking, a rare benign form of chronic inflammatory disorder Harley Septian; Made Widhi Asih; Nyoman Srie Laksminingsih; Anak Agung Ayu Ngurah Susraini
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Kimura's Disease (KD) is a benign, rare form of chronic inflammatory disease of unknown origin, almost exclusively found in Asian males in their second to fourth decades of life. This rare condition is mostly present as soft tissue mass consists of multiple painless solitary subcutaneous nodules mostly localized in the head and neck region, with coexisting lymph node enlargement and eosinophilia. This case study aims to describe Kimura's Disease (KD) characteristics and give an insight into the role of Computed Tomography (CT) scan in identifying KD and its imaging characteristics.Case Presentation: We reported a case of an Asian man with a history of 18 years left-sided painless facial mass, gradually increase in size with no history of hoarseness, epistaxis, previous facial mass or malignancy, and familial malignancy. CT scan findings showed an inhomogeneous contrast enhancement soft tissue mass located on the left parotid-submandibular region with multiple neck lymphadenopathy and left parotid gland involvement. Eosinophilia was found persistently in the laboratory outcomes, and this mass had been confirmed with histological findings consistent with KD features.Conclusion: Recognizing the characteristics of KD and the imaging findings on Ultrasound and CT-scan as accessible and first-line diagnostic tools, might help in facilitating the diagnosis, making a decision and sparing the patient from unnecessary and harmful procedures.

Hubungan antara ekspresi c-MET dengan derajat diferensiasi histologi dan tingkat kedalaman invasi pada infiltrating urothelial carcinoma kandung kemih di RSUP Sanglah, Bali, Indonesia Kadek Agus Suhardinatha Putra; I Gusti Ayu Sri Mahendra Dewi; Herman Saputra; Ni Wayan Winarti; Anak Agung Ayu Ngurah Susraini; Ni Putu Ekawati; I Made Muliarta
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: c-MET is a tyrosine kinase receptor that binds specifically to its ligand, namely hepatocyte growth factor (HGF). c-MET signaling deviations play a role in the progressivity of a wide variety of malignancies including bladder cancer. This study aims to determine the relationship between c-MET expression with the histological differentiation and depth of invasion in infiltrating urothelial carcinoma of bladder.Methods: This study was a cross-sectional analytical study with 42 sample sizes. The samples were taken from a paraffin block of patients with infiltrating urothelial carcinoma of the bladder, that has performed resection and histopathological examination who were examined at the Anatomical Pathology Laboratory of Sanglah Hospital Denpasar from 2015-2020. The c-MET expression was examined by immunohistochemical staining of c-MET and evaluated using the H-score method. Data were analyzed using SPSS version 20 for Windows.Results: Fisher's Exact test showed a statistically significant association between c-MET expression and the histological differentiation grade (p = 0.000). There was also a significant association between c-MET expression and depth of invasion with the Chi-Square test (p = 0.016), the Prevalence Ratio (PR) was 2.0 (95% CI = 1.2-3.6).Conclusion: In conclusion, there is an association between c-MET expression with the histological differentiation grade and depth of invasion in the infiltrating urothelial carcinoma of bladder. High c-MET expression had twice the risk of developing advanced invasion. Latar Belakang: c-MET merupakan reseptor tirosin kinase yang berikatan secara spesifik dengan ligannya, yaitu faktor pertumbuhan hepatosit (HGF). Penyimpangan c-MET signaling diketahui berperan dalam agresivitas berbagai macam keganasan termasuk kanker kandung kemih. Penelitian ini bertujuan untuk mengetahui hubungan antara ekspresi c-MET dengan derajat diferensiasi histologi dan tingkat kedalaman invasi pada infiltrating urothelial carcinoma kandung kemih.Metode: Penelitian ini merupakan studi analitik potong lintang dengan besar sampel adalah 42, yang berasal dari blok parafin penderita infiltrating urothelial carcinoma kandung kemih yang diperiksa histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar dari 2015-2020. Ekspresi c-MET diperiksa dengan pengecatan imunohistokimia c-MET dan dievaluasi menggunakan metode H-score. Data dianalisis dengan SPSS versi 20 untuk Windows.Hasil: Uji Fisher’s Exact menunjukkan hubungan yang bermakna secara statistik antara ekspresi c-MET dengan derajat diferensiasi histologi (p=0,000). Didapatkan juga hubungan yang bermakna antara ekspresi c-MET dengan tingkat kedalaman invasi dengan uji Chi-Square (p=0,016), prevalence ratio 2,0 (IK 95%=1,2-3,6).Kesimpulan: Sebagai simpulan terdapat hubungan antara ekspresi c-MET dengan derajat diferensiasi histologi dan tingkat kedalaman invasi pada infiltrating urothelial carcinoma kandung kemih. Ekspresi c-MET tinggi memiliki risiko dua kali lebih besar mengalami invasi lanjut. c-MET diharapkan dapat menjadi faktor prognostik yang bermanfaat dalam penatalaksanaan infiltrating urothelial carcinoma kandung kemih.

Hubungan antara ekspresi Vascular Cell Adhesion Molecule-1 (VCAM-1) dengan tipe dan stadium T karsinoma epitel permukaan ovarium di RSUP Sanglah, Bali, Indonesia I Made Wirya Sastra; Luh Putu Iin Indrayani Maker; Anak Agung Ayu Ngurah Susraini; I Wayan Juli Sumadi; I Gusti Ayu Sri Mahendra Dewi; Herman Saputra; I Made Muliarta
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Vascular Cell Adhesion Molecule-1 (VCAM-1) is an important protein in oncogenesis, angiogenesis, tumor development, and metastasis. Studies regarding the expression of VCAM-1 in ovarian carcinoma have found both supportive and contradictory results. Therefore, this study evaluates the relationship between VCAM-1 expression and the type and stage of ovarian surface epithelial carcinoma at Sanglah General Hospital, Bali, Indonesia.Methods: This study was a cross-sectional analytical study with a sample size of 36, which came from paraffin block of patients with ovarian surface epithelial carcinoma who were examined histopathologically at the Anatomical Pathology Laboratory of Sanglah Hospital Denpasar from 1 January 2017 to 31 December 2019. Samples are grouped into type I and type II, then the stage I or II and III groups. After that, the VCAM-1 immunohistochemical streak was performed to assess high or low expression in these groups and analyzed its relationship with the type and stage T of ovarian surface epithelial carcinoma. Data were analyzed using SPSS version 25 for Windows.Results: The analysis results using the Chi-Square test showed a statistically significant relationship (p=0.001) between the VCAM-1 expression with type and stage surface epithelial ovarian carcinoma (p=0.007). The results of the mean difference test are 0.48 (95% CI=0.33-0.70) and showed a statistically significant difference (p=0.001) between VCAM-1 expression with a type of ovarian carcinoma.Conclusion: In conclusion, there is an association between expression VCAM-1 with the type of surface epithelial ovarian carcinoma and at a stage, with a 2.3 times higher probability of VCAM-1 expression in the stage III group than in stage I or II group. Latar Belakang: Vascular Cell Adhesion Molecule-1 (VCAM-1) merupakan salah satu protein yang penting dalam onkogenesis, angiogenesis, perkembangan tumor dan metastasis. Penelitian-penelitian mengenai ekspresi VCAM-1 pada karsinoma ovarium mendapatkan hasil yang pro dan kontra. Oleh karena itu, penelitian ini bertujuan untuk mengetahui hubungan antara ekspresi VCAM-1 dengan tipe dan stadium T karsinoma epitel permukaan ovarium di RSUP Sanglah, Bali, Indonesia.Metode: Penelitian ini merupakan studi analitik potong lintang dengan besar sampel adalah 36, yang berasal dari dari blok parafin penderita karsinoma epitel permukaan ovarium yang diperiksa secara histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar dari 1 Januari 2017 sampai 31 Desember 2019. Sampel dikelompokkan menjadi tipe I dan tipe II, kemudian kelompok stadium I atau II dan III. Setelah itu dilakukan pulasan imunohistokimia VCAM-1 untuk menilai ekspresi tinggi ataupun rendah pada kelompok-kelompok tersebut dan dianalisis hubungannya dengan tipe dan stadium T karsinoma epitel permukaan ovarium. Data dianalisis dengan uji Chi-Square dengan nilai p <0,05.Hasil: Hasil penelitian menunjukkan terdapat hubungan yang bermakna secara statistik (p=0,001) antara ekpresi VCAM-1 dengan tipe karsinoma dan stadium T (p=0,007). Hasil uji beda rerata adalah 0,48 (IK 95%=0,33-0,70) dan menunjukkan perbedaan bermakna secara statistik (p=0,001) antara ekspresi VCAM-1 dengan tipe karsinoma ovarium.Kesimpulan: Sebagai simpulan, terdapat hubungan antara ekspresi VCAM-1 dengan tipe karsinoma epitel permukaan ovarium dan pada stadium, dengan kemungkinan 2,3 kali terjadi ekspresi VCAM-1 yang tinggi pada kelompok stadium III dibandingkan stadium I atau II.

Co-Authors Christel Carissa Christianto diah widityasari Felicia Hartono Gde Ngurah Idraguna Pinatih Harley Septian Herman Saputra Herman Saputra Herman Saputra I Gusti Ayu Sri Mahendra Dewi I Made Muliarta I MADE MULIARTA . I Made Wirya Sastra I Wayan Juli Sumadi John Nolan Kadek Agus Suhardinatha Putra Luh Ayu Widayanti Luh Ayu Widayanti Luh Putu Iin Indrayani Maker Made Agus Cahya Nugraha Koriawan Made Widhi Asih Moestikaningsih Moestikaningsih Moestikaningsih Ni Ketut Ari Widhiasih, Ni Ketut Ari Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Winarti Nur Silfiah Nyoman Srie Laksminingsih Putu Agus Aryanda Putra Putu Erika Paskarani Putu Ratna Darmayani Putu Risky Yoga Pradnyana Sabella Wimpie I Pangkahila Yolanda Isabela Simon

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