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Pengaruh Konsumsi Susu Kedelai terhadap Blood Clotting Time Kurniati, Ika Dyah; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (s) (2008): April
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i1 (s).1638

Soy is raw material of food know and tempeh which have so common among Indonesian society. In the reality soy not only made as food. Soy also can be made milk. High enough protein that content at soy milk have important role in calcium metabolism. Calcium besides good for forming of bone and tooth, and also maintain health of nerve function and muscle, also to help blood coagulation at hurt. The objective of this esearch is to measure the duration time of blood coagulation (clotting time) at subject which given soy milk and subject which do not given soy milk, and also compare the result of measurement between both. Research design used is pretest - post test control group design, using subject 10 people and divided randomly in 2 groups. Group I is group of subject which given soy milk 200 cc twice one day during 14 day. Group II is negative control group and subject did not get treatment. Blood sample was taken before and after research, and measured it clotting time using modification way of Lee White â€™s. Result of this research showed that consuming soy milk can quicken clotting time, but this influence were not significantly different (p 0,05). The average of clotting time of group I before given of soy milk 06.26 minut /ml and after it 05.07 minute/ml, average of clotting time of group II before research 04.38 minute/ml and after research 06.36 minut/ml.Kedelai adalah bahan baku makanan pada tahu dan tempe yang sudah begitu melekat di kalangan masyarakat Indonesia. Kedelai juga dapat dijadikan susu. Kandungan protein yang cukup tinggi pada susu kedelai mempunyai peran penting dalam metabolisme kalsium. Kalsium selain berguna untuk pembentukan gigi dan tulang, serta mempertahankan kesehatan fungsi syaraf dan otot, juga membantu pembekuan darah pada luka.Tujuan penelitian ini adalah untuk mengukur lamanya waktu pembekuan darah (bloodclotting time) pada subjek yang diberi susu kedelai dan subjek yang tidak diberi susu kedelai, serta membandingkan hasil pengukuran antara keduanya. Rancangan penelitian yang digunakan adalah pretest - post test control group design, dengan menggunakan subjek sebanyak 10 orang dan dibagi secara acak dalam 2 kelompok. Kelompok I adalah kelompok subjek yang diberikan susu kedelai 200 cc dua kali sehari selama 14 hari. Kelompok II merupakan kelompok kontrol negatif dan subjek tidak mendapat perlakuan. Sample darah diambil pada sebelum dan sesudah penelitian, dan diukur clotting time-nya dengan menggunakan modifikasi dari cara Lee White.â€ƒ Hasil penelitian menunjukkan bahwa susu kedelai dapat mempercepat blood clotting time, namun tidak signifikan (p 0,05) secara statistik. Rerata clotting time kelompok I sebelum pemberian susu kedelai 06.26 menit/ml dan setelah pemberian 05.07 menit/ml. Rerata clotting time kelompok II sebelum penelitian 04.38 menit/ml dan setelah penelitian 06.36 menit/ml.

Perbandingan Kadar Methemoglobin dan Hemoglobin Penduduk Endemis dengan Penduduk Non Endemis Malaria Astuti, Yoni; Handayani, Rini
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2006)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v6i2.1895

One of the effects of Plasmodium infection and consumption of anti-malaria medicine is the increase of free radicals in the body. Free radicals can attack haemoglobin and change it to met-haemoglobin. The aim of this study was to identify the concentration of met- haemoglobin (as a sign of free radicals) and haemoglobin of individuals living in the malaria- endemic area as compared with individuals living in non-malaria-endemic area.This was a cross sectional study. Subjects of the study were 60 individuals and divided into 2 groups, i.e. Endemic Group (EG) and Non-Endemic Group (NEG). The EG included 30people who were men and women between 20-50years old, had suffered or were suffering from malaria and had been living in endemic area for five years. The NEG included 30 people who were men or women between 20-50 years old and had not suffered from malaria. The blood samples were collected and analysed for met-haemoglobin concentration using Betke method and haemoglobin concentration using cyanmethaemoglobin method.The results showed that the average of met-haemoglobin concentration of NEG was (2,188 Â± 0,662)% and EG was (3,728 Â± 0,492)%, while the average of haemoglobin concentration of NEG was (14, 183 Â± 2,593)g% and EG was (10,376 Â± l,447)g%. This demonstrated that the concentration of haemoglobin between NEG and EG was different significantly (p 0,05).Salah satu akibat terinfeksi plasmodium dan dampak mengkonsumsi obat - obatan menyebabkan meningkatnya radikal bebas. Radikal bebas dapat menyerang haemoglobin sehingga menj adi methemoglobin. Tujuan penelitian ini adalah untuk mengetahui kadar methemoglobin (sebagai marker radikal bebas) dan hemoglobin penduduk endemis malaria dibandingkan dengan kadar methemoglobin penduduk non endemis.Penelitian ini adalah penelitian cross sectional dengan subyek sebanyak 60 orang dibagi menjadi 2 kelompok. Kelompok endemik malaria sebanyak 30 orang yaitu laki-laki dan wanita berumur20-50 tahun yang pernah atau sedang menderita malaria dan telah tinggal di daerah endemis selama minimal lima tahun. Kelompok non endemik malaria sebanyak 30 orang yaitu laki-laki dan wanita berusia 20-50 tahun yang tidak pemah menderita penyakit malaria. Subyek diambil darahnya dan selanjutnya dilakukan analisis kadar methemoglobin menurut metode Betke, dan diukur kadar hemoglobin dengan metode cyanmethemoglobin.Hasil penelitian menunjukkan bahwa persentase methemoglobin KNE (Kelompok Non Endemis) adalah (2,188 Â± 0,662) % Hb dan KE (Kelompok Endemis) adalah (3,728 Â± 0,492) % Hb. .Hasil penelitian kadar hemoglobin menunjukkan bahwa persentase hemoglobin KNE adalah (14,183 Â± 2,593) g % dan KE adalah (10,376 Â± 1,447) g %. Hal itu memperlihatkan adanya perbedaan signfikan antara KNE dan KE (p 0,05).

Penurunan Kadar Interleukin-18 Cairan Peritoneal pada Penderita Endometriosis Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2004)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v4i2.1751

Penelitian ini dilakukan dengan tujuan untuk menentukan konsentrasi interleukin- 15 (IL-18) pada cairan peritoneal dan serum penderita endometriosis yang -bandingkan dengan kelompok control( tidak menderita endometriosis). Metode penelitian yang digunakan adalah kajian analitik prospektif. Subyek yang terlibat sebanyak 44 penderita yang melakukan bedah laparoscopic pada penyakit ginekologi ringan. Pengambilan cairan peritoneal dan serum sebagai specimen ulakukan sebelum dan sesudah tindakan bedah laparoskopis untuk analisis kadar IL-18. Konsentrasi IL-18 cairan peritoneal dan serum dihubungkan dengan adanya endometriosis, tingkat penyakit, dan fase siklus menstruasi. Hasilnya menunjukkan bahwa Interleukin -18 dapat dideteksi pada 98% specimen cairan peritoneal dan 84 pada specimen serum. Konsentrasi IL-18 cairan peritoneal secara statistic lebih rendah bermakna pada penderita endometriosis dari pada kelompok control. Sedangkan IL-18 serum tidak menunjukkan perbedaan bermakna antara penderita fndomeriosis dan kelompok kontrol. Konsentrasi IL-18 cairan peritoneal dan serum remyata tidak berhubungan dengan endometriosis, maupun fase siklus menstruasi. Kesimpulan dari hasil penelitian ini adalah turunnya kadar IL-18 pada cairan reritoneal penderita endometriosis berperan penting pada patogenesis penyakit ini.

Aktivitas Fisik Rutin untuk Mencegah Penyakit Degeneratif Kesetyaningsih, Tri Wulandari; Astuti, Yoni; Noor, Zulkhah
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 8, No 1 (2020): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/bdr.8176

Degenerative or metabolic disease is a disease caused by excessive activities that give people no time to maintain their body health. This continuous condition can increase the death risk. This phenomenon is widely found with the existence of obesity in many places including in Gamping hamlet, Ambarketawang village, Gamping district, Sleman regency. Recently, the trend of this disease has gone up. Therefore, creating the societyâ€™s awareness about this issue is necessary to do through an empowerment program. This program is expected to decrease the death risk caused by metabolic or degenerative disease mainly for housewives who have never-ending activities. The society empowerment program is implemented through an organization for women namely Family Welfare Program. This program implementation is done in some stages namely:1) early physical quality examination (body mass index, blood pressure, cholesterol levels, blood sugar and uric acid); 2) a group creation that concerns about healthy life; 3) socialization on healthy life pattern; 4) psychomotor routine gymnastics twice a week for 10 weeks; and 5) final physical quality examination. It is recorded from this empowerment program that 38.29 % suffers from obesity, 6.38 % suffers from diabetes mellitus (DM), 36.17 % suffers from high uric acid and 10.64 % suffers from hypercholesterolemia. After regular gymnastics twice a week in 10 weeks, it is recorded that the obesity decreases to 34.04 % and the DM decreases to 4.26%, while hypercholesterolemia increases to 17.02%. The uric acid, on the other hand, remains stable. To maintain their further health, continuous routine gymnastics, periodic medical check-up (at least once a year), especially for people aged 40 years. Another success of this program is the creation of Healthy Life Caring Community.

Pengaruh Pemberian Ekstrak Pare (Momordica charantia L) terhadap Motilitas dan Morfologi Sperma Mencit Astuti, Yoni; Fitriana, Selly; Rahayu, Nunuk Siti
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2009)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v9i1.1588

The role of man in Family Planning extend o the birth space is rare. Therefore, improvement efforts to create the family planning tools that have characteristic safe and reversible for man â€™s reproductive system are needed.It is wellknown that pare (Momordica charantia,L) showed the effect of spermatogenesis inhibition. The aim of this study is to reveal the influence of bitter melon extract on mice sperm activity. This experimental study used male mice which were given bitter melon extract by oral intubations. Twenty mice were divided into 2 groups. Group A was treated with bitter melon extract for 4 weeks and group B for 6 weeks. Each group were further divided into 5 subgroups which were treated with different dose 500, 600, 700, 800 mg/kg body weight/day and control subgroups were treated with aquadest. After this, mice were decapitated, and the left and right terminals of the epididymis were sectioned. Then the motility and morphology of the sperms cells were examined cupically. The results showed that there was a correlation between dose of extract, motility and morphology of sperms. The ANOVA analysis showed that there were significants differenced, at motility A(r = - 0,583), B(R = - 0,839) p = 0,27, normal morphology A(r = - 0,946), B(r = - 0,962) p = 0,000, abnormal morphology A(r = 0,930), B(r = 0,962) p = 0,000. It is concluded that the decreasing of motility and normal morphology of sperms were liniar with the increasing of dose and duration of extract treatment for sperm motility. The most minimally effective dosage were : 500 mg/weight/day during 4 weeks.Peran pria dalam mengikuti program Keluarga Berencana (KB) untuk menjaga jarak kelahiran anak masih sangat sedikit. Sehingga perlu usaha untuk menciptakan alat KB yang aman dan bersifat sementara bagi pria. Pare (Momordica charantiaL) diketahui memiliki efek penghambatan spermatogenesis. Penelitian ini menggunakan metode eksperimental. Mencit sebanyak 20 ekor terbagi dalam 2 kelompok. Kelompok A (kelompok diberi perlakuan selama 4 minggu dan kelompok B (kelompok yang diberi perlakuan selama 6 minggu). Tiap kelompok terdiri dari 5 sub kelompok dengan dosis berbeda, yaitu 500, 600, 700, 800 mg ekstrak pare/kg BB/hari dan sub kelompok kontrol yang diberi aquadest. Setelah masa perlakuan, mencit didekapitasi, epididimis bagian akhir dari saluran reproduksi sebelah kanan dan kiri diambil, dibuat suspensi dengan NaCl 0,9%. Dihitung motilitas sperma ,dihitung morfologi normal dan morfologi tidak normal. Hasil penelitian ini menunjukkan adanya korelasi antara dosis ekstrak dengan motilitas pada kelompok A : (r = -0,583) sedang pada kelompok B : (r = -0,839) dan korelasi dosis dengan morfologi sel sperma normal pada kelompok A : (r = -0,946), pada kelompok B : (r = -0,962) dan korelasi dosis dengan kelompok abnormal pada kelompok A : (r = 0,930) , pada kelompok B : (r = 0,962).Sedangkan uji ANOVA menunjukkan adanya beda nyata , yaitu antara dosis dengan pada motilitas p = 0,27 antara dosis dengan p = 0,000, morfologi abnormal p = 0,000. Disimpulkan bahwa penurunan motilitas dan morfologi sperma berbanding lurus dengan peningkatan dosis dan lama perlakuan. Dosis efektifminimal adalah 500mg/BB/hari selama waktu 4 minggu.

Pengaruh Pemberian Jus Belimbing Wuluh (Averrhoa bilimbi L) terhadap Kadar HDL dan LDL-Kolesterol pada Tikus Putih Hiperkolesterolemia Anggoro, Dedy Sukmo; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i2.3754

Hiperkolesterolemia terjadi jika kadar kolesterol melebihi batas normal. Belimbing wuluh mempunyai banyak kandungan senyawa yang dibutuhkan manusia diantaranya pektin. Pektin mempunyai peranan dalam menurunkan kadar kolesterol. Penelitian ini bertujuan untuk membuktikanÂ pengaruhÂ jus belimbing wuluh terhadap kadar HDL dan LDL-kolesterol pada tikus putih yang mengalami Hiperkolesterolemia. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian pre and post test design. Penelitian ini menggunakan tikus putih (Strain Wistar) jantan berusia 2 bulan dengan berat badan rata-rata antara 180 - 260Â gram. Jumlah subyek penelitian 16 ekor, dibagi menjadi 4 kelompok masing-masing terdiri dari 4 ekor tikus, yaitu kelompok I adalah kontrol, kelompok II perlakuan dengan dosis 2 ml/200grBB/ hari,Kelompok III dengan perlakuan 3 ml/200grBB/hari danÂ Â kelompok IV dengan perlakuan 4ml/200grBB/ hari). Sebelum diberi perlakuan semua kelompok diberi kuning telur untuk proses hiperkolestrolemia selama 15 hari.Data di uji dengan paired t-test dan one-way anova. Hasil menunjukkan bahwa dosis jus Wuluh yang paling baik dan signifikan (p 0,05) untuk menurunkan LDL-kolesterol dan menaikkan HDL-kolesterol serum darah tikus putih jantan yang mengalami hiperkolesterolemi adalah 4 ml/200grBB/hari. Dapat disimpulkan bahwa jus belimbing wuluh terbukti dapat menurunkan kadar LDL kolesterol dan menaikkan kadar HDL kolesterol pada tikus hiperkolesterolemia.Hypercholesterolemia occurs when cholesterol level exceeds from the normal value. Wuluh star fruit has some beneficial substances for human such asÂ Â pectin. Pectin was able to decrease cholesterol levels. This research aims to prove the influence of wuluh starfruit juice on serum HDL and LDL-cholesterol on hipercholesterolemia rats. This research is an experimental research, with the pre- pro test research design. This study used (Wistar strain) 2-month-old male rats which were an average weight between 180 to 260 grams. The Rats, were divided into 4 groups, each was 4 male rats. The group 1Â asÂ placebo and group II used dose 2 ml/200gr weight/day, Group III usedÂ dose 3 ml/200gr weight/day andÂ group IV used 4ml/ 200gr weight/day. Before treatment, all groups were given egg yolk for 15 days to make hipercholestrolemia. The data analyzed by one-way anova. The results showed that the best dose of wuluh starÂ Juice and most significant (p 0.05) to lower LDL-cholesterol and raise HDL-cholesterol blood serumÂ were 4 ml/200gr weight/day).The conclution of the research was Wuluh star fruit juice wasÂ proved decrease LDL Cholesterol and increase HDL cholesterol on Hipercholesterolemia rats.

Aktivitas Fisik Rutin untuk Mencegah Penyakit Degeneratif Kesetyaningsih, Tri Wulandari; Astuti, Yoni; Noor, Zulkhah
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 8, No 1 (2020): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/bdr.8176

Degenerative or metabolic disease is a disease caused by excessive activities that give people no time to maintain their body health. This continuous condition can increase the death risk. This phenomenon is widely found with the existence of obesity in many places including in Gamping hamlet, Ambarketawang village, Gamping district, Sleman regency. Recently, the trend of this disease has gone up. Therefore, creating the societyâ€™s awareness about this issue is necessary to do through an empowerment program. This program is expected to decrease the death risk caused by metabolic or degenerative disease mainly for housewives who have never-ending activities. The society empowerment program is implemented through an organization for women namely Family Welfare Program. This program implementation is done in some stages namely:1) early physical quality examination (body mass index, blood pressure, cholesterol levels, blood sugar and uric acid); 2) a group creation that concerns about healthy life; 3) socialization on healthy life pattern; 4) psychomotor routine gymnastics twice a week for 10 weeks; and 5) final physical quality examination. It is recorded from this empowerment program that 38.29 % suffers from obesity, 6.38 % suffers from diabetes mellitus (DM), 36.17 % suffers from high uric acid and 10.64 % suffers from hypercholesterolemia. After regular gymnastics twice a week in 10 weeks, it is recorded that the obesity decreases to 34.04 % and the DM decreases to 4.26%, while hypercholesterolemia increases to 17.02%. The uric acid, on the other hand, remains stable. To maintain their further health, continuous routine gymnastics, periodic medical check-up (at least once a year), especially for people aged 40 years. Another success of this program is the creation of Healthy Life Caring Community.

The Effect of Basil Leaf (Oscimum sanctum) to the Thrombocytes Number on Mice Yoni Astuti; Rum Wijayanti
International Journal of Public Health Science (IJPHS) Vol 5, No 1: March 2016
Publisher : Intelektual Pustaka Media Utama

Oscimum sanctum is herbal that was spread widely in Indonesia. Oscimum sanctum contains abundant of substances. One of the functions on Oscimum sanctum was anti-thrombocytes effect. This effect is associated with platelet function as a mechanical plug in the vascular injury during the normal homeostatic response. The disruption in thrombocytes function leads to disturb the blood clotting process. Therefore, The aims of the research were to prove the impact of Oscimum sanctum on the number of thrombocytes. This research used mice that divided into 3 groups, as a group I dose 250 mg/day (Oscimum sanctum infusion), group II dose 500 mg/day and the control group. We used clopidogrel as a positive control to determine the effectiveness of anti platelet effect. Data were analyzed by ANOVA showed that the existence of anti-thrombocyte effect in the Oscimum sanctum dose 500 mg/day was significantly different. This result proved that Oscimum sanctum has anti-thrombocytes effect by decreasing thrombocytes number.

Correlation of body mass index on waist circumference and blood pressure Yoni Astuti; Ikhlas Muhammad Jenie
International Journal of Public Health Science (IJPHS) Vol 9, No 4: December 2020
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v9i4.20443

The increasing number of elderly on these recent days demands an improved quality of health for the elderly. Independence of the elderly is important in order to be happy and not to be a burden on their families. Health monitoring continuously is an effort to prevent disruption on the health conditions of the elderly. The health status of elderly people is important to know to follow up on prevention programs for the emergence of certain diseases in the elderly. This study aims to look for potential health problems for elderly people in Gamping, Sleman, DIY, Indonesia. The method of this research was cross sectional analysis using secondary data. Sample collection is consecutive subjects. Subjects were 158 people with a mean age of men (67.8 ± 7.1) years while women were 67.5 ± 7.3 years. The data was analyzed using the bivariate correlation test with CI 99%. The results of the analysis showed that the average body mass index with an average waist circumference was positively correlated (r= 0.66; p: 0.000), but did not correlate with systole pressure (r= -0.009; p= 0.97) diastole (r= 0.093; p= 0.477), age (-0.05; p= 0.71), and gender (r= -0.146; p= 0. 27). The potential health problems among the elderly is the risk of high BMI due to the larger waist circumference

PELATIHAN LANSIA BEBAS NYERI LUTUT DI PATUKAN AMBARKETAWANG KECAMATAN GAMPING KABUPATEN SLEMAN Yoni Astuti; Triwulandari Kesetyaningsih; Ambar Relawati
Dinamika Journal : Pengabdian Masyarakat Vol 2, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.dj.2020.2.1.969

The increasing of Indonesian life expectancy needs to be balanced with the ability of independence in the health aspect of the elderly community. Patukan Ambarketawang Yogyakarta has high in a number of elderly people. Knee pain experienced by the elderly, which have an impact on reducing their activity and productivity. Isoquadrisep exercises are one of the non-pharmacological efforts that are recommended to prevent knee pain. Elderly Posyandu in Patukan Ambarketawang Gamping Sleman village conducts routine activities to control the health of the elderly in general such as to measure blood pressure. Posyandu cadres and elderly participants are not familiar with isoquadrisep exercises on the knee to reduce knee pain in the elderly. Community partnership service is carried out to form cadres and isoquadrisep exercise training to prevent elderly with knee pain. The method for this activity is Training Of Trainer on quadriceps exercise for cadres and some communities. The results of this activity are cadres have an isoquadricep exercise agenda at each elderly meeting alternating with other exercises that already existed in Patukan Ambarketawang Gamping.

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