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All Journal e-GIGI e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat Jurnal Administrasi Kesehatan Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science Odonto dental journal
Yuliana Mahdiyah Daat Arina
Bagian Periodonsia Fakultas Kedokteran Gigi Universitas Jember
Dentistry Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Dentomaxillofacial Science

 1 
Regulation of caspase-3 expression to maintain fetal growth in Porphyromonas gingivalis-infected pregnant rats Banun Kusumawardani; Yuliana MD Arina; Azham Purwandhono
Journal of Dentomaxillofacial Science Vol. 1 No. 1 (2016): (Available online: 1 April 2016)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v1i1.16

Abstract

Periodontal disease has been involved in a variety of systemic disorders and suspected as a potential risk factor for fetal growth restriction. Periodontal pathogenic bacteria may actively regulate embryonic development, implantation and placental trophoblast cell invasion. This study aimed to analyze the role of TNF-α, IL-10 and caspase-3 to maintain fetal growth in Porphyromonasgingivalis-infected pregnant rats. Female rats were infected with live-Porphyromonas gingivalis at concentration of 2x109 cells/ml into subgingival sulcus area of the maxillary first molar before and during pregnancy. They were sacrificed on gestational day (GD)-14 and GD20. The weight and length of placentas and fetuses were evaluated. The expression of TNF-α, IL-10 and caspase-3 in macrophages and trophoblast cells were detected by immunohistochemistry. On GD14, TNF-α (R2=0.416;P=0.000) and IL-10 (R2=0.187;P=0.012) had an important role to increase expression of caspase-3 in the placenta, but only TNF-α (R2=0.393;P=0.000 ) was able to increase the expression of caspase-3 on GD20. TNF-α and caspase-3 also had an important role (P<0.000) to decrease fetal weight, fetal length and placental weight on GD14 and GD20, but it was not the case with IL-10 (P>0.000). The increasing expressions of TNF-α and IL-10 did not only enhance immune protection, but also maintained the trophoblast cells survival by regulating expression of caspase-3. Porphyromonas gingivalis infection in maternal periodontal tissue can lead to decrease in placental weight, fetal weight and fetal length which mediated by increasing expression of TNF-α, IL-10 and caspase-3 in the placenta. 
The effect of Porphyromonas gingivalis induction on neutrophil’s superoxide production Nahdiya Fitriyana; Yuliana MD Arina; Happy Harmono; IDA Susilawati
Journal of Dentomaxillofacial Science Vol. 12 No. 3 (2013): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v12i3.370

Abstract

Microbicidal mechanism with producing free radical superoxide is one of neutrophil response to the bacterialinvasion. When overproducted, the free radical superoxide greater than antioxidan defense system and destroyed thecell itself. P.gingivalis had been knowed as the major bacteria that induce periodontal inflammation. These bacteriacan stimulated neutrophil activities. This was aimed to determinate the superoxide production from neutrophilstimulated with P.gingivalis. Neutrophil as samples were isolated from subject who fulfill the selected criteria. Theintracelluler superoxide production was determinated by nitroblue tetra zolium (NBT)test and the extracellulerproduction by spectrophotometer with wave length 580 nm. The result showed there was superoxide production fromneutrophil stimulated by P.gingivalis. It was concluded that the stimulation of P.gingivalis on neutrophil can promotesuperoxide production both intracelluler and extracelluler.
Co-Authors Azham Purwandhono Banun Kusumawardani Budi Yanti Depi Praharani Desi S. Sari Desi Sandra Sari Eko Mulyadi Ermita Windya Pratiwi F. Ferdiansyah Happy Harmono IDA Susilawati Koeswadji Koeswadji Melok A. Wahyukundari Melok Aris Wahyukundari Mohamad Rubianto Muhammad Nurul Amin Nahdiya Fitriyana Natalia Sri Martani Nawan Nawan Neira N. Sakinah Nihla Fitriyani Peni Pujiastuti Revi Gama Hatta Novika Rina Sutjiati S. Sunardhi Widyaputra Tantin Ermawati Utama Bramanto Satrya Dimas Wahiduddin Wahiduddin