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All Journal Jurnal Kesehatan Masyarakat Nexus Kedokteran Klinik Sari Pediatri Paediatrica Indonesiana Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Promotion and Behavior Journal of Maternal and Child Health Amerta Nutrition
Harsono Salimo
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Perbedaan Kadar Thyroid Stimulating Hormone dan Free Thyroxine pada Pasien Talasemia Î’-Mayor dengan Kelasi Besi Deferasirox dan Deferiprone Aries - Krisbiyantoro; Harsono Salimo; Annang Giri Moelyo
Sari Pediatri Vol 19, No 4 (2017)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.075 KB) | DOI: 10.14238/sp19.4.2017.209-13

Abstract

Latar belakang. Talasemia β Mayor merupakan kelainan herediter yang disebabkan gangguan produksi rantai globin. Transfusi rutin menyebabkan kelebihan besi yang tertimbun dalam jaringan sehingga menyebabkan kardiomiopati, gangguan liver, dan komplikasi endokrin. Tiroid merupakan kelenjar endokrin yang berperan penting bagi anak. Pengendapan besi di kelenjar tiroid dapat menyebabkan gangguan fungsi tiroid. Pemberian kelasi besi deferiprone dan deferasirox dan pengaruhnya pada kadar TSH dan FT4 perlu dievaluasi lebih lanjut.Tujuan. Menganalisis perbedaan kadar TSH dan FT4 pada pasien anak dengan talasemia β mayor menggunakan kelasi besi deferiprone dan deferasirox Metode. Penelitian analitik dengan rancangan potong lintang (cross sectional) terhadap 43 pasien talasemia β mayor anak berusia 9-18 tahun pada bulan April sampai Juni 2017. Pemilihan subjek dilakukan secara consecutive sampling. Data di analisis dengan SPSS 20 mengunakan uji t independen dan uji man whitney.Hasil. Rerata usia pasien 12,5+3,12 tahun. Rerata kadar TSH kelompok deferiprone dan deferasirox adalah 3.051,78 IU/ml dan 2.351,29 IU/ml. Sedangkan rerata kadar FT4 untuk kelompok deferiprone dan deferasirox 15.424,12 mmol/l dan 15.822,75 IU/ml. Tidak terdapat perbedaan kadar TSH dan FT4 pada kelompok yang mendapatkan deferasirox dan deferiprone berturut-turut nilai TSH (p=0,148; p>0,05) dan FT4 (p=0,836; p>0,05). Kesimpulan. Tidak terdapat perbedaan kadar TSH dan FT4 pada pasien talasemia beta mayor yang mendapatkan kelasi deferasirox maupun deferiprone.
Hubungan antara Kadar Feritin dengan Kreatinin Serum pada Pasien Thalassemia di RSUD Dr. Moewardi Eko Dewi Ratna Utami; Harsono Salimo; Dyah Ratna Budiani
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background : Patients with thalassemia that underwent routine blood transfusion are developing iron overload. In the state of excess iron, ferritin levels increase. When iron storage capacity has been depleted, free iron will cause tissue damage. One of that damaged organ is kidney. One of parameter used to know the function of kidney is GFR (Glomerular Filtration Rate). A simple way to estimate GFR is serum creatinine. Increased 1-2 mg/dL of creatinine serum showed decrease 50% of GFR. This research was aimed to determine the correlation between ferritin levels and serum creatinine of patients with thalassemia. Methods : A cross-sectional study which the subjects were 30 patients with thalassemia in the pediatric ward RSUD Dr. Moewardi who met the inclusion criteria. Ferritin levels and serum creatinine obtained from medical records or patient report book. Data normality was tested with Shapiro-Wilk normality test. Correlation between ferritin levels and serum creatinine were analyzed with non-parametric correlation test Spearman using Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : Ferritin levels ranged from 1004.2 to 9600 ng/mL. Creatinine serum were 0.2 mg/dL; 0.3 mg/dL; 0.4 mg/dL; 0.5 mg/dL with almost equal distribution. Results of the analysis with non-parametric correlation test Spearman obtained R = 0.044 and p = 0.816. Conclusion : There was no correlation between ferritin levels and serum creatinine of patients with thalassemia. Keywords : thalassemia, ferritin, creatinine
Association between C-reactive protein levels and physical fitness in 7 to 9 year old children at poor elementary schools in Surakarta, Indonesia Lilisianawati Lilisianawati; Endang Dewi Lestari; Diana Mayasari Hadianto; Maria Galuh Kamenyangan Sari; Leilani Lestarina; Harsono Salimo
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.27 KB) | DOI: 10.14238/pi49.2.2009.75-81

Abstract

Background  Data  regarding inflammatory factors  in  children arenot  so  well developed  as  in adults. Higher levels  of  physical fitnessmay be helpful in modifying the low-grade inflammatory state  thatis  indexed  by  C-reactive protein (CRP) levels.Objective  To  evaluate the association  of  physical fitness with  CRPlevels in children  and  to identify the possible related factors.Methods  This  cross-sectional study was  conducted  at  poorelementary schools in Surakarta, Indonesia using a group  of  217underweight children aged from 7 to 9 years old. Physical fitnesswas assessed using a modified Harvard Step Test.  CRP  levels weremeasured using a high-sensitivity  assay.  The  association betweenphysical fitness and  CRP  level was assessed using linear regressionanalysis. Multivariate analyses were used to adjust covariates,and statistical analyses were performed using SPSS for Windowssoftware version 15.0.Results  Subjects were 48% female  and  52% male, and elevenchildren (5%) had a  CRP  level  >  5 mg/L. Mean fitness level  andCRP  level did not differ  by  age and gender. Fitness level was notinversely correlated with  CRP  (r=0.10,  P=0.14).  Physical fitnesswas significantly correlated with BMI  (r=0.14;  P=0.04),  physicalactivity  [0R=3.3  (95% CI  1.7  to 6.4)], and fat intake  [0R=0.5(95%  CI  0.2 to 0.9) ].Conclusion  These findings indicate  that  physical fitness  is  notinversely correlated to  CRP  levels in children. However, ourstudy reveased  an  association between high fat intake and lowphysical fitness as well  as  a significant association  betweenhigh physical activiry and physical fitness.
Effect of iron ... zinc fortified milk on iron status and functional outcomes in underweight children Endang Dewi Lestari; Saptawati Bardosono; Leilani Lestarina; Harsono Salimo
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.517 KB) | DOI: 10.14238/pi49.3.2009.139-148

Abstract

Background Iron and zinc are essential micronutrients duringschool-age period. Milk could be an alternative medium formineral fortification because it is consumed frequently bychildren.Objective To evaluate the effect of iron-zinc fortified milksupplementation on iron status and functional outcomes inunderweight children.Methods 44 2 underweight subjects aged 7-10 years attending 10primary schools in Jakarta and Solo were recruited in the study.Subjects who had chronic illnesses, severe anemia, thalassemiaor cow's milk allergy were excluded. Blood samples were analyzedto determine hemoglobin, serum ferritin and serum zinc. SerumCRP was measured in sub sampled subjects (n= 60). Subjectswere randomizedly allocated to receive iron-zinc fortified milk(n = 225) and standard milk (n = 217) for six months. The fortifiedmilk will provide additional6.3 mg iron and 1.5 mg zinc per day (2feeds). The main outcomes measured were iron status, cognitivefunction, growth, physical fitness and morbidity.Results Study groups were comparable at baseline. The fortifiedmilk group had better physical fitness score and exercise durationat baseline. Both milk supplementations reduced the prevalenceof anemia and iron deficiency. Fortified milk improved the speedprocessing score (P< 0.0001), height (P<0.0001) and sittingheight (P=O.Ol) significantly.Conclusion Supplementation of milk reduces the prevalence ofanemia and iron deficiency. Zinc-iron fortified milk gives positiveimpact on cognitive performance, growth, and physical fitness.
Hubungan Pemberian Asi Eksklusif Dan Status Gizi Ibu Dengan Pertumbuhan Lingkar Kepala Bayi Usia 6 Bulan Ivanda Glanny Anindya; Harsono Salimo; Yulia Lanti Retno Dewi
Amerta Nutrition Vol. 3 No. 4 (2019): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v3i4.2019.263-268

Abstract

Background: Measurement of head circumference is highly crucial during the early years of life which considered as an anthropometric parameter substantially correlated with brain size. The emergence of head circumference aberration functions to warn of abnormal brain development. Breast milk is the ideal nutritional provider that babies need for optimal healthy growth. Nursing mothers with good nutrition will affect their nutritional status. The nutritional status will determine the quantity and quality of dairy products that indirectly play a role in determining children’s nutritional status.Objective: Analyzing the relationship between exclusive breastfeeding and maternal nutritional status with the growth of the head circumference of 6 months old infants.Method: Using a cross-sectional design in the Kaliwates, Jember. Subjects were 6 months old infants in which 128 babies were selected by purposive sampling. Data on maternal nutritional status were based on Body Mass Index (BMI). Data on exclusive breastfeeding were based on interviews and KMS data. The baby’s head circumference data were based on direct measurements and those were interpreted using WHO growth charts. Then, the data were analyzed using Chi-Square test.Results: The results showed that there was a significant relationship between exclusive breastfeeding (p<0.001) and maternal nutritional status (p=0.028) with the growth of the baby’s head circumference.Conclusion: Exclusive breastfeeding and maternal nutritional status are associated with the growth of the baby’s head circumference. ABSTRAKLatar Belakang : Pengukuran lingkar kepala sangat penting selama tahun awal kehidupan, hal ini merupakan parameter antropometri yang sangat berkorelasi dengan ukuran otak. Terjadi penyimpangan pada lingkar kepala, maka memperingatkan perkembangan otak yang tidak normal. Air susu ibu merupakan penyedia nutrisi ideal yang dibutuhkan bayi untuk pertumbuhan yang sehat secara optimal. Ibu menyusui dengan pemenuhan gizi yang baik akan mempengaruhi status gizinya. Status gizi tersebut akan menentukan kuantitas dan kualitas produk susu yang secara tidak langsung berperan dalam menentukan status gizi anak.Tujuan : Menganalisis hubungan pemberian ASI eksklusif dan status gizi ibu dengan pertumbuhan lingkar kepala bayi usia 6 bulan.Metode : Menggunakan desain cross-sectional di wilayah Kecamatan Kaliwates, Kabupaten Jember. Subjek penelitian adalah bayi usia 6 bulan, 128 bayi dipilih dengan purposive sampling. Data status gizi ibu berdasarkan IMT. Data pemberian ASI eksklusif berdasarkan wawancara dan data KMS. Data lingkar kepala bayi berdasarkan pengukuran langsung dan diinterprestasikan menggunakan grafik pertumbuhan WHO. Analisis data menggunakan uji Chi-Square.Hasil : Hasil penelitian menunjukkan bahwa ada hubungan yang bermakna antara pemberian ASI eksklusif (ρ = <0,001 dan OR 9,58) dan status gizi ibu (ρ = 0,028 dan OR 0,28) dengan pertumbuhan lingkar kepala bayi usia 6 bulan.Kesimpulan : Pemberian ASI eksklusif pada bayi akan memberikan pertumbuhan lingkar kepala yang normal dibandingkan bayi yang tidak diberikan ASI eksklusif dan pada ibu yang memiliki status gizi baik juga akan memberikan pertumbuhan lingkar kepala bayi yang normal dibandingkan dengan ibu berstatus gizi kurang dan gemuk. Kata kunci : status gizi, ASI eksklusif, lingkar kepala
Co-Authors -, Suradi Abd. Rasyid Syamsuri Adi Magna Patriadi Nuhriawangsa Alfianrisa, Anggityas Alinda Nur Ramadhani Anggraini, Yeni Anindya, Ivanda Glanny Annang Giri Moelyo Annang Giri Moelyo Argyo Demartoto, Argyo Aries - Krisbiyantoro Astuti, Fitriyani Dwi Atika, Zummatul Ayuningrum, Ika Yuli Bachtiar, Harrys Bhisma Murti Burhannudin Ichsan Catur Retno Lestari Desi Ekawati Diana Mayasari Hadianto Didik Tamtomo, Didik Dwi Hidayah Dwi Wijayanti Dyah Ratna Budiani Eko Dewi Ratna Utami Endang Dewi Lestari Endang Sutisna Sulaeman Eti Poncorini Pamungkasari Fauziyah, Rahma Galih Herlambang H.A.A. Soebijanto Hardilla, Dinda Septiani Hartanti, Ainurrizma Tri Ilma, Nabilah Nurul Ilma, Nabilah Nurul Indita, Wiwen Indriasih, Merlita Indriasih, Merlita Indriyani, Eny Inggar Ratna Kusuma Irnawati, Prita Yuliana Iskandar, Nurdin Aji Ivanda Glanny Anindya Juhrotun Nisa, Juhrotun Khalifah, Intan Noor Khalifatunisak, Alfadefi Kusumastuti, Nurry Ayuningtyas Kusumawardhani, Wahyu Kuswandari, Eti Leilani Lestarina Lestari, Nining Lilisianawati Lilisianawati Listiani, Funik Rahma Mei Maria Galuh Kamenyangan Sari Marlinawati, Iin Tri MS, Novi Paramitasari Muslimah, Putri Andini Ningsih, Nur Isniani Nugraha, Sandi Nugroho, Irfan Dzakir Nurahmawati, Dhewi Nurmayanti, Rika Palupi, Endang Poncorini, Eti Rahardjo, Setyo Sri Rita Adriani Benya Adriani Riza, Muhamad Rohaniyati, Retno Dwi Rokhayati, Rokhayati Rokhayati, Rokhayati Safriana, Latifah Saptawati Bardosono Sari, Lutfiana Puspita Sinta, Prabawati Sri Lilijanti Widjaja Sukoco, Amin Susanti, Isne Titah Pujangkara, Ajeng Ayu Trisnawati, Iga Uki Retno Budihastuti Vitri Widyaningsih yulia lanti retno dewi Yulia Lanti Retno Dewi Yulidar Hafidh