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All Journal PHARMACON CHEMISTRY PROGRESS Majalah Obat Tradisional Kartika Jurnal Ilmiah Farmasi Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research Molekul: Jurnal Ilmiah Kimia

Sri Sudewi, Sri

Department Of Pharmacy, University Sam Ratulangi

Author-ID : 514525

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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ISOLATION AND IDENTIFICATION OF FREE RADICALS SCAVENGER FROM Daucus carota L LEAVES Sri Sudewi; Subagus Wahyuono; Puji Astuti
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The presence of free radicals produced inside the cells is thought to cause a range of diseases such as degenerative diseases. Antioxidant properties of carrot root (Daucus carota L.) have been reported elsewhere to inhibit the formation of these free radicals, but the compounds responsible for antioxidant activity inside its leaves have not yet determined. In Indonesia, Daucus carota L. leaves are regarded as waste product after harvesting the root. This study was conducted to isolate and identify the compound having antioxidant activity from the leaves of D.carota. n-Hexane, ethyl acetate, and methanol extracts were examined for free radical scavenger activity by using DPPH method. The n-hexane extract showing free radical scavenger activity was solid-solvent partitioned, fractionated using vacuum liquid chromatography and tested for free radical scavenger activities. The active compound was isolated by using preparative thin layer chromatography and its purity was determined by TLC with three mobile phase systems and two dimensional TLC. Based on spectroscopy UV-Vis, IR as well as 1H-NMR (CDC13) data, the active compound was suggested to be xanthophyll derivate, lutein. The compound at concentration of 0.616, 1.025, and 2.05 ppm had antioxidant activities of 0.94 ± 0.05; 18.53 ± 0.15; and 49.07 ± 0.86, respectively.

THE CHEMICAL CHARACTERISTICS AND ANTIOXIDANT ACTIVITY OF STARCH FROM SAGO BARUK PITH (Arenga microcarpha) Lidya Irma Momuat; Edi Suryanto; Sri Sudewi
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Sago Baruk (Arenga microcarpha) is one of endemic crop type of Archipelago of Sangihe Talaud, North Sulawesi and potential as source bioactivities including antioxidant. The objectives of this research were to determine the chemical characteristics and antioxidant activity of starch sago baruk which was sequentially extracted with water and filtrate. The sago trunks pith was sequentially extracted with water and filtrate at room temparature for 1 hour. After that, starch of sago baruk were analyzed for their chemical composition (moisture, fat, protein, ash crude fiber and charbohydrate) and total phenolic and tannin condensed content. Antioxidant activity of each sago flour were evaluated in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and total antioxidant capacity. After that, the starch was characterized by IR spectroscopic technique. The sequential extraction result indicated percentage yield of starch I and starch II were 41.39% and 38.21%. The chemical characteristics of starch I revealed that percentage protein, ash, crude fibre and fat were below 1% than starch II especially protein and fiber crude. The starch I had highest total phenolic and tannin condensed content than starch II and starch K. The starch I also showed the highest free radical scavenging activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical than starch II and starch K. The result also showed that starch I has strongest total antioxidant capacity than starch II and starch K at all concentration level. Antioxidant activity of three starch increased with the increase in concentration of the samples. The three starch showed of hidroxy (OH), carbonyl (C=O), ether (C-O) and aliphatic group (C-C). It is concluded that starch sago baruk especially the starch I are very rich in antioxidant substituens.

Determination Sun Protecting Factor (SPF) Of Krokot Herbs Extract (Portulacaoleracea L.) Widya Astuty Lolo; Sri Sudewi; Hosea Jaya Edy
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 1 (2017)
Publisher : Universitas Sebelas Maret

Purslane is a plant that thrives in open areas and has a fairly high water content. Hereditary purslane plant has been used for skin protection from the sun. The aim of this study is to determine the value of Sun Protecting Factor (SPF) of ethanol extracts, soluble and insoluble fractions of ethyl acetate from purslane herb.Extraction using maceration method by ethanol 90%. Fractionation process is the partition obtained soluble and insoluble fractions of ethyl acetate. Absorbance values read using UV-VIS spectrophotometry at a wavelength of 290-320 nm. SPF value is obtained for the ethanol extract 19.495, 20.829 for the soluble fraction of ethyl acetate and 30.055 for an insoluble fraction of ethyl acetate.

Co-Authors Adam, Nadia Adithya Yudistira Agnes, Agatha Antasionasti, Irma Atuani, Maria Atuani, Maria T Defny S. Wewengkang, Defny S. Edi Suryanto Edi Suryanto Fangohoy, Juliandro Fatimawali . Gayatri Citraningtyas Henki Rotinsulu, Henki Hosea Jaya Edy Jayanto, Imam Kambey, Bella Katiandagho, Lyone Kosasi, Cicilia Leo Arifsandi Budiarso, Leo Arifsandi Lidya Irma Momuat Manoppo, Triska Melkianus, Brando Muhatir, Ary Muzdhalifah, Balqis Nangaro, Jesica Puji Astuti Puji Astuti Rizky H. Mawardi Rondonuwu, Samuel D. J. Rumoroy, Jhon D. Siampa, Jainer Pasca Subagus Wahyuono Subagus Wahyuono Suoth, Josua Suoth, Josua A.T. Wewengkang, Defny Wewengkang, Defny S Widya Astuty Lolo Widya Astuty Lolo, Widya Astuty

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