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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDIA MEDIKA INDONESIANA Indonesian Journal of Urology Journal of Biomedicine and Translational Research JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) AcTion: Aceh Nutrition Journal Media Keperawatan Indonesia Jurnal Ilmu Keperawatan Maternitas The Shine Cahaya Dunia Ners Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pasopati : Pengabdian Masyarakat dan Inovasi Pengembangan Teknologi The Shine Cahaya Dunia Ners
Achmad Zulfa Juniarto
Departemen Kedokteran, Fakultas Kedokteran, Universitas Diponegoro
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Indonesian Journal of Urology

 1 
PHENOTYPE-GENOTYPE AND PEDIGREE ANALYSIS OF ISOLATED HYPOSPADIAS PATIENTS Vikawati, Nura Eky; Santosa, Ardy; Juniarto, Achmad Zulfa; Faradz, Sultana MH
Indonesian Journal of Urology Vol 25 No 1 (2018)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v25i1.390

Abstract

Objective: Hypospadias is a malformation in urethra which has many range of severity. A patient with Isolated hypospadias (IH), a mild disorder of sex development (DSD) has a hypospadias phenotype only. Hypospadias is considered as multifactorial disease in which genetic factors contribute to its development. Chromosome analysis in DSD including hypospadias is conducted for gender assignment and other possible genetic contributions. This analysis solely could not elucidate all genetic causes of hypospadias. Polymorphism of V89L in SRD5A2 is suggested as one of genetic risk factors of hypospadias. To determine the genetic risk factor and pattern of inheritance, a good pedigree construction is required. Material & methods: 35 eligible subjects with IH admitted to Center for Biomedical Research (CEBIOR) during 2012-2015 were randomly selected. 35 normal male as control were included in this study. Data on three generation pedigrees were collected from medical records in 35 affected subjects. Chromosome analyses were done by using G-banding technique. Polymorphism analysis of V89L in SRD5A2 gene was done using PCR-RFLP technique in all samples. Results: From the 35 affected subjects, the most frequent phenotype was penile hypospadias (47%), a pair of twins were monozygotic and one had a cousin diagnosed with urogenital abnormalities (i.e micropenis and chordae). All subjects had 46,XY chromosome. No chromosomal aberration was found. No positive correlation between polymorphism of V89L in SRD5A2 and risk of hypospadias (PR of CC+CG vs GG=1.0, 95% CI: 0.342−2.921, p value=1.0). Conclusion: The pedigree data from our study implies tendency of genetic involvement in hypospadias cases. There were no chromosomal aberrations in hypospadias cases. The finding on polymorphism of V89L in SRD5A2 gene does not support that of previous studies.
THE EFFECT OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA L) AGAINST MOTILITY OF SPERMATOZOA MICE EXPOSED TO MONOSODIUM GLUTAMATE Ilham Saptia Nugraha; Wibisono, Dimas Sindhu; Saraswati, Indah; Juniarto, Achmad Zulfa
Indonesian Journal of Urology Vol 29 No 1 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i1.731

Abstract

Objective: Excessive use of MSG in everyday life can cause infertility to men. Exposure to MSG can cause cells to experience oxidative stress which subsequently triggers the generation of free radicals. Free radicals can be resisted with antioxidants. Material & Methods: This research was a laboratory experimental test with a post-test only control group design using male mice as the experimental object. The statistical test used the One Way ANOVA test. Results: In this research, 5 male mice were assigned into 4 groups and 1 control group. Using the One Way ANOVA test, it was found that there were significant differences in ≥ 2 treatment groups in the motility group of spermatozoa with active movement (p < 0.001) and the motility group of spermatozoa with weak movement (p = 0.036). The two groups showed significant differences. The Post hoc LSD test in the motility group with active movement showed significant differences between the control group with MSG treatment (p < 0.001) and the treatment group given Moringa leaves extract of 600 mg/kgW (p < 0.001) and 1200 mg/kgW (p < 0.001). Conclusion: Moringa leaves extract can effect the improvement of the motility of spermatozoa exposed to monosodium glutamate at a given dose of 300 mg/kgW and 600 mg/kgW.
Co-Authors - Anggorowati Al-Baarri, Ahmad Ni’matullah Amala, Nur Anang M Legowo Andrew Johan Ardy Santosa Ardy Santosa Ardy Santosa Chandra Bagus Ropyanto Denis Mulanita Pratiwi Denis Mulanita Pratiwi DEWI WIJAYANTI Dhega Anindita Wibowo, Dhega Anindita Dimas Sindhu Wibisono Djuara P Lubis Etika Ratna Noer Ilham Saptia Nugraha Indah Saraswati Kusmiyati Tjahjono Lara Ayu Lestari Legowo, Anang M Lintang Dian Saraswati M. Sulchan Mahayu Dewi Ariani Muh Firman Yudiatma Mulyono, Yehezkiel Andrew Nana Rochana Nurin Aisyiyah Listyasari Nurin Aisyiyah Listyasari Pratiwi, Riska Yulia Prihasna, Septika Nuri R Rokhmat RANIDA ARSI Sri Rejeki Sri Rejeki Sri Rejeki Sultana MH Faradz Surtania Surtania Untung Sujianto Vikawati, Nura Eky Vivi Endar Herawati Ziske Maritska