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All Journal Indonesian Journal of Pharmaceutical Science and Technology Kartika Jurnal Ilmiah Farmasi Chimica et Natura Acta
Achmad Zainuddin
Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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UJI AKTIVITAS ANTIMALARIA EKSTRAK ETANOL DAUN COCOR BEBEK (Kalanchoe blossfeldiana Poelln.) pada Plasmodium falciparum 3D7 Hermanto, Faizal; Yun, Yenny Febriani; Aisyah, Lilis Siti; Saputra, Tri Reksa; Hakim, Arif Rahman; Ningsih, Ade Kania; Herlina, Tati; Julaeha, Euis; Zainuddin, Achmad; Supratman, Unang
Kartika Jurnal Ilmiah Farmasi Vol 2, No 2 (2014)
Publisher : Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.62 KB) | DOI: 10.26874/kjif.v2i2.18

Abstract

Malaria merupakan salah satu masalah serius yang dialami oleh beberapa negara tropis karena meningkatnya parasit malaria (Plasmodium) yang resisten terhadap obat-obat antimalaria. Oleh sebab itu perlu dicari obat antimalari baru, salah satunya tanaman cocor bebek (Kalanchoe blossfeldiana Poelln.) digunakan secara luas oleh masyarakat indonesia sebagai tanaman obat dan tanaman hias. Penelitian ini diawali dengan proses pembuatan ekstrak etanol daun cocor bebek menggunakan alat maserator dan etanol 96% sebagai pelarut. Plasmodium falciparum 3D7 yang akan digunakan dalam uji, terlebih dahulu dilakukan kultur sinambung sesuai metoda Trager and Jansen. P. falciparum  ditempatkan ke dalam lempeng sumur 24 masing-masing berisi 1 mL dengan tingkat  parasitemia ± 1% dalam medium RPHS. Diseluruh sumur, medium RPHS diganti dengan medium RPHS yang mengandung ekstrak etanol daun cocor bebek berbagai konsentrasi (1 sampai1x10-7 µg/mL).  Kultur diinkubasi selama 48 jam, setelah inkubasi parasit dipanen dan dibuat sediaan apusan darah tipis yang diberi pewarnaan Giemsa. Uji aktivitas antimalaria ditentukan dengan parasitemia, persen pertumbuhan dan hambatan parasit. Data dianalisis secara statistika menggunakan metode analisis probit untuk menghitung hambatan parasit sebesar 50% (IC50). Hasil penelitian menunjukan bahwa ekstrak etanol daun cocor bebek memiliki efek antimalaria dengan nilai IC50 sebesar 0,022 µg/mL.
RESOLUTION OF A RACEMIC ISOLEUCINE MIXTURE BY USING METHYL L-MANDELATE Maharani, Rani; Hidayat, Ace Tatang; Sumiarsa, Dadan; Zainuddin, Achmad; Hidayat, Ika Wiani
Chimica et Natura Acta Vol 4, No 3 (2016)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.517 KB) | DOI: 10.24198/cna.v4.n3.10991

Abstract

A methyl ester of L-mandelic acid was found to be an effective resolving agent for resolution of commercial DL-isoleucine. The resolution was based on Steglich esterification between methyl L-mandelate and Boc-DL-isoleucine. The two resolved isomers were easily separated by using a conventional flash-column chromatography, giving quantitatively good yields. Unfortunately, the methyl L-mandelate was found to be ineffective to resolve four stereoisomers of Fmoc- isoleucine.
Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides Husein, Sri Gustini; Zainuddin, Achmad; Hoeruman, Sani
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.687 KB) | DOI: 10.15416/ijpst.v5i3.17931

Abstract

Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine
Co-Authors ?Ainiah, Izzatul Ace Tatang Hidayat Ade Kania Ningsih, Ade Kania Arif Rahman Hakim Dadan Sumiarsa Euis Julaeha Faizal Hermanto Hoeruman, Sani Ika Wiani Lilis Siti Aisyah, Lilis Siti Rani Maharani Sabila, Peny Sri Gustini Husein Tati Herlina Tri Reksa Saputra, Tri Reksa Unang Supratman Yenny Febriani Yun, Yenny Febriani