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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Ophthalmologica Indonesiana JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)
Laksmi Wulandari
Departement Of Pulmonology, Faculty Of Medicine, Airlangga University
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Journal : JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan)

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The effects of age on antibody response towards COVID-19 vaccination: A Systematic Review Hendra Ikhwan Gautama; Gatot Soegiarto; Laksmi Wulandari
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 8, No 1 (2023)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/jumantik.v8i1.13631

Abstract

Background: Mortality rate of COVID-19 infection isexceptionally high in the older population. Various vaccines are being rapidly developed as an attempt to halt the pandemic. Although vaccination has been effective in reducing mortality and hospitalization rate in recent months, lower vaccine effectiveness has been reported among older adults.Aim: This review aims to evaluate and summarize current evidence on the effect of age on antibody response towards COVID-19 vaccines. Methods: Literature search was conducted on PubMed, Scopus, ScienceDirect and ProQuest for studies published up to 9th October 2022. The selected studies were assessed The Joanna Briggs critical appraisal tools. Qualitative analysis was then performed for the final studies.Result: A final of 9 studies were included in this review. A majority of the studies evaluated the responses of BNT162b2 or mRNA-1273 vaccine, while 1 study investigated the response towards ChAdOx1 vaccine. Outcomes were measured in term of IgG antibody levels or serum neutralization. Most studies demonstrated significantly lower antibody response and neutralization in older adults compared to younger vaccinees after administration of first and second vaccine dose. However, two studies reported no significant difference in vaccine responses across age groups after third dose administration.Conclusion: This systematic review highlights lowerimmunogenicity towards COVID-19 vaccines in older population. Further research into strategies to improve vaccine responses in the elderly is required to provide sufficient protection for this vulnerable group. Keywords: COVID-19 vaccine, antibody, neutralization, age, elderly
Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Andreas Infianto Anna Febriani Arif Santoso Aris Widayati Arta Rahman Ayu Rahmanita Putri Soetrisno Barizatul Husniyah Bonfilio Neltio Ariobimo Dana Hendrawan Putra Djoko Poetranto Djoko Poetranto, Djoko Edith Frederika Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Ferry Dwi Kurniawan Gatot Soegiarto Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Gusti Agung Ayu Ira Kencana Dewi Haryati Haryati Hendra Ikhwan Gautama Ida Ayu Jasminarti Indana Eva Ajmala Jamal Zaini Kazufumi Shimizu Khansa Fahira Wisdana Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Linda Dewanti Lu'lu'il Maqnun Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Masaoki Yamaoka Masaoki Yamaoka Masaoki Yamaoka, Masaoki Monica Tiara Arum Kinanthi Muhammad Amin Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Prima Ardiansah Surya Pudji Lestari Putri Mega Juwita Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Sacharissa Zerlina Tsarwah Thirafi Sahrun Sahrun Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny Soedarto Soedarto Sri Melati Munir Sulistiawati Sulistiawati Susilowati Andajani, Susilowati Suwandi Triadi Putra Paladan Utami Meilanie Putri Veda Septian Cahya Budi Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yolanda Ayu Yashinta Zahira Pelangi Rahmadilla Satriadi Zaphiria Loka Pramesthi Zaufy Verlieza Oktaviano Subagyo