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Cut Masyithah Thaib
Program Studi S1 Farmasi, Universitas Sari Mutiara Indonesia
Medicine & Pharmacology

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PENETAPAN KADAR FLAVONOID TOTAL DARI EKSTRAK ETANOL DAUN ANDALIMAN (Zanthoxylum acanthopodium DC.) Cut Masyithah Thaib; Siti Nurbaya; Martha Uli Oktavrina Rajagukguk
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Flavonoids are a class of polyphenolic compounds that have an antioxidant effect by donating hydrogen atoms and linking them with metal ions. Most flavonoids are found in plants. One of the plants that contain lots of flavonoids is andaliman (Zanthoxylum acanthopodium DC). The purpose of this study was to determine the compounds contained in the Andaliman leaf and to determine the total flavonoid content of the Andaliman leaf extract. The type of research conducted was descriptive, including identification of plant material, collection of plant material, phytochemical screening, and examination of total flavonoids with visible ultraviolet spectrophotometry. Samples were taken from LobuSiregar village, Siborong-Borong, North Tapanuli. Andaliman leaf extract (Zanthoxylum acanthopodium DC) was obtained by the maceration method using 96% ethanol. Determination of total flavonoid content was carried out by the colorimetric method. The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and steroids. Determination of total flavonoid content calculated as quercetin with the regression equation y= 0.03278 X + 0.04086, and r = 0.99825. The measurement results of the total flavonoid content of the ethanol extract of Andaliman leaves were 39.65 ± 0.08 mg QE/g.
ANALISA KADAR CEMARAN LOGAM MERKURI PADA IKAN SARDEN (Sardinella lemuru) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Cut Masyithah Thaib; Siti Nurbaya
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.177 KB) | DOI: 10.51544/jf.v4i2.2714

Abstract

Food packaging in cans is a food preservation technology using high-temperature sterilization. Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. This study aims to determine the levels of mercury contamination in canned sardines. The samples used in this study were 6 different brands of canned sardines. The method used to determine mercury (Hg) levels is qualitatively using color reagents and quantitatively using AAS (Atomic Absorption Spectrophotometry). The results obtained from 6 samples of canned sardines that were positive for heavy metal mercury (Hg) were indicated by the formation of orange color with KI reagent, yellow precipitate with NaOH, white precipitate with HCl. The wavelength used is 253.7 nm. The results showed that Brand A mercury 4.9814 ± 0.0301 mg/kg, Brand B 0.8757 ± 0.0308 mg/kg, Brand C 1.4899 ± 0 mg/kg, Brand D 1.4175 ± 0 mg/kg , Brand E 0.7527 ± 0 mg/kg, and Brand F 0.5270 ± 0 mg/kg. This study concludes that the mercury content in canned fish circulating in the Medan Brastagi Supermarket is above the maximum limit allowed by the National Standardization Agency (2016) in SNI 8222-2016, which is 0.5 mg/kg.
FORMULASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) SEBAGAI TABIR SURYA DALAM SEDIAAN LOTION UNTUK WAJAH Maringan Silitonga; Pandapotan Nasution; Cut Masyithah Thaib; Mei Revolinda Haloho
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Corn cobs (Zea mays L.) can be used as sunscreen because it contains phenolic compounds. The purpose of this study was to determine the characteristics of the physical and chemical properties of sunscreen lotion preparations of corncob ethanol extract and the formula and concentration that had the highest effectiveness in the value of Sun Protection Factor (SPF). The lotion was chosen because it is a topical preparation that is often used by the community. Corn cob powder was extracted by the maceration method. The results were formulated with extract concentrations, formulation I (5%), formulation II (10%), and formulation III (15%). The three formulas were tested for organoleptic, pH test, homogeneity, and lotion type. The resulting data were analyzed descriptively. The results showed that all formulas with varying concentrations of extracts had good physicochemical characteristics during storage based on the results of pH, homogeneity, organoleptic, and emulsion-type tests. Corncob ethanol extract sunscreen lotion in Formula 1 (5%) has an SPF value of 2 (UV-A rays) and an SPF value of 7 (UV-B rays). Formula 2 (10%) has an SPF value of 2,3 (UV-A rays) and has an SPF value of 9 (UV-B rays) and Formula 3 (15%) has an SPF value of 3 (UV-A rays) and has a value of SPF 12 (UV-B Rays).
PENGGUNAAN JERUK NIPIS (Citrus aurantifolia) DAN LIDAH BUAYA (Aloe vera L.) SEBAGAI SEDIAAN HAIR TONIC Elly Nurita; Cut Masyithah Thaib; Adiansyah Adiansyah; Irmayanti Hutasoit
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Lignin compounds and polysaccharides, the nutritious substances in aloe vera, are useful as a carrier for the nutrients needed by the skin to repair hair roots, strengthen and stimulate hair growth. The purpose of this study was to determine the efficacy of the combination of lime extract and aloe vera extract as a hair tonic preparation for hair growth. Lime and aloe vera extracts were obtained by maceration method using 96% ethanol as solvent. The combination of lime extract and aloe vera extract is formulated to be a hair tonic, with a combination of 1 (1%:1%), combination 2 (2%:1%), and combination 3 (1%:2%). Then evaluate the stability of the hair tonic preparation, homogeneity, pH, hair growth activity, and hair weight of rabbits. The results of the stability test of the hair tonic preparation of a combination of lime extract and aloe vera extract did not change color, shape, and odor. The results of the homogeneity examination of the formulations of formulas 1, 2, and 3 were homogeneous. The result of pH observation was that the higher the concentration of the combination of lime extract and aloe vera extract, the higher the pH of the preparation. The results of the measurement of rabbit fur length showed that the highest hair growth rate was formula 3 combinations (1%:2%). The results of the three formulations of the combination of lime extract and aloe vera extract showed that the longer the hair growth of the rabbit, the heavier the weight of the rabbit's hair.
FORMULASI SEDIAAN KRIM LULUR KOPI ARABIKA (Coffea arabica) SEBAGAI ANTI-AGING Vivi Purwandari; Maringan Silitonga; Cut Masyithah Thaib; Isra Kristina Sitohang
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Coffee is one of the plantation commodities that has a fairly high economic value among other plantation crops and plays an important role as a source of foreign exchange for the country. Coffee contains important compounds such as antioxidants and caffeine which functions as anti-aging so that it can be used as an anti-aging ingredient in the form of a scrub. The purpose of this study was to determine whether coffee can be formulated in the form of cream as an anti-aging, and in the form of a body scrub cream. The research method using experimental includes the collection of Arabica coffee ingredients, making formulations of Arabica coffee scrub cream preparations, and description of the quality of Arabica coffee cream body scrub preparations. Data analysis in this study used descriptive analysis by presenting the frequency distribution table of each study. The results of the study found that the difference in the concentration of Arabica coffee (Coffea arabica) in body scrub cream preparations had an effect with the best concentration of 15% compared to 5%, 10%, and blank concentrations, and the use of body scrub cream preparations containing Arabica coffee. (Coffea arabica) 15% showed improvement in skin condition for the better, during four weeks of treatment. Thus, Arabica coffee (Coffea arabica) can be formulated in the form of body scrub cream as anti-aging.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.)Merr.) TERHADAP BAKTERI Bacillus cereus ATCC 6633 Cut Masyithah Thaib; Zuhairiah Zuhairiah; Artha Yuliana Sianipar; Eta M. Br Simanullang
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.441 KB) | DOI: 10.51544/jf.v6i1.2745

Abstract

Life-sustaining plants are plants that are widely used by people as natural medicines. Infectious disease is one of the problems in the health sector. Infection can be caused by various microorganisms, one of which is bacteria. This research was conducted at the Microbiology Laboratory, Sari Mutiara University, Indonesia. This study was conducted to examine the antibacterial activity of the ethanolic extract of life-sustaining leaves using the paper disc diffusion method with concentration variants of 20%, 30%, 40%, 50%, and 60% and used a negative control of DMSO and positive control of chloramphenicol. From the research that has been done, the extract of the continued life leaves has antibacterial inhibitory power. At a concentration of 20% (10 mm). At a concentration of 30% (11 mm). At a concentration of 40% (12.67 mm). At a concentration of 50% (13.3 mm). At a concentration of 60% (15.3 mm). It can be concluded that the ethanolic extract of the grafted life leaves has the highest antibacterial inhibition at a concentration of 60%, which is 15.3 mm.
FORMULASI SEDIAAN GEL MASKER WAJAH DARI BAHAN ALAM EKSTRAK RIMPANG TEMU MANGGA (Curcumaamada) Maringan Maringan; Erly Nurita Sitorus; Cut Masyithah Thaib; Windy Afrilla
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (452.257 KB) | DOI: 10.51544/jf.v6i2.2752

Abstract

Temu manggais a plantthat has a highantioxidant content. One type of antioxidant in temu manggais vitamin E which can rejuvenate the skin. There are manyuseful ingredients in the temu mangorhizome, namel ycurcumin, flavonoids, tannins, saponinsandes sential oils. This research method was carried out experimentally. The temu mangga rhizomewas extractedusing 70% ethanolsolventbymaceration method then concentrate dusing a rotary evaporator. The extractof temu mangga rhizome was then formulate dinto a gel maskwith a concentrationof F0 as a blank, using a base gel mask without extractand with the addition of F1 (1%) and F2 (3%) extracts. Evaluationof gel mask preparations includesorganoleptictests, namely observing with the five human sensessuch as odor, color, shape, pH test, homogeneity, dryingtimetest, irritationtest, and effectiveness test as a facial moisturizer using a skin analyzeron the facial skin of volunteers. Parameters measured include moisturecontent, poresize, and wrinkles. The resultsof this study indicate that the gel maskpreparation has a drying time of 20-30 minutes, isstablefor 4 weeks of storage anddoes not irritatethe skin. The measure mentresults of facial moisturizing activity showed that 3% extra gel mask was the best by increasing water content, shrinkingporeson facial skin and reducing wrinkleson the face.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL JERAMI NANGKA (Artocarpus heterophyllus) SECARA SPEKTROFOTOMETRI-Visible Jon Kennedy Marpaung; Zuhairiah Nasution; Cut Masyithah Thaib; Junisan Siringoringo
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Flavonoids are compounds consisting of 15 carbon atoms which are generally distributed in the plant world. Flavonoid compounds are a group of the largest phenolic compounds found in nature, these compounds are red, purple, and blue dyes as well as yellow dyes found in plants. This study aims to determine the total flavonoid content of the jackfruit straw ethanol extract by using the UV-VIS spectrophotometric method, this study includes sample preparation, simplicia phytochemical screening, and extract manufacture, then determine the total flavonoid content of the jackfruit straw ethanol extract which is equivalent to quercetin (Quercetin). Equivalent (QE)) using aluminum chloride reagent with a wavelength of 437 nm by Visible spectrophotometry. Based on the research conducted, the total flavonoid content of jackfruit straw extract determined by Visible spectrophotometry using aluminum chloride reagent was 114.7590± 52.1263 mg QE/g extract.
ANALISIS MIKROBIOLOGI Escherichia coli JAJANAN MINUMAN DI SEKITAR JALAN KAPTEN MUSLIM KOTA MEDAN Siti Maimunah; Artha Yuliana Sianipar; Cut Masyithah Thaib
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Escherichia coli is a gram-negative rod bacteria, not encapsulated and is a normal flora in the digestive tract of animals and humans that easily pollutes water. Escherichia coli can turn into an opportunist pathogen if it lives outside the intestine, for example in urinary tract infections, wound infections and mastitis. Drinks contaminated with microorganisms can cause health problems in the form of disturbances in the digestive tract with symptoms of nausea, heartburn, vomiting and diarrhea. The purpose of this study was to determine the presence of Escherichia coli bacterial contamination in snacks sold around the Kapten Muslimstreet. This descriptive study used 4 samples of iced drinks, namely young coconut ice, sugar cane ice, mixed ice and dawet ice. The sample testing technique uses the Most Probable Number (MPN) method. The media used in this study were lactose Broth, Brilliant Green Lactose Bile Broth, Eosin Methylene Blue Agar. This research was conducted at the Pharmacy Microbiology Laboratory, Sari Mutiara University, Indonesia. After the research, the results showed that 1 of 4 samples of snacks found on Jalan Captain Muslim was detected with Escherichia coli bacteria ranging from 2,800 cells/100 ml so that it was included in the poor criteria, in the category These snacks are not suitable for consumption and do not meet the criteria set out in the Indonesian Ministry of Health No.492/Menkes/Per/IV/2010 (Colifrom and Escherichia coli 0/100 ml).
PENENTUAN KADAR KAFEIN DALAM KOPI INSTAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET Supartiningsih Supartiningsih; Zuhairiah Zuhairiah; Cut Masyithah Thaib; Naim Bahagia
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Caffeine in coffee has clinically beneficial pharmacological effects, such as stimulating the central nervous system, relieving fatigue, drowsiness and also increasing concentration. However, excessive use of caffeine can cause heart palpitations and stomach upset. According to SNI 01-7152-2006, the maximum limit of caffeine in food and beverages is 150 mg/day and 50 mg/serving. The purpose of this study was to determine the level of caffeine in instant coffee circulating in supermarkets in Medan City by Ultraviolet Spectrophotometry. Determination of caffeine content was carried out by the UV Spectrophotometry method after extraction using chloroform in an alkaline environment. The caffeine concentration can be calculated from the calibration curve regression equation. The results showed that the three instant coffee samples were determined to have different levels of caffeine, namely instant coffee sample code A 5.2585 mg/gram, code sample B 4.2348 mg/gram, and code C 133564. mg/gram. When viewed from the requirements, the caffeine content in the instant coffee samples coded A and B has exceeded the portion limit of 131.4625 mg and 84,768 mg, respectively, but is still within the limits set by SNI 01-7152-2006 if consumed in one pack. per day, henceforth the code C sample does not exceed the caffeine content limit of serving, which is 26.7128 mg of caffeine.
Co-Authors Adiansyah Adiansyah Ahmad Gazali Sofwan Ahmad Ghazali Sofwan Aprili Yanti Simatupang Cut Windy Afrilla Dina Riani Purba Eka Margaret Sinaga Eka Margaret Sinaga Elly Nurita Elly Nurita Sitorus Elly Sitorus Erly Nurita Sitorus Eta M. Br Simanullang Fitri, Raissa Irmayanti Hutasoit Isra Kristina Sitohang Jon Kennedy Marpaung Junisan Siringoringo Kesaktian Manurung Maringan Maringan Maringan Silitonga Martha Uli Oktavrina Rajagukguk Mei Revolinda Haloho Monica Suryani Naim Bahagia Pandapotan Nasution Sianipar, Artha Yuliana Siti Maimunah Siti Nurbaya Supartiningsih Supartiningsih Taruli Rohana Sinaga Vivi Purwandari Vivid Angelina Sarumaha Windy Afrilla Yettri Simarmata Yohana Monica Yosy Cinthya Eriwaty Silalahi Zuhairiah Nasution Zuhairiah Zuhairiah