cover
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota surakarta,
Jawa tengah
INDONESIA
Indonesian Journal of Medicine
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
Arjuna Subject : -
Articles 290 Documents
Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L. Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.88 KB)

Abstract

Background: Streptozotocin as diabetogenic can damage the pancreatic β cells of animals tried through the oxidative stress process to increase blood sugar levels. Giving ethanolic extract of squash fruit has hypoglycemia effect because it contains flavonoids that act as antioxidants and antihiperglichemia. This study aimed is analyze the effect of ethanol extract of squash fruit to decrease blood sugar level and the change of pancreatic β cell diameter.Subjects and Method: This study was an experimental study with post-randomized controlled group design, using male white mice (Mus musculus L.) DD Webster strains randomized into 4 groups: negative control group, positive control group, group with extract ethanol of 100 mg/ kgBB, and a group of ethanol extract of 200 mg/ kgBW of pumpkin.Results: The results showed a significant reduction in blood sugar levels if compared with the control group. The presence of changes in β pankreas cell diameter on ethanol extract of 100 mg/ kgBB and 200 mg/ kgBB.Conclusion: The conclusion of this study is the extract of ethanol fruit of 200mg/ kgBB squash significantly reduce blood sugar level of mice, the change of β pankreas cell diameter on ethanol extract of 100mg/ kgBB and 200mg/ kgBB.Keywords: streptozotocin, antihipoglikemia, flavonoidCorrespondence: Jekson Martiar Siahaan. Physiology Teaching Staff ofMedicine Faculty, Methodist University of Indonesia Medan, Jl. Setia Budi Pasar 2, Medan 20132, Indonesia.Journal of Medicine (2017), 2(2): 86-93https://doi.org/10.26911/theijmed.2017.02.02.02
miR-21 Expression in Grade I, II, and III Breast Cancer -, Juwita; Ompusunggu, Henny E.S.; Nauphar, Donny; Pardede, Sumondang M.; Lim, Hadyanto; Siregar, Yahwardiah
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.473 KB)

Abstract

Background: Breast cancer is the second largest cancer in the world.The gold standard for breast cancer diagnosis and prognosis is grade assessment (mitotic, nuclear pleiomorphism, tubular formation), based on breast tissue histopathology. However, this assessment has limitation in that it is subjective and semi quantitative. A genetic biomarker known as  microRNA (miRNA) may regulate human gene expression by targetting mRNA. One of the miRNA, i.e. miR-21, is able to suppress tumor suppressor mRNA, resulting in increased cellular proliferation andneoplastic transformation, and decreased apoptosis. This study aimed to investigate the expression of miR-21in breast cancer with histopathologic grade I, II, and III.Subjects and Method: This was a descriptive study with cross-sectional design involving paraffin block (FFPE) samples of ductal-type breast cancer tissue. Sixty four samples were obtained from the department of Anatomical Pathology, Haji Adam Malik Hospital, Medan. Patients history were obtained through medical records followed by sample processing (Total RNA Isolation, cDNA Synthesis, and Examination of miR-21 Expression using Real-Time qPCR). MiR-21 expression from every hystopathologic grade was obtained using Fold Change Calculation.Results: Breast cancer occurred more frequently in age group of 30-49 years old. Based on the histopathologic grade, most breast cancer was found in grade II. Analysis of miR-21 expression showed that miR-21 expression was higher in grade III compared to other grade.Conclusion: Breast cancer occured more frequently in the productive age group.Most breast cancer were found in grade II. Increased miR-21 expression in grade III may suggest that miR-21 is an oncomiR, which plays an important role in the development of malignant breast cancer.Keywords: breast cancer, histopathology grade, miRNA, miR-21.Correspondence: Juwita. Masters Program in Biomedical Sciences, Faculty of Medicine, North SumateraUniversity, Medan. Mobile: 08125262339.Indonesian Journal of Medicine (2016), 1(1): 26-33https://doi.org/10.26911/theijmed.2016.01.01.04
Relationship between Knowledge and Family Support regarding Hypertension with Blood Pressure Control in Elderly Kusumawardana, Iin; Tamtomo, Didik; -, Sugiarto
Indonesian Journal of Medicine Vol 2, No 1 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.598 KB)

Abstract

Background: Hypertension is one of the degenerative diseases that have frequently been found among the group of elderly. If hypertension goes uncontrolled, then it might escalate and cause complication. The level of knowledge for both of patients and their families in terms of preventive actions toward hypertension complication is expected to be able to control blood pressure. Among the hypertension patients, the role of family support is very important in order to maintain and to control that the blood pressure will not increase and to return it to the normal state. In relation to this background, the objective in conducting this study was to analyze the relationship between knowledge and family support regarding hypertension with blood pressure control among the elderly with hypertension in the Sangkrah Center of Public Health, City of Surakarta.Subjects and Method: This was an analytic observational study with cross sectional design. This study was conducted in Sangkrah Community Health Center in the City of Surakarta on November 2016. A total sample of 147 elderly were selected for this study by purposive sampling. The dependent variables in this study was blood pressure and was measured by sphygnomanometer. The independent variables were knowledge and family support and were collected by a set of questionnaire. The data analyzed by logistic regression.Results: Family knowledge (OR= 0.38; 95% CI= 0.13 to 1.08; p= 0.070) increased the likelihood of blood pressure control. Elderly who came from family with good knowledge regarding hypertension had 0.4 times better blood pressure control in comparison to those who came from family with poor knowledge regarding hypertension. Family support (OR= 0.43; 95% CI= 0.18 to 1.02; p= 0.046) increased the likelihood of blood pressure control. Elderly with good family support had 0.4 times better blood pressure than those who had poor family support.Conclusion: Family knowledge and family support increase the probability of blood pressure control among elderly with hypertension.Keywords: knowledge, family support, blood pressure control, elderlyCorrespondence: Iin Kusumawardana. Masters Program in Family Medicine, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: iinkusuma90@gmail.comIndonesian Journal of Medicine (2017), 2(1): 1-9https://doi.org/10.26911/theijmed.2017.02.01.01
Does HBA1C Correlate with Lipid Profile in Type 2 Diabetes Mellitus? A New Evidence from Medan, North Sumatera Julianto, Endy; Silitonga, Hendrika Andriana; Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 3 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.036 KB)

Abstract

Background: Diabetes mellitus (type 2 DM) is now ranked first in health problems and its prevalence tends to increase worldwide. The Diabetes Control and Complication Trial (DCCT) study showed that lowering HbA1c rates may delay or prevent chronic complications. One of the risk factors for CHD in type 2 DM is dyslipidemia, i.e lipid metabolism disorders in the form of elevated total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and decreased levels of high-density lipoprotein (HDL). This study aimed to determine the correlation between HBA1C and blood sugar, as well as the lipid profile in patients with type 2 DM.Subject and Methods: This was an analytic observational study with a cross-sectional design. The study was conducted at the Endocrinology and Metabolic polyclinic Pirngadi Hospital, Medan, North Sumatera, from January to February 2018. A total sample of 10 patients diagnosed with type 2 diabetes mellitus with obesity was selected for this study. The independent variables were blood sugar, lipid profile including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. The dependent variable was the HbA1c level. Lipid profile was measured by blood serum examination. HbA1c level was measured by blood serum examination. The data were analyzed by Pearson correlation.Results: Hba1c was positively correlated with blood sugar levels and was statistically significant (r= 0.81; p= 0.005). HbA1c correlated weakly and was statistically non-significant with total cholesterol (r= 0.14, p= 0.702), LDL (r= 0.15; p= 0.683), HDL (r= 0.04; p= 0.922), and triglycerides (r= 0.06; p= 0.860).Conclusion: HbA1c correlates with blood sugar levels but does not show a correlation with lipid profiles.Keywords: HBA1C, lipid profile, blood sugar, type 2 diabetes mellitusCorrespondence:Endy Julianto. Department of Parasitology, Faculty of Medicine, Methodist University, Medan.Indonesian Journal of Medicine (2017), 2(3): 207-212https://doi.org/10.26911/theijmed.2017.02.03.08
Difference in Anxiety between Left and Right Hemispheric Lesions of Ischemia among Patients with Stroke at Dr. Moewardi Hospital Shofri, M Maulana; Hartanto, O S; Murti, Bhisma
Indonesian Journal of Medicine Vol 1, No 3 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.396 KB)

Abstract

Background: The difference of lesion location and anxiety usually manifests into different signs and symptomps based on the patient’s lesion location. This study aimed to determine the difference in anxiety between left and right hemispheric lesions of ischemia among patients with stroke.Subjects and Method: This was an analytic observational study with cross sectional design. A total sample of 30 patients with stroke consisting of 15 patients with left hemisphere lesion and 15 patients with right hemisphere lesion of ischemia was selected by random sampling. Anxiety was assessed using Hamilton Rating Scale for Anxiety (HRSA) questionnaire. The data were analyzed by multiple linear regression.Results: After controlling for family supports as confounding factor, this study showed significantly lower anxiety in patients with left hemispheric lesion ischemia than patients right hemispheric lesion (b= -2.77; p = 0.039). Family support lessened anxiety among patients with stroke (b=-5.21; p=0.003).Conclusion: Anxiety in stroke patients with left hemispheric lesion of ischemia is lower than stroke patients with right hemispheric lesion.Keywords: anxiety, ischemic stroke, left hemispheric lesion, right hemispheric lesionCorrespondence: M. Maulana Shofri. Faculty of Medicine, Sebelas Maret University, Surakarta.Indonesian Journal of Medicine (2016), 1(3): 146-151https://doi.org/10.26911/theijmed.2016.01.03.01
Comparison of β-Hydroxylase Enzyme 11 Serum in Obese, Overweight, and Normoweight Young Men Sitepu, Jenny Novina; Sari, Mutiara Indah; Tann, Gino
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.887 KB)

Abstract

Background: Previous studies showed that cardiovascular risk factor was increased in obese and overweight subjects. Obesity and cardiovascular risk factor are associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that causes hypercortisolism, cortisol level is associated with cardiovascular risk factor on obesity. 11 β-hydroxylase is an enzyme that involved in cortisol synthesis. The aim of this study was to investigate 11 β-Hydroxylase concentration in obesity, overweight, and normal weight young men.Subjects and Method: This was analytic-observational study using cross-sectional design. The study was conducted at HKBP Nommensen University, Medan. The study subjects included by 76 young men aged 18-28 years old, consisting of 25 obese subjects, 25 overweight, and 25 normoweight. The concentration of 11 β-Hydroxylase was evaluated in blood sample after 10 hours fasting. The data was analyzed bivariately.Results: Mean of 11 β-Hydroxylase concentration was 52.76 ± 44.27 in obese subjects, 70.16 ± 46.83 in overweight subjects, and 43.42 ± 27.75 in normoweight subjects. The 11 β-Hydroxylase concentration in overweight subjects was statistically higher than normoweight subjects (p = 0.007), but the 11 β-Hydroxylase concentration on obese subjects statistically was not different from normoweight subjects (p = 0.362).Conclusion: The 11 β-Hydroxylase concentration on overweight subject is higher than normoweight subject. There is no difference of 11 β-Hydroxylase concentration on obese and normoweight subject. Mitochondrial stress and mitochondrial failure mechanism on overweight and obesity merit further investigation.Keywords: 11 β-Hydroxylase, cortisol, obesity, overweightCorrespondence: Jenny Novina Sitepu. Faculty of Medicine, HKBP Nommensen Medan University, Medan.Indonesian Journal of Medicine (2016), 1(1): 71-75https://doi.org/10.26911/theijmed.2016.01.01.09
Factors Causing Acinetobacter Baumannii Resistance to Carbapenem Antibiotics in Patients with Healthcare Associated Infection (HCAI) at Dr. Moewardi Hospital, Surakarta Primaningtyas, Widana; Pamungkasari, Eti Poncorini; -, Sugiarto
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.688 KB)

Abstract

Background: Acinetobacterbaumannii is a negative gram opportunistic bacteriumhaving high survival ability in the environment. Carbapenem is a drug of choice for infections caused by Acinetobacterbaumannii, which in the last decade prevalence of Carbapenem Resistant Acinetobacterbaumannii (CRAB) has increased. CRAB is commonly found in a nosocomial infection case and even into disease outbreak and epidemics in various hospitals. However, CRAB in community-associated infection data is still limited primarily in Indonesia. Therefore the researchers intend to do study factors causing CRAB in hospital and community setting in patients with Healthcare Associated Infection (HCAI).Subjects and Method: This study was an observational analytic study, with case control design. The study was conducted in RS Dr. Moewardi Surakarta in March-August 2017. Taking subject used fixed disease sampling method with the number of samples were 104 subjects. The dependent variable was the incidence of Acinetobacterbaumannii resistance to carbapenem antibiotics in HCAI patients. Independent variables were history of antibiotic use, patient functional status, intensive unit maintenance and comorbid conditions. Dependent and independent variables were measured by using a questionnairechecklist and then analyzed by using multiple logistic regression analysis.Results: Previous antibiotic conformity history (OR = 0.12; 95% CI = 0.03 to 0.45; p = 0.002) and the patient functional status (OR = 6.72; 95% CI = 2.08 to 21.68; p = 0.001) increased risk of resistance of Acinetobacterbaumannii to carbapenem (CRAB) in Healthcare-Associated Infections (HCAI) patients and was statistically significant. Treatment at intensive unit (OR = 0.76; 95% CI = 0.26 to 2.23; p = 0.613) and comorbid conditions (OR = 0.38; 95% CI = 0.12 to 1.23; p = 0.106) increased risk of Acinetobacterbaumannii resistance to carbapenem (CRAB) in Healthcare Associated Infections (HCAI) patients although it was statistically insignificant.Conclusion:Previous antibiotic conformity history and functional status of patients are a factor affecting Acinetobacterbaumannii resistance to carbapenem (CRAB) in Healthcare-Associated Infections (HCAI) patients.Keyword: Acinetobacterbaumannii, carbapenem, healthcare associated infection.Correspondence: Widana Primaningtyas. Master Program in Public Health, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: widanadoctor@gmail.com Mobile: +6285229035800.Indonesian Journal of Medicine (2017), 2(2): 125-138https://doi.org/10.26911/theijmed.2017.02.02.07
The Effectiveness of Chronic Disease Management Program in Blood Pressure Control among Hypertensive Patients Dyanneza, Frieska; Tamtomo, Didik; -, Sugiarto
Indonesian Journal of Medicine Vol 2, No 1 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.266 KB)

Abstract

Background: The prevention and management of hypertension are major public health challenges for Indonesia and the rest of the world. If the rise in blood pressure with age could be prevented or diminished, much of hypertension, cardiovascular and renal disease, and stroke might be prevented. In Indonesia, the Social Security Administration Agency (BPJS) has administered a government program to control chronic diseases, including hypertension, namely Prolanis (chronic disease management program). This study aimed to determine the effectiveness of chronic disease management program in controlling systolic blood pressure in hypertensive patients.Subjects and Method: This was an analytic observational study with case control design. The study was conducted at Pratama Griya Husada Clinic 2 Tasikmadu, Karanganyar, Central Java, in April 2017. A sample of 120 hypertensive patients, consisting of 60 controlled hypertensive patients and 60 uncontrolled hypertension patients, were selected for this study using fixed disease sampling. The dependent variable was systolic blood pressure. The independent variable was chronic disease management program for systolic blood pressure control, consisting of health status monitoring, reminder, club activity, home visit, dietary education, and physical activity education. Data on diet were collected by Food Frequency Questionnaire (FFQ) based on the DASH eating plan. Physical activity data were collected by short-form International Physical Activity Questionnaire (IPAQ). The other data were collected using questionnaires. Multiple linear regression was used to analyze the data.Results: Blood pressure of hypertensive patients was reduced by chronic disease management program, including monitoring health status (ƅ= -6.34; 95% CI= -12.42 to -0.26; p= 0.041), reminder (b= -6.22; 95% CI = -13.30 to -0.87; p= 0.085), club activity (b= -3.46; 95% CI= -6.40 to -0.53; p= 0.021), home visit (b= -22.01; 95% CI= -41.85 to -2.17; p= 0.030), dietary education (b= -3.61; 95% CI= -6.66 to -0.57; p = 0.020), and physical activity education (b= -0.40; 95% CI= -0.79 to -0.01; p= 0.001).Conclusion: Chronic disease management program is effective to control blood pressure of hypertensive patients. The program’s components including monitoring health status, reminder, club activity, home visit, dietary education, and physical activity education, are effective in reducing blood pressure in hypertensive patients.Keywords: hypertension, chronic disease management programCorrespondence: Frieska Dyanneza. Masters Program in Public Health, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta, Central Java. Email: frieskadyanneza@yahoo.co.id. Mobile: +6285741667850Indonesian Journal of Medicine (2017), 2(1): 52-62https://doi.org/10.26911/theijmed.2016.01.03.06
Effect of Gestational Biological, Social, Economic Factors on Undernutrition in Infants 6-12 Months in Cilacap Septikasari, Majestika; Akhyar, Muhammad; Wiboworini, Budiyanti
Indonesian Journal of Medicine Vol 1, No 3 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.775 KB)

Abstract

Background: Undernutrition in children under five can cause disorder in the physical growth, mental development, low intellegence, or even death. This study aimed to test the hypothesis that under nutrition in infants aged 6-12 months is associated with gestational biological, social, and economic factors.Subjects and Method: This was an analytic and observational study with case control design. This study was conducted in Cilacap, Central Java. A total of 144 infants aged 6-12 months were selected by fixed disease sampling, consisting of 72 undernutrition cases and 72 control. The dependent variable was undernutrition. The independent variables were birthweight, breastfeeding complementary food intake, exclusive breastfeeding, maternal education, paternal education, family income, MUAC at pregnancy, intra-household food allocation, and rural-urban residence. The data were collected by questionnaire and anthropometry. The data were analyzed by multiple logistic regression.Results: Birthweight <2500 gram (OR=8.12; 95% CI=0.92 to 71.64; p=0.059), inadequate intake of breastfeeding complementary food (OR=3.93; 95% CI=1.59 to 9.75; p=0.003), and non-exclusive breastfeeding (OR=2.46; 95% CI=1.13 to 5.36;  p=0.023) increased the risk of undernutrition in infants aged 6-12 months. Paternal education (OR=1.50; 95% CI=0.61 to 3.71; p=0.377), family income (OR=2.54; 95% CI= 1.03 to 6.28; p=0.43), MUAC (OR=1.32; 95% CI=0.512 to 3.38; p=0.562), intra-household food allocation (OR=1.84; 95% CI=0.85 to 4.02; p=0.123), maternal education (OR=0.78; 95% CI=0.31 to 1.97; p=0.599) and rural-urban residence (OR=0.82; 95% CI= 0.36 to 1.85; p=0.630) had non-significant effect on the risk of undernutrition in infants aged 6-12 months.Conclusion: Birthweight <2500 gram, inadequate intake of breastfeeding complementary food, and non-exclusive breastfeeding increase the risk of undernutrition in infants aged 6-12 months. Paternal education, family income, MUAC, intra-household food allocation, maternal education and rural-urban residence have non-significant effect on the risk of undernutrition in infants aged 6-12 months.Keywords: birthweight, gestational, biological, social, economic factors, undernutrition, infants aged 6-12 monthsCorrespondence: Majestika Septikasari. School of Health Al-Irsyad Al-Islamiyyah Cilacap, Central Java. Email: jeaflava@gmail.comIndonesian Journal of Medicine (2016), 1(3): 184-194https://doi.org/10.26911/theijmed.2017.02.01.06
Antimicrobial Activity of Cladosporiumoxysporum Endophytic Fungus Extract Isolated From Aglaiaodorata Lour Sugijanto, Noor Erma; Dorra, Bella Lexmita
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.685 KB)

Abstract

Background: Endophytic fungi have econo­mi­c potential as enzymes, medicines and biological control agents. Cladosporiumoxysporum endophytic fungi can be isolated from a plant named Aglaia­o­dorata Lour (Indonesian: Paca rCina). This plant can be found inPurwodadi Botanical Garden, Pasu­ruan, East Java. This study aimed to assess the antimicrobial activity from the ethyl ace­tate extract of the Cladosporiumoxysporum endophytic fungi against Escherichia coli, Staphylo­coc­cu­saureus, and Candida albicans.Subjects and Method: This was a descriptive study. C. oxysporum was cultivated, extracted, and fractionated. The fractions then were applied to antimicrobial activity assay. Disc diffusion method was used in this project with 2 mg/disc concentration extracts.Results: Some fractions of ethyl acetate extracts C. oxysporum showed anti­mi­cro­bial activity against all microbials tested. 6 of 13 fractions exhibited inhibition zone against S. aureusATCC 6538, E. coli ATCC 8739, and C. albicansATCC 10231. The seventh fraction exhibited the highest inhibition zone against S. aureusATCC 6538, and C.albicans ATCC 10231.The tenth fraction exhibit  ed the highest zone against E. coli ATCC 8739.Conclusion: Cladosporiumo­xysporum from Aglaiaodorata could be a good source of anti­microbial substance.It produces bioactiveagent that can be developed into a new drug at a larger commercial scale.Keywords: endophytic fungi, cladosporiumn oxysporum, aglaiaodorata lour, antimicrobial activityCorrespondence: Noor Erma Sugijanto, Bella Lexmita Dorra. Faculty of Pharmacy, Airlangga University.Indonesian Journal of Medicine (2016), 1(2): 108-115https://doi.org/10.26911/theijmed.2016.01.02.04

Page 1 of 29 | Total Record : 290