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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Ophthalmologica Indonesiana JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)

Laksmi Wulandari

Departement Of Pulmonology, Faculty Of Medicine, Airlangga University

Author-ID : 3289685

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Profile of Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus in Pulmonary Department Dr. Soetomo General Hospital Surabaya Ayu Rahmanita Putri Soetrisno; Rebekah Juniati Setiabudi; Laksmi Wulandari
Jurnal Respirasi Vol. 6 No. 2 (2020): May 2020
Publisher : Faculty of Medicine Universitas Airlangga

Background: Pulmonary tuberculosis (TB) is the most important infectious disease, caused by Mycobacterium tuberculosis (MTB). Indonesia is the third country with the most prevalent TB cases in the world. Not all people who were exposed to MTB will become active TB, because the immune response is the main determinant. Immunocompromised person, such as patients who have type 2 diabetes mellitus (DM) as a comorbid are more prone to develop active TB infection. This study aimed to analyze the profile of pulmonary TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya.Methods: This was an observational descriptive study with a cross-sectional design. The research data were obtained from the medical records of TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya in January - December 2017.Results: Out of a total of 414 hospitalized patients, 74 patients with pulmonary TB were found with type 2 DM. Only 53 patients fulfilled the inclusion criteria. Gene Xpert results were sensitive (66.7%), previous TB treatment history (54.7%), unregulated type 2 DM (88.4%), RBG with the average of 311.83 mg/dl, PPBS with the average of 263.31 mg/dl, FBG with the average of 238 mg/dl, and HbA1C > 10% (68%).Conclusion: The majority of the patients of pulmonary TB with type 2 DM have average high blood glucose and unregulated DM.

Problem Penegakkan Diagnostik Pasien dengan Massa di Paru: [Diagnostic Problems in Lung Mass Management] Laksmi Wulandari; Nikson Eduard Faot
Jurnal Respirasi Vol. 3 No. 2 (2017): Mei 2017
Publisher : Faculty of Medicine Universitas Airlangga

Background: Lung cancer are divided into 2 groups; i.e. Small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). About 30% of NSCLC is squamus cell carcinoma and the other is adeno carcinoma. Late diagnosis makes such a high mortality rate. Early diagnosis plays a very important role in the management of therapy. Case: Patients complain of chronic cough more than 6 months, decreased appetite and weight loss. Chest X-ray and CT scan show a density of round shape mass, with firm border and smooth regular edge, also lympnodes enlargement (T2N2Mx) stage IIb. Appearance of lung mass is benign according to clinically and radiologically. FNAB-CT Guiding results are difference each time examination. The first result is squamous cell carcinoma but the last result is teratoma. Discussion: Based on the multidisciplinary discussion on Tumor Board Meeting, the diagnosis was decide as Squamous cell Carcinoma. The choice management of stage IIb lung cancer is surgery (Lobectomy). Histopathology finding post surgery is a Squamus Cell Carcinoma. Patients were then given adjuvant chemotherapy for 4 cycles with Platinum Base regimen paxuscarboplatin with the aim of clearing micrometastase that may still be left behind. The complete respons of platinum based chemotherapy following surgery in early stage of squamous cell carcinoma. Conclusion: Difficulties of lung cancer diagnostic are still the problem in the management of lung mass. Difference of diagnostic makes difference treatment choice. Multidiscipline discussion is needed to decide the diagnostic and treatment judgment.

Terapi ARV pada Penderita Ko-Infeksi TB-HIV: [Antiretroviral Therapy in TB-HIV Co-Infection Patient] Indana Eva Ajmala; Laksmi Wulandari
Jurnal Respirasi Vol. 1 No. 1 (2015): Januari 2015
Publisher : Faculty of Medicine Universitas Airlangga

TB and HIV have a very close relationship since the development of AIDS. Through a significant reduction in cellular immunity, HIV affects the pathogenesis of tuberculosis, thereby increasing the risk of TB in HIV co-infected individuals. In 2006, there were an estimated 9.2 million new TB cases worldwide, there were 710.00 in patients with HIV and 500,000 cases with MDR-TB. Sensitivity to TB associated with cytokine production by T lymphocytes (IFN gamma and TNF are like alpha). During HIV infection, IFN gamma production declined dramatically in line with the decrease in CD4 T lymphocytes This leads to an increased risk of developing reactivation or reinfection Mycobacterium tuberculosis. Clinical symptoms of pulmonary TB in people living with HIV are often non-specific. Clinical symptoms often found are fever and significant weight loss. The other symptoms usually associated with extrapulmonary TB. Antiretrovirals are drugs that inhibit HIV replication. The main priority in patients co-infected with TB-HIV is a start of TB therapy, followed by cotrimoxazole and ARV. ARV treatment recommendation on co-infection tuberculosis is starting ARV therapy to all people living with HIV with active TB, regardless of CD4 cell count. Antiretroviral therapy start as soon as possible after TB treatment can be tolerated, as soon as 2 weeks and no more than 8 weeks. Regimen set by WHO for first-line regimen containing two nucleoside reverse transcriptase inhibitors (NRTIs) plus one non-nucleoside reverse transcriptase inhibitors (NNRTIs). In the co-infection of TB-HIV nucleoside was elected WHO recommended Zidovudine (AZT) or tenofovir disoproxil fumarate (TDF), in combination with lamivudine (3TC) or emricitabine (FTC). For NNRTI, WHO recommends efavirenz (EFV) or nevirapine (NVP).

Tumor Mediastinum Anterior (Yolk Sac Tumor) pada Seorang Laki-Laki Dewasa Muda: Sebuah Kasus yang Jarang: [Yolk Sac Tumor in a Young Man: A Rare Case] Risnawati Risnawati; Laksmi Wulandari
Jurnal Respirasi Vol. 2 No. 2 (2016): Mei 2016
Publisher : Faculty of Medicine Universitas Airlangga

Background: Primary mediastinal yolk sac tumor is an extremely rare and highly malignant tumors occuring in children and young adult. They are more common in men. The most common symptoms on ptesentation were dyspnea, chest pain, cought, fever, night sweat, or weight loss. Primary mediastinal tumor are considered to have poor prognosis. Case: A 18- year-old man who presented with shorthness of breath, chest pain, fever, night sweat, and generalized weakness. He had no significant surgical, familiy or social history. The chest X-Ray and computed tomographic scan of the chest showed a large anterior mediasti nal mass. The serum level of alpha- fetoprotein and β-HCG was elevated. The histological examination revealed the finding of yolk sac tumor. This supported the diagnosis of yolk sac tumor. The patient received a combination chemotherapy consisting of cisplatin, etoposide and bleomycin every 3 weeks for total of 4 cycles. Conclusions: Primary mediastinal yolk sac tumor is a rare tumor. The diagnosis should be made not only by morphological studies but the also the patients age and the elevation of serum alpha-fetoprotein. In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.

Hemoptisis pada Pasien Aspergilloma Paru Kiri: [Hemoptysis in Aspergiloma Patient: A Case Report] Gilang Muhammad Setyo Nugroho; Laksmi Wulandari
Jurnal Respirasi Vol. 4 No. 2 (2018): Mei 2018
Publisher : Faculty of Medicine Universitas Airlangga

Background: Aspergilloma is a fungus ball (misetoma) that occurs because there is a cavity in the parenchyma due to previous lung disease. This fungus ball can move inside the cavity but does not invate the cavity wall. The presence of fungus ball causes recurrent hemoptysis. Case: We present a 45-year-old female patient with left lung Aspergilloma. Diagnosis of Aspergilloma was based on histopathology from FNAB CT guiding of left pulmonary which showed Aspergillus. Patient was treated with left superior lobe lobectomy at the hospital. The examination result of anatomical patology obtained from lung tissue was aspergillosis, from GeneXpert examination lung tissue showed positive MTB with rifampisin sensitive. Post-operative condition of the patient was stable, surgical wound improved, took off drain patient. There were clinical improvements after the surgery. Discussion: Diagnosis of Aspergilloma was based on clinical, radiology, and microbiology. Aspergilloma with severe symptoms (hemoptysis massive with life-threatening or other complications that require more than 1 time hospitalisation) and good physical condition should undergo surgical therapy in the form of lobectomy in accordance with the extent of lung abnormalities. Patient got first category anti tuberculosis drugs for 6 months and fluconazole for 2 months. Conclusion: It is necessary to consider the suspicion of Aspergillus infection, in patient with history of previous tuberculosis accompanied by a history of recurrent hemoptysis. Patient with reccurent hemoptysis and good physical condition should undergo surgical therapy.

Prevalence of Lung Cancer with a History of Tuberculosis Nadira Putri Nastiti; Laksmi Wulandari; Sulistiawati Sulistiawati; Anna Febriani; Wiwin Is Effendi
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.87-92

Introduction: Lung cancer ranks as the second most common diagnosis of malignancy cases in the world with the highest mortality, while Indonesia is the country with the largest tuberculosis (TB) burden after India. Although these two diseases have a high incidence and mortality rate and are one of the main causes of health problems, coexistence between these two diseases is very rare. A similar clinical and radiological feature complicates the diagnosis and worsens the prognosis. This study aimed to determine the prevalence and distribution patterns of lung cancer incidence with a history of TB. Methods: This was a descriptive study. The data were obtained retrospectively from the electronic medical records of lung cancer patients from one roof oncology clinic, Dr. Soetomo General Hospital, Surabaya, in 2018–2020, meeting the inclusion and exclusion criteria. Results: Specifically, 76 out of 1,044 (7.3%) lung cancer patients had a history of TB, with the distribution being men (71.1%), in an age range of 50-59 years old (34.2%), who were active smokers (36.9%), had an adenocarcinoma type of cancer (90.8%), had a positive EGFR gene mutation (50%), and had a diagnosis of non–small cell lung cancer (NSCLC) during stage IV (79%) after a TB diagnosis (54%) with a time interval of 1 or >10 years. Conclusion: The prevalence of lung cancer with a history of TB was 7.3%. Lung cancer screening is important in TB patients after one or even >10 years of diagnosis to reduce the morbidity and mortality rates because of this risk of coexistence.

Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Andreas Infianto Anna Febriani Arif Santoso Aris Widayati Arta Rahman Ayu Rahmanita Putri Soetrisno Barizatul Husniyah Bonfilio Neltio Ariobimo Dana Hendrawan Putra Djoko Poetranto Djoko Poetranto, Djoko Edith Frederika Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Ferry Dwi Kurniawan Gatot Soegiarto Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Gusti Agung Ayu Ira Kencana Dewi Haryati Haryati Hendra Ikhwan Gautama Ida Ayu Jasminarti Indana Eva Ajmala Jamal Zaini Kazufumi Shimizu Khansa Fahira Wisdana Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Linda Dewanti Lu'lu'il Maqnun Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Masaoki Yamaoka Masaoki Yamaoka Masaoki Yamaoka, Masaoki Monica Tiara Arum Kinanthi Muhammad Amin Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Prima Ardiansah Surya Pudji Lestari Putri Mega Juwita Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Sacharissa Zerlina Tsarwah Thirafi Sahrun Sahrun Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny Soedarto Soedarto Sri Melati Munir Sulistiawati Sulistiawati Susilowati Andajani, Susilowati Suwandi Triadi Putra Paladan Utami Meilanie Putri Veda Septian Cahya Budi Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yolanda Ayu Yashinta Zahira Pelangi Rahmadilla Satriadi Zaphiria Loka Pramesthi Zaufy Verlieza Oktaviano Subagyo

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