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All Journal e-GIGI e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat Jurnal Administrasi Kesehatan Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science Odonto dental journal
Yuliana Mahdiyah Daat Arina
Bagian Periodonsia Fakultas Kedokteran Gigi Universitas Jember
Dentistry Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : e-Journal Pustaka Kesehatan

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Daya Hambat Ekstrak Daun Pepaya (Carica papaya L.) terhadap Adhesi Bakteri Porphyromonas gingivalis pada Neutrofil (Inhibition of Papaya (Carica papaya L.) Leaves Extract on Adhesion of Porphyromonas gingivalis Bacteria to Neutrophils) Ermita Windya Pratiwi; Depi Praharani; Yuliana Mahdiyah Da'at Arina
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Adhesion process of Porphyromonas gingivalis on neutrophils significantly play a role in the onset of periodontal infection. Papaya leaves contain several active substances that might impact to bacterial adhesion. This study was aimed to determine inhibition potency of papaya leaf extract (PLE) to adhesion of Porphyromonas gingivalis to neutrophils and at different concentration. This was an experimental laboratories in vitro study on neutrophils cells from peripheral blood. Samples divided into 5 group: group I/control (without PLE), group II (PLE 25%), group III (PLE 50 %), group IV (PLE 75%), and group V (PLE 100%). Isolated neutrofil was incubated by PLE in 3 hours, then incubated to the P. gingivalis in 2.5 hours. The index of adhesion was determined by calculating average number of P. gingivalis on 100 neutrophils. The result found that inhibition potency of PLE was significantly different to all groups. The conclusion was PLE inhibited P. gingivalis adhesion on neutrophils; and there were differences of inhibition potency of bacterial adhesion of P. gingivalis bacteria among PLE at 25%, 50%, 75% and 100% concentration, which higher concentration had higher inhibition effect.   Keywords: adhesion, neutrophils, papaya leaf, Porphyromonas gingivalis
Pengaruh Ekstrak Daun Pepaya Terhadap Jumlah Sel Limfosit Pada Gingiva Tikus Wistar Jantan Yang Mengalami Periodontitis (The effect of papaya leaves extract to the number of lymphocytes cells to the male-wistar rat's gingiva that undergo periodontitis) Utama Bramanto Satrya Dimas; Yuliana Mahdiyah Da’at Arina; Muhammad Nurul Amin
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Background. Porphyromonas gingivalis (P. gingivalis) is plaque bacteria caused periodontitis with proteolitic characterised that makes some damages to the periodontal tissues. Lymphocytes are chronic inflamed cells which have specific characteristic when periodontitis was occured. Papaya is known as herbal plants, which contains substances which have antimicroba and antiinflamation activities in its leaves. The purpose of this research is to determinate the effect of papaya leaves extract to the number of limfocyte cells to the male-wistar rats gingival that was periodontitis. Twenty male-wistar rats that were divided to the five groups with different treatments. The first group is control of other group, the second group is treatment group that was induced with P. gingivalis and assembled with a ligature, while the remaining of groups were added with the extract of papaya leaves sondation by certain concentration 25% for the third group, 50% for the fourth group, and 75% for the last group after getting some treatments as the second group. The result of the research showed that the highest lymphocytes cells was found to group that was induced by P. gingivalis and assembled with a ligature. In the contrary, the lowest lymphocytes cells was found to the fifth group that was treated with the extract of papaya leaves 75%. It concluded that papaya leaves extract decreased the number of lymphocytes in periodontitis male-wistar rats gingival. The most effectively of papaya leaves extract that was used is 75%. Advanced research about the compound of the extract of papaya leaves which most influential and the mechanism to the decrease of the number of lymphocytes cells are needed. Keywords: Papaya Leaves Extract, Periodontitis, P. gingivalis
Co-Authors Azham Purwandhono Banun Kusumawardani Budi Yanti Depi Praharani Desi S. Sari Desi Sandra Sari Eko Mulyadi Ermita Windya Pratiwi F. Ferdiansyah Happy Harmono IDA Susilawati Koeswadji Koeswadji Melok A. Wahyukundari Melok Aris Wahyukundari Mohamad Rubianto Muhammad Nurul Amin Nahdiya Fitriyana Natalia Sri Martani Nawan Nawan Neira N. Sakinah Nihla Fitriyani Peni Pujiastuti Revi Gama Hatta Novika Rina Sutjiati S. Sunardhi Widyaputra Tantin Ermawati Utama Bramanto Satrya Dimas Wahiduddin Wahiduddin