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All Journal Indonesian Journal of Tropical and Infectious Disease journal of Basic Medical Veterinary PCJN Pharmaceutical and Clinical Journal of Nusantara

Maslichah Mafruchati

Department Of Anatomy Faculty Of Veterinary Medicine, Universitas Airlangga

Author-ID : 4007408

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Articles

PREVALENCE OF HELMINTH EGGS IN CAT FECES CONTAMINATING PUBLIC AREAS IN SURABAYA Nurul Tri Wahyudi; Lucia Tri Suwanti; Kusnoto Kusnoto; Sri Mumpuni; Ira Sari Yudaniayanti; Maslichah Mafruchati
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 6 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Helminthiasis can be transmitted from animals to humans (zoonosis). Helminthiasis can cause cutaneus larva migrants, visceral larva migrant, and occular larva migrants. Cats are the most easily animals can found in public areas. cats have a habit of defecating in areas, such as dusty soil, gardens, sand pits, trash cans, and even children’s playgrounds. Proximity of human life with a stray cats is one of the potential that can helminthiasis transmited to humans. The purpose of this study was to assess the prevalence of helminth eggs (species and number) observed in cat feces contaminating public areas in Surabaya. Cross-sectional study have been observations cats existense and examination laboratory of 180 cat fecal samples were collected from canteens, markets, villages, schools, and parks across 5 areas in Surabaya. Helminth eggs present in fecal samples were identified using direct smear, sedimentation, and flotation methodes, and quantified as fecal egg count (eggs per gram of feces) with McMasster method. The test results positive for helminthiasis if found one or more types of helminth eggs in fecal samples. Helminth eggs were present in 68 (37.8%) of the 180 cat fecal samples contaminating public areas in Surabaya. Results of chi-squared analysis confirmed the prevalence of helminth eggs in cat fecal samples contaminating canteen, markets, villages, schools, and parks in Surabaya (p > 0.05). The species causing environmental contamination included Ancylostoma sp. eggs, Toxocara cati eggs, and Toxascaris leonina eggs. The level of environmental contamination, as assessed using ANOVA, was 200 eggs per gram of feces.

PENGARUH PEMBERIAN EKSTRAK KULIT PISANG KEPOK (Musa acuminata) TERHADAP PENURUNAN KADAR MALONDIALDEHID (MDA) PARU MENCIT JANTAN (Mus musculus) YANG DIPAPAR ASAP ROKOK Sapna Kurnia Dewi; Widya Paramitha Lokapirnasari; Dewa Ketut Meles; Imam Mustofa; Maslichah Mafruchati; Iwan Sahrial Hamid
Journal of Basic Medical Veterinary Vol. 8 No. 2 (2019): Journal of Basic Medical Veterinary, December 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v8i2.20416

This research aimed to determine the effect of kepok banana peel extract (Musa acuminata) given by per oral in decreasing levels of malondialdehyde (MDA) in lung of male mice (Mus musculus) which was exposed to cigarette smoke. The 24 experimental male mice were divided into 6 groups. The therapy was given for 14 days, all mice were sacrificed and lung MDA level were examined with thiobarbituricacid (TBA) methods. The result of the data analysis test using one-way ANOVA (Analysis of Variance) showed that there were significant differences between the group of animals that exposed to cigarette smoke ( = 840.50± 186.47 nmol / g) and the group of animals that were given with extract of kepok banana peel 56 mg / kg bw ( = 6471.25 ± 69.25 nmol/g). Besides that, there was an significant difference between the groups of animals that were exposed cigarette smoke ( = 840.50± 186.47 nmol / g) with the group of animals that were given with vitamin C 260 mg/kg bw ( = 555.25± 61.16 nmol / g). It could be concluded that extract of kepok banana peel and vitamin C could decrease MDA levels in lung of male mice which was exposed cigarette smoke. The increased therapy dose gave affect in lowering levels of malondialdehyde in lung.

PENGARUH PEMAPARAN KARBOFURAN PADA INDUK MENCIT (Mus musculus) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL ANAK MENCIT MASA LAKTASI Edi Purnomo; Epy Muhammad Luqman; Hermin Ratnani; Hani Plumeriastuti; Maslichah Mafruchati; Yeni Dhamayanti
Journal of Basic Medical Veterinary Vol. 9 No. 1 (2020): Journal of Basic Medical Veterinary, June 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v9i1.21095

Carbofuran is a broad spectrum carbamat insecticide which is used in various farm practices. An exposure of carbofuran has been reported able to induce Reactive Oxygen Species (ROS) or free radical in kidney. Free radical caused cells damage. The present study was designed to investigate the effect of carbofuran in kidneys histopathologic of mice pup whose dam were exposed by carbofuran during the lactation period. High levels of ROS can bind to various biomolecules such as proteins, lipids and nucleic acids so that carbofuran has a negative effect on tissue functions and structures. Free radical caused changes in the pathological conditions of the tissue including the kidneys. The dams were devided into four groups of five animals each. P0 animal group was received aquadest 0,1 ml per body weight (BW), P1 animal group was treated carbofuran at the dose of 1/16 LD50 (0,3125 mg per BW), P2 animal group was treated carbofuran at the dose of 1/8 LD50 (0, 625 mg per BW), and P3 animal group was treated carbofuran at the dose of 1/4 LD50 (1,25 mg per BW). The carbofuran was exposed via oral postnatal day 1st until 9th postnatal day after delivery. At postnatal day 10th, offspring were sacrified. The kidney of mice pup was collected and processed for microscopic examination with hematoxilin-eosin staining. Microscopic observations on the histology of the mice pup kidney showed an increase in the degree of kidney damage as an increase in the dose of carbofuran given to the dams. The results showed tubular changes in the form of tubular degeneration, inflammatory cell infiltration and tubular necrosis in the kidney of mice pups.

Protection Effectiveness Of Bit (Beta vulgaris) Fruit Extract In Maintaining Spermatogenesis Ability In White Rats (Rattus novergicus) Induced Carbon Tetracloride (CCl4) Alvyan Lantang Anugrah; Hana Eliyani; Budi Utomo; Suherni Susilowati; Maslichah Mafruchati; Rochmah Kurnijasanti
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31812

The aim of this research was to know whether beetroot (Beta Vulgaris) extract could protect spermatogenesis by maintaining spermatogenic and sertoli cell count in rats (Rattus novergicus) induced with CCl4. Rats were given beetroot extract daily, for 14 days and 3ml/kg BW CCl4 intraperitoneally one hour after last treatment. This study used twenty rats which were devided equally into 5 groups. K(-), the negative control group was not induced with CCL4 and only given 1% CMC-Na suspension. K(+), the positive control group was induced with CCl4 and given 1% CMC-Na suspension. P1, P2 and P3 were given beet root extract with doses of 200, 400, and 800 mg/kg BW daily before feeding. All of the beetroot treatment were given orally (2 ml). After 24 hours CCl4 induction, rats were sacrificed and testis were collected to make histology slides. The observations showed significantly different (p<0,05) in all of variables. Result showed significant differences in spermatogenic and sertoli cells between K(-) and K(+) groups, K(+) with P2 and P3 group, and showed insignificant difference between P2 and P3 group in spermatogenic and sertoli cells. The result of this research showed that beetroot extract could protect the spermatogenic and sertoli cells in male rats induced with CCl4.

Analysis of Embryo Development and Early Performance of Larvae of Barbonymus Schwanenfeldii: A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Tengadak fish is a freshwater fish that can be found in rivers, lakes and canals and ditches. One of the important phases in fish development is the embryo. Embryo development (embryogenesis) is more in the process of formation and development of the embryo, not only the increase in the number and mass of embryonic blastomer cells but also the activity of blastomeric cells.The purpose of this study was to analyze the stages of embryonic development and early larval performance in Tengadak fish (Barbonymus schwanenfeldii). This study used systematic literature review using data from PubMed, NCBI, Google Scholar databases using keywords, namely, “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. Approximately, 350 articles were obtained for the keywords “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. All articles were selected based on inclusion criteria and exclusion and obtained as many as 27 articles that meet the inclusion criteria From the results of research conducted, it can be concluded that this research has sequentially described the embryonic development and early performance of the larvae of the barbonymus schwanenfeldii. Need research on the other animal for future research.

Analysis Of Medicinal Plants On Embryo Development Of Mice (Mus Musculus L.) And White Rats (Rattus Novergicus): A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

White rats are often used to assess protein quality, toxicity, carcinogenic, and pesticide content of an agricultural food product. M. Musculus mice are rodents that are very easy to breed, and easy to maintain. Embryogenesis is the process of growth and development of the embryo. The purpose of this study was to analyze medicinal plants on the embryonic development of Mice (Mus musculus L) and White Rats (Rattus Novergicus). This method uses a Systematic Review approach which is based on the Preferred Guide to Reporting Items for Systematic Review and Meta-analysis (PRISMA). Total of 700 articles were obtained which then entered the elimination stage resulting in 50 articles on medicinal plants (Mus musculus L) and White Rats (Rattus Novergicus). Based on the results of the study, it can be concluded that the identification of medicinal plants that are toxic to the embryonic development of Mice (Mus musculus L.) White Rats (Rattus Novergicus).

Apis Mellifera Propolis Extract As A Stimulator Of Brain Cell Development (Study On Experimental Animals) Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Apis mellifera could have potential as cell growth stimulator ability of the propolis. It also expected to increase the growth and proliferation of brain cells. This study aimed to analyze Apis mellifera Propolis Extract as a Stimulator of Brain Cell Development in Experimental Animals. This research is an experimental study using a completely randomized design (CRD) with 6 treatments and 4 replications. The research consisted of making Propolis Extract, Making Media (DMEM Stock Media, Washing Media, Culture and Treatment Media), Brain Cell Isolation and Culture, Observation of Culture Results (Cell Viability, Population Doubling Time, The results found that all treatments with propolis extract showed higher average viability than the control, which had average viability of 86.3%. Based on PDT (Population Doubling Time value), propolis extract has a good effect on brain cell growth, hence increasing cell proliferation. In addition, the confluent brain cells of rats given propolis extract had higher average confluency than those not given propolis extract. Propolis extract can protect neurons from damage by increasing the brain-derivatedneurotrophic factor (BDNF) gene expression in cell line neuron cultures.

Testing Honey on Chicken Embryos as Candidates for Herbal Medicine in Indonesia Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

The nutrients in honey had function as antioxidants. The aim of this study was to testing honey on chicken embryos as candidates for herbal medicine in Indonesia. This study used treatment method, consisting of 6 (six) doses of honey products. The solution volume of each treatment dose was fixed at 10 l/egg via the route to the air bag. At the age of 13 days, embryo morphology and possible abnormalities were observed in all treatments. Each two eggs are cracked. The remainder was continued by incubation in the incubator until day 21. During this time the eggs were observed and the number was recorded to find out which eggs would die and which eggs would hatch at the end of the incubation period. Newborn chicks (DOC) were weighed and observed for possible morphological abnormalities. From the results of the research conducted, it was found that the percentage of viable chicken eggs sprouted after being injected with honey (days 13-21 after inoculation) and the morphology of chicken embryos after being injected with honey. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. The conclusion of the study is that propolis from honey products can be used as herbal medicine.

Co-Authors Alvyan Lantang Anugrah Budi Utomo Edi Purnomo Epy Muhammad Luqman Hana Eliyani Hani Plumeriastuti Hermin Ratnani Imam Mustofa Ira Sari Yudaniayanti Iwan Sahrial Hamid Jonathan Makuwira Kusnoto Kusnoto Lucia Tri Suwanti, Lucia Tri Meles, Dewa Ketut Nurul Tri Wahyudi Rochmah Kurnijasanti Sapna Kurnia Dewi Sri Mumpuni Suherni Susilowati Widya Paramitha Lokapirnasari Yeni Dhamayanti

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