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Journal : Majalah Biomorfologi (Biomorphology Journal)

BACTERIAL AND SENSITIVITY PATTERN OF PATHOGENS CAUSING VENTILATOR-ASSOCIATED PNEUMONIA IN INTENSIVE CARE UNIT Marsheila Harvy Mustikaningtyas; Bambang Pujo Semedi; Kuntaman Kuntaman
Majalah Biomorfologi Vol. 32 No. 1 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i1.2022.22-28

Abstract

Highlight:1. Antimicrobial resistance bacteria isolated from VAP patients are often associated with high mortality and length of hospital stay. 2. Mortality in VAP patients was 33.3% and the VAP group had a longer hospital stay compared to the non-VAP group. 3. The three most predominant bacteria that were found were A. baumannii, P. aeruginosa, K. pneumoniae. Cefoperazone-sulbactam, meropenem and amikacin were more than 70% sensitive against these bacteria.Abstract:Background: Ventilator-Associated Pneumonia (VAP) is the most common nosocomial infection in Intensive Care Unit (ICU). Antimicrobial resistant bacteria isolated from VAP patients are often associated with high mortality and length of hospital stay. Objective: This study aimed to analyze the pattern and sensitivity among pathogens that caused VAP in ICU. Materials and Methods: The study was conducted retrospectively by extracting the data of bacterial isolates from sputum specimens in the Laboratory of Clinical Microbiology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia and confirming the clinical data on patients suffering from VAP in ICU ward. The study started from January until December 2017. Results: The total 148 pathogens were isolated, 18 of them were diagnosed as VAP, and 130 were not VAP. The most predominant isolates in the VAP group were Acinetobacter baumannii as many as 38 (9%) followed by Pseudomonas aeruginosa 22 (2%), E. coli 16 (7%), and Klebsiella pneumoniae 11 (1%). The pathogens showed a sensitivity rate above 70% to cefoperazone-sulbactam (SCF), meropenem (MEM) and amikacin (AK). Mortality in VAP patients was 33.3% and the VAP group had a longer hospital stay compared to non-VAP group. Conclusion: The three most predominant bacteria that were found were A. baumannii, P. aeruginosa, K. pneumoniae. The pathogens had sensitivity rate above 70% to cefoperazone-sulbactam, meropenem, and amikacin.
Co-Authors Abdul Khairul Rizki Purba Agus Subagjo Agustina Salinding Ahmad Lukman Hakim Airi Mutiar Alivery Raihanada Armando Andre Ferdinand Karema Ardiansyah Arie Utariani Arie Utariani Arifoel Hajat Aryati Aryati Avidar, Yoppie Prim Bambang Herwanto Bambang Purwanto Bambang Purwanto betty Agustina Tambunan, betty Agustina Budiono Budiono Christrijogo Soemartono Waloejo Cornellius Hendra Purnama Aria Sumantrie Eddy Rahardjo Eddy Rahardjo Edwar, Pesta Parulian Maurid Elizeus Hanindito Faizatuz Azzahrah Syamsudi Fajar Perdhana Fajra Arif Hatman Habibah Teniya Ariq Fauziyah Hamzah Hamzah Hanif Hanif Hardiono Hardiono Harida Zahraini Herdiani Sulistyo Putri IG Eka Sugiartha IGAA Putri Sri Rejeki Imam Susilo Inna Maya Sufiyah Khildan Miftahul Firdaus Kuntaman Kuntaman Lila Tri Harjana Lucky Andriyanto Marsha Zahrani Marsheila Harvy Mustikaningtyas Maulydia, Maulydia Mirza Koeshardiandi Muh Kemal Putra Nanang Nurofik Ninik Asmaningsih Soemyarso Nugroho Setia Budi Nurofik, Nanang Philia Setiawan Prananda Surya Airlangga Prihatma Kriswidyatomo Pudji Lestari Purwo Sri Rejeki Puspa Wardhani Puspa Wardhani Puspitasari, Yessy Putu Laksmi Febriyani Rahmat Sayyid Zharfan Rama Azalix Rianda Rehatta, Nancy Margarita Rezki Muhammad Hidayatullah Robby Dwestu Nugroho Samuel Hananiel Rory Sandi Ardiya Rasitullah SATRIYAS ILYAS Soni Sunarso Sulistiawan Sulistiawan, Soni Sunarso Sundari Indah Wiyasihati Teguh Sylvaranto Tri Wahyu Martanto Utariani, Arie Verio Damar Erlantara Putra Vincent Geraldus Enoch Lusida Wahyu Krishna Adjie Arsana Wahyu Mananda Widodo Widodo Yopie Wiguna Zulfikar Loka Wicaksana