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Sri Teguh Rahayu, Sri Teguh
Faculty of Health Sciences Esa Unggul University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Pharmaceutical Sciences and Research (PSR)

 1 
Uji Aktivitas Penghambatan Xantin Oksidase secara In-Vitro oleh Isolat 6,4’-Dihidroksi-4-Metoksibenzofenon-2-O-β-D Glukopiranosida(C20H22O10) yang Diisolasi dari Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Rina Yanti Eff, Aprilita; Rahayu, Sri Teguh; Syachfitri, Resta Dwi
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Hyperuricemia is a condition in which an increasing in uric acid levels abovenormal. Hyperuricemia is a major factor in the development of gout. Gout is adisease caused by the accumulation of monosodium urate crystals in the tissues dueto elevated levels of uric acid. Crown gods (Phaleria macrocarpa (Scheff.) Boerl) is Indonesia native medicinal that has effect such as lowering blood pressure, diabetes mellitus drugand lowering uric acid levels. One of the chemical constituents of this plant is abenzopheneon compound that is 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10). Research was conducted to determine the activity of 6,4’-dihydroxy -4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) that isolated from Crown gods in inhibiting xanthine oxidase by in-vitro method using spechtrofotometer with allopurinol as a positive control.The results showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) has inhibitory activity against xanthine oxidase with IC50 values 15.705 mg / mL. However, allopurinol has xanthine oxidase inhibitory activity higher than isolates with IC50value of 0.091 mg/mL. Lineweaver-Burk plot showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida(C20H22O10) has a competitive inhibitory activity.
Respon Bioakumulator Eceng Gondok (Eichhornia crassipes) Terhadap Logam Berat Pb dan Cd di Sungai Pegangsaan Dua Rahayu, Sri Teguh; Faradilla, Meutia; Verawati, Ester Yani; Triana, Muchrip
Pharmaceutical Sciences and Research Vol. 1, No. 1
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Eichhornia crassipes is one of Indonesia’s wild plant that considered as weed. Its presence can disrupt ecosystems in the river. However, it is proven to absorb Pb and Fe. It is also believed that E.crassipes can absorb other metals such as Hg , Zn , Cu and Cd which were belong to the same group as Pb and Fe. In addition to heavy metal sequestration, Eichhornia crassipes can also absorb pesticide residues. This descriptive research was done to determine the bioaccumulator response to Pb and Cd in Pegangsaan Dua river using Inductively Coupled Plasma method. Bioaccumulator response of Eichhornia crassipes were analyzed from the stem. The results of the study also showed that the Eichhornia crassipes plants were able to accumulate heavy metals of Pb and Cd. The organs most potential to absorb Cd and Pb were stem organ with average point 1 of Cd : 0,056 ppm and Pb : 0,5002 ppm, then the average point 2 of Cd : 0,0328 ppm and Pb : 0,0215 ppm , and the average point 3 of Cd : 0.0143 ppm and Pb : 1,293 ppm . In this end, it is suggested that the stem organ could be developed as bioaccumulation agent.
Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Eff, Aprilita Rina Yanti; Ayu Pertiwi, Reza; Ehe Hurit, Hermanus; Rahayu, Sri Teguh; Eden, Yonatan
Pharmaceutical Sciences and Research Vol. 9, No. 1
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Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.
Co-Authors Abna, Inherni Marti Agung Setiawan Ahmad Mahfud Angelina Pasaribu Ani Vivi Listiyowati Aprilita Rina Yanti Eff Aprilita Rinayanti Ayu Pertiwi, Reza Ayu Puspita Lena De Vita Enjelin Dea Fauziyah Eden, Yonatan Ehe Hurit, Hermanus Elsa Deni Pebrianti Erry Yudha Mulyani Ester Yani Verawati, Ester Yani Harizal Harizal Hermanus Ehe Hurit Itsna Taufiqur Rohmah Ivana Thresia Yenhart Luqyyana Hanifah Maulina Rizkyana Megawati Mellova Amir Meutia Faradilla, Meutia Miftahul Ilmy Setiawan Miza Mustika Muchammad Reza Ghozaly Muchrip Triana, Muchrip Muh Dewa Putra Muhammad Raihan Muhammat Khairun Nafa Nesya Rizadilla Nur Septiyani Nur, Syurya Muhammad Putu Gita Maya Widyaswari Mahayasih Rafi Perdana Tamher Resta Dwi Syachfitri, Resta Dwi Rina Yanti Eff, Aprilita Robby Rijal Sauri Safira Sholihat Silviana Dewi Tria Saras Pertiwi Tyas Putri Utami Wafiq Qutrotul Aeni Soba Wahyuni, Yulia Yosi Valencia Yuliati Yuliati