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INDONESIA
Journal of Pharmacopolium
Published by STIKes Bakti Tunas Husada
ISSN : 26208563     EISSN : 26211521     DOI : -
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Other
Arjuna Subject : -
Articles 89 Documents
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STUDY OF DRUG INTERACTION POTENCY ON DIABETES MELLITUS PATIENT’S PRESCRIPTION IN OUTPATIENT GUNUNG JATI HOSPITAL CIREBON CITY Susilo, Rinto
Journal of Pharmacopolium Vol 1, No 2 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases with characteristics of hyperglycemia that occur due to abnormalities in insulin secretion, insulin performance or both. Drug interactions are one of the drug-related problems that can affect patient therapy. The possibility of drug interactions increasing 2.5 times for each drug added to the patients prescription, and in patients with diabetes mellitus is more susceptible to side effects from drug interactions. This study was conducted to find out what the number of potential events of drug interactions, how the severity of drug interactions, and how the type and amount of diabetes mellitus drugs interacted at the Outpatient Gunung Jati Hospital in Cirebon City. This research was conducted with observational design with descriptive analysis method by taking retrospective DM patient prescription data in January 2018. The results showed that from 100 prescriptions stated as a sample, 84 prescriptions (84%) experienced potential drug interactions, and 84 prescriptions there were 425 occurrences of drug interactions, potential drug interactions based on the severity, the number of incidence drug interactions of strict monitor/ significant / moderate were 291 (68.14%), minor were 120 (28.10%), serious were 15 (3.51%) and contra indication were 0 (0%). The results of the study of antidiabetic mellitus drugs that caused the most potential drug interactions, namely metformin, were 115 events. Keywords: Diabetes Mellitus (DM), Drug Interaction Potential, Gunung Jati Hospital Cirebon City.
IDENTIFIKASI TARGET RESEPTOR SENYAWA 10,11-DIHIDROERISODIN SEBAGAI KANDIDAT ANTIKANKER SECARA IN SILICO Endah, Srie Rezeki Nur
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Cancer is one of the most feared diseases and is considered the leading cause of death worldwide. Generally, cancer drugs are synthetic drugs with relatively more expensive prices and have harmful side effects, so many people turn to traditional medicine, for example by utilizing herbal medicine. Erythrina poeppigiana is one of the plants that can be used as a medicinal plant containing 10.11-dihidroerisodin compounds that are useful anticancer etnofarmakologi. The purpose of this study was to identify the target of 10,11 dihydroerisodin receptor compound as an insertiico anticancer candidate. The pure isolate was then tested physicochemically MS, UV-Vis, IR, 13C-NMR, 1H-NMR, to obtain the structure of 10.11-dihydroerisodin alkaloid compound which then to target receptors in silico. From the results of the study it was found that 10.11-dihydroerisodin compound can work on the Serine / threonine-protein kinase Chk1 receptor that serves as an anti-cancer candidate. Keywords : 10,11-dihidroerisodin, anti-cancer, target receptors
ISOLASI SENYAWA AKTIF ANTIOKSIDAN RIMPANG GANDASULI (HEDYCHIUM CORONARIUM) Suhardiman, Aris
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Antioxidants are compounds that can inhibit the formation of free radicals and protect the body from various degenerative diseases and cancer. One of the plants of Zingiberaceae tribe that could potentially be an antioxidant is Hedychium coronarium. This plant grows in several countries in Asia and Africa, has been widely used to treat various diseases. This study aims to isolate the antioxidant active compound from Hedychium coronarium. The sample was extracted by maseration using 96% ethanol. The fractionation was carried out by liquid-liquid extraction using n-hexane and ethyl acetate. The fractionation fraction of ethyl acetate continued with vacuum liquid chromatography (VLC) method. Purification by preparative thin layer chromatography. Purity test was done with single development with three different eluents and two dimensional thin layer chromatography. Identification of isolate using UV-Vis and infrared spectrophotometry. Testing of antioxidant activity of isolate was done qualitatively using DPPH free radical reduction method. Pure isolates were obtained from the fraction number 6 of VLC yields and has antioxidant activity with yellow spot after being sprayed with 0.2% DPPH in metanol. The isolate has a maximum wavelength of 262 nm and 270 nm and the isolate contains O-H, C-H, and C=C groups.
PENGARUH EKSTRAK ETANOL DAUN RAMBUTAN (NAPALEUM LAPPACEUM L.) TERHADAP KADAR LDL DAN HDL PADA TIKUS JANTAN Susilawati, Elis
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

The leaves of the rambutan (Napaleum lappaceum l.) is alleged to have activity as antihiperlipidemia. This research aims to know the activity of ethanol extract of antihiperlipidemia leaves on animal model of rambutan induced with foods high in carbohydrates and fat. Research methodology used in modeling animal experiments as much as 30 white rats Wistar strain males aged 2-3 months and weight 150-220 grams are grouped into 6 groups  , namely the Group of negative control positive control group (Group induction), the standar group (simvastatin 0,9 mg/kgBw) and group test of ethanol extract of rambutan leave with a dose of 17,5, 35 and 70 mg/kgBw. All groups except the negative control induced eating high carbs and fats as food every day for 29 days. The comparison test and extract given every day in per-oral 3 hours after animals induced. The observed parameters i.e. LDL and HDL cholesterol levels specified are enzymatic. From the results of the study showed that ethanol extracts of leaves of herbs against LDL levels and can increase HDL levels at 70 mg/dose KgBB has the same activity with the activity checklist 0.9 mg/dose simvastatin KgBB. It can be concluded that ethanol extracts of leaves of herbs have lower levels of activity in the LDL and increase HDL levels is best with a dose of 70 mg/kgBw.
DETEKSI FORMALIN DALAM MAKANAN DENGAN INDIKATOR ALAMI DARI EKSTRAK BUNGA TELANG (CLITORIA TERNATEA L.) Yuliantini, Anne
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Anthocyanin is a plant dye that can change in the presence of protein. Formalin-containing foods such as fish, chicken, wet noodles, and tofu have proteins that can methylene bond with formalin so that the protein becomes damaged. Anthocyanin color will be change if added to proteins that contain formalin and only protein because proteins are able to change and stabilize anthocyanin color. This study aims to detect the presence of formalin in foods with telang flower extract (Clitoria ternatea L.) which contains high levels of blue anthocyanins. The method used in this study is the result of visual observations assisted by visible spectrophotometer and confirmed by chromatropic acid method. The results showed that the flower extract of telang ethanol was able to detect formalin in food by not showing discoloration when added with telang flower extract which gradually turned into greenish ash while for the negative color results it was stabilized green turkey with a limit of detection of fish, chicken, wet noodles , and know, respectively 1.9654; 1,6987; 2,2514; and 1.5821 mg / g, with a SBR value of 10.845; 9,372; 22,625; and 5.908%. From the results of testing the samples with telang flower extract showed 4 positive samples while the chromatropic acid method 6 positive samples contained formalin.
PREPARASI DAN KARAKTERISASI SELULOSA MIKROKRISTAL DARI NATA DE PINA SEBAGAI BAHAN EKSIPIEN DALAM SEDIAAN TABLET Rum, Ira Adiyati
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Microcrystalline cellulose is one of the excipients of the tablet. So far the pharmaceutical industry uses microcrystalline cellulose from synthetic materials, not much development of microcrystalline cellulose from natural materials. Pineapple fruit with abundant availability in Indonesia can be used as a base material in microcrystalline cellulose manufacturing process, pineapple fruit previously processed first into nata de pina. Pineapple fruit can be used as the basic ingredients of nata because pineapple fruit contains carbohydrates, vitamins and water needed in the process of fermentation of pineapple juice by Acetobacter xylinum bacteria. Objective: To find out whether nata de pina can be used as raw material for microcrystalline cellulose manufacture. Find out the characterization of microcrystalline cellulose from nata de pina and compare it with avicel PH 102 Knowing the characterization of tablets using microcrystalline cellulose nata de pina as excipient material. Methodology: Preparation of nata de pina, evaluation of nata de pina, manufacturing of microcrystalline cellulose nata de pina, evaluation of microcrystalline cellulose nata de pina, optimization of furosemide tablet formulations, evaluation of furosemide tablets, comparison test. Result: Nata de pina can be used as raw material in making microcrystalline cellulose. The SEM test shows the existence of size and shape equation between microcrystalline cellulose nata de pina and avicel PH 102. The formula with the best tablet that is the 2nd formula using microcrystalline cellulose nata de pina of 60%, tablet formula 2 has a break time 5,91 minutes With the amount of dissolved furosemide in the 60th minute of 87.20%. Tablets using microcrystalline cellulose nata de pina as 60% concentrates have faster disintegration time and better dissolution profiles than tablets using avicel PH 102 at the same amount. In the dissolution profile comparison test, tablets using avicel PH 102 had a reduced number of furosemides in the 60th minute ie only 86.56%. This is related to the time destroyed tablets avicel PH 102 is longer that is 8.32 minutes.
PEMANFAATAN TUMBUHAN TESPONG (OENANTHE JAVANICA DC), SINTRONG (CRESSOCEPHALUM CREPIDIOIDES ), DAN POHPOHAN (PILEA TRINERVIA W) DALAM MENGHAMBAT PERTUMBUHAN BAKTERI STAPHYLOCOCCUS EPIDERMIDIS & PSEUDOMONAS AERUGENOSAE Roni, Asep
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Tespong (Oenanthe javanica), sintrong (Crassocephalum crepidioides), and pohpohan (Pilea trinervia) is a type of indigenous vegetables which have antibacterial activity and consumed by Indonesian people, especially people of West Java. The study was conducted to determine the most powerful antibacterial activity among leave extracts of tespong, sintrong, and pohpohan and also to determine the active compound that responsible for inhibiting Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. The extraction was done by maceration method using ethanol 96% solvent. Antibacterial activity test was conducted by microdilution method and using tetracycline as a comparison. The measured parameters was the Minimum Inhibitory Concentration (MIC). The highest antibacterial activity was pohpohan leaf extract with MIC values of 640 mg/mL againts Staphylococcus epidermidis and 1280 mg/mL againts Pseudomonas aeruginosa, as well as n-hexane fraction of pohpohan with MIC 1280 ug/mL inhibit Staphylococcus epidermidis and MIC values of 2560 mg/mL inhibit Pseudomonas aeruginosa. The results of bioautography test of n-hexane fraction showed the content of flavonoid which was suspected as the active antibacterial..
AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT BUAH KACANG KRATOK (PHASEOLUS LUNATUS) DAN KULIT BUAH KACANG GUDE (CAJANUS CAJAN) DENGAN METODE DPPH SERTA PENETAPAN KADAR TOTAL FLAVONOID DAN FENOL Budiana, Wempi
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Free radicals are molecules or atoms that have one or more unpaired electrons. Free radical compounds are very reactive and always try to find an electron pair so that the condition is stable. The presence of free radicals in the body is the cause of various chronic and degenerative diseases. This study aimed to determine the antioxidant activity and total flavonoid content and total phenolics from plant extracts of rind Phaseolus lunatus and Cajanus cajan. Extraction was carried out by using reflux method using solvents in stages, n-hexane, ethyl acetate, and ethanol. Evaluation of antioxidant activity was carried out by TLC and visible UV-Vis spectrophotometry with DPPH method. Determination of total flavonoid content, total phenolics using UV-Vis spectrophotometry. The results of antioxidant activity testing, the total content of flavonoids and phenols showed that ethanol extract of Cajanus cajan rind was the best with IC50 values of 22.07 µg / mL, 2.39 mg QE / 100 mg, 9.83mg GAE / 100 mg. The conclusion was that the ethanol extract of rind of Cajanus cajan had very strong antioxidant activity. 
MODIFIKASI AMILUM GANYONG (CANNA DISCOLOR LINDL) SECARA ENZIMATIS DENGAN BAKTERI LACTOBACILUS ACIDOPHILUS SEBAGAI EKSIPIEN TABLET Azhary, Deny Puriyani
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Canna starch is one type of starch that has potentially to be used as tablet excipient. Natural canna starch has poor flow properties and compressibility. Therefore, canna starch is modified by enzymatically with Lactobacillus acidophilus (lactic acid bacteria) that can produce α-amylase enzyme. The α-amylase enzyme capable of decomposing and altering microscopic structure of starch then can improve the flow properties and starch compressibility. The aim of this research to know the influence of enzymatically modified with Lactobacillus acidophilus bacteria on physical properties of canna starch. Enzymatically modified was conducted by using Lactobacillus acidophilus 3% (b/v) for 72 hours. The results showed that enzymatically modified using Lactobacillus acidophilus bacteria significantly influence the physical properties of canna  starch, change the particle size of starch, improve the flow properties and compressibility  and can be used as tablet excipient 
HUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS ANTIMALARIA SENYAWA TURUNAN QUINOLINE-PYRAZOLOPYRIDINE Mardianingrum, Richa
Journal of Pharmacopolium Vol 1, No 3 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Indonesia one of the high endemic countries of malarial disease, while the use of drugs that are still resistant can spread parasites and cause death. The purpose of this study was to find new antimalarial drug candidates through the Quantitative-Structure and Activity Relationship (QSAR) of quinolin-pyrazolopiridine derivative compounds. QSAR is an important part of drug design in an effort to obtain a new drug with greater activity, higher effectiveness, toxicity or the smallest possible side effects and greater comfort. In reviewing QSAR, it can use the Hansch approach parameter in the form of electronic, lipophilic and steric. From the modeling of 20 quinolin-pyrazolopiridine derivatives the best QSAR equation: Log EC50 = 134,137 + 5,067 (LogP) + 0,036 (ETot) – 5,539 (Polarisibility) – 0,218 (Dipol) + 0,309 (BM) + 0,004 (MTI) + 0,028 (CMA) + 0,227 (VMol) n = 20  r = 0,984   r2 = 0,968  SE = 0,661824

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