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All Journal Majalah Kedokteran Bandung Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Smart Medical Journal Indonesian Journal of Medicine Journal of Maternal and Child Health Indonesia Jurnal Kebidanan YARSI Medical Journal Abdimas Universal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Nexus Kedokteran Translasional

 1 
The Effect of Beans Extract (Phaseolus vulgaris L.) to LDL Cholesterol Level in White Rats Hypercholesterolemia Model Sari, Noni Kartika; Nurwati, Ida; Hermawan, Danus
Nexus Kedokteran Translasional Vol 5, No 1 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.209 KB)

Abstract

Introduction: Low Density Lipoprotein (LDL) cholesterol level related with Coronary Heart Disease (CHD) which is the most common death cause in the world. Beans contains flavonoid, phytosterol, saponin, niasin, vitamin C, and fiber which have hypolipidemic effect. This study aimed to determine the effect of beans extract to the LDL cholesterol level in white rats hypercholesterolemia model. Methods: This study was a laboratory experimental research using the posttest only controlled group design, that have done in Histology Laboratorium of Sebelas Maret University Surakarta. Samples of research were 30 male white rats, Wistar strain. Control Group (KK) was given pellets and aquades for 28 days. Group 1 until 4 (KP1-4) were given duck egg yolk 5 gram/200 gram BW white rat/day and PTU 0,01% for 28 days. On days 15-28, Group 2 (KP2) was given simvastatin 0,72 mg/200 gram BW white rat/day, Group 3 was (KP3) given beans extract 100 mg/200 gram BW white rat/day, and Group 4 (KP4) was given beans extract 150 mg/200 gram BW white rat/day. The datas of LDL cholesterol level were analyzed with One-way ANOVA test and Post Hoc test. Result: Result of this study shows that LDL cholesterol levels of KK = 33.83 ± 14.442 mg/dl, KP1 = 54.00 ± 27.943 mg/dl, KP2 = 18.83 ± 7.672 mg/dl, KP3 = 77.33 ± 20.954 mg/dl and KP4 = 80.17 ± 31.923 mg/dl. The statistical analysis with One- way ANOVA shows a significant difference in LDL cholesterol level among the five groups of treatment with p = 0.000 (p < 0.05). Post Hoc Test shows a significant difference in LDL cholesterol level between KP1 – KP2 with p = 0.011 (p < 0.05) and non significant difference in LDL cholesterol level between KK – KP1 with p = 0.129, KP1 – KP3 with p = 0.081, and KP1 – KP4 with p = 0.052 (p > 0.05). Conclusions: The beans extract (Phaseolus vulgaris L.) does not give any effect to decrease of the LDL cholesterol level in white rats (Rattus norvegicus) hypercholesterolemia model. Keywords: Beans extract, LDL, Rattus norvegicus, hypercholesterolemia. 
The Influence of Brotowali Extract (Tinospora crispa (L.) Miers.)onCholesterol Blood Level of Rattus norvegicus with High Cholesterol Intake Lazuardi, Dicky Maulana; Nurwati, Ida; Wiyono, Nanang
Nexus Kedokteran Translasional Vol 5, No 2 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Coronary Heart Disease is the disease that often suffered by Indonesian people which known with high cholesterol rate.Brotowali’s stem contains saponin, flavonoid and polifenol, which potential to inhibit blood  total cholesterolincrease. The research is for to know more the influence of the content of the brotowali’s stem extract against total blood cholesterol levels. Method: This  research is as experimental laboratoric research with Randomized Controlled Trial design that post-test only control group design, have done in Histology Laboratorium of the Sebelas Maret University, Surakarta. The subject are 32 male white rats, Wistar strain, aged 2 months, weighing more or less than 200 grams. Brotowali’s stem extract made by using maceration method in Biological Pharmacy Laboratory, Pharmacy Faculty, Gadjah Mada University. The rat were divided randomly into 4 groups, each group consisting of 8 rats. In the negative control group was only given regular feed, propiltiourasil (PTU) and distilled water, the positive control group was given 5 gramduck egg yolk per 4,5 ml of aquadest, regular feed, PTU and distilled water. Whereas in the treatment group I and II was given 5 gram/4,5 ml of duck egg yolk suspense, regular feed, PTU, water and given 50 mg/200 gr and 100 mg/200gr extract of the brotowali’s stem. Rats were fasted during 12 hours and then their blood cholesterol levels checked after the 21 days treatment period. The sample measured with TMS 24i Premium spectrophotometer with 600 nm wave. The data were analyzed by one-way ANOVA with SPSS for Windows version 22. Result:Total cholesterol levels of negative control group is 91,00±19,46 mg/dl,on the positive control group is 104,12±13,66 mg/dl,on treatment group I is 91,50±16,08 mg/dl and on treatment group 2 is 84,62±13,45 mg/dl.The result of  one-way ANOVA test showed there is no significant total cholesterol blood level difference between 4 groups of rats with p=0,120. Conclusion:Brotowali’s stem extract has not give an effect on total cholesterol blood levels of Rattus norvegicus with high cholesterol intake. Keywords: Brotowali’s stem extract, total cholesterol, Rattus norvergicus  
The Influence of Brotowali Extract (Tinospora crispa (L.) Miers.)onCholesterol Blood Level of Rattus norvegicus with High Cholesterol Intake Dicky Maulana Lazuardi; Ida Nurwati; Nanang Wiyono
Nexus Kedokteran Translasional Vol 5, No 2 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.209 KB)

Abstract

Introduction: Coronary Heart Disease is the disease that often suffered by Indonesian people which known with high cholesterol rate.Brotowalis stem contains saponin, flavonoid and polifenol, which potential to inhibit blood total cholesterolincrease. The research is for to know more the influence of the content of the brotowalis stem extract against total blood cholesterol levels. Method: This research is as experimental laboratoric research with Randomized Controlled Trial design that post-test only control group design, have done in Histology Laboratorium of the Sebelas Maret University, Surakarta. The subject are 32 male white rats, Wistar strain, aged 2 months, weighing more or less than 200 grams. Brotowalis stem extract made by using maceration method in Biological Pharmacy Laboratory, Pharmacy Faculty, Gadjah Mada University. The rat were divided randomly into 4 groups, each group consisting of 8 rats. In the negative control group was only given regular feed, propiltiourasil (PTU) and distilled water, the positive control group was given 5 gramduck egg yolk per 4,5 ml of aquadest, regular feed, PTU and distilled water. Whereas in the treatment group I and II was given 5 gram/4,5 ml of duck egg yolk suspense, regular feed, PTU, water and given 50 mg/200 gr and 100 mg/200gr extract of the brotowalis stem. Rats were fasted during 12 hours and then their blood cholesterol levels checked after the 21 days treatment period. The sample measured with TMS 24i Premium spectrophotometer with 600 nm wave. The data were analyzed by one-way ANOVA with SPSS for Windows version 22. Result:Total cholesterol levels of negative control group is 91,0019,46 mg/dl,on the positive control group is 104,1213,66 mg/dl,on treatment group I is 91,5016,08 mg/dl and on treatment group 2 is 84,6213,45 mg/dl.The result of one-way ANOVA test showed there is no significant total cholesterol blood level difference between 4 groups of rats with p=0,120. Conclusion:Brotowalis stem extract has not give an effect on total cholesterol blood levels of Rattus norvegicus with high cholesterol intake. Keywords: Brotowalis stem extract, total cholesterol, Rattus norvergicus
The Effect of Beans Extract (Phaseolus vulgaris L.) to LDL Cholesterol Level in White Rats Hypercholesterolemia Model Noni Kartika Sari; Ida Nurwati; Danus Hermawan
Nexus Kedokteran Translasional Vol 5, No 1 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.209 KB)

Abstract

Introduction: Low Density Lipoprotein (LDL) cholesterol level related with Coronary Heart Disease (CHD) which is the most common death cause in the world. Beans contains flavonoid, phytosterol, saponin, niasin, vitamin C, and fiber which have hypolipidemic effect. This study aimed to determine the effect of beans extract to the LDL cholesterol level in white rats hypercholesterolemia model. Methods: This study was a laboratory experimental research using the posttest only controlled group design, that have done in Histology Laboratorium of Sebelas Maret University Surakarta. Samples of research were 30 male white rats, Wistar strain. Control Group (KK) was given pellets and aquades for 28 days. Group 1 until 4 (KP1-4) were given duck egg yolk 5 gram/200 gram BW white rat/day and PTU 0,01% for 28 days. On days 15-28, Group 2 (KP2) was given simvastatin 0,72 mg/200 gram BW white rat/day, Group 3 was (KP3) given beans extract 100 mg/200 gram BW white rat/day, and Group 4 (KP4) was given beans extract 150 mg/200 gram BW white rat/day. The datas of LDL cholesterol level were analyzed with One-way ANOVA test and Post Hoc test. Result: Result of this study shows that LDL cholesterol levels of KK = 33.83 14.442 mg/dl, KP1 = 54.00 27.943 mg/dl, KP2 = 18.83 7.672 mg/dl, KP3 = 77.33 20.954 mg/dl and KP4 = 80.17 31.923 mg/dl. The statistical analysis with One- way ANOVA shows a significant difference in LDL cholesterol level among the five groups of treatment with p = 0.000 (p < 0.05). Post Hoc Test shows a significant difference in LDL cholesterol level between KP1 KP2 with p = 0.011 (p < 0.05) and non significant difference in LDL cholesterol level between KK KP1 with p = 0.129, KP1 KP3 with p = 0.081, and KP1 KP4 with p = 0.052 (p > 0.05). Conclusions: The beans extract (Phaseolus vulgaris L.) does not give any effect to decrease of the LDL cholesterol level in white rats (Rattus norvegicus) hypercholesterolemia model. Keywords: Beans extract, LDL, Rattus norvegicus, hypercholesterolemia.
Co-Authors A. Guntur Hermawan Betty Saptiwi Betty Saptiwi Betty Saptiwi Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Eriana Melinawati Eric Edwin Yuliantara Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Hermawan, Danus Ika Tristanti Jarot Subandono Jarot Subandono Jarot Subandono Lazuardi, Dicky Maulana Martini Martini Martini Martini Martini Martini Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nanang Wiyono Noni Kartika Sari Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Prihandjojo Andri Putranto Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Sari, Noni Kartika Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Sigit Setyawan Siti Marufah Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Uki Retno Budihastuti Wesliaprilius, Todung Antony Wiyono, Nanang yoseph Indrayanto Yulia Sari Yulyanti, Yulyanti