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All Journal BALI MEDICAL JOURNAL (BMJ) INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Journal Pharmaceutical Science and Application (JPSA) Jurnal Kimia (Journal of Chemistry) International Journal of Biosciences and Biotechnology Buletin Udayana Mengabdi Jurnal Farmasi Udayana INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Jurnal Biologi Udayana Jurnal Farmasi Klinik Indonesia Jurnal Kefarmasian Indonesia Journal of Health Sciences and Medicine Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Rini Noviyani
Department Of Pharmacy, Faculty Of Mathematics And Sciences, Udayana University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Journal of Health Sciences and Medicine

 1 
DIFFERENCE OF SGOT AND SGPT LEVEL IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS BEFORE AND AFTER CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR R. Noviyani
Journal of Health Sciences and Medicine Vol 2 No 1 (2018): JHSM (February 2018)
Publisher : Institute for Research and Community Services Udayana University

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Abstract

Objective:Cervical cancer became Indonesia’s highest prevalent gynecological cancer in 2013 and the highest prevalent gynecological cancer at Sanglah Hospital.Paclitaxel Carboplatin is one of the regimens used for cervical cancer treatment at Sanglah Hospital, Denpasar. Aside of providing therapeutic effect, this regimen also causes hepatotoxicity. This research was trying to determine the toxic effect of Paclitaxel Carboplatin towards liver function based on the difference of SGOT and SGPT levels before chemotherapy cycle I and after chemotherapy cycle VI. Method:This wasa prospective observational research with a study case method conducted from January 2017 until June 2017 at Obstetric Polyclinic of Sanglah Hospital, Denpasar.Samples’ SGOT and SGPT level before and after chemotherapy I and VI were recorded and were then analysed with Shapiro-Wilk normality test. If the data were distributed normally, they would undergo tpaired test and Wilcoxon test at 95% confidence level if they were not distributed normally. Results: Tenpatients fulfilled the research criteria. There was a meaningless increase for SGOT level (p=0.575) along with a meaningless increase for SGPT level (p=0.074) before and after Paclitaxel Carboplatin chemotherapy cycle I and VI respectively.Conclusion: Research of toxic effect from Paclitaxel Carboplatin chemotherapy in 10 squamous cell cervical cancer patients showed a meaningless difference of both SGOT and SGPT level with the value of p>0.05 in stadium IIB-IIIB squamous cell cervical cancer patients before and after Paclitaxel Carboplatin chemotherapy cycle I and VI respectively.
Co-Authors A.A Ayu Dessy Satriani Putri A.A. Raka Karsana AA Agustia Sinta Dewi Anak A. A. W. P. Dewi Budiana, Nyoman Dewa Ayu Swastini Dewi, Anak A. A. W. P. F.S. Suherman Gusti Ayu Putu Prima Purnamasari I Ketut Suwiyoga I Ketut Tunas I Nyoman G. Budiana I Nyoman Gede Budiana I Nyoman Gede Piliarta I Putu Triyasa I. F. W. Putra I. Lesmana Indah Mei Rahajeng Intan Puspa Ketut Ariawati Ketut Widyani Astuti Luh Putu Mirah Kusuma Dewi Mahardika Aprilia Iflahah Ni Kd Rintan Listiani Ekayanti Ni Made Intan Pertiwi Ni Putu Ariantari Puspa, Intan Putu Ayu Indrayathi Putu Ita Purnama Dewi R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Sagun Chandra Yowani Sagung Chandra Yowani Sari Mynarti Sita Udayanti