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Vivi Purwandari
Program Studi S1 Farmasi, Universitas Sari Mutiara Indonesia
Medicine & Pharmacology

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UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus Vivi Purwandari; Artha Yuliana Sianipar; Yosy Cinthya Eriwaty Silalahi; Dinda Juita Nasution
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2776

Abstract

Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsion aims to make nanoparticle-sized nanogel preparations and as an antibacterial active substance in nanogel preparations against Staphylococcus aureus bacteria. Nanogel preparations were made by adding cinnamon extract nanoemulsion with varying concentrations of F1(2%), F2(4%), F3(6%), and blank formula (F0) as the basis for nanogels without cinnamon extract nanoemulsion. The results showed that the cinnamon extract nanoemulsion could be made into nanogels to produce a thick, brown-colored gel with a characteristic cinnamon smell. The result of the pH of the preparation is 6 according to the pH of the skin, has good homogeneity, and is not irritating to the skin. The PSA test produces a nanoparticle size of 24.2 nm, and the antibacterial effectiveness test of the nanogel preparation can inhibit Staphylococcus aureus bacteria. Produced a moderate inhibition zone category (6.7-7.1 mm) and the F3 formulation (6%) was the best formulation.
UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI Vivi Purwandari; Jon Kenedy Marpaung; Suharyanisa Suharyanisa
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i2.2797

Abstract

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.
Co-Authors Ahmad Gazali Sofwan Ahmad Hafizullah Ritonga Cut Masyithah Thaib Dinda Juita Nasution Isra Kristina Sitohang Jon Kenedy Marpaung Ledy Lenta Dirga Indah Mendrofa Maringan Silitonga Maringan Silitonga Nelson Simanjuntak Nina Paramita Sianipar, Artha Yuliana Siti Nurbaya Suharyanisa Wantri Veronica Yettrie Simarmata Yosy Cinthya Eriwaty Silalahi Zuhairiah Zuhairiah