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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Respirasi (JR) Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology

Resti Yudhawati

Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, Indonesia.

Author-ID : 359632

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Other

Published : 17 Documents Claim Missing Document

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Articles

Title

The Role of N-Acetyl Sistein in Pulmonary Tuberculosis Resti Yudhawati; Nitya Prasanta
Jurnal Respirasi Vol. 6 No. 1 (2020): January 2020
Publisher : Faculty of Medicine Universitas Airlangga

Pulmonary Tuberculosis is a chronic infection that caused by Mycobacterium tuberculosis (M.tb) infection and it is still the major health problem worldwide. Mycobacterium tuberculosis infection can induce oxidative stress. Some studies has proved that active TB patients have an association with excessive oxidative stress which causes glutathione (GSH) level decrease and free radicals increase. Glutathione (GSH) facilitates the control of M.TB intracellular bacterial growth in macrophages and has direct antimicrobial activity. N-acetylcysteine (NAC) is thiol, a precursor of L-cysteine and glutathione synthesis (GSH) that has been used for decades as a mucolytic agent in the treatment of respiratory diseases. Some studies report beneficial role of NAC as immunomodulator, besides NAC also has anti-inflammatory and antimicrobial effect in TB management.

Biological Therapy for Asthma Resti Yudhawati; Megawati Rif’atyyah Nozomi Guntur
Jurnal Respirasi Vol. 7 No. 1 (2021): January 2021
Publisher : Faculty of Medicine Universitas Airlangga

Asthma is a heterogeneous chronic inflammatory disease in the respiratory tract that leads to recurrent episodic symptoms. Study about the mechanism of pathophysiology and immunology which stimulates chronic inflammation in asthma has been greatly developed. The understanding of inflammation mediator that is predominant on various asthma phenotypes could be useful for development of diagnosis and targeted therapy. Standard asthma therapy administered through the airway has limited effects only in the airway. The knowledge of molecular pathophysiology and immunology of this disease developed interest of the drugs that perform proximally from inflammation process in the airway, in this case is biological therapy. Several biological therapies have been investigated for its efficacy on human, including Anti IgE (Omalizumab), Anti Interleukin-5 (Mepolizumab, Reslizumab, Benralizumab), Anti Interleukin-4/Interleukin-13 (Dupilumab), and Anti Interleukin-17 (Secukinumab and Brodalumab).

Imunopatogenesis Asma: [Immunopathogenesis of Asthma Bronchiale] Resti Yudhawati; Desak Putu Agung Krisdanti
Jurnal Respirasi Vol. 3 No. 1 (2017): Januari 2017
Publisher : Faculty of Medicine Universitas Airlangga

Asthma is a chronic inflammatory disease of the airways characterized by recurrent wheezing, shortness of breath, chest tightness and cough especially at night and or early morning. Airflow resistance in asthma were caused by changes in the airways include bronchoconstriction, airway edema, hyperresponsiveness and airway remodeling. The inflammatory response in asthma patients varies among individuals, whether it can be immediate or late (slow-type) response. Different types of cells are known to play role in this process, especially mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Degranulation of mast cells in the airways release inflammatory mediators and various metabolites that directly lead to smooth muscle hypersponsive resulting in airway obstruction. While eosinophil cells, mast cells and lymphocytes associated with slow-type responses, will release various mediators including leukotriene, prostaglandins and a number of proinflammatory cytokines. Type 2 immune response in the lower respiratory tract is a central immunologic process in asthma. This type 2 immune response is mediated by Th2 cells of CD4 + and IgE. The CD4 + Th2 cell is characterized by the large amount of transacting T-cell-specific transcription factor GATA-3 and the secretion of type 2 cytokines (IL-4, IL-5, IL-9 and IL-13). Excessive type 2 cytokines in the lower airway will trigger IgE-mediated hypersensitivity, epithelial cell activation, inflammatory cell inflation mediation into the airways, and cause remodeling responses in the epithelium and subepithelial matrices. This inflammatory cascade of type 2 cytokines is the pathological basis of the main symptoms of asthma.

Hubungan Kadar Interleukin-10 dan Tuberkulosis Multi-Drug Resistant: [Interleukin-6 Serum Level in Multidrug-Resistant Tuberculosis] Nurjanah Lihawa; Resti Yudhawati
Jurnal Respirasi Vol. 1 No. 2 (2015): Mei 2015
Publisher : Faculty of Medicine Universitas Airlangga

Background: Prevalence of multi-drug resistant tuberculosis (MDR-TB) is increased by the time. In Indonesia, there were an estimated 1.9% of new cases and 12% of previously treated cases. Protection against Mycobacterium tuberculosis is dependent on Th1 cell CD4+ that produced pro-inflammatory cytokines such as IFN-γ and TNF-α. T cell regulators (Tregs) produced IL-10 as anti- inflammatory cytokine is against the function of those pro-inflammatory cytokines. It is believed that immune suppression is responsible for MDR-TB. The previous study showed impaired Th1 responses and enhanced regulatory T-cell levels in circulatory blood of MDR- TB patients. The study of IL-10 represented anti-inflammation cytokine as immune suppression never been conducted in Indonesia. Objective: To analyze relationship between level of interleukin-10 and Multi-drug resistant tuberculosis. Methods: The study was conducted at the outpatient department of MDR-TB and DOTS of Dr. Soetomo hospital in Surabaya. Total sample was 38 of TB patients that consist of 19 MDR-TB patients (secondary resistant) and 19 non-MDR TB patients as control. Results: In this study we found that the median level of IL-10 as 5.7±3.3 pg/mL in the group of MDR-TB patients with minimum level was 1.3 pg/mL and maximum level was 14.0 pg/mL while median level of IL-10 in non-MDR TB patients was 7.0±3.4 pg/mL with 3.2 pg/mL and 16.5 pg/mL, respectively. To analyze correlation between time to first of having TB until became MDR-TB and level of IL-10 by using Pearson’s correlation, we showed that no statistical correlation (p>0.05). According to statistical classification, we found that no statistical correlation between level of IL-10 and the history of treatment in MDR-TB patients (p>0.05). Data showed that all the history of treatment classification dominated by MDR-TB patients with the low level of IL-10. We also found that no statistical difference with the level of IL-10 in MDR- TB and non-MDR TB patients (p>0.05) although in descriptive state we found the level of IL-10 was higher in non-MDR TB patients. And also there was no relationship between level of IL-10 and MDR-TB (p>0.05). It could be explained that the host factor was not involved and in the other side we still not known the factor of agents, yet. The low level of IL-10 that was observed in this study could be interfering by the strain of M.tb which not assessed in this study. Conclusion: In this study we found that level of IL-10 is not increase in MDR-TB patients and there was no relationship between level of IL-10 and MDR-TB (p>0.05).

Peran Imunitas Mukosa terhadap Infeksi Mycobacterium Tuberculosis: [The Role of Mucosal Immunity in Mycobacterium tuberculosis Infection] Irmi Syafa’ah; Resti Yudhawati
Jurnal Respirasi Vol. 2 No. 2 (2016): Mei 2016
Publisher : Faculty of Medicine Universitas Airlangga

Tuberculosis (TB) is one of major health problems in the world, with high morbidity and mortality rates. According to Global Tuberculosis Report 2015, Indonesia ranks as country with the 2nd highest number of TB cases in the world. Airway was described as a ‘gateway’ to the main pathogens, allergens and particles from the external environment. It has surveillance function that filtering beneficial and non-beneficial antigens, including Mycobacterium tuberculosis (MTB) as the causative agent of TB. MTB is a mucosal transmitted pathogen, infects human through mucosal tissue of respiratory tract. Airway mucosa was considered as the first barrier as well as inductive sites to initiate mucosal immune response against MTB. In this literature, the role of mucosal immune system, in this case especially airway mucosa, and its role against Mycobacterium tuberculosis infection in humans will be further discussed.

Imunopatogenesis Penyakit Paru Obstruktif Kronik : [Immunopathogenesis Update of COPD] Resti Yudhawati; Yuyus Dwi Prasetiyo
Jurnal Respirasi Vol. 4 No. 1 (2018): Januari 2018
Publisher : Faculty of Medicine Universitas Airlangga

Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory airway disease and complicated lung tissue. The airways of patients with COPD contain many inflammatory cells including neutrophils, macrophages, CD8 T lymphocytes, CD4 T lymphocytes and dendritic cells, each of which has its own role and interacts with COPD immunopathogenesis. The inflammatory response in people with COPD involves innate immunity (neutrophils, macrophages, eosinophils, mast cells, natural killer cells, and dendritic cells) and adaptive immunity (T and B lymphocytes), but there is also activation of structual cells such as alveolar epithelial cells endothelial cells and fibroblasts. Inflammation of the respiratory tract in COPD will persist even after quitting smoking, this can be caused by damage to the extracellular matrix will release proinflammatory cytokines which are neutrophil and monocyte chemotaxis, impaired alveolar macrophages which result in impaired cleaning of apoptotic cells and pathogenic microbes and oxidative stress will cause DNA double chain damage.

Peran Steroid pada Pneumocystis Pneumonia Ditinjau Berdasarkan Imunopatogenesis : [Immunopathogenesis of Steroid in Pneumocystis Pneumonia] Resti Yudhawati; Whendy Wijaksono
Jurnal Respirasi Vol. 5 No. 2 (2019): Mei 2019
Publisher : Faculty of Medicine Universitas Airlangga

Pneumocystis Pneumonia (PCP) is a potentially life-threatening infection that can occur in individuals who are immunocompromised. In PCP steroid use is still recommended especially in patients with moderate and severe severity. Corticosteroids are given along with anti-pneumocystis therapy and are known to reduce the incidence of mortality and respiratory failure associated with PCP. Innate immunity and adaptive immunity are symbiotic relationships to provide optimal defense for the lungs and other organs and tissues from infection PCP. The corticosteroid mechanism in PCP is based on an anti-inflammatory mechanism especially its role in inhibiting neutrophils. Many clinicians believe the administration of anti-pneumocystis causes the acceleration of inflammation. Because the inflammatory process increases when anti-pneumocystis therapy is started, corticosteroid therapy is useful before inflammation occurs which causes extensive damage to the lungs.

First-Line Anti-Tuberculosis Drug Resistance Pattern Ayurveda Zaynabila Heriqbaldi; Rebekah Juniati Setiabudi; Resti Yudhawati
Jurnal Respirasi Vol. 8 No. 1 (2022): January 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: An important concern regarding TB currently is the case of anti-TB drug resistance; hence research on resistance patterns and risk factors is essential. This study aimed to identify the pattern of first-line anti-TB drug resistance. Methods: This descriptive retrospective study was conducted at MDR-TB polyclinic Dr. Soetomo General Hospital, Surabaya, in 2017-2019. Only complete medical records were included. The variables were first-line anti-TB drug resistance (isoniazid, rifampicin, ethambutol, streptomycin) and patients’ characteristics (age, gender, treatment history, and comorbidities). The drug resistance test was performed using certified culture methods. Results: Among 239 patients, the incidences of resistance to H, R, E, and S were 79.08%, 94.14%, 25.94%, and 20.08%, respectively. The most common patterns were HR (42.26%), R (18.83%), and HRE (12.55%). The largest age group was 45-54 years old (38%). The dominant gender was male (56.49%). The most treatment history category was relapsed patients (48%) and there were more patients with comorbidity (57%). Conclusion: The highest incidence rate of resistance was rifampicin and the most common resistance pattern was HR. Most of the patients were of working age, male, relapse patients, and had comorbidities. An appropriate TB therapy treatment plays an important role in preventing resistance.

Co-Authors Aldise M Nastri Aldise Mareta Aldise Mareta Nastri Aldise Mareta, Aldise Ariani Permatasari Ayurveda Zaynabila Heriqbaldi Bakhtiar, Arief Bambang Pudjo Semedi Bramantono - Danti Nur Indiastuti Desak Putu Agung Krisdanti Djoko Poetranto Djoko Poetranto, Djoko Dwi Wahyu Indrawanto Edith Frederika Edith Frederika, Edith Emmanuel Djoko Poetranto Erwin Winaya Gatot Soegiarto Irmi Syafa'ah Kazufumi Shimizu Kowiy Akbar Laksmi Wulandari Landia Setiawati Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Masaoki Yamaoka Masaoki Yamaoka Masaoki Yamaoka, Masaoki Megawati Rif’atyyah Nozomi Guntur Muhammad Jusuf Wibisono Muhammad Raihan Habibi Musofa Rusli Nitya Prasanta Nurjanah Lihawa Pius Sebastian Ginting Rebekah Setiabudi, Rebekah Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Rosy Setiawati Rosyid, Alfian Nur Soedarsono Soedarsono Tutik Kusmiati Whendy Wijaksono Yuyus Dwi Prasetiyo

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