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All Journal BioWallacea Journal of Biological Research Jurnal Pengabdian Masyarakat Peternakan As-syifaa Jurnal Farmasi Jurnal Pengabdian Pada Masyarakat JURNAL EDUCATION AND DEVELOPMENT ARSHI Veterinary Letters Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI JURNAL KAJIAN VETERINER Wellness And Healthy Magazine Indonesia Berdaya Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Jurnal Farmasi Sains dan Praktis Jurnal Media Tropika Jurnal Veteriner Nusantara Parapemikir Jurnal Ilmiah Farmasi
Novian, Dede Rival
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Journal : As-syifaa%20Jurnal%20Farmasi

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EKSPLORASI POTENSI ANTI MALARIA SENYAWA BIOAKTIF MORINGA OLEIFERA DENGAN PENDEKATAN IN SILICO Novian, Dede Rival
Jurnal Ilmiah As-Syifaa Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

Malaria is a global human health problem and also a leading cause of death in tropical and subtropical countries. Over the past fifteen years, the prevalence of malaria has decreased by more than half. However, a new problem emerged, namely the emergence of resistance to existing malaria drugs. Therefore, efforts to develop new malaria drugs are needed to combat the malariad disease. Moringa oleifera is one of the important plants that is widely cultivated in NTT. This plant contains many important pharmacological effects such as anti-asthma, antidiabetic, anti-inflammatory, anticancer, antimicrobial, and others. However, the pharmacological effects of MO plants as antimalarials are not yet clearly known. The aim of this study is to use the in silico approach to investigate the potential of the Moringa oleifera compound which functions as a Plasmodium falciparum dihydrofolate reductase-thymidine synthase (pfDHFR-TS) receptor inhihibitor. The research method used is the in silico approach using TCMSP web based application and molecular docking simulation using USCF Chimera. The results of pharmacological tests and molecular docking simulations show that the bioactive pyhtol compound from Moringa oleifera has potential as a new malaria drug compound. Phytol compound has a MW of 296.6; the number of Hdon and Hacc is 1; OB of 33.82%; TPSA of 20.23 and the number of HL is 2.34. While the energy affinity of pyhtol compounds is -6.4 kcal / mol.
Co-Authors Aji Winarso Aji Winarso Aji Winarso Aji Winarso Aji Winarso Arif, Yudabbirul Asrul Asrul Azra Zahrah Nadhirah Ikhwani Chalies Diah Pratiwi Dewi F.L. Djungu Dewi Fesbayati Lestari Djungu Eka Puspitasari Filphin Adolfin Amalo Gaina, Cynthia Dewi heny Nitbani Inggrid Trinidad Maha Inggrid Trinidad Maha Jayusman A. Joesoef Maha, Inggrid Trinidad Meity M Laut Meity Marviana Laut Meity Marviana Laut Natasha Imanuelle Nemay Anggadewi Ndaong Nemay Anggadewi Ndaong Nitbani, Heny Nur Hasanah Tangkonda, Elisabet Turista, Dora Dayu Rahma Yeremia Yobellano Sitompul yudabbirul arif Yudabbirul Arif Yustinus Oswin Primajuni Wuhan