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Captopril Mencegah Stres Oksidatif pada Tikus Wistar Jantan dengan Diet Tinggi Lemak Ikhlas Muhammad Jenie; Rizki Afrian; Barii Hafidz Pramono
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2016): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v16i1.4723

Abstract

Stres oksidatif berperan dalam terjadinya penyakit-penyakit kardiovaskular. Stres oksidatif ditandai dengan peningkatan radikal bebas dan penurunan sistem antioksidan. Sumber utama radikal bebas pada sirkulasi adalah enzim NAD(P)H oksidase. Enzim tersebut dimodulasi oleh angiotensin II. Angiotensin II dihasilkan dari konversi Angiotensin I oleh enzim angiotensin converting enzyme (ACE). Timbul pertanyaan apakah pemberian captopril, suatu penghambat ACE, dapat mencegah stres oksidatif. Untuk itu dilakukan penelitian pra-eksperimental pada hewan coba dengan rancangan post test only measurement. Sebanyak 24 ekor tikus Wistar jantan dikelompokkan ke dalam 3 kelompok: kelompok I mendapat diet normal 20g/hr, kelompok II diet tinggi lemak (10%) 20g/hr dan kelompok III diet tinggi lemak (10%) 20g/hr dan captopril 50 mg/kgBB/hr. Perlakuan diberikan selama 2 bulan. Variabel yang diukur adalah berat badan, kadar kolesterol total, kadar hidrogen peroksida (H2O2) dan histopatologi aorta. Data dianalisis dengan ANOVA satu arah. Berat badan tikus antarkelompok tidak berbeda bermakna pada awal dan akhir perlakuan. Kadar kolesterol total antarkelompok berbeda bermakna, dengan kadar kolesterol total pada tikus kelompok III lebih rendah secara bermakna daripada kelompok I dan II. Kadar H2O2 antarkelompok berbeda bermakna, dengan kadar H2O2) pada tikus kelompok II lebih tinggi secara bermakna daripada kelompok I dan III. Pada pemeriksaan histopatologi, lesi aterosklerotik ditemukan pada kelompok II dan III. Disimpulkan bahwa pemberian captoprildapat mencegah stres oksidatif pada tikus Wistar jantan dengan diet tinggi lemak.  
PENGARUH KOMBINASI VITAMIN ORAL B1, B6 DAN B12 TERHADAP WAKTU REAKSI PADA SUBJEK DEWASA MUDA YANG SEHAT: STUDI ACAK TERKENDALI Imaniar Ranti; Ikhlas Muhammad Jenie
Biomedika Vol 13, No 1 (2021): Biomedika Februari 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i1.9883

Abstract

ABSTRAKWaktu reaksi adalah waktu yang diperlukan oleh mahluk hidup untuk berespon secara sengaja terhadap stimulus yang diberikan. Waktu reaksi ini mampu menunjukkan kemampuan koordinasi sistem saraf motorik dan sensorik.  Waktu reaksi akan menurun saat terjadi penurunan fungsi sistem saraf. Salah satu vitamin yang dapat menjaga fungsi saraf adalah  kombinasi vitamin oral B1, B6 dan B12. Penelitian ini bertujuan untuk mengkaji efek pemberian vitamin oral B1, B6, dan B12 terhadap waktu reaksi. Desain penelitian menggunakan uji acak terkendali double blind.  Subyek sebanyak 20 orang laki-laki dan perempuan usia 18-20 tahun, yang terbagi secara acak 10 orang sebagai kelompok intervensi dan 10 orang sebagai kelompok kontrol.  Kombinasi vitamin oral B1 100 mg, B6 200 mg dan B12 200 mcg diberikan dalam bentuk kapsul dan diminum satu kali sehari selama 14 hari.  Subyek kelompok kontrol diberi kapsul yang berisi amylum lactose sebagai plasebo.  Pada hari ke-14, dilakukan pengukuran waktu reaksi sederhana dan waktu reaksi pilihan menggunakan alat pengukur kecepatan respon.  Hasil penelitian ini menunjukkan bahwa tidak ada perbedaan bermakna waktu reaksi sederhana dan waktu reaksi pilihan antara kelompok intervensi dan kelompok kontrol.  Akan tetapi, pada sub analisis berdasarkan gender, subyek perempuan kelompok intervensi mempunyai waktu reaksi pilihan yang lebih cepat dibandingkan kontrol. Kata Kunci: Waktu Reaksi, Kombinasi Vitamin Oral B1, B6, B12, Uji Acak TerkendaliABSTRACTReaction time is the time it takes for organisme to respond the given stimulus voluntarily. This reaction time is a good indicator of sensorimotor nervous system coordination. The reaction time will decrease when there is a decrease in nervous system function. One of the vitamins that can maintain nerve function is an combination of oral vitamins B1, B6 and B12. This study aimed to examine the effect of oral vitamins B1, B6, and B12 on reaction time. The study design used a double blind randomized controlled trial. Subjects were 20 men and women aged 18-20 years, which were randomly divided 10 people as the intervention group and 10 people as the control group. The combination of oral vitamins B1 100 mg, B6 200 mg and B12 200 mcg were given in capsule form and taken once a day for 14 days. The control group subjects were given a capsule containing amylum lactose as a placebo. On day 14th, a simple and selected reaction time was measured using a response velocity measuring device. The results of this study indicate that there were no significant difference in simple and selected reaction time between the intervention group and the control group. In a further analysis stratified by gender, female subjects in the intervention group had a faster selected reaction time than controls.   Keywords: Reaction Time, Oral Vitamin B1, B6, B12, Randomized Controlled Trial
Latihan Pernapasan Diafragma Meningkatkan Arus Puncak Ekspirasi (APE) dan Menurunkan Frekuensi Kekambuhan Pasien Asma Dian Kartikasari; Ikhlas Muhammad Jenie; Yanuar Primanda
Jurnal Keperawatan Indonesia Vol 22, No 1 (2019): March
Publisher : Faculty of Nursing Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.7454/jki.v22i1.691

Abstract

 Salah satu penatalaksanaan asma yaitu latihan pernapasan diafragma yang dapat meningkatkan fungsi paru pasien asma. Tujuan penelitian untuk menguji pengaruh latihan pernapasan diafragma terhadap peningkatan Arus Puncak Ekspirasi (APE) dan penurunan frekuensi kekambuhan pasien asma. Penelitian true experiment pretest-posttest with control group melibatkan 28 subyek penelitian secara random. Subyek dibagi menjadi kelompok intervensi dan kelompok kontrol melalui randomisasi sejumlah 14 orang untuk masing-masing kelompok. Pengukuran APE menggunakan peak flow meter dan frekuensi kekambuhan dicatat dengan lembar catatan observasi. Hasil penelitian terdapat perbedaan yang signifikan rerata selisih APE kelompok intervensi (mean 126,43±22,05 L/menit) dan kelompok kontrol (mean 52,14±56,45 L/menit) dengan p 0,001, serta terdapat perbedaan yang signifikan rerata selisih frekuensi kekambuhan kelompok intervensi (mean 1,29±0,61) dan kelompok kontrol (mean 0,79±0,57) dengan p 0,038. Latihan pernapasan diafragma menjadi pertimbangan dalam penatalaksanaan pasien asma. Kata kunci: arus puncak ekspirasi, asma, frekuensi kekambuhan, latihan pernapasan diafragma  AbstractEffect of Diaphragmatic Breathing Exercises on Peak Expiratory Flow Rate (PEFR) Enhancement and The Mild-Moderate Asthma Patients’ Relapse Frequency Reduction. One of the management of asthma is diaphragmatic breathing exercises that could improve lung function of asthma patients. The objective of the study was to examine the effect of diaphragmatic breathing exercises on Peak Expiratory Flow Rate (PEFR) and decreased frequency of mild-moderate asthma relapse on the patients. True experiment method pretest-posttest with control group was applied in this study with involved 28 random research subject. Subjects were divided into intervention groups and control groups through randomization of 14 people for each group. PEFR measurements using peak flow meter and relapse frequency were recorded with an observation note sheet. There was a significant difference of difference PEFR mean between intervention groups (mean 126.43±22.05) and control group (mean 52.14±56.45) with p 0.001. There was a significant difference of difference mean frequency between intervention group (mean 1.29±0.61) and control group (mean 0.79±0.57) with p 0.038. Diaphragmatic breathing exercise is a consideration in the management of asthma patients.Keywords: asthma, diaphragmatic breathing exercises, frequency of recurrence, peak expiratory flow rat
PEMBERDAYAAN KADER POSYANDU LANSIA PADA MASA PANDEMI COVID-19 Ikhlas Muhammad Jenie; Zulkhah Noor; Maya Um Husna; Muhammad Herjuna; Lutfi Putra Perdana
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2020: 2. Kemitraan dalam Pemberdayaan Masyarakat
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (521.028 KB) | DOI: 10.18196/ppm.32.178

Abstract

Pos pelayanan terpadu (posyandu) mengalami vakum kegiatan semenjak pandemi Corona Virus Disease-2019 (Covid-19). Walikota Yogyakarta menerbitkan surat edaran mengenai operasional Posyandu di masa pandemi Covid-19 dengan protokol kesehatan. Pusat Kesehatan Masyarakat (Puskesmas) Mergangsan menunjuk Posyandu Keji Beling RW 05 Kampung Pujokusuman sebagai posyandu pertama di lingkungan Kecamatan Mergangsan Kota Yogyakarta untuk menyelenggarakan posyandu lanjut usia (lansia) dengan protokol kesehatan. Tujuan kegiatan pengabdian masyarakat ini adalah mempersiapkan dan mendampingi kader kesehatan posyandu Keji Beling untuk dapat menyelenggarakan posyandu lansia di masa pandemi Covid-19. Metode pengabdian pada kegiatan pertama adalah dengan ceramah. Kader posyandu diberikan refreshing pengetahuan mengenai landasan hukum penanganan wabah penyakit menular di Indonesia, usaha-usaha untuk meningkatkan imunitas tubuh, panduan pencegahan dan pengendalian Covid-19 dari Kementrian Kesehatan Republik Indonesia, serta pembagian hand sanitizer dan face shield. Metode pengabdian pada kegiatan kedua adalah pendampingan kegiatan lapangan dalam pelaksanaan posyandu lansia di masa pandemi Covid-19. Posyandu Lansia Keji Beling pada masa pandemi Covid-19 dilaksanakan dengan membatasi jumlah peserta (25%) dan kader posyandu (50%). Peserta posyandu lansia yang diundang berjumlah 17 orang, terdiri atas 4 laki-laki (24%) dan 13 perempuan (76%) dengan rentang usia 60-69 tahun 11 orang (65%), 70-79 tahun 5 orang (29%), dan 80-89 tahun 1 orang (6%). Pemeriksaan kesehatan lansia meliputi penimbangan berat badan, pengukuran tekanan darah, pemeriksaan kadar glukosa darah sewaktu dan kadar kolesterol. Hasilnya adalah prevalensi hiperkolesterolemia 53%, hipertensi 47%, obesitas 12%, dan diabetes 5,9%. Kesimpulannya adalah posyandu lansia dapat terselenggara pada masa pandemi Covid-19 melalui pemberdayaan kader posyandu, pembatasan jumlah peserta, dan penerapan protokol kesehatan.
PENINGKATAN KEBUGARAN JASMANI ANAK DI PANI ASUHAN Ikhlas Muhammad Jenie; Zulkhah Noor; Mahendro Prasetyo Kusumo
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2021: 1. Peningkatan Kapasitas Kelembagaan Publik
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.03 KB) | DOI: 10.18196/ppm.41.795

Abstract

Panti asuhan merupakan lembaga usaha untuk meningkatkan kesejahteraan anak dalam pengentasan ketelantaran anak. Panti Asuhan Panti Asuhan Yatim Putra Muhammadiyah Yogyakarta (PAY Lowanu) merupakan salah satu panti asuhan yang tertua di Provinsi Daerah Istimewa Yogyakarta. PAY Lowanu mempunyai enam puluh tujuh anak asuh. Dari komunikasi personal terdapat masalah yang dihadapi anak asuh PAY Lowanu saat ini, yakni penurunan kemampuan kognitif dan psikomotor. Hal ini terkait dengan kondisi pandemi Covid-19 setahun terakhir ini. Diusulkan solusi masalah berupa survei aktivitas fisik pada anak-anak panti. Apabila hasil kuesioner menunjukkan aktivitas fisik yang kurang atau rendah maka dilakukan pembekalan mengenai dasar-dasar olahraga. Diharapkan pembekalan tersebut dapat meningkatkan motivasi dan kemampuan anak asuh PAY Lowanu untuk melakukan olahraga yang baik dan benar, yang selanjutnya dapat meningkatkan kebugaran jasmani dan kemampuan kognitif dan psikomotor anak asuh PAY Lowanu. Gambaran iptek transfer materi ilmu pengetahuan Fisiologi Olahraga terkait dengan adaptasi tubuh saat berolahraga, peresepan olahraga, dan kebugaran jasmani.
Efektifitas Terapi Komplementer dalam Meningkatkan Kekuatan Otot Pasien Stroke : A Literature Review Ianah Al Azizah; Ikhlas Muhammad Jenie
Jurnal Keperawatan Muhammadiyah Vol 5 No 1 (2020): JURNAL KEPERAWATAN MUHAMMADIYAH
Publisher : UNIVERSITAS MUHAMMADIYAH SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.339 KB) | DOI: 10.30651/jkm.v5i1.4726

Abstract

Abstract Background:Irregular life style such as irregular eating pattern, lack of exercise, overwork and excessive consumption of fast food has become common habit and is potential for developing a risk of stroke. Post stroke patients are generally experiencing muscle weakness on their parts of limb, postural disorder and muscle atrophy. Complementary therapy can be an alternative to increase muscle strength of patient with stroke.Objective:Identifying the effectiveness of complementary therapy to increase muscle strength of patient with stroke.Method:This literature review used database from PubMed, Proquest, and Google Scholar.  During the initial stage, the keyword of: “((Complementary AND Muscle strength AND Stroke Complementary Therapy))” resulted in the total of 12 international articles ranging from year 2016 to 2018 which all are in line with the criteria of inclusion and exclusion.Result:The research articles used were those of conducted in various countries such as: Turkey, South Korea, China, Australia, Dutch, Germany, Brazil, New Zealand, America and Indonesia. The number of articles being compiled was in total of 12 articles, the majority of the research respondents were patients with stroke. The literature review consisted of the effectiveness of several complementary therapies to increase muscle strength of patient with stroke. The review gave description of how complementary therapy intervene with the increasing of muscle strength of patient with stroke in several countries. The type of research included within the review found by the author was that of quantitative research in total of 12 articles.Conclusion:It was concluded that those various articles were related with several complementary therapies to increase muscle strength on patient with stroke. There are several complementary therapies that can be used to increase muscle strength on patient with stroke; those are: mirror therapy, mental practice (MP) and mental practice mirror therapy (MPMT), aquatic treadmill, robotic therapy, and acupuncture.
Evaluasi Penggunaan Surgical Safety Checklist terhadap Kematian Pasien setelah Laparotomi Darurat di Kamar Operasi Joni Krismanto; Ikhlas Muhammad Jenie
Journal of Telenursing (JOTING) Vol 3 No 2 (2021): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v3i2.2556

Abstract

This study aims to analyze articles about surgical safety checklists on patient deaths after emergency surgery in the operating room, especially in Indonesia. The literature database search method was carried out on Google Scholar and Pubmed. The literature used is literature that meets the inclusion criteria and was published in the last five years. The results showed that the use of the surgical safety checklist is highly expected to be applied to preoperative and postoperative procedures that reduce surgical complications and determine the evaluation of the use of the surgical safety checklist on patient mortality after emergency laparotomy in the operating room. In conclusion, the application of a surgical safety checklist in emergency laparotomy surgery will be very helpful in reducing the occurrence of errors in operating procedures and complications of emergency laparatomy operations. Keywords: Patient mortality, Emergency Laparotomy, Surgical Safety Checklist
HYPOGLYCAEMIC EFFECTS OF JAVANESE GINSENG (Talinum paniculatum (Jacq.) Gaertn.) ROOT INFUSION ON ALLOXAN-INDUCED DIABETIC RATS Ikhlas Muhammad Jenie; Rosefani Intan Indraswari
Jurnal Kedokteran Hewan Vol 15, No 3 (2021): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.486 KB) | DOI: 10.21157/j.ked.hewan.v15i3.19568

Abstract

To examine whether Javanese ginseng root has an antihyperglycaemic effect, twenty-one male Rattus norvegicus rats were randomly divided into four groups: negative control (n= 3), positive control (n= 4), treatment (n= 7), and placebo (n= 7). Alloxan was injected intraperitoneally at a single dose of 80 mg/kg BW to rats to induce hyperglycaemia. Infusion of Javanese ginseng root or distilled water was given at a dose of 2% w/v solution with a volume of 1.8 mL/200 g BW per day for 14 days through an enteral feeding tube to either the treatment or placebo group, respectively. Blood glucose levels were measured using the colorimetric method. One-way analysis of variance (ANOVA) was used to examine differences in the mean of delta blood glucose (post intervention minus post alloxan blood glucose levels) among groups, followed by Tukey’s post hoc analysis. A P value 0.05 was considered statistically significant. There was a significant difference (P= 0.0001) in delta blood glucose among groups. Post hoc analysis revealed that delta blood glucose in the treatment group (-102.99±2.26 mg/dL) was significantly (P= 0.0001) greater than in the placebo (2.45±0.29 mg/dL), positive control (3.05±0.70 mg/dL) and negative control (1.60±0.17 mg/dL) grou p. In conclusion, Javanese ginseng root has potential as a hypoglycemic agent in alloxan-induced diabetic animal models
Breathing Exercise for Chronic Obstructive Pulmonary Disease Patient: Scoping Review Umifa, Kaslinda Nur; Jenie, Ikhlas Muhammad
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 4: December 2021
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (693.768 KB) | DOI: 10.30604/jika.v6i4.749

Abstract

 Chronic Obstructive pulmnonary disease is a respiratory disorder that cause several symptoms as dyspnea, chronic cough and fatigue. These symptoms can be overcome by doing breathing exercise. This scoping review to determine the benefits and types of breathing exercises in COPD patient. The databases used in the scoping revieware PubMed, Science Direct, ClincalKey for Nursing. The inclusion criteria were English articles, COPD patients. The final results obtained 7 articles that meet the criteria in scoping review. The analysis shows that yoga breathing exercise. Pursed-lips breathing, inspiratory and expiratory muscle training which can increase oxygen saturation, mucus production, vital lung capacity, the value of six minute walk tests, reduce dyspnea and frequency exhalation. The conclusion of the review of the seven articles that the Breathing exercise consist of several types of exercises that can reduce symptoms or problems experienced in COPD patient. Penyakit Paru Obstruktif Kronik adalah gangguan yang menyebabkan beberapa gejala seperti sesak napas, batuk kronis dan kelelahan. Gejala tersebut dapat diatasi dengan melakukan latihan pernapasan. Scoping review ini untuk mengetahui manfaat dan jenis latihan pernapasan pada pasien PPOK. Data dasar yang digunakan dalam pelingkupan adalah PubMed, Science Direct, ClincalKey untuk Keperawatan. Kriteria inklusi adalah artikel berbahasa Inggris, pasien PPOK. Hasil akhir diperoleh 7 artikel yang memenuhi kriteria dalam mengikuti pelingkupan. Analisis menunjukkan bahwa yoga adalah latihan pernapasan.Latihan pernapasan bibir, inspirasi dan ekspirasi yang dapat meningkatkan saturasi oksigen, produksi lendir, kapasitas vital paru-paru, nilai tes jalan enam menit, mengurangi dispnea dan frekuensi pernafasan. 
HYPOGLYCAEMIC EFFECTS OF JAVANESE GINSENG (Talinum paniculatum (Jacq.) Gaertn.) ROOT INFUSION ON ALLOXAN-INDUCED DIABETIC RATS Ikhlas Muhammad Jenie; Rosefani Intan Indraswari
Jurnal Kedokteran Hewan Vol 15, No 3 (2021): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i3.19568

Abstract

To examine whether Javanese ginseng root has an antihyperglycaemic effect, twenty-one male Rattus norvegicus rats were randomly divided into four groups: negative control (n= 3), positive control (n= 4), treatment (n= 7), and placebo (n= 7). Alloxan was injected intraperitoneally at a single dose of 80 mg/kg BW to rats to induce hyperglycaemia. Infusion of Javanese ginseng root or distilled water was given at a dose of 2% w/v solution with a volume of 1.8 mL/200 g BW per day for 14 days through an enteral feeding tube to either the treatment or placebo group, respectively. Blood glucose levels were measured using the colorimetric method. One-way analysis of variance (ANOVA) was used to examine differences in the mean of delta blood glucose (post intervention minus post alloxan blood glucose levels) among groups, followed by Tukey’s post hoc analysis. A P value 0.05 was considered statistically significant. There was a significant difference (P= 0.0001) in delta blood glucose among groups. Post hoc analysis revealed that delta blood glucose in the treatment group (-102.99±2.26 mg/dL) was significantly (P= 0.0001) greater than in the placebo (2.45±0.29 mg/dL), positive control (3.05±0.70 mg/dL) and negative control (1.60±0.17 mg/dL) grou p. In conclusion, Javanese ginseng root has potential as a hypoglycemic agent in alloxan-induced diabetic animal models