This study examines the literature regarding the Technological Pedagogical Contents Knowledge (TPACK) competency framework needed for teachers to face the challenges and demands of learning with global issues, such as the industrial revolution 4.0 and the SDGs 2030 agenda. The research method used is Narrative Literature Review with conducted studies on various published articles related to the TPACK theme, teacher competence, and challenges to global issues in education. The articles reviewed were articles published in the last ten years, with a total of 25 articles. The literature review results show that: 1) The form and type of technology integration in learning needs to pay attention to aspects of pedagogy and content so that the determination and use of technology in learning can work effectively according to the characteristics of students and the content being taught. 2) Forms and types of technology integration that have been used include virtual labs, molecular and particle animation media, smartphone applications, and Augmented Reality. 3) Technology integration in the learning process, consisting of initial, core, and closing activities, requires a different approach. In the initial, core, and closing activities, the integration of technology used in the process will vary in type and form according to pedagogical aspects (setting learning objectives) and content aspects (depth and breadth of material at each stage)