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All Journal Jurnal Keperawatan Jurnal Penelitian dan Evaluasi Pendidikan Proceeding International Conference on Information Technology and Business Dunia Keperawatan : Jurnal Keperawatan dan Kesehatan Pharmascience Paedagogie JIAFE (Jurnal Ilmiah Akuntansi Fakultas Ekonomi) Jurnal Ilmiah Dikdaya J-Dinamika: Jurnal Pengabdian Kepada Masyarakat CIVITAS (JURNAL PEMBELAJARAN DAN ILMU CIVIC) Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences JURNAL BIOSHELL Jurnal Ilmiah Wahana Pendidikan Proceeding Biology Education Conference Proceeding International Seminar of Islamic Studies Pancaran Pendidikan JRAP (Jurnal Riset Akuntansi dan Perpajakan) Prosiding Seminar Nasional Pascasarjana
Suratno Suratno
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Journal : Pharmascience

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Formulasi dan Evaluasi Gel Topikal Antibakteri Fraksi Aktif Akar Kuning (Arcangelisia flava Merr.) Evi Mulyani; Suratno Suratno; Mohammad Rizki Fadhil Pratama
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8081

Abstract

ABSTRAK Akar kuning (Arcangelisia flava Merr.) merupakan salah satu tanaman yang tumbuh di Kalimantan Tengah dan secara turun temurun digunakan sebagai pilihan pengobatan beberapa penyakit kulit dan terbukti mempunyai aktivitas antibakteri. Pembuatan sediaan topikal antibakteri berbahan fraksi aktif A. flava sangat potensial dilakukan untuk mengoptimalkan penggunaan dalam pengobatan sekaligus meningkatkan nilai ekonomis dari A. flava. Tujuan penelitian ini untuk mendapatkan formula gel fraksi aktif A. flava sebagai antibakteri yang paling baik secara fisik.Formula gel dibuat dengan variasi jenis dan konsentrasi gelling agent.Gel fraksi aktif A. flava diuji secara fisika, kimia, dan biologi seperti organoleptis, homogenitas, daya sebar, pH, daya lekat, dan daya hambat terhadap Staphylococcus aureus. Hasil formulasi sediaan gel fraksi aktif A. flava dengan basis NaCMC memenuhi syarat sifat fisik dan zona hambatan 11,6 mm pada Formula 1 dan 13,4 mm pada Formula 2, sedangkan sediaan gel dengan basis Carbophol 943 pada Formula 1 dan 2 memenuhi syarat sifat fisik dan zona hambat 10,9 mm pada Formula 2.Formula gel yang memenuhi kriteria secara fisik adalah Formula 2 dengan Carbophol 1,5% sebagai gelling agent. Kata Kunci: Akar kuning, antibakteri, gel, Staphylococcus aureus  ABSTRACT Akar kuning (Arcangelisia flava Merr.) is a plant that grows in Central Kalimantan and has been used as a treatment option for several skin diseases and has been shown to have antibacterial activity. The making of topical antibacterial preparations made from the active fraction of A. flava is very potential to be done to optimize the use in treatment while increasing the economic value of A. flava. The purpose of this study was to obtain the active A. flava fraction gel formula as the best natural antibacterial. The gel formula was made with variations in the type and concentration of the gelling agent. Arcangelisia flava Merr. active fraction gel was tested physical, chemical, and biological, such as organoleptic, homogeneity, spreadability, pH, adhesion, and bacterial inhibitionagainst Staphylococcus aureus. The results of the formulation of the active gel of A. flava based on NaCMC base fulfills physical condition requirements and shows an inhibition zone of 11.6 mmin Formula 1 and 13.4 mm in Formula 2, while gel preparation based on Carbophol 943 Formula 1 and 2 fulfill the physical characteristic requirements and show the inhibition zone of 10.9 mm in Formula 2.Gel formula that meets the physical criteria is Formula 2, with 1.5% Carbophol as a gelling agent. Keywords: Akar kuning, antibacterial, gel, Staphylococcus aureus
Co-Authors Acep Suherman Ahmad Syaifudin Alif Mardiana Alwan Abdurahman Amilin Amilin Anak Agung Istri Sri Wiadnyani Ariani Palupi Djaddang, Syahril Doni Al Ifhan Donni Al Ifhan Dr. Ir. M. Syarief, MP Dwi Husiano Eka Budi Yulianti Elok Nur Faiqoh Evi Mulyani Fika Purnamasari Fitri Akbariah Haning Hasbiyati Hieronimus Amandus Hotma P. Panggabean I Ketut I Ketut Mahardika Ida Zulaeha Ilmiyono, Agung Fajar Inggita Sukma Anggreini J.M.V Mulyadi Mohammad Rizki Fadhil Pratama Muhammad Muhyi Nizlel Huda Nurjannah Nurjannah Nurmala Ahmar Nurul Hidayah Puji Lestari Pakarti Riswanto Pipit Awwalina Farihin Yadinta Retno Dwi Handayani Rima Rianti Rina Nurmalina Sailendra Sailendra Selvi Novita Fouziah Silvia Qaulina Damayanti Sukma Dewi Hapsari Sumiati Sumiati Sumiati Sumiati Sunti. A. Pratiwi Timbul Bona Nainggolan Tri Widyastuti Triowali Rosandy Ulyana Maulidiyah Widarto Rachbini Widarto Rachbini Wiwin Setio Wati Yeni Nur’aeni Yushardi Yushardi Zulkifli Zulkifli