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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Ophthalmologica Indonesiana JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)
Laksmi Wulandari
Departement Of Pulmonology, Faculty Of Medicine, Airlangga University
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Journal : Indian Journal of Forensic Medicine

 1 
Viral Profile and Clinical Characteristic in Acute Asthma Exacerbation Patients Resti Yudhawati; Erwin Winaya; Laksmi Wulandari; Aldise M Nastri; Retno A Setyoningrum; Kazufumi Shimizu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14872

Abstract

Background: Asthma is a heterogeneous disease characterized by chronic airway inflammation. Thevirus infection in respiratory tract will activate greater pro-inflammatory cytokines in asthma patients.The enhancement of pro-inflammatory cytokines induces various clinical symptoms. This study aims toinvestigate the respiratory virus and clinical characteristics among patients with acute asthma exacerbation.Methods: In this study, subjects were divided into 3 groups based on acute asthma exacerbation triggers.The first group triggered by virus infection; the second group triggered by non-virus infection with ILI; andthe third group without any infection. Nasopharynx or throat swabs were collected to detect any respiratoryvirus. Virus was detected by Multiplex PCR (xTAG Respiratory Viral Panel Fast V2/ LUMINEX)Results: According to PCR examination, the prevalence of virus infection was 46.2%. Only two types ofviruses identified, which were Influenza A virus and Rhinovirus. All patients in the second groups showeda symptom of cough with purulent sputum, while no patients from the other two groups showed similarsymptoms. PEFR and % PEFR prediction of patients with Influenza A virus infection were higher than inRhinovirus infected-patients (210 L/min and 48.6% vs 195 L/min and 45%).Conclusion: Acute asthma exacerbation is one of the most reasons patients came to emergency ward. Themajority of acute asthma exacerbation was caused by infection, and most of it was viral infection. Clinicalsign differs according to the trigger, therefore the use of antibiotics should be avoided, unless there are signsand symptoms of bacterial infections
Comparison of the Efficacy of Generation 1 and 2 Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Patients with EGFR Positive Mutations Suwandi; Laksmi Wulandari; Gatot Soegiarto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15970

Abstract

Background: The use of TKI generation 1 (Gefitinib, Erlotinib) and Generation 2 (Afatinib) has become thestandard therapy for JPIC pulmonary adenocarcinoma type with positive EGFR gene mutations.Objective: to analyze the comparison of the efficacy of TKI generation 1 and 2 in NSCLC patients withpositive EGFR mutations.Methods: The design of this study used a retrospective in which the participants who received EGFR therapyfor TKI generations 1 and 2 were compared its efficacy. Data collected included health-related quality of life(HRQOL), body weight, performance status (PS), Response Evaluation Criteria in Solid Tumors (RECIST)of thoracic CT, Common Terminology Criteria for Adverse Events (CTCAE), progression free survival(PFS) and overall survival (OS). The statistical analysis used was the independent t test, Mann Whitney test,or Kruskal Wallis test with p <0.05.Results: Most of the participants’ quality of life scores did not change before and after therapy, where theEQ5D value was 67.5% (group 1 = 60.6%; Group 2 = 94.1%; p = 0.806). The participant’s weight decreasedby 49.5% (group 1 = 45.9%; group 2 = 60.0%; p = 0.658) and the participant’s PS was stable (group 1 =29.4%; group 2 = 50.0%; p = 0.014). The RECIST value of the participant was progressive disease 51.0% (p= 0.338). CTCAE differed in stomatitis (p <0.001), paronychia (p <0.001), and diarrhea (p <0.001). Therewas no significant difference between the first and second groups in the PFS (p = 0.197) and OS (p = 0.740)values.Conclusion: EGFR therapy for TKI generations 1 and 2 have almost the same efficacy, in which there is nosignificant difference in the quality of life of the participants.
Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Andreas Infianto Anna Febriani Arif Santoso Aris Widayati Arta Rahman Ayu Rahmanita Putri Soetrisno Barizatul Husniyah Bonfilio Neltio Ariobimo Dana Hendrawan Putra Djoko Poetranto Djoko Poetranto, Djoko Edith Frederika Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Ferry Dwi Kurniawan Gatot Soegiarto Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Gusti Agung Ayu Ira Kencana Dewi Haryati Haryati Hendra Ikhwan Gautama Ida Ayu Jasminarti Indana Eva Ajmala Jamal Zaini Kazufumi Shimizu Khansa Fahira Wisdana Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Linda Dewanti Lu'lu'il Maqnun Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Masaoki Yamaoka Masaoki Yamaoka Masaoki Yamaoka, Masaoki Monica Tiara Arum Kinanthi Muhammad Amin Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Prima Ardiansah Surya Pudji Lestari Putri Mega Juwita Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Sacharissa Zerlina Tsarwah Thirafi Sahrun Sahrun Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny Soedarto Soedarto Sri Melati Munir Sulistiawati Sulistiawati Susilowati Andajani, Susilowati Suwandi Triadi Putra Paladan Utami Meilanie Putri Veda Septian Cahya Budi Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yolanda Ayu Yashinta Zahira Pelangi Rahmadilla Satriadi Zaphiria Loka Pramesthi Zaufy Verlieza Oktaviano Subagyo