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All Journal EKSAKTA: Journal of Sciences and Data Analysis KOVALEN: Jurnal Riset Kimia Jurnal Pendidikan Kimia (JPKim) Jurnal Kartika Kimia Jurnal Ilmiah Teknik Kimia

Micha Mahardika

Jurusan Kimia, Sekolah Tinggi Analis Kimia Cilegon

Author-ID : 6029311

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Materials Science & Nanotechnology

Published : 8 Documents Claim Missing Document

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Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material Micha Mahardika; Fauzan Amin; Ika Agustia Umami; Boima Situmeang; Agus Malik Ibrahim
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 1 (2021): April
Publisher : Pascasarjana Universitas Negeri Medan

Drug delivery system is a system that describes the journey of a drug to its target location. The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%; 266,7%; 303.3%; 586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes.Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, Seaweed

Synthesis and characterization of gold nanoparticles using fruit extract of Crescentia cujete L Fauzan Amin; Micha Mahardika; Nada Morisca
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 3 (2019): December
Publisher : Pascasarjana Universitas Negeri Medan

Nanoparticles play important role in biotechnology such as food and drug industries. Gold nanoporticles(Au-NPS) have been wdely used in any drug therapies like drug delivery system for cancer, tumor, and diabetes treatment. Recently, Au-NPS have been devoleped to increase drug selectivity between tumor and normal cells. In the present studies, we use the fresh fruit ekstract (FFE) of crescentia cujete L mediated blue green alga for the synthesis of Au-NPS. The characterization of Au-NPS was carried out by using UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and Transmission Electron spectroscopy (TEM). UV-VIS spectrometry indicated formation of nanoparticles which produces an intense absorbance peak at 531 nm. FTIR reveales the functional group involved in reduction and stabilization of Au-NPS. TEM have shown the morphology of Au-NPS with mean size 10,11 nm.Keywords: Crescentia cujete; gold nanoparticles; green alga

Iron Fortification and bioavailibility of homemade tempeh with sesame seed Fauzan Amin; Micha Mahardika; Dianastya Yuniarti
Jurnal Pendidikan Kimia (JPKim) Vol 12, No 3 (2020): December
Publisher : Pascasarjana Universitas Negeri Medan

Iron deficiency anemia is caused by the low intake of iron from foods. The purpose of this research was to make fortified tempeh using sesame seed with a high potential utility as iron fortificant. The iron bioavailability was carried out in vitro by simulating human digestion for raw and cooked tempeh. The iron fortificant added were 0, 10, 20, 25, 30 ,40 and 50% of sesame seed to substitute 100 grams of soybeans. The results of this study showed that the highest Fe content of 0.4539 mg was obtained by replacing 50% soybean with sesame seed. But after cooking, there is a decrease in boiled for 10, 20, 30,40,50% variants and increase in fried for 0, 10, 25, 30% variants.Keywords: Anemia, Tempeh, Fortification, Sesame seed

Co-Authors Agus Malik Ibrahim Aisyiah Restutiningsih Putri Utami Arda Ganda Risdiyono Boima Ramses Situmeang Boima Situmeang Boima Situmeang Dany Dewaldo Dianastya Yuniarti Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Ibrahim, Agus Malik Ika Agustia Umami Isna Lailatusholihah - Nada Morisca Ninik Triayu Susparini Siti Fatimah Umar Fauzi Uvi Dwiyana

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