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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Al-Tadzkiyyah E-Dimas: Jurnal Pengabdian kepada Masyarakat Prosiding Penelitian dan Pengabdian kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) Lentera: Jurnal Ilmiah Kependidikan Journal of Pharmacopolium MATAPPA: Jurnal Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia JURNAL ILMU KEFARMASIAN INDONESIA Unnes Journal of Mathematics Education Research Pharmacoscript J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Pengabdian Pada Masyarakat Jurnal Kesehatan Bakti Tunas Husada
Ruswanto, Ruswanto
Department Of Pharmacy, Faculty Of Pharmacy, Universitas Bakti Tunas Husada Tasikmalaya
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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
Total phenol, flavonoid, and anthocyanin content and antioxidant activity of Etlingera elatior extract and nanoparticle Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Ruswanto, Ruswanto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.338 KB) | DOI: 10.12928/pharmaciana.v8i1.7511

Abstract

Despite the long and wide application, traditional medicine is known for its minimum efficacy. Nanoparticle technology has reported to optimally address this weakness by enhancing the ability of the medicine to penetrate the biological membrane and, thereby, increasing the absorption. In this research, Etlingera elatior (ginger flower) extract, which has antioxiandt activity, was formulated into nanoparticles with ionotropic gelation method using chitosan (0.08, 0.09, 0.1, 0.2, and 0.3%) and 0.01% NaTPP. The nanoparticles were characterized by their particle size, polydispersity index, zeta potential, and entrapment efficiency against total phenolic compound, flavonoid, and anthocyanin. The ones with the best properties were then analyzed with Scanning Electron Microscopic (SEM) method and tested for its antioxidant activity against DPPH. The results showed that all of the formula variations produced particle size in the range of 147.0-566.2 nm with a polydispersity index of < 0.5 and zeta potential between 0.45-45.90 mV. Also, the absorption efficiencies of phenol, flavonoid, and anthocyanin were 72.62-84.24%, 55.18-92.05%, and 75.67-97.96%, respectively. Overall, the best characteristics were presented by the combination of 0.1% chitosan and 0.01% NaTPP, which produced 246.4-nm nanoparticles with a polydispersity index of 0.418, and zeta potential of 26.60 mV. These nanoparticles also contained phenol, flavonoid, and anthocyanin with good absorption efficiencies, namely 78.5186%, 92.05%, and 97.96%, respectively. SEM analysis showed that these nanoparticles were round and had a soft surface. The radical scavenging activities of the extract and the nanoparticles against DPPH, as presented by the IC50 values, were 19.614 ppm and 160 ppm.
In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto, Ruswanto; Mardianingrum, Richa; Lestari, Tresna; Nofianti, Tita; Tuslinah, Lilis; Nurmalik, Dudi
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB) | DOI: 10.12928/pharmaciana.v8i2.8993

Abstract

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORα that is goyaglikosida-h and more potent than Rosiglitazon
In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto Ruswanto; Richa Mardianingrum; Tresna Lestari; Tita Nofianti; Lilis Tuslinah; Dudi Nurmalik
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.456 KB) | DOI: 10.12928/pharmaciana.v8i2.8993

Abstract

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORα that is goyaglikosida-h and more potent than Rosiglitazon
Total phenol, flavonoid, and anthocyanin content and antioxidant activity of Etlingera elatior extract and nanoparticle Tresna Lestari; Tita Nofianti; Lilis Tuslinah; Ruswanto Ruswanto; Yulia Salmini; Dewi Dewi; Leli Siti Zaqiah; Anggi Agustira; Putri Pratiwi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.338 KB) | DOI: 10.12928/pharmaciana.v8i1.7511

Abstract

Despite the long and wide application, traditional medicine is known for its minimum efficacy. Nanoparticle technology has reported to optimally address this weakness by enhancing the ability of the medicine to penetrate the biological membrane and, thereby, increasing the absorption. In this research, Etlingera elatior (ginger flower) extract, which has antioxiandt activity, was formulated into nanoparticles with ionotropic gelation method using chitosan (0.08, 0.09, 0.1, 0.2, and 0.3%) and 0.01% NaTPP. The nanoparticles were characterized by their particle size, polydispersity index, zeta potential, and entrapment efficiency against total phenolic compound, flavonoid, and anthocyanin. The ones with the best properties were then analyzed with Scanning Electron Microscopic (SEM) method and tested for its antioxidant activity against DPPH. The results showed that all of the formula variations produced particle size in the range of 147.0-566.2 nm with a polydispersity index of < 0.5 and zeta potential between 0.45-45.90 mV. Also, the absorption efficiencies of phenol, flavonoid, and anthocyanin were 72.62-84.24%, 55.18-92.05%, and 75.67-97.96%, respectively. Overall, the best characteristics were presented by the combination of 0.1% chitosan and 0.01% NaTPP, which produced 246.4-nm nanoparticles with a polydispersity index of 0.418, and zeta potential of 26.60 mV. These nanoparticles also contained phenol, flavonoid, and anthocyanin with good absorption efficiencies, namely 78.5186%, 92.05%, and 97.96%, respectively. SEM analysis showed that these nanoparticles were round and had a soft surface. The radical scavenging activities of the extract and the nanoparticles against DPPH, as presented by the IC50 values, were 19.614 ppm and 160 ppm.
Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate Ruswanto Ruswanto; Winda Trisna Wulandari; Richa Mardianingrum; Indah Cantika
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.942 KB) | DOI: 10.12928/pharmaciana.v11i1.17837

Abstract

Thiourea derivatives were much used in drug discovery and drug-making, such as for an anticancer. The formation of drug complexes can increase lipophilicity through chelation formation, and the drug action is significantly upward due to the effective permeability to the center. In another study, the alteration of the compound becomes the complex with metal will grow in its activity so recently we have synthesized the Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron (III) complex.  The synthesis of Fe (III) metal with the 4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide in ethanol by reflux at 75oC for 7 hours. Hot Stage Microscopy, UV-Visible Spectrophotometry Infrared Spectrophotometry, and Massa Spectrophotometry were used to characterize the complex. This study concerns representing, inferring, and predicting pharmacokinetics and toxicity and molecular docking complexes. The complex weight was 0.29469 g. Its purity has been tested using the melting point determination and has obtained its range was 113o-115oC. The Characteristics of Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron(III) complex have a maximum wavelength of 260,0 nm and provide absorption of Fe-O vibrations at wavenumbers 478,2 cm-1and 588 cm-1, and the m/z complex of spectrophotometry mass was 559,31. The molecular docking process was performed using AutodockTools-1.5.6 software. It showed that Bis-(4-(Tert-Butyl)-N-(Methylcarbamo-thioyl)Benzamide)-Iron(III) complex could interact with ribonucleotide reductase enzyme, and it has better interaction than the 4-(Tert-Butyl)-N-(Methylcarbamothioyl)Benzamide with the binding affinity energy (ΔG)of  -8,52 kcal/mole and the constant inhibition (Ki ) of 568,55 nM.
Co-Authors A.A. Ketut Agung Cahyawan W Aas Nuraisah Aas Nuraisah Aas Nuraisah Ade Dwi Septian Aguslina Kirtishanti Ahmad Tantowi Jaohari Aimi Ratnasari Aimi Ratnasari, Aimi Alicia Nadira Alifia Nurfadhilah S Anggi Agustira Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anna Yuliana, Anna Annazalia Rustandi Putri Annisa Pebiansyah Annisa Pebiansyah Arry Yanuar Asep Nugraha Citra Dewi Salasanti Deden Makbuloh Deliani Deliani Delis Susilawati Dewi Dewi Diana Sri Zustika Dini Febianeu Ditha Rizqi Aulia Utami Dudi Nurmalik Dwijanto Dwijanto, Dwijanto Elsa Oktavia Angelica Elsi Eryanti Fajar Setiawan FAJAR SETIAWAN Fanisa Riadhiani Fathurohman, Mochamad Firman Gustaman Gatut Ari Wardani Gatut Ari Wardani Gatut Ari Wardani Gatut Ari Wardani Gatut Ari Wardani Gatut Ari Wardani Gina Maya Lestari Gina Septiani Agustien Gina Yulias Triyani Ginna Sri Nuryani Hendy Suhendy Heri Herdiana Hery Wibowo, Hery Himyatul Hidayah Ilham Alifiar Ilham Alifiar Ilham Alifiar Imam Mustaqim Garna Indah Cantika Ira Rahmiyani Kamiel Roesman Bachtiar Korry Novitriani Korry Novitriani, Korry Leli Siti Zaqiah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah, Lilis Lusi Nurdianti Lusi Nurdianti, Lusi M. Faturohman Mardhiah Mardhiah Mardhiah Mardhiah Melia Fujiyanti Meylany Sity Rossy Lestary Mina Fauziah Mitha Anggitha Moch. Zainuddin, Moch. Mochamad Fajar Deliaz Mochamad Fathurahman Mochamad Fathurohman Muharam Priatna Muharam Priatna Muharam Priatna Neni Sri Gunarti Neta Ekayanti Suganda Nida Puspa Dewi Nisa Uswatun Khasanah Nofianti, Tita Nofianti, Tita Nofriyaldi, Ali Nugraha, Asep Nur Aji Nur Laeli Dwi Hidayati Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih Nur Rahayuningsih Nurlaili Dwi Hidayati Nurmalik, Dudi Nurul Kamilah Oktaviani Ayu Saputri Paras Layna Safa Pikri Adit Praditya R Pratita, Anindita Tri Kusuma Putri Pratiwi Raja Ramadiansyah Richa Mardianingrum Richa Mardianingrum Richa Mardianingrum Richa Mardianingrum Richa Mardianingrum Richa Mardianingrum Richa Mardianingrum Rika Zahara Dewi Rissa Putri Aulia Yulianto Rivaldi Muhsin Saeful Amin Saeful Amin Saeful Amin Sarwatiningsih, Yunia Sedin Renadi Shal Nurdinda Fauziah Sindi Lestari Siswandono, Siswandono Sri Asih Srie Rezeki Nur Endah Sukma Ayudia Susanti Susanti Susanti Susanti Taufik Hidayat Tiara Permata Sari Tifa Nofianti Tira Mutiara Utami Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tresna Lestari, Tresna Tuslinah, Lilis Tuslinah, Lilis Vera Nurviana Wardani, Gatut Ari Wemfi Riska Roswandi Widya Oktaviani Wildan Rizki Asilmi Wina Aprilia Setiawati Winda Trisna Wulandari Wini Wahyuni Wiwin Kristiana Yana Herdiana Yulia Salmini Yundari, Yundari